Cited by 1,763Cardiac pacing and defibrillation studiesCardiac Arrest and ResuscitationHeart Failure Treatment and Management

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Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure

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Køber, Lars, Thune, Jens J., Nielsen, Jens C., Haarbo, Jens, Videbæk, Lars, Korup, Eva, Jensen, Gunnar, Hildebrandt, Per, Steffensen, Flemming H., Bruun, Niels E., Eiskjær, Hans, Brandes, Axel, Thøgersen, Anna M., Gustafsson, Finn, Egstrup, Kenneth, Videbæk, Regitze, Hassager, Christian, Svendsen, Jesper H., Høfsten, Dan E., Torp-Pedersen, Christian, Pehrson, Steen·2016·New England Journal of Medicine

DOI 10.1056/nejmoa1608029

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Abstract

BACKGROUND: The benefit of an implantable cardioverter-defibrillator (ICD) in patients with symptomatic systolic heart failure caused by coronary artery disease has been well documented. However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failure that is not due to coronary artery disease has been based primarily on subgroup analyses. The management of heart failure has improved since the landmark ICD trials, and many patients now receive cardiac resynchronization therapy (CRT). METHODS: In a randomized, controlled trial, 556 patients with symptomatic systolic heart failure (left ventricular ejection fraction, ≤35%) not caused by coronary artery disease were assigned to receive an ICD, and 560 patients were assigned to receive usual clinical care (control group). In both groups, 58% of the patients received CRT. The primary outcome of the trial was death from any cause. The secondary outcomes were sudden cardiac death and cardiovascular death. RESULTS: After a median follow-up period of 67.6 months, the primary outcome had occurred in 120 patients (21.6%) in the ICD group and in 131 patients (23.4%) in the control group (hazard ratio, 0.87; 95% confidence interval [CI], 0.68 to 1.12; P=0.28). Sudden cardiac death occurred in 24 patients (4.3%) in the ICD group and in 46 patients (8.2%) in the control group (hazard ratio, 0.50; 95% CI, 0.31 to 0.82; P=0.005). Device infection occurred in 27 patients (4.9%) in the ICD group and in 20 patients (3.6%) in the control group (P=0.29). CONCLUSIONS: In this trial, prophylactic ICD implantation in patients with symptomatic systolic heart failure not caused by coronary artery disease was not associated with a significantly lower long-term rate of death from any cause than was usual clinical care. (Funded by Medtronic and others; DANISH ClinicalTrials.gov number, NCT00542945 .).

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Corrigendum to: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC.
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
Moss, A. J., Zaręba, W., Hall, W. J., Klein, H., Wilber, D. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Brown, M. W., & Andrews, M. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013474 · Cited by 6,885
Amiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure
Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Packer, D. L., Boineau, R., Domanski, M., Troutman, C., Anderson, J., Johnson, G., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043399 · Cited by 6,552
Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
Bristow, M. R., Saxon, L. A., Boehmer, J., Krueger, S., Kass, D. A., De Marco, T., Carson, P., DiCarlo, L., DeMets, D., White, B. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032423 · Cited by 5,812
Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia
Moss, A. J., Hall, W. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Klein, H., Levine, J. H., Saksena, S., Waldo, A. L., Wilber, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352601 · Cited by 4,165
2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8807 · Cited by 3,304
A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease
Buxton, A. E., Lee, K. L., Fisher, J. D., Josephson, M. E., Prystowsky, E. N., & Hafley, G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912163412503 · Cited by 2,489
Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy
Kadish, A. H., Dyer, A. R., Daubert, J. P., Quigg, R. J., Estes, N. A. M., Anderson, K. P., Calkins, H. G., Hoch, D., Goldberger, J. J., Shalaby, A. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033088 · Cited by 2,078
Reduction in Inappropriate Therapy and Mortality through ICD Programming
Moss, A. J., Schuger, C. D., Beck, C. A., Brown, M. W., Cannom, D. S., Daubert, J. P., Estes, N. A. M., Greenberg, H., Hall, W. J., Huang, D. T.-C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211107 · Cited by 1,369

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Ebert, M., Wijnmaalen, A. P., Riva, M., Trines, S. A. I. P., Androulakis, A. F. A., Glashan, C. A., Schalij, M. J., van Tintelen, J. P., Jongbloed, J. D. H., & Zeppenfeld, K. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2020.04.025 · Cited by 47
Combination of late gadolinium enhancement and genotype improves prediction of prognosis in non‐ischaemic dilated cardiomyopathy
Mirelis, J. G., Escobar-López, L., Ochoa, J. P., Espinosa, M. Á., Villacorta, E., Peñalver, M. N., Casas, G., Ayestarán, N. M., Villa, R. B., Mogollón‐Jiménez, M. V., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2514 · Cited by 46
Cardiac MRI to Predict Sudden Cardiac Death Risk in Dilated Cardiomyopathy
Li, Y., Xu, Y., Li, W., Guo, J., Wan, K., Wang, J., Xu, Z., Han, Y., Sun, J., & Chen, Y. (2023) · Radiology · doi:10.1148/radiol.222552 · Cited by 46
Hopes and disappointments with antiarrhythmic drugs
Camm, A. J. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.03.056 · Cited by 46
Long-term complications, reoperations and survival following cardioverter-defibrillator implant
Hawkins, N. M., Grubisić, M., Andrade, J. G., Huang, F., Ding, L., Gao, M., & Bashir, J. G. (2017) · Heart · doi:10.1136/heartjnl-2017-311638 · Cited by 46
Primary prevention implantable cardioverter-defibrillator and opportunities for sudden cardiac death risk assessment in non-ischaemic cardiomyopathy
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Chyou, J. Y., Qin, H., Butler, J., Voors, A. A., & Lam, C. S. P. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-00996-1 · Cited by 37
Emerging concepts in arrhythmogenic dilated cardiomyopathy
Zegkos, T., Panagiotidis, T., Parcharidou, D. G., & Efthimiadis, G. K. (2020) · Heart Failure Reviews · doi:10.1007/s10741-020-09933-z · Cited by 36
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Cardiac arrhythmias in arterial hypertension
Varvarousis, D., Kallistratos, M. S., Poulimenos, L. E., Triantafyllis, A. S., Tsinivizov, P., Giannakopoulos, A., Kyfnidis, K., & Manolis, A. J. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.13989 · Cited by 32
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Balaban, G., Halliday, B. P., Porter, B., Bai, W., Nygaard, S., Owen, R., Hatipoğlu, S., Ferreira, N. D., İzgi, C., Tayal, U., et al. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2020.08.036 · Cited by 32
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Wang, J., Yang, F., Wan, K., Mui, D., Han, Y., & Chen, Y. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12865 · Cited by 32
Treatment of ventricular arrhythmias: What's New?
Markman, T. M., & Nazarian, S. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.09.014 · Cited by 34
Right Ventricular Dysfunction and the Effect of Defibrillator Implantation in Patients With Nonischemic Systolic Heart Failure
Elming, M. B., Hammer‐Hansen, S., Voges, I., Nyktari, E. G., Raja, A. A., Svendsen, J. H., Pehrson, S. M., Signorovitch, J., Køber, L., Prasad, S. K., et al. (2019) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.118.007022 · Cited by 32
Self-citation
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Prediction and Prevention of Sudden Cardiac Death
Morin, D. P., Homoud, M. K., & Estes, N. A. M. (2017) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2017.07.012 · Cited by 31

Authors: Køber, L., Thune, J. J., Nielsen, J. C., Haarbo, J., Videbæk, L., Korup, E., Jensen, G., Hildebrandt, P., Steffensen, F. H., Bruun, N. E., Eiskjær, H., Brandes, A., Thøgersen, A. M., Gustafsson, F., Egstrup, K., Videbæk, R., Hassager, C., Svendsen, J. H., Høfsten, D. E., Torp-Pedersen, C., & Pehrson, S.
Affiliations: University of Copenhagen (DK)
ORCID: Køber, Lars
Thune, Jens J.
Nielsen, Jens C.
Videbæk, Lars
Steffensen, Flemming H.
Bruun, Niels E.
Eiskjær, Hans
Brandes, Axel
Thøgersen, Anna M.
Gustafsson, Finn
Egstrup, Kenneth
Hassager, Christian
Svendsen, Jesper H.
Høfsten, Dan E.
Torp-Pedersen, Christian
Pehrson, Steen
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2016-09-29
Volume: 375
Issue: 13
Pages: 1221-1230
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1608029
OpenAlex: W2518530324
Cited by: 1,763
References: 18
Citations by year: 2026: 104 · 2025: 138 · 2024: 139 · 2023: 170 · 2022: 182 · 2021: 177 · 2020: 196 · 2019: 212 · 2018: 200 · 2017: 213 · 2016: 28
FWCI: 179.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, other-oa)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Scopus (Elsevier) (submittedVersion)
VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Funders: Bristol-Myers Squibb
Pfizer
AstraZeneca
Sanofi
Gilead Sciences
Hjerteforeningen
Boston Scientific Corporation
TrygFonden
Servier
St. Jude Medical
Biosense Webster
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Keywords: implantable cardioverter-defibrillator, prophylactic ICD, heart failure with reduced ejection fraction, non-ischemic heart failure, sudden cardiac death, all-cause mortality, cardiac resynchronization therapy, device-related infection, left ventricular ejection fraction, DANISH trial
MeSH terms: Aged, Cardiac Pacing, Artificial, Cardiovascular Diseases, Electrocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mortality, Stroke Volume, Death, Sudden, Cardiac, Defibrillators, Implantable, Heart Failure, Systolic

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Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure

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