The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Genetic Variant of the Scavenger Receptor BI in Humans
Open accessAbstract
BACKGROUND: In mice, the scavenger receptor class B type I (SR-BI) is essential for the delivery of high-density lipoprotein (HDL) cholesterol to the liver and steroidogenic organs. Paradoxically, elevated HDL cholesterol levels are associated with increased atherosclerosis in SR-BI-knockout mice. It is unclear what role SR-BI plays in human metabolism. METHODS: We sequenced the gene encoding SR-BI in persons with elevated HDL cholesterol levels and identified a family with a new missense mutation (P297S). The functional effects of the P297S mutation on HDL binding, cellular cholesterol uptake and efflux, atherosclerosis, platelet function, and adrenal function were studied. RESULTS: Cholesterol uptake from HDL by primary murine hepatocytes that expressed mutant SR-BI was reduced to half of that of hepatocytes expressing wild-type SR-BI. Carriers of the P297S mutation had increased HDL cholesterol levels (70.4 mg per deciliter [1.8 mmol per liter], vs. 53.4 mg per deciliter [1.4 mmol per liter] in noncarriers; P<0.001) and a reduced capacity for efflux of cholesterol from macrophages, but the carotid artery intima-media thickness was similar in carriers and in family noncarriers. Platelets from carriers had increased unesterified cholesterol content and impaired function. In carriers, adrenal steroidogenesis was attenuated, as evidenced by decreased urinary excretion of sterol metabolites, a decreased response to corticotropin stimulation, and symptoms of diminished adrenal function. CONCLUSIONS: We identified a family with a functional mutation in SR-BI. The mutation carriers had increased HDL cholesterol levels and a reduction in cholesterol efflux from macrophages but no significant increase in atherosclerosis. Reduced SR-BI function was associated with altered platelet function and decreased adrenal steroidogenesis. (Funded by the European Community and others.).
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“common genetic variants near SCARB1 have been found to be correlated with plasma HDL-C levels (57, 58)”
From The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance (2019) · cites this paper as [58]
In the citing paper
“Only recently, mutations of scavenger receptor (SR-BI) (P279S, P376L) have been described which are associated with both significant increases in HDL-C and increased cardiovascular risk [38–40].”
From HDL cholesterol: reappraisal of its clinical relevance (2017) · cites this paper as [38]
Citations
Cites
A simplified system for generating recombinant adenoviruses
He, T., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., & Vogelstein, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2509 · Cited by 3,209
Effects of torcetrapib in patients at high risk for coronary events
Barter, P. J., Caulfield, M., Eriksson, M., Grundy, S. M., Kastelein, J. J. P., Komajda, M., Lopez-Sendon, J., Mosca, L., Tardif, J.-C., Waters, D. D., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa0706628 · Cited by 3,139
Self-citationMajor lipids, apolipoproteins, and risk of vascular disease
The Emerging Risk Factors Collaboration* (2009) · JAMA · doi:10.1001/jama.2009.1619 · Cited by 2,731
Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Acton, S., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., & Krieger, M. (1996) · Science · doi:10.1126/science.271.5248.518 · Cited by 2,026
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687
Self-citationPrediction of deleterious human alleles
Sunyaev, S. R. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.6.591 · Cited by 1,053
Cholesteryl Ester Transfer Protein
Barter, P. J., Brewer, H. B., Chapman, M. J., Hennekens, C. H., Rader, D. J., & Tall, A. R. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000054658.91146.64 · Cited by 868
Rigotti, A., Trigatti, B. L., Penman, M., Rayburn, H., Herz, J., & Krieger, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12610 · Cited by 860
Scavenger Receptor BI Promotes High Density Lipoprotein-mediated Cellular Cholesterol Efflux
Ji, Y. I., Jian, B., Wang, N., Sun, Y., Moya, M. D. L. L., Phillips, M. C., Rothblat, G. H., Swaney, J. B., & Tall, A. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20982 · Cited by 694
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo
Wang, X., Collins, H. L., Ranalletta, M., Fuki, I. V., Billheimer, J. T., Rothblat, G. H., Tall, A. R., & Rader, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32057 · Cited by 593
Flagged first, then by citations
1 of the 40 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 301–315 of 315
Kontush, A., & Chapman, M. J. (2011) · Wiley eBooks · doi:10.1002/9781118158678.ch4
Lipoprotein and Lipid Metabolism
Hegele, R. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.05568-9
Gaine, S. P., Jones, S. R., & Toth, P. P. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-41192-2_7
Hoekstra, M., Zhang, Z., Lindenburg, P. W., & Eck, M. V. (2024) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2024.13.1.69
Self-citationImpact of Rare and Common Genetic Variants on Lipoprotein Metabolism
Motazacker, M. M., Kastelein, J. J. P., & Kuivenhoven, J. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-28786-9.00006-2
Self-citationROLE OF SCAVENGER RECEPTOR CLASS B TYPE I IN THYMOPOIESIS
Zheng, Z. (2014) · UKnowledge (University of Kentucky)
Low HDL and high HDL syndromes
Yamashita, S., & Matsuzawa, Y. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00305-8
Long-term artificial sweetener exposure increases the risk of atherosclerosis
Xie, J., Song, Z., Fang, W., Zhu, Y., Chao, Y., Wang, S., & Liu, S. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05241-9 · Cited by 1
Delgado, S. E. (2017) · theses.fr (ABES) · doi:10.70675/d8aabbbazd750z4f3cz824czd7ae7217f99a
Hardy, L. M. (2019) · theses.fr (ABES) · doi:10.70675/2f5f4b0dzc92fz4cb4z9c5bzeb6d3fd3e791
Rosso, L. A. G., Botta, E., Pierini, F. S., Martín, M., Sáez, M. S. C., Davico, B., Cerda, O., Citera, G., Gandino, I. J., Rosa, J., et al. (2026) · Journal of clinical lipidology · doi:10.1016/j.jacl.2026.08.018
Lipid signaling and foam cell formation in atherosclerosis and spinal cord injury
Tan, G., Wang, X., Chen, J., Feng, R., Chu, H., Yang, D., Li, J., Yang, M., Li, J., Huang, Y., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101153
Cholesterol Absorption: Mechanisms, Regulation, and Therapeutic Targets
Abdalqadir, N., & Adeli, K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27658-3.00059-7
Metadata
- Authors
- Vergeer, M., Korporaal, S. J. A., Franssen, R., Meurs, I., Out, R., Hovingh, G. K., Hoekstra, M., Sierts, J. A., Dallinga-Thie, G. M., Motazacker, M. M., Holleboom, A. G., Van Berkel, T. J. C., Kastelein, J. J. P., Van Eck, M., & Kuivenhoven, J. A.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Leiden University (NL)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2011-01-13
- Volume
- 364
- Issue
- 2
- Pages
- 136-145
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2077942032
- Cited by
- 317
- References
- 40
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 18 · 2021: 17 · 2020: 14 · 2019: 19 · 2018: 17 · 2017: 29 · 2016: 14 · 2015: 29 · 2014: 34 · 2013: 34 · 2012: 31
- FWCI
- 42.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- scavenger receptor class B type I, HDL cholesterol, high HDL cholesterol, cholesterol absorption, HDL binding, macrophage cholesterol efflux, atherosclerosis, platelet function, adrenal steroidogenesis, familial hypercholesterolemia
- MeSH terms
- Adolescent, Adrenal Insufficiency, Adrenal Glands, Adult, Aged, Aged, 80 and over, Animals, Carotid Arteries, Cholesterol, DNA Mutational Analysis, Female, Heterozygote, Homeostasis, Humans, Hydrocortisone, Cholesterol, HDL, Macrophages, Male, Middle Aged, Pedigree, Triglycerides, Platelet Activation, Mice, Knockout, Mutation, Missense, Atherosclerosis, Scavenger Receptors, Class B, Mice, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
