The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Association Between Arterial Hyperoxia Following Resuscitation From Cardiac Arrest and In-Hospital Mortality
Abstract
CONTEXT: Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking. OBJECTIVE: To test the hypothesis that postresuscitation hyperoxia is associated with increased mortality. DESIGN, SETTING, AND PATIENTS: Multicenter cohort study using the Project IMPACT critical care database of intensive care units (ICUs) at 120 US hospitals between 2001 and 2005. Patient inclusion criteria were age older than 17 years, nontraumatic cardiac arrest, cardiopulmonary resuscitation within 24 hours prior to ICU arrival, and arterial blood gas analysis performed within 24 hours following ICU arrival. Patients were divided into 3 groups defined a priori based on PaO(2) on the first arterial blood gas values obtained in the ICU. Hyperoxia was defined as PaO(2) of 300 mm Hg or greater; hypoxia, PaO(2) of less than 60 mm Hg (or ratio of PaO(2) to fraction of inspired oxygen <300); and normoxia, not classified as hyperoxia or hypoxia. MAIN OUTCOME MEASURE: In-hospital mortality. RESULTS: Of 6326 patients, 1156 had hyperoxia (18%), 3999 had hypoxia (63%), and 1171 had normoxia (19%). The hyperoxia group had significantly higher in-hospital mortality (732/1156 [63%; 95% confidence interval {CI}, 60%-66%]) compared with the normoxia group (532/1171 [45%; 95% CI, 43%-48%]; proportion difference, 18% [95% CI, 14%-22%]) and the hypoxia group (2297/3999 [57%; 95% CI, 56%-59%]; proportion difference, 6% [95% CI, 3%-9%]). In a model controlling for potential confounders (eg, age, preadmission functional status, comorbid conditions, vital signs, and other physiological indices), hyperoxia exposure had an odds ratio for death of 1.8 (95% CI, 1.5-2.2). CONCLUSION: Among patients admitted to the ICU following resuscitation from cardiac arrest, arterial hyperoxia was independently associated with increased in-hospital mortality compared with either hypoxia or normoxia.
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Citations
Cites
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
Bernard, S. A., Gray, T. W., Buist, M. D., Jones, B. M., Silvester, W., Gutteridge, G., & Smith, K. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa003289 · Cited by 5,401
Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012689 · Cited by 5,220
Jacobs, I., Nadkarni, V., the ILCOR Task Force on Cardiac Arrest and Cardiopulmonary Resuscitation Outcomes, PARTICIPANTS, C., Bahr, J., Berg, R. A., Billi, J. E., Bossaert, L., Cassan, P., Coovadia, A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000147236.85306.15 · Cited by 2,560
Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication
Nolan, J. P., Neumar, R. W., Adrie, C., Aibiki, M., Berg, R. A., Böttiger, B. W., Callaway, C., Clark, R. S. B., Geocadin, R. G., Jauch, E. C., et al. (2008) · Resuscitation · doi:10.1016/j.resuscitation.2008.09.017 · Cited by 1,499
Neumar, R. W., Nolan, J. P., Adrie, C., Aibiki, M., Berg, R. A., Böttiger, B. W., Callaway, C., Clark, R. S. B., Geocadin, R. G., Jauch, E. C., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.190652 · Cited by 1,436
Peberdy, M. A., Kaye, W., Ornato, J. P., Larkin, G. L., Nadkarni, V., Mancini, M. E., Berg, R. A., Nichol, G., & Lane-Trultt, T. (2003) · Resuscitation · doi:10.1016/s0300-9572(03)00215-6 · Cited by 1,242
(2005) · Circulation · doi:10.1161/circulationaha.105.166550 · Cited by 1,000
Advanced Cardiac Life Support in Out-of-Hospital Cardiac Arrest
Stiell, I. G., Wells, G. A., Field, B., Spaite, D. W., Nesbitt, L. P., De Maio, V. J., Nichol, G., Cousineau, D., Blackburn, J., Munkley, D., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040325 · Cited by 835
New concepts in reactive oxygen species and cardiovascular reperfusion physiology
Becker, L. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.025 · Cited by 704
HESS, M., & MANSON, N. (1984) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(84)80011-5 · Cited by 540
Cited by
Conservative Oxygen Therapy during Mechanical Ventilation in the ICU
The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1903297 · Cited by 511
Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest
Kilgannon, J. H., Jones, A. E., Parrillo, J. E., Dellinger, R. P., Milcarek, B., Hunter, K., Shapiro, N. I., & Trzeciak, S. (2011) · Circulation · doi:10.1161/circulationaha.110.001016 · Cited by 320
Self-citationOut-of-hospital cardiac arrest: prehospital management
Ong, M. E. H., Perkins, G. D., & Cariou, A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30316-7 · Cited by 226
Bench-to-bedside review: the effects of hyperoxia during critical illness
Helmerhorst, H. J. F., Schultz, M. J., van der Voort, P. H. J., de Jonge, E., & van Westerloo, D. J. (2015) · Critical Care · doi:10.1186/s13054-015-0996-4 · Cited by 187
Crowley, P., Stuttgen, V., O'Carroll, E., Ash, S., Buggy, D., & Gallagher, H. (2017) · Medical Gas Research · doi:10.4103/2045-9912.222446 · Cited by 7
Metadata
- Authors
- Kilgannon, J. H.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2010-06-02
- Volume
- 303
- Issue
- 21
- Pages
- 2165
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2163104804
- Cited by
- 873
- References
- 24
- FWCI
- 64.70
- Type
- journal article
- Language
- en
- Open access
- closed
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