Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
Zinman, Bernard, Wanner, Christoph, Lachin, John M., Fitchett, David, Bluhmki, Erich, Hantel, Stefan, Mattheus, Michaela, Devins, Theresa +4 more·2015·New England Journal of Medicine
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- Sodium–glucose cotransporter 2 inhibitor‐induced changes in body composition and simultaneous changes in metabolic profile: 52‐week prospective LIGHT (Luseogliflozin: the Components of Weight Loss in Japanese Patients with Type 2 Diabetes Mellitus) StudyTakashi Sasaki, Masahiro Sugawara, Masahiro Fukuda · 2018 · Journal of Diabetes Investigation
- The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathwayZiyu Meng, Xiaohuan Liu, Ting Li, Ting Fang, Ying Cheng, Liping Han, Bei Sun, Liming Chen · 2021 · International Immunopharmacology
- Effects of canagliflozin on human myocardial redox signalling: clinical implicationsHidekazu Kondo, Ioannis Akoumianakis, Ileana Badi, Nadia A. Akawi, Christos P. Kotanidis, Murray Polkinghorne, Ilaria Stadiotti, Elena Sommariva, Alexios S. Antonopoulos, Maria Cristina Carena et al. · 2021 · European Heart Journal
- Cardiovascular Benefits of Empagliflozin Are Associated With Gut Microbiota and Plasma Metabolites in Type 2 DiabetesXinru Deng, Chenhong Zhang, Pengxu Wang, Wei Wei, Xiaoyang Shi, Pingping Wang, Junpeng Yang, Limin Wang, Shasha Tang, Yuanyuan Fang et al. · 2022 · The Journal of Clinical Endocrinology & Metabolism
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- Assessment of Cardiac Energy Metabolism, Function, and Physiology in Patients With Heart Failure Taking Empagliflozin: The Randomized, Controlled EMPA-VISION TrialMoritz Hundertmark, Amanda Adler, Charalambos A. Antoniades, Ruth L. Coleman, Julian Leether Griffin, Rury R. Holman, Hanan Lamlum, Jisoo Lee, Daniel Massey, Jack J. J. J. Miller et al. · 2023 · Circulation
- Effects of liraglutide on cardiovascular outcomes in patients with diabetes with or without heart failureMarso, Steven P., Baeres, Florian M.M., Bain, Stephen C., Goldman, Bryan, Husain, Mansoor, Nauck, Michael A., Poulter, Neil R., Pratley, Richard E., Thomsen, Anne Bloch, Buse, John B. · 2020 · Journal of the American College of Cardiology
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- Sodium‐glucose co‐transporter‐2 inhibitors and diabetic ketoacidosis:
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n updated review of the literatureBonora, Benedetta Maria, Avogaro, Angelo, Fadini, Gian Paolo · 2018 · Diabetes, Obesity and Metabolism
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- Changing use of antidiabetic drugs in the UK: trends in prescribing 2000–2017Samantha Wilkinson, Ian Douglas, Heide A. Stirnadel-Farrant, Damian G. Fogarty, Ana Pokrajac, Liam L Smeeth, Laurie A. Tomlinson · 2018 · BMJ Open
- Carbotoxicity—Noxious Effects of CarbohydratesGuido Kroemer, Carlos López-Otı́n, Frank Madeo, Rafael de Cabo · 2018 · Cell
- Sodium glucose cotransporter 2 inhibitors and risk of major adverse cardiovascular events: multi-database retrospective cohort studyKristian B. Filion, Lisa Marie Lix, Oriana HY Yu, Sophie Dell’Aniello, Antonios Douros, Baiju R. Shah, Audray St-Jean, Anat Fisher, Éric Tremblay, Shawn Bugden et al. · 2020 · BMJ
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- Increases in circulating levels of ketone bodies and cardiovascular protection with SGLT2 inhibitors: Is low‐grade inflammation the neglected component?Francesco Prattichizzo, Valeria De Nigris, Stefano Micheloni, Lucia La Sala, Antonio Ceriello · 2018 · Diabetes Obesity and Metabolism
- SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefitsElisa Marilly, Judith Cottin, Natalia Cabrera, Catherine Cornu, Rémy Boussageon, Philippe Moulin, Jean‐Christophe Lega, François Gueyffier, Michel Cucherat, Guillaume Grenet · 2022 · Diabetologia
- Cardiometabolic-Based Chronic Disease, Addressing Knowledge and Clinical Practice GapsMechanick, Jeffrey I., Farkouh, Michael E., Newman, Jonathan D., Garvey, W. Timothy · 2020 · Journal of the American College of Cardiology
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- Metabolic Support for the Heart: Complementary Therapy for Heart Failure?Ward Heggermont, Anna‐Pia Papageorgiou, Stephane R B Heymans, Marc van Bilsen · 2016 · European Journal of Heart Failure
- A model-based meta-analysis of 24 antihyperglycemic drugs for type 2 diabetes: comparison of treatment effects at therapeutic dosesMaloney, Alan, Rosenstock, Julio, Fonseca, Vivian · 2019 · Clinical Pharmacology & Therapeutics
- A Randomized Trial of Empagliflozin to Increase Plasma Sodium Levels in Patients with the Syndrome of Inappropriate AntidiuresisJulie Celine Refardt, Cornelia Imber, Clara Odilia Sailer, Nica Jeanloz, Laura Potasso, Alexander Kutz, Andrea Widmer, Sandrine Andrea Urwyler, Fahim Ebrahimi, D. Vogt et al. · 2020 · Journal of the American Society of Nephrology
- Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogrammingYue-Ming Gao, Songtao Feng, Yi Wen, Tao‐Tao Tang, Bin Wang, Bi‐Cheng Liu · 2022 · EBioMedicine
- Exploring the Complex Connection Between Diabetes and Cardiovascular Disease: Analyzing Approaches to Mitigate Cardiovascular Risk in Patients With DiabetesFNU Jyotsna, Areeba Ahmed, Kamal Kumar, Paramjeet Kaur, Mitul Hareshkumar Chaudhary, Sagar Kumar, Ejaz Ahmad Khan, Bushra Khanam, Syeda Urooba Shah, Giustino Varrassi et al. · 2023 · Cureus
- The Prognostic Value of Fasting Plasma Glucose, Two-Hour Postload Glucose, and HbA1c in Patients With Coronary Artery Disease: A Report From EUROASPIRE IVShahim, Bahira, De Bacquer, Dirk, De Backer, Guy, Gyberg, Viveca, Kotseva, Kornelia, Mellbin, Linda, Schnell, Oliver, Tuomilehto, Jaakko, Wood, David, Rydén, Lars · 2017 · Diabetes Care
- Gender difference in cardiovascular outcomes with SGLT-2 inhibitors and GLP-1 receptor agonist in type 2 diabetes: a systematic review and meta-analysis of cardio-vascular outcome trialsSingh, Awadhesh Kumar, Singh, Ritu · 2020 · Diabetes & Metabolic Syndrome: Clinical Research & Reviews
- Empagliflozin, via Switching Metabolism Toward Lipid Utilization, Moderately Increases LDL Cholesterol Levels Through Reduced LDL CatabolismFrançois Briand, Eric Mayoux, Emmanuel Brousseau, Noémie Burr, Isabelle Urbain, Clément Costard, Michael Mark, Thierry Sulpice · 2016 · Diabetes
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- Update on heart failure management and future directionsHong‐Mi Choi, Myung‐Soo Park, Jong‐Chan Youn · 2018 · The Korean Journal of Internal Medicine
- Empagliflozin attenuates transient cerebral ischemia/reperfusion injury in hyperglycemic rats via repressing oxidative–inflammatory–apoptotic pathwayEntesar Farghaly Amin, Rehab Ahmed Rifaai, Rania Abdellatif · 2020 · Fundamental and Clinical Pharmacology
- Improving exercise capacity and quality of life using non‐invasive heart failure treatments: evidence from clinical trialsStephan von Haehling, Michael E. Arzt, Wolfram Doehner, Frank Edelmann, Ruben Evertz, Nicole Ebner, Christoph Herrmann‐Lingen, Tania Garfias‐Veitl, Michael Johann Koziolek, Michel Noutsias et al. · 2020 · European Journal of Heart Failure
- Cardiovascular benefits of SGLT2 inhibitors and GLP-1 receptor agonists through effects on mitochondrial function and oxidative stressLuna-Marco, Clara, Iannantuoni, Francesca, Hermo-Argibay, Alberto, Devos, Deédeni, Salazar, Juan D., Víctor, Víctor M., Rovira-Llopis, Susana · 2024 · Free Radical Biology and Medicine
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- Association of Second-line Antidiabetic Medications With Cardiovascular Events Among Insured Adults With Type 2 DiabetesMatthew James O’Brien, Susan Karam, Amisha Wallia, Raymond H. Kang, Andrew Cooper, Nicola Lancki, Margaret R. Moran, David T. Liss, Theodore A. Prospect, Ronald T. Ackermann · 2018 · JAMA Network Open
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- Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes AtherosclerosisLaurienne Edgar, Naveed Akbar, Adam T. Braithwaite, Thomas Krausgruber, Héctor Gallart‐Ayala, Jade D. Bailey, Alastair Corbin, Tariq E. Khoyratty, Joshua T. Chai, Mohammad Alkhalil et al. · 2021 · Informationszentrum Lebenswissenschaften (ZB MED)
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