The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
Tai Chi and Postural Stability in Patients with Parkinson's Disease
Open accessAbstract
BACKGROUND: Patients with Parkinson's disease have substantially impaired balance, leading to diminished functional ability and an increased risk of falling. Although exercise is routinely encouraged by health care providers, few programs have been proven effective. METHODS: We conducted a randomized, controlled trial to determine whether a tailored tai chi program could improve postural control in patients with idiopathic Parkinson's disease. We randomly assigned 195 patients with stage 1 to 4 disease on the Hoehn and Yahr staging scale (which ranges from 1 to 5, with higher stages indicating more severe disease) to one of three groups: tai chi, resistance training, or stretching. The patients participated in 60-minute exercise sessions twice weekly for 24 weeks. The primary outcomes were changes from baseline in the limits-of-stability test (maximum excursion and directional control; range, 0 to 100%). Secondary outcomes included measures of gait and strength, scores on functional-reach and timed up-and-go tests, motor scores on the Unified Parkinson's Disease Rating Scale, and number of falls. RESULTS: The tai chi group performed consistently better than the resistance-training and stretching groups in maximum excursion (between-group difference in the change from baseline, 5.55 percentage points; 95% confidence interval [CI], 1.12 to 9.97; and 11.98 percentage points; 95% CI, 7.21 to 16.74, respectively) and in directional control (10.45 percentage points; 95% CI, 3.89 to 17.00; and 11.38 percentage points; 95% CI, 5.50 to 17.27, respectively). The tai chi group also performed better than the stretching group in all secondary outcomes and outperformed the resistance-training group in stride length and functional reach. Tai chi lowered the incidence of falls as compared with stretching but not as compared with resistance training. The effects of tai chi training were maintained at 3 months after the intervention. No serious adverse events were observed. CONCLUSIONS: Tai chi training appears to reduce balance impairments in patients with mild-to-moderate Parkinson's disease, with additional benefits of improved functional capacity and reduced falls. (Funded by the National Institute of Neurological Disorders and Stroke; ClinicalTrials.gov number, NCT00611481.).
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“Findings from these studies show that, following 24 weeks of twice weekly sessions, Tai Chi leads to improved stride length and maximum excursion as well as reduced falls compared to resistance training or stretching.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [17]
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“These benefits were retained for at least 2 months 17.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [17]
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Fox, S. H., Katzenschlager, R., Lim, S., Barton, B. R., de Bie, R. M. A., Seppi, K., Coelho, M. M., & Sampaio, C. (2018) · Movement Disorders · doi:10.1002/mds.27372 · Cited by 1,009
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798
Su, D., Cui, Y., He, C., Yin, P., Bai, R., Zhu, J., Lam, J. S. T., Zhang, J., Yan, R., Zheng, X., et al. (2025) · BMJ · doi:10.1136/bmj-2024-080952 · Cited by 751
Long-term effects of exercise and physical therapy in people with Parkinson disease
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Metadata
- Authors
- Li, F., Harmer, P., Fitzgerald, K., Eckstrom, E., Stock, R., Galver, J., Maddalozzo, G., & Batya, S. S.
- Affiliations
- Oregon Research Institute (US)
- Willamette University (US)
- Oregon Health & Science University (US)
- Oregon State University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-02-09
- Volume
- 366
- Issue
- 6
- Pages
- 511-519
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3285459
- OpenAlex
- W2150072209
- Cited by
- 890
- References
- 39
- Citations by year
- 2026: 42 · 2025: 54 · 2024: 47 · 2023: 53 · 2022: 63 · 2021: 69 · 2020: 52 · 2019: 67 · 2018: 50 · 2017: 58 · 2016: 62 · 2015: 75 · 2014: 79 · 2013: 81 · 2012: 37
- FWCI
- 216.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS047130, R01NS047130)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Social Sciences › Arts and Humanities › Visual Arts and Performing Arts › Diversity and Impact of Dance
- Keywords
- Tai Chi, Parkinson's disease, postural stability, balance disorders, falls, exercise intervention, resistance training, stretching, limits of stability test, gait, functional reach test, fall prevention
- MeSH terms
- Aged, Postural Balance, Female, Gait, Humans, Male, Parkinson Disease, Outcome Assessment, Health Care, Tai Ji, Muscle Stretching Exercises, Resistance Training
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