The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Liberal or Restrictive Transfusion after Cardiac Surgery
Open accessAbstract
BACKGROUND: Whether a restrictive threshold for hemoglobin level in red-cell transfusions, as compared with a liberal threshold, reduces postoperative morbidity and health care costs after cardiac surgery is uncertain. METHODS: We conducted a multicenter, parallel-group trial in which patients older than 16 years of age who were undergoing nonemergency cardiac surgery were recruited from 17 centers in the United Kingdom. Patients with a postoperative hemoglobin level of less than 9 g per deciliter were randomly assigned to a restrictive transfusion threshold (hemoglobin level <7.5 g per deciliter) or a liberal transfusion threshold (hemoglobin level <9 g per deciliter). The primary outcome was a serious infection (sepsis or wound infection) or an ischemic event (permanent stroke [confirmation on brain imaging and deficit in motor, sensory, or coordination functions], myocardial infarction, infarction of the gut, or acute kidney injury) within 3 months after randomization. Health care costs, excluding the index surgery, were estimated from the day of surgery to 3 months after surgery. RESULTS: A total of 2007 patients underwent randomization; 4 participants withdrew, leaving 1000 in the restrictive-threshold group and 1003 in the liberal-threshold group. Transfusion rates after randomization were 53.4% and 92.2% in the two groups, respectively. The primary outcome occurred in 35.1% of the patients in the restrictive-threshold group and 33.0% of the patients in the liberal-threshold group (odds ratio, 1.11; 95% confidence interval [CI], 0.91 to 1.34; P=0.30); there was no indication of heterogeneity according to subgroup. There were more deaths in the restrictive-threshold group than in the liberal-threshold group (4.2% vs. 2.6%; hazard ratio, 1.64; 95% CI, 1.00 to 2.67; P=0.045). Serious postoperative complications, excluding primary-outcome events, occurred in 35.7% of participants in the restrictive-threshold group and 34.2% of participants in the liberal-threshold group. Total costs did not differ significantly between the groups. CONCLUSIONS: A restrictive transfusion threshold after cardiac surgery was not superior to a liberal threshold with respect to morbidity or health care costs. (Funded by the National Institute for Health Research Health Technology Assessment program; Current Controlled Trials number, ISRCTN70923932.).
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Cites
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
Mehta, R. L., Kellum, J. A., Shah, S. V., Molitoris, B. A., Ronco, C., Warnock, D. G., Levin, A., & the Acute Kidney Injury Network (2007) · Critical Care · doi:10.1186/cc5713 · Cited by 7,048
Guidelines on the management of valvular heart disease (version 2012)
Authors/Task Force Members, Vahanian, A., Alfieri, O., Andreotti, F., Antunes, M. J., Barón-Esquivias, G., Baumgartner, H., Borger, M. A., Carrel, T. P., De Bonis, M., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs109 · Cited by 3,559
Developed with the special contribution of the European Association for Percutaneous Cardiovascular Interventions (EAPCI), Authors/Task Force Members, Wijns, W., Kolh, P., Danchin, N., Di Mario, C., Falk, V., Folliguet, T., Garg, S., Huber, K., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq277 · Cited by 3,184
Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
Villanueva, C., Colomo, A., Bosch, A., Concepción, M., Hernandez-Gea, V., Aracil, C., Graupera, I., Poca, M., Alvarez-Urturi, C., Gordillo, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211801 · Cited by 1,735
Murphy, G. J., Reeves, B. C., Rogers, C. A., Rizvi, S. I. A., Culliford, L., & Angelini, G. D. (2007) · Circulation · doi:10.1161/circulationaha.107.698977 · Cited by 1,371
Self-citationLiberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery
Carson, J. L., Terrin, M. L., Noveck, H., Sanders, D. W., Chaitman, B. R., Rhoads, G. G., Nemo, G., Dragert, K., Beaupre, L., Hildebrand, K., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1012452 · Cited by 1,328
Ferraris, V. A., Brown, J. R., Despotis, G. J., Hammon, J. W., Reece, T. B., Saha, S. P., Song, H. K., Clough, E. R., Shore-Lesserson, L. J., Goodnough, L. T., et al. (2011) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2010.11.078 · Cited by 1,289
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion
Carson, J. L., Stanworth, S. J., Roubinian, N., Fergusson, D. A., Triulzi, D., Doree, C., & Hebert, P. C. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002042.pub4 · Cited by 1,250
Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB*
Carson, J. L., Grossman, B. J., Kleinman, S., Tinmouth, A. T., Marques, M. B., Fung, M. K., Holcomb, J. B., Illoh, O., Kaplan, L. J., Katz, L. M., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-1-201206190-00429 · Cited by 1,084
Cited by
Roffi, M., Patrono, C., Collet, J.-P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv320 · Cited by 8,261
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion
Carson, J. L., Stanworth, S. J., Roubinian, N., Fergusson, D. A., Triulzi, D., Doree, C., & Hebert, P. C. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002042.pub4 · Cited by 1,250
Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference
Mueller, M. M., Van Remoortel, H., Meybohm, P., Aranko, K., Aubron, C., Burger, R., Carson, J. L., Cichutek, K., De Buck, E., Devine, D., et al. (2019) · JAMA · doi:10.1001/jama.2019.0554 · Cited by 632
2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery
Boer, C., Meesters, M. I., Milojevic, M., Benedetto, U., Bolliger, D., von Heymann, C., Jeppsson, A., Koster, A., Osnabrugge, R. L., Ranucci, M., et al. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2017.06.026 · Cited by 466
Red Blood Cell Transfusion: 2023 AABB International Guidelines
Carson, J. L., Stanworth, S. J., Guyatt, G., Valentine, S., Dennis, J., Bakhtary, S., Cohn, C. S., Dubon, A., Grossman, B. J., Gupta, G. K., et al. (2023) · JAMA · doi:10.1001/jama.2023.12914 · Cited by 435
Metadata
- Authors
- Murphy, G. J., Pike, K., Rogers, C. A., Wordsworth, S., Stokes, E. A., Angelini, G. D., & Reeves, B. C.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-03-12
- Volume
- 372
- Issue
- 11
- Pages
- 997-1008
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2125178621
- Cited by
- 787
- References
- 35
- FWCI
- 70.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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