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A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas
Open accessAbstract
BACKGROUND: Epidemiologic and preclinical data suggest that higher intake and serum levels of vitamin D and higher intake of calcium reduce the risk of colorectal neoplasia. To further study the chemopreventive potential of these nutrients, we conducted a randomized, double-blind, placebo-controlled trial of supplementation with vitamin D, calcium, or both for the prevention of colorectal adenomas. METHODS: We recruited patients with recently diagnosed adenomas and no known colorectal polyps remaining after complete colonoscopy. We randomly assigned 2259 participants to receive daily vitamin D3 (1000 IU), calcium as carbonate (1200 mg), both, or neither in a partial 2×2 factorial design. Women could elect to receive calcium plus random assignment to vitamin D or placebo. Follow-up colonoscopy was anticipated to be performed 3 or 5 years after the baseline examinations, according to the endoscopist's recommendation. The primary end point was adenomas diagnosed in the interval from randomization through the anticipated surveillance colonoscopy. RESULTS: Participants who were randomly assigned to receive vitamin D had a mean net increase in serum 25-hydroxyvitamin D levels of 7.83 ng per milliliter, relative to participants given placebo. Overall, 43% of participants had one or more adenomas diagnosed during follow-up. The adjusted risk ratios for recurrent adenomas were 0.99 (95% confidence interval [CI], 0.89 to 1.09) with vitamin D versus no vitamin D, 0.95 (95% CI, 0.85 to 1.06) with calcium versus no calcium, and 0.93 (95% CI, 0.80 to 1.08) with both agents versus neither agent. The findings for advanced adenomas were similar. There were few serious adverse events. CONCLUSIONS: Daily supplementation with vitamin D3 (1000 IU), calcium (1200 mg), or both after removal of colorectal adenomas did not significantly reduce the risk of recurrent colorectal adenomas over a period of 3 to 5 years. (Funded by the National Cancer Institute; ClinicalTrials.gov number, NCT00153816.).
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“Deciding how to balance external and internal validity is a challenge for many trials 52, but is particularly salient for trials of DHI.”
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“However, there are real questions as to how well approaches developed to reduce bias in drug trials translate to trials of complex interventions in general 52 and to digital interventions in particular, including concerns about the degree to which design features that enhance internal validity jeopardise external validity.”
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Cites
Norman, A. W. (1979) · Cited by 3,769
Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
Lappe, J. M., Travers‐Gustafson, D., Davies, K. M., Recker, R. R., & Heaney, R. P. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1586 · Cited by 1,445
The role of vitamin D in reducing cancer risk and progression
Feldman, D., Krishnan, A. V., Swami, S., Giovannucci, E. L., & Feldman, B. J. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3691 · Cited by 1,351
Trivedi, D. P., Doll, R., & Khaw, K. (2003) · BMJ · doi:10.1136/bmj.326.7387.469 · Cited by 1,273
Bolland, M. J., Avenell, A., Baron, J. A., Grey, A., MacLennan, G. S., Gamble, G. D., & Reid, I. R. (2010) · BMJ · doi:10.1136/bmj.c3691 · Cited by 1,099
Self-citationCalcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer
Wactawski‐Wende, J., Kotchen, J. M., Anderson, G. L., Assaf, A. R., Brunner, R. L., O’Sullivan, M. J., Margolis, K. L., Ockene, J. K., Phillips, L. S., Pottern, L. M., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055222 · Cited by 980
Calcium Supplements for the Prevention of Colorectal Adenomas
Baron, J. A., Beach, M. A., Mandel, J. S., van Stolk, R. U., Haile, R. W., Sandler, R. S., Rothstein, R. I., Summers, R. W., Snover, D. C., Beck, G. J., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400204 · Cited by 865
Self-citationGandini, S., Boniol, M., Haukka, J. K., Byrnes, G. B., Cox, B., Sneyd, M. J., Mullie, P., & Autier, P. (2010) · International Journal of Cancer · doi:10.1002/ijc.25439 · Cited by 504
Bonithon‐Kopp, C., Kronborg, O., Giacosa, A., Räth, U., & Faivre, J. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02813-0 · Cited by 475
Chung, M., Lee, J., Terasawa, T., Lau, J., & Trikalinos, T. A. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-12-201112200-00005 · Cited by 421
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Research works printed but not linked: 2
- Brown AJ, 1999, Am J Physiol, 277, F157
- Institute of Medicine Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D and fluoride. Washington, DC: National Academies Press, 1997.
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Camacho, P. M., Petak, S. M., Binkley, N., Diab, D. L., Eldeiry, L. S., Farooki, A., Harris, S. T., Hurley, D. L., Kelly, J., Lewiecki, E. M., et al. (2020) · Endocrine Practice · doi:10.4158/gl-2020-0524suppl · Cited by 1,182
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions
Bouillon, R., Marcocci, C., Carmeliet, G., Bikle, D. D., White, J. H., Dawson-Hughes, B. F., Lips, P. T. A. M., Munns, C. F., Lazaretti‐Castro, M., Giustina, A., et al. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00126 · Cited by 1,257
Camacho, P. M., Petak, S. M., Binkley, N., Clarke, B. L., Harris, S. T., Hurley, D. L., Kleerekoper, M., Lewiecki, E. M., Miller, P. D., Narula, H. S., et al. (2016) · Endocrine Practice · doi:10.4158/ep161435.esgl · Cited by 1,140
Evaluating Digital Health Interventions
Murray, E., Hekler, E. B., Andersson, G., Collins, L. M., Doherty, A., Hollis, C., Rivera, D. E., West, R., & Wyatt, J. C. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2016.06.008 · Cited by 847
American Cancer Society guideline for diet and physical activity for cancer prevention
Rock, C. L., Thomson, C., Gansler, T., Gapstur, S. M., McCullough, M. L., Patel, A. V., Andrews, K. S., Bandera, E. V., Spees, C. K., Robien, K., et al. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21591 · Cited by 789
Vitamin D for the prevention of disease: An Endocrine Society clinical practice guideline
Demay, M. B., Pittas, A. G., Bikle, D. D., Diab, D. L., Kiely, M. E., Lazaretti-Castro, M., Lips, P., Mitchell, D. M., Murad, M. H., Powers, S., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae290 · Cited by 639
Camacho, P. M., Petak, S. M., Binkley, N., Clarke, B. L., Harris, S. T., Hurley, D. L., Kleerekoper, M., Lewiecki, E. M., Miller, P. D., Narula, H. S., et al. (2016) · Endocrine Practice · doi:10.4158/ep161435.gl · Cited by 491
Gupta, S. N., Lieberman, D. A., Anderson, J. C., Burke, C. A., Dominitz, J. A., Kaltenbach, T. R., Robertson, D. J., Shaukat, A., Syngal, S., & Rex, D. K. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.10.026 · Cited by 482
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Barbarawi, M., Kheiri, B., Zayed, Y., Barbarawi, O., Dhillon, H., Swaid, B., Yelangi, A., Sundus, S., Bachuwa, G. I., Alkotob, M. L., et al. (2019) · JAMA Cardiology · doi:10.1001/jamacardio.2019.1870 · Cited by 377
Association between vitamin D supplementation and mortality: systematic review and meta-analysis
Zhang, Y., Fang, F., Tang, J., Jia, L., Feng, Y., Xu, P., & Faramand, A. M. (2019) · BMJ · doi:10.1136/bmj.l4673 · Cited by 402
Keum, N., Lee, D. H., Greenwood, D. C., Manson, J. E., & Giovannucci, E. L. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz059 · Cited by 363
Gupta, S., Lieberman, D., Anderson, J. C., Burke, C. A., Dominitz, J. A., Kaltenbach, T., Robertson, D. J., Shaukat, A., Syngal, S., & Rex, D. K. (2020) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000544 · Cited by 343
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Self-citationAutier, P., Mullie, P., Macacu, A., Dragomir, M., Boniol, M., Coppens, K., Pizot, C., & Boniol, M. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30357-1 · Cited by 322
Controversies in Vitamin D: Summary Statement From an International Conference
Giustina, A., Adler, R. A., Binkley, N., Bouillon, R., Ebeling, P. R., Lazaretti‐Castro, M., Marcocci, C., Rizzoli, R., Sempos, C. T., & Bilezikian, J. P. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01414 · Cited by 291
Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts
McCullough, M. L., Zoltick, E. S., Weinstein, S. J., Fedirko, V., Wang, M., Cook, N. R., Eliassen, A. H., Zeleniuch‐Jacquotte, A., Agnoli, C., Albanes, D., et al. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy087 · Cited by 281
Dietary supplements and disease prevention — a global overview
Rautiainen, S., Manson, J. E., Lichtenstein, A. H., & Sesso, H. D. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.54 · Cited by 252
Lactose Intolerance, Dairy Avoidance, and Treatment Options
Szilagyi, A., & Ishayek, N. (2018) · Nutrients · doi:10.3390/nu10121994 · Cited by 271
Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women
Lappe, J. M., Watson, P. A., Travers‐Gustafson, D., Recker, R. R., Garland, C. F., Gorham, E. D., Baggerly, K., & McDonnell, S. L. (2017) · JAMA · doi:10.1001/jama.2017.2115 · Cited by 246
The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management
Fletcher, J. M., Cooper, S. C., Ghosh, S. K., & Hewison, M. (2019) · Nutrients · doi:10.3390/nu11051019 · Cited by 230
Chen, Y., Gao, Q., Zou, T., Wang, B., Liu, S., Sheng, J., Ren, J., Zou, X., Liu, Z., Song, Y., et al. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30409-1 · Cited by 210
Dai, Q., Zhu, X., Manson, J. E., Song, Y., Li, X., Franke, A. A., Costello, R. B., Rosanoff, A., Nian, H., Fan, L., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy274 · Cited by 199
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González, N., Prieto, I., del Puerto‐Nevado, L., Portal‐Núñez, S., Ardura, J. A., Cortón, M., Fernández‐Fernández, B., Aguilera, Ó., Gómez‐Guerrero, C., Mas, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14472 · Cited by 177
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Malihi, Z. A., Wu, Z., Stewart, A. W., Lawes, C. M. M., & Scragg, R. K. R. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.134981 · Cited by 154
O’Connor, E. A., Evans, C. V., Ivlev, I., Rushkin, M. C., Thomas, R. G., Martin, A., & Lin, J. S. (2022) · JAMA · doi:10.1001/jama.2021.15650 · Cited by 151
Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence
Dou, R., Ng, K., Giovannucci, E. L., Manson, J. E., Qian, Z. R., & Ogino, S. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516000696 · Cited by 153
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Wei, J., Suriawinata, A. A., Vaickus, L. J., Ren, B., Liu, X., Lisovsky, M., Tomita, N., Abdollahi, B., Kim, A. S., Snover, D. C., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.3398 · Cited by 112
Self-citationVaughan-Shaw, P., Buijs, L., Blackmur, J., Theodoratou, E., Zgaga, L., Din, F., Farrington, S., & Dunlop, M. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01060-8 · Cited by 91
Dulai, P. S., Singh, S., Marquez, E. O., Khera, R., Prokop, L. J., Limburg, P. J., Gupta, S. N., & Murad, M. H. (2016) · BMJ · doi:10.1136/bmj.i6188 · Cited by 92
Davenport, J. R., Su, T., Zhao, Z., Coleman, H. G., Smalley, W. E., Ness, R. M., Zheng, W., & Shrubsole, M. J. (2016) · Gut · doi:10.1136/gutjnl-2016-312893 · Cited by 92
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Barry, E. L., Peacock, J. L., Rees, J. R., Bostick, R. M., Robertson, D. J., Bresalier, R. S., & Baron, J. A. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5917 · Cited by 90
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Umezawa, S., Higurashi, T., Komiya, Y., Arimoto, J., Horita, N., Kaneko, T., Iwasaki, M., Nakagama, H., & Nakajima, A. (2019) · Cancer Science · doi:10.1111/cas.14149 · Cited by 91
Anderson, J. C., Baron, J. A., Ahnen, D. J., Barry, E. L., Bostick, R. M., Burke, C. A., Bresalier, R. S., Church, T. R., Cole, B. F., Cruz–Correa, M., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.02.010 · Cited by 88
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Self-citationKuznia, S., Zhu, A., Akutsu, T., Buring, J. E., Camargo, C. A., Cook, N. R., Chen, L., Cheng, T. D., Hantunen, S., Lee, I.-M. M., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101923 · Cited by 80
He, Y., Timofeeva, M. N., Farrington, S. M., Vaughan-Shaw, P. G., Svinti, V., Walker, M., Zgaga, L., Meng, X., Li, X., Spiliopoulou, A., et al. (2018) · BMC Medicine · doi:10.1186/s12916-018-1119-2 · Cited by 78
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Kong, S. H., Jang, H. N., Kim, J. H., Kim, S. W., & Shin, C. S. (2022) · Endocrinology and Metabolism · doi:10.3803/enm.2021.1374 · Cited by 72
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Cianferotti, L., Bertoldo, F., Bischoff-Ferrari, H. A., Bruyère, O., Cooper, C. C., Cutolo, M., Kanis, J. А., Kaufman, J., Reginster, J., Rizzoli, R., et al. (2017) · Endocrine · doi:10.1007/s12020-017-1290-9 · Cited by 72
Crockett, S. D., Barry, E. L., Mott, L. A., Ahnen, D. J., Robertson, D. J., Anderson, J. C., Wallace, K., Burke, C. A., Bresalier, R. S., Figueiredo, J. C., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315242 · Cited by 72
Self-citationZhang, X., Keum, N., Wu, K., Smith‐Warner, S. A., Ogino, S., Chan, A. T., Fuchs, C. S., & Giovannucci, E. L. (2016) · International Journal of Cancer · doi:10.1002/ijc.30293 · Cited by 68
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Wesselink, E., Kok, D. E. G., Bours, M. J. L., de Wilt, J. H. W., van Baar, H., van Zutphen, M., Geijsen, A. J. M. R., Keulen, E. T. P., Hansson, B. M. E., van den Ouweland, J., et al. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa049 · Cited by 59
Yang, W., Liu, L., Masugi, Y., Qian, Z. R., Nishihara, R., Keum, N., Wu, K., Smith‐Warner, S. A., Ma, Y., Nowak, J. A., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-314163 · Cited by 60
Vleugels, J. L. A., Hassan, C., Senore, C., Cassoni, P., Baron, J. A., Rex, D. K., Ponugoti, P. L., Pellisé, M., Parejo, S., Bessa, X., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.10.050 · Cited by 58
Self-citationHuang, D., Lei, S., Wu, Y., Weng, M., Zhou, Y., Xu, J., Xia, D., Xu, E., Lai, M., & Zhang, H. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.11.012 · Cited by 58
Ruiz‐García, A., Pallarés‐Carratalá, V., Turégano-Yedro, M., Torres, F., Sapena, V., Martín-Gorgojo, A., & Martin-Moreno, J. M. (2023) · Nutrients · doi:10.3390/nu15081810 · Cited by 53
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Toporcov, T. N., & Filho, V. W. (2018) · Clinics · doi:10.6061/clinics/2018/e627s · Cited by 57
Fedirko, V., Mandle, H. B., Zhu, W., Hughes, D. J., Siddiq, A., Ferrari, P., Romieu, I., Ríboli, E., Bueno-de-Mesquita, B. H., van Duijnhoven, F., et al. (2019) · Nutrients · doi:10.3390/nu11081954 · Cited by 50
Bonovas, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i18.4594 · Cited by 51
López-Caleya, J. F., Ortega-Valín, L., Fernández‐Villa, T., Delgado‐Rodríguez, M., Martín, V., & Molina, A. J. (2021) · Cancer Causes & Control · doi:10.1007/s10552-021-01512-3 · Cited by 48
Hoepner, R., Bagnoud, M., Pistor, M., Salmen, A., Briner, M., Synn, H., Schrewe, L., Guse, K., Ahmadi, F., Demir, S., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02018-8 · Cited by 47
Mandle, H. B., Jahan, F. A., Bostick, R. M., Baron, J. A., Barry, E. L., Yacoub, R., Merrill, J., Rutherford, R. E., Seabrook, M. E., & Fedirko, V. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.23010 · Cited by 45
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Song, M., Lee, I.-M. M., Manson, J. E., Buring, J. E., Dushkes, R., Gordon, D., Walter, J. N., Wu, K., Chan, A. T., Ogino, S., et al. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.02.013 · Cited by 45
Zhang, R., Zhang, Y., Liu, Z., Pei, Y., Xu, P., Chong, W., Hai, Y., He, L., He, Y., Yu, J., et al. (2022) · Cancers · doi:10.3390/cancers14153717 · Cited by 50
Yang, B., Campbell, P. T., Gapstur, S. M., Jacobs, E. J., Bostick, R. M., Fedirko, V., Flanders, W. D., & McCullough, M. L. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.117994 · Cited by 47
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Niedermaier, T., Gredner, T., Kuznia, S., Schöttker, B., Mons, U., & Brenner, H. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12924 · Cited by 44
Stucci, L. S., D’Oronzo, S., Tucci, M., Macerollo, A., Ribero, S., Spagnolo, F., Marra, E., Picasso, V., Orgiano, L., Marconcini, R., et al. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.05.016 · Cited by 41
Stokes, C. S., Lammert, F., & Volmer, D. A. (2018) · Anticancer Research · doi:10.21873/anticanres.12332 · Cited by 40
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Na, S., Kim, K. B., Lim, Y. J., & Song, H. J. (2022) · Journal of Cancer Prevention · doi:10.15430/jcp.2022.27.3.147 · Cited by 39
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Hull, M. A. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120000051 · Cited by 43
Larsson, S. C., Mason, A. M., Kar, S., Vithayathil, M. K., Carter, P., Baron, J. A., Michaëlsson, K., & Burgess, S. (2020) · BMC Medicine · doi:10.1186/s12916-020-01839-9 · Cited by 39
Self-citationGibbs, D. C., Fedirko, V., Baron, J. A., Barry, E. L., Flanders, W. D., McCullough, M. L., Yacoub, R., Raavi, T., Rutherford, R. E., Seabrook, M. E., et al. (2020) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0140 · Cited by 38
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Yang, W., Ma, Y., Smith‐Warner, S. A., Song, M., Wu, K., Wang, M., Chan, A. T., Ogino, S., Fuchs, C. S., Poylin, V. Y., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2965 · Cited by 39
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Guo, Z., Huang, M. X., Fan, D., Yuan, H., Zhao, M., Ding, R., Cheng, Y., & Duan, S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2056574 · Cited by 37
Ponda, M. P., Liang, Y., Kim, J., Hutt, R., Dowd, K., Gilleaudeau, P., Sullivan-Whalen, M. M., Rodrick, T. C., Kim, D. J., Barash, I., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.150367 · Cited by 37
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Haykal, T., Samji, V., Zayed, Y., Gakhal, I., Dhillon, H., Kheiri, B., Kerbage, J., Veerapaneni, V., Obeid, M., Danish, R., et al. (2019) · Journal of Community Hospital Internal Medicine Perspectives · doi:10.1080/20009666.2019.1701839 · Cited by 35
Vo, H. V. T., Nguyen, Y. T., Kim, N., & Lee, H. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242317038 · Cited by 37
Massironi, S., Zilli, A., Bernasconi, S., Fanetti, I., Cavalcoli, F., Ciafardini, C., Felicetta, I., & Conte, D. (2017) · Neuroendocrinology · doi:10.1159/000456619 · Cited by 34
Bolland, M. J., Grey, A. B., & Avenell, A. (2018) · BMC Medical Research Methodology · doi:10.1186/s12874-018-0555-1 · Cited by 35
Pei, Y., Zhang, Y., Peng, X., Liu, Z., Xu, P., & Fang, F. (2022) · Nutrients · doi:10.3390/nu14153158 · Cited by 35
Sasso, A., & Latella, G. (2017) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2017.1393503 · Cited by 34
Calderwood, A. H., Baron, J. A., Mott, L. A., Ahnen, D. J., Bostick, R. M., Figueiredo, J. C., Passarelli, M. N., Rees, J. R., Robertson, D. J., & Barry, E. L. (2019) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-19-0023 · Cited by 33
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Marcinkowska, E., Wallace, G. R., & Brown, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050729 · Cited by 33
Zhang, X., & Niu, W. (2019) · Bioscience Reports · doi:10.1042/bsr20190369 · Cited by 32
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Grant, W. B., Boucher, B. J., Cheng, R. Z., Płudowski, P., & Wimalawansa, S. J. (2025) · Nutrients · doi:10.3390/nu17132102 · Cited by 30
Frankling, M. H., Klasson, C., Sandberg, C., Nordström, M., Warnqvist, A., Bergqvist, J., Bergman, P., & Björkhem‐Bergman, L. (2021) · Cancers · doi:10.3390/cancers13153707 · Cited by 30
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Cummings, S. R., Kiel, D. P., & Black, D. M. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.7568 · Cited by 33
Metadata
- Authors
- Baron, J. A., Barry, E. L., Mott, L. A., Rees, J. R., Sandler, R. S., Snover, D. C., Bostick, R. M., Ivanova, A., Cole, B. F., Ahnen, D. J., Beck, G. J., Bresalier, R. S., Burke, C. A., Church, T. R., Cruz-Correa, M., Figueiredo, J. C., Goodman, M., Kim, A. S., Robertson, D. J., Rothstein, R., Shaukat, A., Seabrook, M. E., & Summers, R. W.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Fairview Southdale Hospital (US)
- Emory University (US)
- University of Vermont (US)
- Cleveland Clinic (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Minnesota (US)
- University of Southern California (US)
- MNGI Digestive Health (US)
- Dartmouth–Hitchcock Medical Center (US)
- University of Iowa (US)
- ORCID
- Baron, John A.
- Barry, Elizabeth L.
- Mott, Leila A.
- Rees, Judy R.
- Sandler, Robert S.
- Snover, Dale C.
- Bostick, Roberd M.
- Ivanova, Anastasia
- Cole, Bernard F.
- Ahnen, Dennis J.
- Beck, Gerald J.
- Bresalier, Robert S.
- Burke, Carol A.
- Church, Timothy R.
- Figueiredo, Jane C.
- Goodman, Michael
- Kim, Adam S.
- Robertson, Douglas J.
- Shaukat, Aasma
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-10-15
- Volume
- 373
- Issue
- 16
- Pages
- 1519-1530
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4643064
- OpenAlex
- W2259846353
- Cited by
- 315
- References
- 26
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 15 · 2023: 26 · 2022: 29 · 2021: 32 · 2020: 29 · 2019: 39 · 2018: 36 · 2017: 33 · 2016: 49 · 2015: 3
- FWCI
- 32.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA098286, CA098286, P30CA023108)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056338)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- colorectal adenoma, vitamin D3 supplementation, calcium supplementation, chemoprevention, recurrent adenoma, advanced adenoma, serum 25-hydroxyvitamin D, colorectal neoplasia, surveillance colonoscopy
- MeSH terms
- Adenoma, Aged, Calcium, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Risk, Vitamin D, Vitamins, Colorectal Neoplasms, Treatment Failure, Dietary Supplements
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