Cited by 797Cardiac Arrest and ResuscitationPalliative Care and End-of-Life IssuesCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest

Open access

Perkins, Gavin D., Ji, Chen, Deakin, Charles D., Quinn, Tom, Nolan, Jerry P., Scomparin, Charlotte, Regan, Scott, Long, John, Slowther, Anne, Pocock, Helen, Black, John J.M., Moore, Fionna, Fothergill, Rachael T., Rees, Nigel, O’Shea, Lyndsey, Docherty, Mark, Gunson, Imogen, Han, Kyee, Charlton, Karl, Finn, Judith, Petrou, Stavros, Stallard, Nigel, Gates, Simon, Lall, Ranjit·2018·New England Journal of Medicine

DOI 10.1056/nejmoa1806842

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Concern about the use of epinephrine as a treatment for out-of-hospital cardiac arrest led the International Liaison Committee on Resuscitation to call for a placebo-controlled trial to determine whether the use of epinephrine is safe and effective in such patients. METHODS: In a randomized, double-blind trial involving 8014 patients with out-of-hospital cardiac arrest in the United Kingdom, paramedics at five National Health Service ambulance services administered either parenteral epinephrine (4015 patients) or saline placebo (3999 patients), along with standard care. The primary outcome was the rate of survival at 30 days. Secondary outcomes included the rate of survival until hospital discharge with a favorable neurologic outcome, as indicated by a score of 3 or less on the modified Rankin scale (which ranges from 0 [no symptoms] to 6 [death]). RESULTS: At 30 days, 130 patients (3.2%) in the epinephrine group and 94 (2.4%) in the placebo group were alive (unadjusted odds ratio for survival, 1.39; 95% confidence interval [CI], 1.06 to 1.82; P=0.02). There was no evidence of a significant difference in the proportion of patients who survived until hospital discharge with a favorable neurologic outcome (87 of 4007 patients [2.2%] vs. 74 of 3994 patients [1.9%]; unadjusted odds ratio, 1.18; 95% CI, 0.86 to 1.61). At the time of hospital discharge, severe neurologic impairment (a score of 4 or 5 on the modified Rankin scale) had occurred in more of the survivors in the epinephrine group than in the placebo group (39 of 126 patients [31.0%] vs. 16 of 90 patients [17.8%]). CONCLUSIONS: In adults with out-of-hospital cardiac arrest, the use of epinephrine resulted in a significantly higher rate of 30-day survival than the use of placebo, but there was no significant between-group difference in the rate of a favorable neurologic outcome because more survivors had severe neurologic impairment in the epinephrine group. (Funded by the U.K. National Institute for Health Research and others; Current Controlled Trials number, ISRCTN73485024 .).

Integrity signals

Registry

Crossref · 10.1056/nejmoa1806842

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
European Resuscitation Council and European Society of Intensive Care Medicine Guidelines for Post-resuscitation Care 2015
Nolan, J. P., Soar, J., Cariou, A., Cronberg, T., Moulaert, V. R. M., Deakin, C. D., Böttiger, B. W., Friberg, H., Sunde, K., & Sandroni, C. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.07.018 · Cited by 1,139
Self-citation
Early Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest
Hasselqvist‐Ax, I., Riva, G., Herlitz, J. D., Rosenqvist, M., Hollenberg, J., Nordberg, P., Ringh, M., Jonsson, M. N., Axelsson, C., Lindqvist, J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1405796 · Cited by 992
Mode of death after admission to an intensive care unit following cardiac arrest
Laver, S. R., Farrow, C., Turner, D., & Nolan, J. P. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2425-z · Cited by 984
Self-citation
European Resuscitation Council Guidelines for Resuscitation 2015
Monsieurs, K. G., Nolan, J. P., Bossaert, L. L., Greif, R., Maconochie, I. K., Nikolaou, N. I., Perkins, G. D., Soar, J., Truhlář, A., Wyllie, J. P., et al. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.07.038 · Cited by 962
Self-citation
Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest
Perkins, G. D., Jacobs, I. G., Nadkarni, V. M., Berg, R. A., Bhanji, F., Biarent, D., Bossaert, L. L., Brett, S. J., Chamberlain, D., de Caen, A. R., et al. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2014.11.002 · Cited by 726
Self-citation
Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial
Jacobs, I. G., Finn, J., Jelinek, G. A., Oxer, H. F., & Thompson, P. L. (2011) · Resuscitation · doi:10.1016/j.resuscitation.2011.06.029 · Cited by 472
Self-citation
Hypoxic-ischemic brain injury: Pathophysiology, neuropathology and mechanisms
Busl, K. M., & Greer, D. M. (2010) · Neurorehabilitation · doi:10.3233/nre-2010-0531 · Cited by 368
Public-Access Defibrillation and Out-of-Hospital Cardiac Arrest in Japan
Kitamura, T., Kiyohara, K., Sakai, T., Matsuyama, T., Hatakeyama, T., Shimamoto, T., Izawa, J., Fujii, T., Nishiyama, C., Kawamura, T., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmsa1600011 · Cited by 332
Validation of a Rule for Termination of Resuscitation in Out-of-Hospital Cardiac Arrest
Morrison, L. J., Visentin, L. M., Kiss, A., Theriault, R., Eby, D., Vermeulen, M. J., Sherbino, J., & Verbeek, P. R. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052620 · Cited by 325

Flagged first, then by citations

Show all 35 references

Research works printed but not linked: 1

Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. 6. Advanced cardiovascular life support: section 6: pharmacology II: agents to optimize cardiac output and blood pressure. Circulation 2000;102:Suppl:I-129–I-135.10966670

Sorted by citations

Items 301–400 of 797

The effect of intravenous adrenaline on electrocardiographic changes during resuscitation in patients with initial pulseless electrical activity in out of hospital cardiac arrest
Skjeflo, G. W., Skogvoll, E., Loennechen, J. P., Olasveengen, T. M., Wik, L., & Nordseth, T. (2019) · Resuscitation · doi:10.1016/j.resuscitation.2019.01.021 · Cited by 8
Impact of epinephrine administration frequency in out-of-hospital cardiac arrest patients: a retrospective analysis in a tertiary hospital setting
Al-Mulhim, M. A., Alshahrani, M. S. S., Asonto, L. P., Abdulhady, A., AlMutairi, T. M., Hajji, M., Alrubaish, M. A., Almulhim, K. N., Alsulaiman, M. H., & Al-Qahtani, L. B. (2019) · Journal of International Medical Research · doi:10.1177/0300060519860952 · Cited by 8
Management of Out-of-Hospital Cardiac Arrest Complicating Acute Coronary Syndromes
Bell, S. M., Kovach, C. P., Kataruka, A., Brown, J. N., & Hira, R. S. (2019) · Current Cardiology Reports · doi:10.1007/s11886-019-1249-y · Cited by 8
Visual assessment of interactions among resuscitation activity factors in out-of-hospital cardiopulmonary arrest using a machine learning model
Kawai, Y., Okuda, H., Kinoshita, A., Yamamoto, K., Miyazaki, K., Takano, K., Asai, H., Urisono, Y., & Fukushima, H. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273787 · Cited by 8
Augmented-Medication CardioPulmonary Resuscitation (AMCPR) trial: a study protocol for a randomized controlled trial
Oh, D. K., Kim, J., Ryoo, S. M., Kim, Y., Kim, S. M., Hong, S., Chae, B., & Kim, W. Y. (2022) · Clinical and Experimental Emergency Medicine · doi:10.15441/ceem.22.367 · Cited by 7
Hemodynamic Effect of Repeated Epinephrine Doses Decreases With Cardiopulmonary Resuscitation Cycle Progression
Roh, Y., Ahn, G. J., Lee, J. H., Jung, W. J., Kim, S., Im, H. Y., Lee, Y., Im, D., Lim, J., Hwang, S. O., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.030776 · Cited by 7
Early versus late administration of adrenaline in pediatric patients with out-of-hospital cardiac arrest
Oishi, T., Amagasa, S., Iwamoto, S., Kashiura, M., Yasuda, H., Kishihara, Y., & Uematsu, S. (2024) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2024.12.028 · Cited by 7
Impact of epinephrine on neurological outcomes in out-of-hospital cardiac arrest after automated external defibrillator use in Japan
Kubo, A., Hiraide, A., Shinozaki, T., Shibata, N., Miyamoto, K., Tamura, S., & Inoue, S. (2025) · Scientific Reports · doi:10.1038/s41598-024-84950-8 · Cited by 7
Phenomenological study exploring ethics in prehospital research from the paramedic’s perspective: experiences from the Paramedic-2 trial in a UK ambulance service
Charlton, K., Franklin, J. D., & McNaughton, R. J. (2019) · Emergency Medicine Journal · doi:10.1136/emermed-2019-208556 · Cited by 7
Self-citation
Neurological outcomes associated with prehospital advanced airway management in patients with out-of-hospital cardiac arrest due to foreign body airway obstruction
Otomune, K., Hifumi, T., Jinno, K., Nakamura, K., Okazaki, T., Inoue, A., Kawakita, K., & Kuroda, Y. (2021) · Resuscitation Plus · doi:10.1016/j.resplu.2021.100140 · Cited by 7
Effect of Prehospital Epinephrine on Out-of-Hospital Cardiac Arrest Outcomes: A Propensity Score-Matched Analysis
Han, E., Kong, T., You, J. S., Park, I., Park, G., Lee, S., & Chung, S. P. (2022) · Yonsei Medical Journal · doi:10.3349/ymj.2022.63.2.187 · Cited by 7
The first case series analysis on efficacy of esmolol injection for in-hospital cardiac arrest patients with refractory shockable rhythms in China
Lian, R., Zhang, G., Yan, S., Sun, L., Gao, W., Yang, J., Li, G., Huang, R., Wang, X., Liu, R., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.930245 · Cited by 7
Temporal Changes in Epinephrine Dosing in Out-of-Hospital Cardiac Arrest: A Review of EMS Protocols across the United States
Garfinkel, E. M., Michelsen, K., Johnson, B. A., Margolis, A. M., & Levy, M. J. (2022) · Prehospital and Disaster Medicine · doi:10.1017/s1049023x22001418 · Cited by 7
Adrenaline can restart the heart, but is no good for the brain
Cook, R., Davidson, P., & Martin, R. (2019) · BMJ · doi:10.1136/bmj.k4259 · Cited by 7
Cardiac Surgical Resuscitation
Ley, S. J. (2019) · Critical Care Nursing Clinics of North America · doi:10.1016/j.cnc.2019.05.010 · Cited by 7
Optimising ambulance service contribution to clinical trials: a phenomenological exploration using focus groups
Pocock, H., Thomson, M., Taylor, S. A., Deakin, C. D., & England, E. (2019) · British Paramedic Journal · doi:10.29045/14784726.2019.12.4.3.55 · Cited by 7
Self-citation
Effect of Epinephrine Administered during Cardiopulmonary Resuscitation on Cerebral Oxygenation after Restoration of Spontaneous Circulation in a Swine Model with a Clinically Relevant Duration of Untreated Cardiac Arrest
Lee, H. Y., Shamsiev, K., Mamadjonov, N., Jung, Y. H., Jeung, K. W., Kim, J. W., Heo, T., & Min, Y. I. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115896 · Cited by 7
Epinephrine dosing interval and neurological outcome in out-of-hospital cardiac arrest
Fukuda, T., Kaneshima, H., Matsudaira, A., Chinen, T., Sekiguchi, H., Ohashi-Fukuda, N., Inokuchi, R., & Kukita, I. (2021) · Perfusion · doi:10.1177/02676591211025163 · Cited by 7
Aortic occlusion during cardiac arrest – Mechanical adrenaline?
Brede, J. R. (2022) · Resuscitation · doi:10.1016/j.resuscitation.2022.08.007 · Cited by 7
Protocol for a cluster randomised controlled feasibility study of Prehospital Optimal Shock Energy for Defibrillation (POSED)
Pocock, H., Deakin, C. D., Lall, R., Michelet, F., Contreras, A., Ainsworth-Smith, M., King, P., Devrell, A., Smith, D. E., & Perkins, G. D. (2022) · Resuscitation Plus · doi:10.1016/j.resplu.2022.100310 · Cited by 7
Self-citation
Predictors of In-Hospital Mortality after Recovered Out-of-Hospital Cardiac Arrest in Patients with Proven Significant Coronary Artery Disease: A Retrospective Study
Trêpa, M., Bastos, S., Oliveira, M. F., Costa, R. G., Dias‐Frias, A., Luz, A., Dias, V., Santos, M., & Torres, S. (2020) · The Journal of Critical Care Medicine · doi:10.2478/jccm-2020-0006 · Cited by 7
In-hospital cardiac arrest (IHCA): survival status and its determinants in Malaysian public healthcare
Mostapha, M., Bahari, M. S., Fui, W. M., Raman, S., Aminuddin, F., Kunusagaran, M. S. J. M. N. S., Zaimi, N. A., Hassan, N. Z. A. M., Goh, H.-J., Yoon, C. K., et al. (2025) · PeerJ · doi:10.7717/peerj.19509 · Cited by 6
Pre-hospital blood product transfusion and calcium management in the United Kingdom: a multicentre service evaluation
Forbes, A., Simpson, C., Griggs, J., Barrett, J. W., Lyon, R., & Leech, C. (2025) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-025-01446-8 · Cited by 6
A prospective observational study on impact of epinephrine administration route on acute myocardial infarction patients with cardiac arrest in the catheterization laboratory (iCPR study)
Aldujeli, A., Haq, A., Tecson, K. M., Kurnickaite, Z., Lickunas, K., Bailey, S., Tatarūnas, V., Braukylienė, R., Bakšytė, G., Aldujeili, M., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04275-8 · Cited by 6
A Narrative Review of Drug Therapy in Adult and Pediatric Cardiac Arrest
Jaeger, D., Marquez, A. M., Kosmopoulos, M., Gutiérrez, A., Gaisendrees, C., Orchard, D. A., Chouihed, T., & Yannopoulos, D. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2406163 · Cited by 6
Epinephrine in Prehospital Traumatic Cardiac Arrest—Life Saving or False Hope?
Witt, C. E., Shatz, D. V., Robinson, B. R. H., Campion, E. M., Shapiro, M. L., Bui, E. H., Meizoso, J. P., & Dorlac, W. C. (2025) · Prehospital Emergency Care · doi:10.1080/10903127.2025.2461283 · Cited by 6
Outcomes from out-of-hospital cardiac arrest in nursing and care homes: a cohort study
Battin, E., Brown, T. P., & Couper, K. (2025) · Emergency Medicine Journal · doi:10.1136/emermed-2024-214362 · Cited by 6
Emergency medicine updates: Cardiac arrest medications
Long, B., & Gottlieb, M. A. (2025) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2025.03.023 · Cited by 6
First Results of Our Local Practice Guide Used During the Late Phase of Resuscitation in Patients with Refractory VF in Out of Hospital Cardiac Arrest
Slagt, C., van Kuijk, S. M. J., Bruhn, J., van Geffen, G., & Mommers, L. (2025) · Open Access Emergency Medicine · doi:10.2147/oaem.s510483 · Cited by 6
Communicating risks and benefits to cardiology patients
Recchia, G. L., & Freeman, A. L. J. (2020) · Heart · doi:10.1136/heartjnl-2020-317593 · Cited by 6
Analysis of the Relationships between Multiple Endocrine Hormones and Return of Spontaneous Circulation (ROSC) in Cardiac Arrest Patients: Possible Association of the Serum Free T4 Level with ROSC
Koizumi, G., Mikura, K., Iida, T., Kaji, M., Hashizume, M., Murai, N., Kigawa, Y., Endo, K., Iizaka, T., Saiki, R., et al. (2020) · International Journal of Endocrinology · doi:10.1155/2020/4168420 · Cited by 6
Patient Partner Perspectives Regarding Ethically and Clinically Important Aspects of Trial Design in Pragmatic Cluster Randomized Trials for Hemodialysis
Nicholls, S. G., Carroll, K. A., Goldstein, C. E., Brehaut, J., Weijer, C., Zwarenstein, M., Dixon, S. N., Grimshaw, J., Garg, A. X., & Taljaard, M. (2021) · Canadian Journal of Kidney Health and Disease · doi:10.1177/20543581211032818 · Cited by 6
Preclinical evaluation of triiodothyronine nanoparticles as a novel therapeutic intervention for resuscitation from cardiac arrest
Weil, B. R., Allen, S. E., Barbaccia, T., Wong, K., Beaver, A. M., Slabinski, E. A., Mellott, J. G., Dickinson, P., & Mousa, S. A. (2023) · Resuscitation · doi:10.1016/j.resuscitation.2023.109735 · Cited by 6
Non-shockable rhythms: A parametric model for the immediate probability of return of spontaneous circulation
Unneland, E., Norvik, A., Bergum, D., Buckler, D. G., Bhardwaj, A., Eftestøl, T. C., Aramendi, E., Nordseth, T., Abella, B. S., Kvaløy, J. T., et al. (2023) · Resuscitation · doi:10.1016/j.resuscitation.2023.109895 · Cited by 6
Effects of Different Doses of Pralidoxime Administered During Cardiopulmonary Resuscitation and the Role of α‐Adrenergic Receptors in Its Pressor Action
Jung, Y. H., Mamadjonov, N., Lee, H. Y., Jeung, K. W., Lee, B. K., Youn, C. S., Heo, T., & Min, Y. I. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015076 · Cited by 6
Targeted Temperature Management in Cardiac Arrest Patients With an Initial Non-Shockable Rhythm: A Systematic Review and Meta-Analysis
Barbarawi, M., Al‐Abdouh, A., Barbarawi, O., Lakshman, H. G., kasasbeh, M. A., Rizk, F., Bachuwa, G. I., & Alkotob, M. L. (2020) · Shock · doi:10.1097/shk.0000000000001550 · Cited by 6
A Time-Dependent Propensity Score Matching Approach to Assess Epinephrine Use on Patients Survival Within Out-of-Hospital Cardiac Arrest Care
Baert, V., Hubert, H., Chouihed, T., Claustre, C., Wiel, É., Escutnaire, J., Jaeger, D., Vilhelm, C., Segal, N., Adnet, F., et al. (2020) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2020.06.016 · Cited by 6
Immediate intravenous epinephrine versus early intravenous epinephrine for in-hospital cardiopulmonary arrest
Bakhsh, A. A., Safhi, M. A., Alghamdi, A., Alharazi, A., Alshabibi, B., Alobaidi, R., & Alnashri, M. M. (2021) · BMC Anesthesiology · doi:10.1186/s12871-021-01346-1 · Cited by 6
Accumulated Epinephrine Dose is Associated With Acute Kidney Injury Following Resuscitation in Adult Cardiac Arrest Patients
Gao, Q., Mok, H., Qiu, H., Cen, J., Chen, J., & Zhuang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.806592 · Cited by 6
Effect of adrenaline dose on neurological outcome in out-of-hospital cardiac arrest: a nationwide propensity score analysis
Jaeger, D., Baert, V., Javaudin, F., Debaty, G. P., Duhem, H., Koger, J., Gueugniaud, P., Tazarourte, K., Khoury, C. E., Hubert, H., et al. (2021) · European Journal of Emergency Medicine · doi:10.1097/mej.0000000000000891 · Cited by 6
Use of a novel smartphone-based application tool for enrolment and randomisation in pre-hospital clinical trials
Bloom, J. E., Partovi, A., Bernard, S. A., Okyere, D. O., Heritier, S. R., Mahony, E., Eliakundu, A. L., Dawson, L. P., Voskoboinik, A., Anderson, D., et al. (2023) · Resuscitation · doi:10.1016/j.resuscitation.2023.109787 · Cited by 6
Dose-dependent Effects of Esmolol-epinephrine Combination Therapy in Myocardial Ischemia and Reperfusion Injury
Oyama, Y., Blaskowsky, J., & Eckle, T. D. L. G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190618124829 · Cited by 6
Establishing a multicenter, preclinical consortium in resuscitation: A pilot experimental trial evaluating epinephrine in cardiac arrest
Lin, S., Ramadeen, A., Sundermann, M. L., Dorian, P., Fink, S., Halperin, H. R., Kiss, A., Koller, A. C., Kudenchuk, P. J., McCracken, B. M., et al. (2022) · Resuscitation · doi:10.1016/j.resuscitation.2022.04.016 · Cited by 6
The impact of defibrillation current and pad position on return of spontaneous circulation during refractory ventricular fibrillation
Cheskes, S., Drennan, I. R., Turner, L., Pandit, S. V., Walker, R. G., Taylor, T. G., McLeod, S. L., & Dorian, P. (2026) · Resuscitation · doi:10.1016/j.resuscitation.2026.111061 · Cited by 5
Interkingdom Hormonal Regulations between Plants and Animals Provide New Insight into Food Safety
Cheng, H., Wen, W., Wang, W., Yang, M.-Y., & Zhou, Y. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c04712 · Cited by 5
Delivering manual cardiopulmonary resuscitation (CPR) in a diving bell: an analysis of head-to-chest and knee-to-chest compression techniques
Johnson, G. D., Bryson, P., International SOS, F. G. H., Tilbury, N., McGregor, B., affiliation, N. S., Wesson, A., affiliation, N. S., Hughes, G. D., Hughes, G. R., et al. (2023) · Diving and Hyperbaric Medicine Journal · doi:10.28920/dhm53.3.172-180 · Cited by 5
Outcomes of out-of-hospital cardiac arrest in Ireland 2012-2020: Protocol for an observational study
Barry, T., Kasemiire, A., Quinn, M., Deasy, C., Bury, G., Masterson, S., Segurado, R., & Murphy, A. W. (2023) · HRB Open Research · doi:10.12688/hrbopenres.13699.1 · Cited by 5
Statewide implementation of the cardiac arrest registry to enhance survival in Ohio
Nassal, M., Wang, H. E., Benoit, J. L., Kühn, A., Powell, J. R., Keseg, D. P., Sauto, J., & Panchal, A. R. (2023) · Resuscitation Plus · doi:10.1016/j.resplu.2023.100528 · Cited by 5
Retrospective Comparison of Upper and Lower Extremity Intraosseous Access During Out-of-Hospital Cardiac Arrest Resuscitation
Smida, T., Crowe, R. P., Jarvis, J. L., Ratcliff, T., & Goebel, M. (2024) · Prehospital Emergency Care · doi:10.1080/10903127.2024.2321285 · Cited by 5
Identifying organ donors attended by prehospital healthcare professionals – A scoping review
Lawson, B., & Williams, B. A. (2024) · International Emergency Nursing · doi:10.1016/j.ienj.2024.101448 · Cited by 5
Mildly Reduced Doses of Adrenaline Do Not Affect Key Hemodynamic Parameters during Cardio-Pulmonary Resuscitation in a Pig Model of Cardiac Arrest
Jaeger, D., Koger, J., Duhem, H., Fritz, C., Jeangeorges, V., Duarte, K., Lévy, B., Debaty, G. P., & Chouihed, T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10204674 · Cited by 5
Oxford Handbook of Clinical Specialties
(2020) · doi:10.1093/med/9780192888501.001.0001 · Cited by 5
Delayed arrival of advanced life support adversely affects the neurological outcome in a multi-tier emergency response system
Yang, H. C., Park, S. M., Lee, K. J., Jo, Y. H., Kim, Y. J., Lee, D., & Jang, D. (2023) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2023.06.001 · Cited by 5
Pralidoxime administered during cardiopulmonary resuscitation facilitates successful resuscitation in a pig model of cardiac arrest
Jung, Y. H., Lee, H. Y., Jeung, K. W., Lee, B. K., Youn, C. S., Yun, S. W., Heo, T., & Min, Y. I. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13198 · Cited by 5
Relationship between the Plasma Levels of Catecholamines and Return of Spontaneous Circulation in Patients with Out-of-Hospital Cardiac Arrest
Ichikawa, Y., Sawada, Y., Nakajima, J., Isshiki, Y., Fukushima, K., Aramaki, Y., & Oshima, K. (2021) · Emergency Medicine International · doi:10.1155/2021/5324038 · Cited by 5
FDG-PET/CT Assessment of the Cerebral Protective Effects of Hydrogen in Rabbits with Cardiac Arrest
Huang, G., Li, X., Tang, Y., Yao, Z., Hu, S., Zhou, H., Mo, X., She, C., & Lu, X. (2022) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/1573405618666220321122214 · Cited by 5
Pharmacologic Agents for the Treatment of Vasodilatory Shock
Knotzer, H., Poidinger, B., & Kleinsasser, A. T. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190704101907 · Cited by 5
Epinephrine in Out-of-Hospital Cardiac Arrest
Wnent, J., Bein, B., & Fischer, M. (2019) · New England Journal of Medicine · doi:10.1056/nejmc1816187 · Cited by 5
Need for speed in out-of-hospital cardiac arrest
Wengenmayer, T., & Staudacher, D. L. (2019) · Resuscitation · doi:10.1016/j.resuscitation.2019.08.033 · Cited by 5
Randomized controlled trials in resuscitation
Drennan, I. R., McLeod, S. L., & Cheskes, S. (2024) · Resuscitation Plus · doi:10.1016/j.resplu.2024.100582 · Cited by 4
Vasopressor or Advanced Airway First in Cardiac Arrest?
Wang, H. E., Daya, M. R., Schmicker, R. H., Nassal, M., Okubo, M., Aramendi, E., Alonso, E., Idris, A. H., Panchal, A. R., Jaureguibeitia, X., et al. (2024) · Resuscitation · doi:10.1016/j.resuscitation.2024.110422 · Cited by 4
Optimal timing for epinephrine administration in adult patients with out‐of‐hospital cardiac arrest: A retrospective observational study
Sakamoto, K., Yasuda, H., Shinzato, Y., Kishihara, Y., Amagasa, S., Kashiura, M., & Moriya, T. (2025) · Academic Emergency Medicine · doi:10.1111/acem.15089 · Cited by 4
An exploratory study on the effect of rescuer team size on basic and advanced life support technical skills in a high‐fidelity simulation of canine cardiopulmonary arrest
Hoehne, S. N., Cary, J. A., Bailey, L. N., Davidow, E. B., Martin, L. G., & DeJong, T. L. (2025) · Journal of Veterinary Emergency and Critical Care · doi:10.1111/vec.13445 · Cited by 4
Association of epinephrine and outcome in cardiac arrest with refractory shockable rhythm: a population-based, propensity-score matched analysis
Fanet, L., Javaudin, F., Dumas, F., Beganton, F., Empana, J. P., Lamhaut, L., Jost, D., Marijon, É., Jouven, X., Cariou, A., et al. (2025) · Critical Care · doi:10.1186/s13054-025-05417-4 · Cited by 4
Pediatric Life Support: 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment Recommendations
Scholefield, B. R., Acworth, J., Ng, K.-C., Tiwari, L. K., Raymond, T. T., Christoff, A., Katzenschlager, S., Escalante-Kanashiro, R., Bansal, A., Topjian, A., et al. (2025) · PEDIATRICS · doi:10.1542/peds.2025-074853 · Cited by 4
Self-citation
Automated aortic endovascular balloon volume titration prevents re-arrest immediately after return of spontaneous circulation in a swine model of nontraumatic cardiac arrest
Nowadly, C. D., Johnson, M. A., Youngquist, S. T., Williams, T. K., Neff, L. P., & Hoareau, G. L. (2022) · Resuscitation Plus · doi:10.1016/j.resplu.2022.100239 · Cited by 4
Trend of Outcome Metrics in Recent Out-of-Hospital-Cardiac-Arrest Research: A Narrative Review of Clinical Trials
Htet, N. N., Jafari, D., Walker, J., Pourmand, A., Shaw, A., Dinh, K., & Tran, Q. K. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12227196 · Cited by 4
The cerebral and cardiac effects of Norepinephrine in an experimental cardiac arrest model
Jaeger, D., Kosmopoulos, M., Gaisendrees, C., Kalra, R., Marquez, A. M., Chouihed, T., Duarte, K., & Yannopoulos, D. (2024) · Resuscitation Plus · doi:10.1016/j.resplu.2024.100619 · Cited by 4
Factors predicting the return of spontaneous circulation rate of cardiopulmonary resuscitation in China: Development and evaluation of predictive nomogram
Yan, L., Wang, L., Zhou, L., Jin, Q., Liao, D., Hongxia, S., & Lu, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35903 · Cited by 4
Adrenaline for traumatic cardiac arrest: A post hoc analysis of the PARAMEDIC2 trial
Ji, C., Pocock, H., Deakin, C. D., Quinn, T., Nolan, J. P., Rees, N., Charlton, K., Finn, J., Rosser, A., Lall, R., et al. (2025) · Resuscitation Plus · doi:10.1016/j.resplu.2025.100890 · Cited by 4
Self-citation
Epinephrine at 25°C Core Body Temperature and During Rewarming
Mann, C., Baer, W., & Riedel, T. (2019) · Pediatric Emergency Care · doi:10.1097/pec.0000000000001766 · Cited by 4
Trauma Anesthesiology Perioperative Management Update
Perlman, R., Tsai, K. J., & Lo, J. (2023) · Advances in Anesthesia · doi:10.1016/j.aan.2023.06.003 · Cited by 4
Predicting survival post-cardiac arrest: An observational cohort study
Drennan, I. R., Thorpe, K. E., Scales, D. C., Cheskes, S., Mamdani, M., & Morrison, L. J. (2023) · Resuscitation Plus · doi:10.1016/j.resplu.2023.100447 · Cited by 4
The effects of methylene blue during and after cardiac arrest in a porcine model; a randomized, blinded, placebo-controlled study
Johannsen, C. M., Nørholt, C. H., Baltsen, C. D., Eggertsen, M. A., Magnussen, A., Vormfenne, L., Mortensen, S. Ø., Hansen, E. S. S., Vammen, L., Andersen, L. W., et al. (2023) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2023.08.041 · Cited by 4
Resuscitation with pre-hospital blood products in adults with trauma-related haemorrhagic shock: the RePHILL RCT
Crombie, N. C., Doughty, H. A., Bishop, J. R. B., Desai, A., Dixon, E. F., Hancox, J. M., Herbert, M., Leech, C., Lewis, S. J., Nash, M. R., et al. (2024) · Efficacy and Mechanism Evaluation · doi:10.3310/tdnb9214 · Cited by 4
Self-citation
Association between defibrillation-to-adrenaline interval and short-term outcomes in patients with out-of-hospital cardiac arrest and an initial shockable rhythm
Kawakami, S., Tahara, Y., Noguchi, T., Yasuda, S., Koga, H., Nishi, J.-I., Yonemoto, N., Nonogi, H., & Ikeda, T. (2024) · Resuscitation Plus · doi:10.1016/j.resplu.2024.100651 · Cited by 4
Mortality, morbidity & clinical outcome with different types of vasopressors in out of hospital cardiac arrest patients- a systematic review and meta-analysis
Chander, S., Parkash, O., Luhana, S., Lohana, A. C., Sadarat, F., Sapna, F., Raja, F., Rahaman, Z., Mohammed, Y. N., Shiwlani, S., et al. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-03962-4 · Cited by 4
A critical reappraisal of vasopressin and steroids in in-hospital cardiac arrest
Mentzelopoulos, S. D., & Chalkias, A. F. (2024) · Critical Care · doi:10.1186/s13054-024-04962-8 · Cited by 4
Intra-aortic balloon pump synchronized with chest compressions improves outcome during cardiopulmonary resuscitation in experimental cardiac arrest
Dogan, E. M., Dogan, E. A., Nilsson, K. F., & Edström, M. (2024) · Resuscitation · doi:10.1016/j.resuscitation.2024.110433 · Cited by 4
Social Media in Critical Care
Barrett, K. P., & Sweeney, R. M. (2019) · International Anesthesiology Clinics · doi:10.1097/aia.0000000000000227 · Cited by 4
Outcomes after out‐of‐hospital cardiac arrests by anaphylaxis: A nationwide population‐based observational study
Ota, I., Kubota, Y., Uejima, T., Shigeoka, H., & Hiraide, A. (2019) · Acute Medicine & Surgery · doi:10.1002/ams2.458 · Cited by 4
Pralidoxime-Induced Potentiation of the Pressor Effect of Adrenaline and Hastened Successful Resuscitation by Pralidoxime in a Porcine Cardiac Arrest Model
Lee, H. Y., Mamadjonov, N., Jeung, K. W., Jung, Y. H., Lee, B. K., Moon, K., Heo, T., & Min, Y. I. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07026-5 · Cited by 4
The Latest in Resuscitation Science Research: Highlights From the 2018 American Heart Association's Resuscitation Science Symposium
Teran, F., McGovern, S. K., Dainty, K. N., Sawyer, K. N., Blewer, A. L., Kurz, M. C., Reynolds, J. C., Rittenberger, J. C., Rios, M. D., & Leary, M. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012256 · Cited by 4
The critical care literature 2021
Winters, M. E., Hu, K. M., Martinez, J. P., Mallemat, H. A., & Brady, W. J. (2022) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2022.10.025 · Cited by 4
The related factors for the recovery and maintenance time of sinus rhythm in hospitalized patients with cardiopulmonary resuscitation
Lv, J., Wang, D., Zhang, M. N., Bai, Z.-H., Sun, J., Shi, Y., Pei, H. H., Zhang, Z., & Wang, H. (2019) · Medicine · doi:10.1097/md.0000000000014303 · Cited by 4
Bayesian statistical methods and their application to resuscitation trials
Gates, S., Brock, K., & Ryan, E. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.01.030 · Cited by 4
Self-citation
Assessment of Cardiopulmonary Resuscitation Quality among Healthcare Providers: A Randomized Experimental Study of the Italian Resuscitation Council
Cucino, A., Babini, G., Scapigliati, A., & Ristagno, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185476 · Cited by 3
Intraosseous vs. intravenous access during out-of-hospital cardiac arrest: a Bayesian secondary analysis of a randomised clinical trial
Vallentin, M. F., Holmberg, M. J. J., Granfeldt, A., Klitgaard, T., Mikkelsen, S. S., Folke, F., Christensen, H. C., Povlsen, A. L., Petersen, A. H., Winther, S., et al. (2025) · Resuscitation · doi:10.1016/j.resuscitation.2025.110634 · Cited by 3
Comparative effectiveness of vasopressin, steroids, and epinephrine-based regimens in cardiac arrest: A network Meta-analysis of clinical trials
Saghafi, F., Dehghani, M. H., Erami, S., Salehi‐Abargouei, A., Omrani, M. A., Hoseinzade, F., Shojaeifard, M., & Sahebnasagh, A. (2025) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2025.09.040 · Cited by 3
Prospective Validation of the MIRACLE 2 Score for Early Neurological Stratification After Out-of-Hospital Cardiac-Arrest: The GLOBAL-MIRACLE Registry
Razak, M. A., Vamvakas, G., McGarvey, M., McGrath, S., Rathod, K. S., Elamin, A., Yao, Z., Kordis, P., Simpson, R. F. G., Sajjad, U., et al. (2026) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.125.015918 · Cited by 3
Sodium Bicarbonate for In-Hospital Cardiac Arrest
Granfeldt, A., Kirkegaard, B. L., Vallentin, M. F., Holmberg, M. J. J., Stankovic, N., Lind, P., Kjærgaard, A. G., Houe, N., Vested, M., Isbye, D. L., et al. (2026) · JAMA · doi:10.1001/jama.2026.10628 · Cited by 3
Impact of intravenous accessibility and prehospital epinephrine use on survival outcomes of adult nontraumatic out-of-hospital cardiac arrest patients
Park, S. Y., Choi, B., & Kim, S. H. (2024) · BMC Emergency Medicine · doi:10.1186/s12873-024-00998-9 · Cited by 3
Does Single Dose Epinephrine Improve Outcomes for Patients with Out-of-Hospital Cardiac Arrest and Bystander CPR or a Shockable Rhythm?
George, T. S., Ashburn, N. P., Snavely, A. C., Beaver, B., Chado, M. A., Cannon, H., Costa, C. G., Winslow, J. E., Nelson, R. D., Stopyra, J. P., et al. (2024) · Prehospital Emergency Care · doi:10.1080/10903127.2024.2348663 · Cited by 3
Association between sub-phenotypes identified using latent class analysis and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan
Tamura, H., Yasuda, H., Oishi, T., Shinzato, Y., Amagasa, S., Kashiura, M., & Moriya, T. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-03975-z · Cited by 3
Amiodarone Administration during Cardiopulmonary Resuscitation Is Not Associated with Changes in Short-Term Mortality or Neurological Outcomes in Cardiac Arrest Patients with Shockable Rhythms
Kramser, N., Duse, D. A., Gröne, M., Stücker, B., Voß, F., Tokhi, U., Jung, C., Horn, P., Kelm, M., & Erkens, R. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133931 · Cited by 3
Epinephrine, Pregabalin, and Crizotinib as Three Medicines with Polish Implications over Three Last Centuries and in View of Three Different Drug Discovery Approaches
Kawczak, P., Feszak, I. J., & Bączek, T. (2024) · Biomedicines · doi:10.3390/biomedicines12092021 · Cited by 3
Design projections for prospective studies evaluating the clinical effectiveness of cardiac arrest detection technologies
Hutton, J., Khalili, M., Lingawi, S., Askari, Z., Nourizadeh, M., Sekhon, M., Shadgan, B., Kuo, C., Puyat, J. H., Morrison, L. J., et al. (2025) · Resuscitation · doi:10.1016/j.resuscitation.2025.110681 · Cited by 3
Pediatric Life Support: 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment Recommendations
Scholefield, B. R., Acworth, J., Ng, K.-C., Tiwari, L. K., Raymond, T. T., Christoff, A., Katzenschlager, S., Escalante-Kanashiro, R., Bansal, A., Topjian, A., et al. (2025) · Resuscitation · doi:10.1016/j.resuscitation.2025.110813 · Cited by 3
Self-citation
Outcomes of Patients From All‐Japan Utstein Registry Managed by 2015 Cardiopulmonary Resuscitation Guidelines for Nonshockable Out‐of‐Hospital Cardiac Arrest
Yagi, T., Nagao, K., Yonemoto, N., Tachibana, E., Chiba, N., Ashida, T., Tani, S., Matsumoto, N., Okumura, Y., Tahara, Y., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.125.044171 · Cited by 3
Frequency of Advanced Cardiac Life Support Medication Use and Association With Survival During In-hospital Cardiac Arrest
Benz, P., Chong, S., Woo, S. M.-L., Brenner, N., Wilson, M., Dubin, J. S., Heinrichs, D., Titus, S., Ahn, J., & Goyal, M. K. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.11.001 · Cited by 3

Authors: Perkins, G. D., Ji, C., Deakin, C. D., Quinn, T., Nolan, J. P., Scomparin, C., Regan, S., Long, J., Slowther, A., Pocock, H., Black, J. J. M., Moore, F., Fothergill, R. T., Rees, N., O’Shea, L., Docherty, M., Gunson, I., Han, K., Charlton, K., Finn, J., Petrou, S., Stallard, N., Gates, S., & Lall, R.
Affiliations: University of Warwick (GB)
National Institute for Health and Care Research (GB)
St George's, University of London (GB)
Royal United Hospital (GB)
North East Ambulance Service NHS Foundation Trust (GB)
Curtin University (AU)
ORCID: Perkins, Gavin D.
Ji, Chen
Deakin, Charles D.
Quinn, Tom
Nolan, Jerry P.
Scomparin, Charlotte
Regan, Scott
Long, John
Slowther, Anne
Pocock, Helen
Black, John J.M.
Moore, Fionna
Fothergill, Rachael T.
Rees, Nigel
O’Shea, Lyndsey
Docherty, Mark
Gunson, Imogen
Han, Kyee
Charlton, Karl
Finn, Judith
Petrou, Stavros
Stallard, Nigel
Gates, Simon
Lall, Ranjit
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2018-08-23
Volume: 379
Issue: 8
Pages: 711-721
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1806842
OpenAlex: W2883159984
Cited by: 794
References: 35
Citations by year: 2026: 59 · 2025: 88 · 2024: 101 · 2023: 87 · 2022: 74 · 2021: 105 · 2020: 150 · 2019: 102 · 2018: 27
FWCI: 117.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.nejmgroup.org/legal/terms-of-use.htm (vor)
Locations: New England Journal of Medicine (publishedVersion)
Monash University Research Portal (Monash University) (publishedVersion, other-oa)
PubMed (publishedVersion)
Research Repository (Kingston University London) (acceptedVersion)
Warwick Research Archive Portal (University of Warwick) (acceptedVersion, other-oa)
eSpace (Curtin University) (submittedVersion)
amber - ambulance research repository (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
Explore Bristol Research (submittedVersion)
Funders: Health Technology Assessment Programme (12/127/126)
Topics: Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: out-of-hospital cardiac arrest, epinephrine, cardiopulmonary resuscitation, 30-day survival, neurological outcome, modified Rankin Scale, paramedics, ambulance services, United Kingdom National Health Service, resuscitation guidelines
MeSH terms: Aged, Combined Modality Therapy, Double-Blind Method, Electric Countershock, Emergency Medical Services, Epinephrine, Female, United Kingdom, Humans, Male, Middle Aged, Nervous System Diseases, Sympathomimetics, Survival Rate, Cardiopulmonary Resuscitation, Hospital Mortality, Out-of-Hospital Cardiac Arrest, Time-to-Treatment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks