The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Trial of Continuous or Interrupted Chest Compressions during CPR
Open accessAbstract
BACKGROUND: During cardiopulmonary resuscitation (CPR) in patients with out-of-hospital cardiac arrest, the interruption of manual chest compressions for rescue breathing reduces blood flow and possibly survival. We assessed whether outcomes after continuous compressions with positive-pressure ventilation differed from those after compressions that were interrupted for ventilations at a ratio of 30 compressions to two ventilations. METHODS: This cluster-randomized trial with crossover included 114 emergency medical service (EMS) agencies. Adults with non-trauma-related cardiac arrest who were treated by EMS providers received continuous chest compressions (intervention group) or interrupted chest compressions (control group). The primary outcome was the rate of survival to hospital discharge. Secondary outcomes included the modified Rankin scale score (on a scale from 0 to 6, with a score of ≤3 indicating favorable neurologic function). CPR process was measured to assess compliance. RESULTS: Of 23,711 patients included in the primary analysis, 12,653 were assigned to the intervention group and 11,058 to the control group. A total of 1129 of 12,613 patients with available data (9.0%) in the intervention group and 1072 of 11,035 with available data (9.7%) in the control group survived until discharge (difference, -0.7 percentage points; 95% confidence interval [CI], -1.5 to 0.1; P=0.07); 7.0% of the patients in the intervention group and 7.7% of those in the control group survived with favorable neurologic function at discharge (difference, -0.6 percentage points; 95% CI, -1.4 to 0.1, P=0.09). Hospital-free survival was significantly shorter in the intervention group than in the control group (mean difference, -0.2 days; 95% CI, -0.3 to -0.1; P=0.004). CONCLUSIONS: In patients with out-of-hospital cardiac arrest, continuous chest compressions during CPR performed by EMS providers did not result in significantly higher rates of survival or favorable neurologic function than did interrupted chest compressions. (Funded by the National Heart, Lung, and Blood Institute and others; ROC CCC ClinicalTrials.gov number, NCT01372748.).
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Cites
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Maximum Likelihood Estimation of Misspecified Models
White, H. (1982) · Econometrica · doi:10.2307/1912526 · Cited by 4,098
Maximum Likelihood Estimation of Misspecified Models
White, H. (1983) · Econometrica · doi:10.2307/1912004 · Cited by 3,674
Kleinman, M. E., Chameides, L., Schexnayder, S. M., Samson, R. A., Hazinski, M. F., Atkins, D. L., Berg, M. D., de Caen, A. R., Fink, E. L., Freid, E. B., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.971101 · Cited by 1,949
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Self-citationQuality of Cardiopulmonary Resuscitation During Out-of-Hospital Cardiac Arrest
Wik, L. (2005) · JAMA · doi:10.1001/jama.293.3.299 · Cited by 1,538
Kilgannon, J. H. (2010) · JAMA · doi:10.1001/jama.2010.707 · Cited by 873
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Panchal, A. R., Bartos, J. A., Cabañas, J. G., Donnino, M. W., Drennan, I. R., Hirsch, K. G., Kudenchuk, P. J., Kurz, M. C., Lavonas, E. J., Morley, P. T., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000916 · Cited by 2,105
Self-citationTopjian, A. A., Raymond, T. T., Atkins, D., Chan, M., Duff, J. P., Joyner, B. L., Lasa, J. J., Lavonas, E. J., Levy, A., Mahgoub, M., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000901 · Cited by 1,258
European Resuscitation Council Guidelines 2021: Basic Life Support
Olasveengen, T. M., Semeraro, F., Ristagno, G., Castren, M., Handley, A., Kuzovlev, A., Monsieurs, K. G., Raffay, V., Smyth, M., Soar, J., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.02.009 · Cited by 734
Soar, J., Berg, K. M., Andersen, L. W., Böttiger, B. W., Cacciola, S., Callaway, C. W., Couper, K., Cronberg, T., D’Arrigo, S., Deakin, C. D., et al. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.09.012 · Cited by 616
Self-citationAmiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Kudenchuk, P. J., Brown, S. P., Daya, M., Rea, T., Nichol, G., Morrison, L. J., Leroux, B., Vaillancourt, C., Wittwer, L., Callaway, C. W., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1514204 · Cited by 477
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Metadata
- Authors
- Nichol, G., Leroux, B., Wang, H., Callaway, C. W., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L. J., Aufderheide, T. P., Cheskes, S., Christenson, J., Kudenchuk, P., Vaillancourt, C., Rea, T. D., Idris, A. H., Colella, R., Isaacs, M., Straight, R., Stephens, S., Richardson, J., Condle, J., Schmicker, R. H., Egan, D., May, S., & Ornato, J. P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-12-03
- Volume
- 373
- Issue
- 23
- Pages
- 2203-2214
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2178502634
- Cited by
- 299
- References
- 32
- FWCI
- 35.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nichol, G., Leroux, B., Wang, H., Callaway, C. W., Sopko, G., Weisfeldt, M., Stiell, I., Morrison, L. J., Aufderheide, T. P., Cheskes, S., Christenson, J., Kudenchuk, P., Vaillancourt, C., Rea, T. D., Idris, A. H., Colella, R., Isaacs, M., Straight, R., Stephens, S., . . . Ornato, J. P. (2015). Trial of Continuous or Interrupted Chest Compressions during CPR. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1509139
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