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Cited by 285

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Chimpanzee Adenovirus Vector Ebola Vaccine

Open access
Ledgerwood, Julie E., DeZure, Adam D., Stanley, Daphne A., Coates, Emily E., Novik, Laura, Enama, Mary E., Berkowitz, Nina M., Hu, Zonghui, Joshi, Gyan, Ploquin, Aurélie, Sitar, Sandra, Gordon, Ingelise J., Plummer, Sarah A., Holman, LaSonji A., Hendel, Cynthia S., Yamshchikov, Galina, Roman, Francois, Nicosia, Alfredo, Colloca, Stefano, Cortese, Riccardo, Bailer, Robert T., Schwartz, Richard M., Roederer, Mario, Mascola, John R., Koup, Richard A., Sullivan, Nancy J., Graham, Barney S.·2017·New England Journal of Medicine
DOI 10.1056/nejmoa1410863
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Abstract

BACKGROUND: The unprecedented 2014 epidemic of Ebola virus disease (EVD) prompted an international response to accelerate the availability of a preventive vaccine. A replication-defective recombinant chimpanzee adenovirus type 3-vectored ebolavirus vaccine (cAd3-EBO), encoding the glycoprotein from Zaire and Sudan species, that offers protection in the nonhuman primate model, was rapidly advanced into phase 1 clinical evaluation. METHODS: particle units. Primary and secondary end points related to safety and immunogenicity were assessed throughout the first 8 weeks after vaccination; in addition, longer-term vaccine durability was assessed at 48 weeks after vaccination. RESULTS: particle-unit dose. CONCLUSIONS: particle-unit dose, glycoprotein Zaire-specific antibody responses were in the range reported to be associated with vaccine-induced protective immunity in challenge studies involving nonhuman primates, and responses were sustained to week 48. Phase 2 studies and efficacy trials assessing cAd3-EBO are in progress. (Funded by the Intramural Research Program of the National Institutes of Health; VRC 207 ClinicalTrials.gov number, NCT02231866 .).

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Research works printed but not linked: 22

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Metadata

Authors
Ledgerwood, J. E., DeZure, A. D., Stanley, D. A., Coates, E. E., Novik, L., Enama, M. E., Berkowitz, N. M., Hu, Z., Joshi, G., Ploquin, A., Sitar, S., Gordon, I. J., Plummer, S. A., Holman, L. A., Hendel, C. S., Yamshchikov, G., Roman, F., Nicosia, A., Colloca, S., Cortese, R., Bailer, R. T., Schwartz, R. M., Roederer, M., Mascola, J. R., Koup, R. A., Sullivan, N. J., & Graham, B. S.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2017-03-09
Volume
376
Issue
10
Pages
928-938
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa1410863
OpenAlex
W2155802193
Cited by
285
References
3
FWCI
24.01
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Chimpanzee Adenovirus Vector Ebola Vaccine. https://app.cochat.ai/papers/10.1056/nejmoa1410863
The paper
Ledgerwood, J. E., DeZure, A. D., Stanley, D. A., Coates, E. E., Novik, L., Enama, M. E., Berkowitz, N. M., Hu, Z., Joshi, G., Ploquin, A., Sitar, S., Gordon, I. J., Plummer, S. A., Holman, L. A., Hendel, C. S., Yamshchikov, G., Roman, F., Nicosia, A., Colloca, S., . . . Graham, B. S. (2017). Chimpanzee Adenovirus Vector Ebola Vaccine. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1410863

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.