The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Colonoscopy versus Fecal Immunochemical Testing in Colorectal-Cancer Screening
Open accessAbstract
BACKGROUND: Colonoscopy and fecal immunochemical testing (FIT) are accepted strategies for colorectal-cancer screening in the average-risk population. METHODS: In this randomized, controlled trial involving asymptomatic adults 50 to 69 years of age, we compared one-time colonoscopy in 26,703 subjects with FIT every 2 years in 26,599 subjects. The primary outcome was the rate of death from colorectal cancer at 10 years. This interim report describes rates of participation, diagnostic findings, and occurrence of major complications at completion of the baseline screening. Study outcomes were analyzed in both intention-to-screen and as-screened populations. RESULTS: The rate of participation was higher in the FIT group than in the colonoscopy group (34.2% vs. 24.6%, P<0.001). Colorectal cancer was found in 30 subjects (0.1%) in the colonoscopy group and 33 subjects (0.1%) in the FIT group (odds ratio, 0.99; 95% confidence interval [CI], 0.61 to 1.64; P=0.99). Advanced adenomas were detected in 514 subjects (1.9%) in the colonoscopy group and 231 subjects (0.9%) in the FIT group (odds ratio, 2.30; 95% CI, 1.97 to 2.69; P<0.001), and nonadvanced adenomas were detected in 1109 subjects (4.2%) in the colonoscopy group and 119 subjects (0.4%) in the FIT group (odds ratio, 9.80; 95% CI, 8.10 to 11.85; P<0.001). CONCLUSIONS: Subjects in the FIT group were more likely to participate in screening than were those in the colonoscopy group. On the baseline screening examination, the numbers of subjects in whom colorectal cancer was detected were similar in the two study groups, but more adenomas were identified in the colonoscopy group. (Funded by Instituto de Salud Carlos III and others; ClinicalTrials.gov number, NCT00906997.).
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
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Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer
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The Effect of Fecal Occult-Blood Screening on the Incidence of Colorectal Cancer
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A Randomized Trial of Aspirin to Prevent Colorectal Adenomas
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Cited by
Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement
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Multitarget Stool DNA Testing for Colorectal-Cancer Screening
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Colorectal cancer screening: a global overview of existing programmes
Schreuders, E. H., Ruco, A., Rabeneck, L., Schoen, R. E., Sung, J. J. Y., Young, G. P., & Kuipers, E. J. (2015) · Gut · doi:10.1136/gutjnl-2014-309086 · Cited by 1,328
Metadata
- Authors
- Quintero, E., Castells, A., Bujanda, L., Cubiella, J., Salas, D., Lanas, Á., Andreu, M., Carballo, F., Morillas, J. D., Hernández, C., Jover, R., Montalvo, I., Arenas, J., Laredo, E., Hernández, V., Iglesias, F., Cid, E., Zubizarreta, R., Sala, T., Ponce, M., Andrés, M., Teruel, G., Peris, A., Roncales, M.-P., Polo-Tomás, M., Bessa, X., Ferrer-Armengou, O., Grau, J., Serradesanferm, A., Ono, A., Cruzado, J., Pérez-Riquelme, F., Alonso-Abreu, I., de la Vega-Prieto, M., Reyes-Melian, J. M., Cacho, G., Díaz-Tasende, J., Herreros-de-Tejada, A., Poves, C., Santander, C., & González-Navarro, A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-02-23
- Volume
- 366
- Issue
- 8
- Pages
- 697-706
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2118256990
- Cited by
- 916
- References
- 37
- FWCI
- 38.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Quintero, E., Castells, A., Bujanda, L., Cubiella, J., Salas, D., Lanas, Á., Andreu, M., Carballo, F., Morillas, J. D., Hernández, C., Jover, R., Montalvo, I., Arenas, J., Laredo, E., Hernández, V., Iglesias, F., Cid, E., Zubizarreta, R., Sala, T., . . . González-Navarro, A. (2012). Colonoscopy versus Fecal Immunochemical Testing in Colorectal-Cancer Screening. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1108895
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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