The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer
Open accessAbstract
BACKGROUND: Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, and response to interferon alfa in both men and women with the disease. METHODS: We analyzed three independent cohorts that included a total of 455 patients with hepatocellular carcinoma who had undergone radical tumor resection between 1999 and 2003. MicroRNA-expression profiling was performed in a cohort of 241 patients with hepatocellular carcinoma to identify tumor-related microRNAs and determine their association with survival in men and women. In addition, to validate our findings, we used quantitative reverse-transcriptase-polymerase-chain-reaction assays to measure microRNAs and assess their association with survival and response to therapy with interferon alfa in 214 patients from two independent, prospective, randomized, controlled trials of adjuvant interferon therapy. RESULTS: In patients with hepatocellular carcinoma, the expression of miR-26a and miR-26b in nontumor liver tissue was higher in women than in men. Tumors had reduced levels of miR-26 expression, as compared with paired noncancerous tissues, which indicated that the level of miR-26 expression was also associated with hepatocellular carcinoma. Moreover, tumors with reduced miR-26 expression had a distinct transcriptomic pattern, and analyses of gene networks revealed that activation of signaling pathways between nuclear factor kappaB and interleukin-6 might play a role in tumor development. Patients whose tumors had low miR-26 expression had shorter overall survival but a better response to interferon therapy than did patients whose tumors had high expression of the microRNA. CONCLUSIONS: The expression patterns of microRNAs in liver tissue differ between men and women with hepatocellular carcinoma. The miR-26 expression status of such patients is associated with survival and response to adjuvant therapy with interferon alfa.
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Global Cancer Statistics, 2002
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Sorafenib in advanced hepatocellular carcinoma
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MicroRNA expression profiles classify human cancers
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Sorafenib in Advanced Hepatocellular Carcinoma
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Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
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Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
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Self-citationA MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
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Self-citationGender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
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Cited by
EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma
European Association for the Study of the Liver, & European Organisation for Research and Treatment of Cancer (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.001 · Cited by 5,218
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741
MicroRNA profiling: approaches and considerations
Pritchard, C. C., Cheng, H. H., & Tewari, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3198 · Cited by 1,765
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
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Self-citationMicroRNAs in Stress Signaling and Human Disease
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Metadata
- Authors
- Ji, J., Shi, J., Budhu, A., Yu, Z., Forgues, M., Roessler, S., Ambs, S., Chen, Y., Meltzer, P. S., Croce, C. M., Qin, L.-X., Man, K., Lo, C.-M., Lee, J., Ng, I. O. L., Fan, J., Tang, Z.-Y., Sun, H.-C., & Wang, X. W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-10-08
- Volume
- 361
- Issue
- 15
- Pages
- 1437-1447
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2065543285
- Cited by
- 802
- References
- 23
- FWCI
- 23.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ji, J., Shi, J., Budhu, A., Yu, Z., Forgues, M., Roessler, S., Ambs, S., Chen, Y., Meltzer, P. S., Croce, C. M., Qin, L.-X., Man, K., Lo, C.-M., Lee, J., Ng, I. O. L., Fan, J., Tang, Z.-Y., Sun, H.-C., & Wang, X. W. (2009). MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer. New England Journal of Medicine. https://doi.org/10.1056/nejmoa0901282
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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