The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure
Open accessAbstract
BACKGROUND: The benefit of an implantable cardioverter-defibrillator (ICD) in patients with symptomatic systolic heart failure caused by coronary artery disease has been well documented. However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failure that is not due to coronary artery disease has been based primarily on subgroup analyses. The management of heart failure has improved since the landmark ICD trials, and many patients now receive cardiac resynchronization therapy (CRT). METHODS: In a randomized, controlled trial, 556 patients with symptomatic systolic heart failure (left ventricular ejection fraction, ≤35%) not caused by coronary artery disease were assigned to receive an ICD, and 560 patients were assigned to receive usual clinical care (control group). In both groups, 58% of the patients received CRT. The primary outcome of the trial was death from any cause. The secondary outcomes were sudden cardiac death and cardiovascular death. RESULTS: After a median follow-up period of 67.6 months, the primary outcome had occurred in 120 patients (21.6%) in the ICD group and in 131 patients (23.4%) in the control group (hazard ratio, 0.87; 95% confidence interval [CI], 0.68 to 1.12; P=0.28). Sudden cardiac death occurred in 24 patients (4.3%) in the ICD group and in 46 patients (8.2%) in the control group (hazard ratio, 0.50; 95% CI, 0.31 to 0.82; P=0.005). Device infection occurred in 27 patients (4.9%) in the ICD group and in 20 patients (3.6%) in the control group (P=0.29). CONCLUSIONS: In this trial, prophylactic ICD implantation in patients with symptomatic systolic heart failure not caused by coronary artery disease was not associated with a significantly lower long-term rate of death from any cause than was usual clinical care. (Funded by Medtronic and others; DANISH ClinicalTrials.gov number, NCT00542945 .).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Heart transplantation could be considered in end-stage HF, but a large, prospective study of transplanted patients indicated a decreased likelihood of 10-year survival in those with diabetes.526”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [526]
In the citing paper
“In pre-specified subgroup analysis, there was no significant difference in treatment effect in patients with and without T2DM (HRs 0.92 and 0.85, respectively, interaction P=0.60).”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [166]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
Moss, A. J., Zaręba, W., Hall, W. J., Klein, H., Wilber, D. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Brown, M. W., & Andrews, M. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013474 · Cited by 6,885
Amiodarone or an Implantable Cardioverter–Defibrillator for Congestive Heart Failure
Bardy, G. H., Lee, K. L., Mark, D. B., Poole, J. E., Packer, D. L., Boineau, R., Domanski, M., Troutman, C., Anderson, J., Johnson, G., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043399 · Cited by 6,552
Bristow, M. R., Saxon, L. A., Boehmer, J., Krueger, S., Kass, D. A., De Marco, T., Carson, P., DiCarlo, L., DeMets, D., White, B. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032423 · Cited by 5,812
Moss, A. J., Hall, W. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Klein, H., Levine, J. H., Saksena, S., Waldo, A. L., Wilber, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352601 · Cited by 4,165
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8807 · Cited by 3,304
A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease
Buxton, A. E., Lee, K. L., Fisher, J. D., Josephson, M. E., Prystowsky, E. N., & Hafley, G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912163412503 · Cited by 2,489
Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy
Kadish, A. H., Dyer, A. R., Daubert, J. P., Quigg, R. J., Estes, N. A. M., Anderson, K. P., Calkins, H. G., Hoch, D., Goldberger, J. J., Shalaby, A. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033088 · Cited by 2,078
Reduction in Inappropriate Therapy and Mortality through ICD Programming
Moss, A. J., Schuger, C. D., Beck, C. A., Brown, M. W., Cannom, D. S., Daubert, J. P., Estes, N. A. M., Greenberg, H., Hall, W. J., Huang, D. T.-C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211107 · Cited by 1,369
Kirkfeldt, R. E., Johansen, J. B., Nohr, E. A., Jorgensen, O. D., & Nielsen, J. C. (2014) · European Heart Journal · doi:10.1093/eurheartj/eht511 · Cited by 871
Self-citationPrimary Prevention of Sudden Cardiac Death in Idiopathic Dilated Cardiomyopathy
Bänsch, D., Antz, M., Boczor, S., Volkmer, M., Tebbenjohanns, J., Seidl, K., Block, M. S., Gietzen, F. H., Berger, J., & Kück, K. (2002) · Circulation · doi:10.1161/01.cir.0000012350.99718.ad · Cited by 644
Strickberger, S. A., Hummel, J. D., Bartlett, T. G., Frumin, H., Schuger, C. D., Beau, S. L., Bitar, C., & Morady, F. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00297-3 · Cited by 588
Barsheshet, A., Moss, A. J., Huang, D. T.-C., McNitt, S. A., Zaręba, W., & Goldenberg, I. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.036 · Cited by 153
Lam, S., & Owen, A. (2007) · BMJ · doi:10.1136/bmj.39343.511389.be · Cited by 118
Marijon, É., Leclercq, C., Narayanan, K., Bovéda, S., Klug, D., Lacaze-Gadonneix, J., Defaye, P., Jacob, S., Piot, O., Deharo, J., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv455 · Cited by 110
Colquitt, J. L., Mendes, D., Clegg, A. J., Harris, P., Cooper, K., Picot, J., & Bryant, J. (2014) · Health Technology Assessment · doi:10.3310/hta18560 · Cited by 75
Thune, J. J., Pehrson, S. M., Nielsen, J. C., Haarbo, J., Videbæk, L. M., Korup, E., Jensen, G. V. H., Hildebrandt, P. R., Steffensen, F. H., Bruun, N. E., et al. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.06.016 · Cited by 37
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab368 · Cited by 13,344
Self-citationZeppenfeld, K., Tfelt‐Hansen, J., Riva, M., Winkel, B. G., Behr, E. R., Blom, N. A., Charron, P., Corrado, D., Dagres, N., de Chillou, C., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac262 · Cited by 3,432
Self-citation2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862
2023 ESC guidelines for the management of cardiomyopathies
Arbelo, E., Protonotarios, A., Gimeno, J. R., Arbustini, E., Barriales-Villa, R., Basso, C., Bezzina, C. R., Biagini, E., Blom, N. A., de Boer, R. A., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad194 · Cited by 2,844
Self-citation
Metadata
- Authors
- Køber, L., Thune, J. J., Nielsen, J. C., Haarbo, J., Videbæk, L., Korup, E., Jensen, G., Hildebrandt, P., Steffensen, F. H., Bruun, N. E., Eiskjær, H., Brandes, A., Thøgersen, A. M., Gustafsson, F., Egstrup, K., Videbæk, R., Hassager, C., Svendsen, J. H., Høfsten, D. E., Torp-Pedersen, C., & Pehrson, S.
- Affiliations
- University of Copenhagen (DK)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-09-29
- Volume
- 375
- Issue
- 13
- Pages
- 1221-1230
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2518530324
- Cited by
- 1,763
- References
- 18
- Citations by year
- 2026: 104 · 2025: 138 · 2024: 139 · 2023: 170 · 2022: 182 · 2021: 177 · 2020: 196 · 2019: 212 · 2018: 200 · 2017: 213 · 2016: 28
- FWCI
- 179.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, other-oa)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Scopus (Elsevier) (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- Sanofi
- Gilead Sciences
- Hjerteforeningen
- Boston Scientific Corporation
- TrygFonden
- Servier
- St. Jude Medical
- Biosense Webster
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- implantable cardioverter-defibrillator, prophylactic ICD, heart failure with reduced ejection fraction, non-ischemic heart failure, sudden cardiac death, all-cause mortality, cardiac resynchronization therapy, device-related infection, left ventricular ejection fraction, DANISH trial
- MeSH terms
- Aged, Cardiac Pacing, Artificial, Cardiovascular Diseases, Electrocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mortality, Stroke Volume, Death, Sudden, Cardiac, Defibrillators, Implantable, Heart Failure, Systolic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
