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The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis

Open access
Cooper, Christopher J., Murphy, Timothy P., Cutlip, Donald E., Jamerson, Kenneth, Henrich, William, Reid, Diane M., Cohen, David J., Matsumoto, Alan H., Steffes, Michael, Jaff, Michael R., Prince, Martin R., Lewis, Eldrin F., Tuttle, Katherine R., Shapiro, Joseph I., Rundback, John H., Massaro, Joseph M., D'Agostino, Ralph B., Dworkin, Lance D.·2014·New England Journal of Medicine

Abstract

BACKGROUND: Atherosclerotic renal-artery stenosis is a common problem in the elderly. Despite two randomized trials that did not show a benefit of renal-artery stenting with respect to kidney function, the usefulness of stenting for the prevention of major adverse renal and cardiovascular events is uncertain. METHODS: We randomly assigned 947 participants who had atherosclerotic renal-artery stenosis and either systolic hypertension while taking two or more antihypertensive drugs or chronic kidney disease to medical therapy plus renal-artery stenting or medical therapy alone. Participants were followed for the occurrence of adverse cardiovascular and renal events (a composite end point of death from cardiovascular or renal causes, myocardial infarction, stroke, hospitalization for congestive heart failure, progressive renal insufficiency, or the need for renal-replacement therapy). RESULTS: Over a median follow-up period of 43 months (interquartile range, 31 to 55), the rate of the primary composite end point did not differ significantly between participants who underwent stenting in addition to receiving medical therapy and those who received medical therapy alone (35.1% and 35.8%, respectively; hazard ratio with stenting, 0.94; 95% confidence interval [CI], 0.76 to 1.17; P=0.58). There were also no significant differences between the treatment groups in the rates of the individual components of the primary end point or in all-cause mortality. During follow-up, there was a consistent modest difference in systolic blood pressure favoring the stent group (-2.3 mm Hg; 95% CI, -4.4 to -0.2; P=0.03). CONCLUSIONS: Renal-artery stenting did not confer a significant benefit with respect to the prevention of clinical events when added to comprehensive, multifactorial medical therapy in people with atherosclerotic renal-artery stenosis and hypertension or chronic kidney disease. (Funded by the National Heart, Lung and Blood Institute and others; ClinicalTrials.gov number, NCT00081731.).

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Research works printed but not linked: 3

  1. 10.1097/00041552-199711000-00014 · doi:10.1097/00041552-199711000-00014
  2. 10.1161/01.CIR.102.14.1671 · doi:10.1161/01.cir.102.14.1671
  3. 10.1177/1358863X11419998 · doi:10.1177/1358863x11419998

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Metadata

Authors
Cooper, C. J., Murphy, T. P., Cutlip, D. E., Jamerson, K., Henrich, W., Reid, D. M., Cohen, D. J., Matsumoto, A. H., Steffes, M., Jaff, M. R., Prince, M. R., Lewis, E. F., Tuttle, K. R., Shapiro, J. I., Rundback, J. H., Massaro, J. M., D'Agostino, R. B., & Dworkin, L. D.
Venue
New England Journal of Medicine
Published
2014-01-02
Volume
370
Issue
1
Pages
13-22
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2148367988
Cited by
1,021
References
28
FWCI
83.55
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis. https://app.cochat.ai/papers/10.1056/nejmoa1310753
The paper
Cooper, C. J., Murphy, T. P., Cutlip, D. E., Jamerson, K., Henrich, W., Reid, D. M., Cohen, D. J., Matsumoto, A. H., Steffes, M., Jaff, M. R., Prince, M. R., Lewis, E. F., Tuttle, K. R., Shapiro, J. I., Rundback, J. H., Massaro, J. M., D'Agostino, R. B., & Dworkin, L. D. (2014). Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1310753

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.