The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest
Open accessAbstract
BACKGROUND: Concern about the use of epinephrine as a treatment for out-of-hospital cardiac arrest led the International Liaison Committee on Resuscitation to call for a placebo-controlled trial to determine whether the use of epinephrine is safe and effective in such patients. METHODS: In a randomized, double-blind trial involving 8014 patients with out-of-hospital cardiac arrest in the United Kingdom, paramedics at five National Health Service ambulance services administered either parenteral epinephrine (4015 patients) or saline placebo (3999 patients), along with standard care. The primary outcome was the rate of survival at 30 days. Secondary outcomes included the rate of survival until hospital discharge with a favorable neurologic outcome, as indicated by a score of 3 or less on the modified Rankin scale (which ranges from 0 [no symptoms] to 6 [death]). RESULTS: At 30 days, 130 patients (3.2%) in the epinephrine group and 94 (2.4%) in the placebo group were alive (unadjusted odds ratio for survival, 1.39; 95% confidence interval [CI], 1.06 to 1.82; P=0.02). There was no evidence of a significant difference in the proportion of patients who survived until hospital discharge with a favorable neurologic outcome (87 of 4007 patients [2.2%] vs. 74 of 3994 patients [1.9%]; unadjusted odds ratio, 1.18; 95% CI, 0.86 to 1.61). At the time of hospital discharge, severe neurologic impairment (a score of 4 or 5 on the modified Rankin scale) had occurred in more of the survivors in the epinephrine group than in the placebo group (39 of 126 patients [31.0%] vs. 16 of 90 patients [17.8%]). CONCLUSIONS: In adults with out-of-hospital cardiac arrest, the use of epinephrine resulted in a significantly higher rate of 30-day survival than the use of placebo, but there was no significant between-group difference in the rate of a favorable neurologic outcome because more survivors had severe neurologic impairment in the epinephrine group. (Funded by the U.K. National Institute for Health Research and others; Current Controlled Trials number, ISRCTN73485024 .).
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In contrast, a strict requirement for pre-enrolment consent may delay the initiation of an experimental intervention, thereby hampering its potential benefit to the patient. 327”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [327]
Citations
Cites
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
Nolan, J. P., Soar, J., Cariou, A., Cronberg, T., Moulaert, V. R. M., Deakin, C. D., Böttiger, B. W., Friberg, H., Sunde, K., & Sandroni, C. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.07.018 · Cited by 1,139
Self-citationEarly Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest
Hasselqvist‐Ax, I., Riva, G., Herlitz, J. D., Rosenqvist, M., Hollenberg, J., Nordberg, P., Ringh, M., Jonsson, M. N., Axelsson, C., Lindqvist, J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1405796 · Cited by 992
Mode of death after admission to an intensive care unit following cardiac arrest
Laver, S. R., Farrow, C., Turner, D., & Nolan, J. P. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2425-z · Cited by 984
Self-citationEuropean Resuscitation Council Guidelines for Resuscitation 2015
Monsieurs, K. G., Nolan, J. P., Bossaert, L. L., Greif, R., Maconochie, I. K., Nikolaou, N. I., Perkins, G. D., Soar, J., Truhlář, A., Wyllie, J. P., et al. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.07.038 · Cited by 962
Self-citationPerkins, G. D., Jacobs, I. G., Nadkarni, V. M., Berg, R. A., Bhanji, F., Biarent, D., Bossaert, L. L., Brett, S. J., Chamberlain, D., de Caen, A. R., et al. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2014.11.002 · Cited by 726
Self-citationJacobs, I. G., Finn, J., Jelinek, G. A., Oxer, H. F., & Thompson, P. L. (2011) · Resuscitation · doi:10.1016/j.resuscitation.2011.06.029 · Cited by 472
Self-citationHypoxic-ischemic brain injury: Pathophysiology, neuropathology and mechanisms
Busl, K. M., & Greer, D. M. (2010) · Neurorehabilitation · doi:10.3233/nre-2010-0531 · Cited by 368
Public-Access Defibrillation and Out-of-Hospital Cardiac Arrest in Japan
Kitamura, T., Kiyohara, K., Sakai, T., Matsuyama, T., Hatakeyama, T., Shimamoto, T., Izawa, J., Fujii, T., Nishiyama, C., Kawamura, T., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmsa1600011 · Cited by 332
Validation of a Rule for Termination of Resuscitation in Out-of-Hospital Cardiac Arrest
Morrison, L. J., Visentin, L. M., Kiss, A., Theriault, R., Eby, D., Vermeulen, M. J., Sherbino, J., & Verbeek, P. R. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052620 · Cited by 325
Flagged first, then by citations
Research works printed but not linked: 1
- Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. 6. Advanced cardiovascular life support: section 6: pharmacology II: agents to optimize cardiac output and blood pressure. Circulation 2000;102:Suppl:I-129–I-135.10966670
Cited by
Sorted by citations
Items 401–500 of 797
Miraglia, D., & Ramzy, M. M. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.12.031 · Cited by 3
(2021) · Signa Vitae · doi:10.22514/sv.2021.046 · Cited by 3
Poth, J. M., Buschmann, C. M., Kappler, J., Heister, U., Ehrentraut, S., Muenster, S., Diepenseifen, C. J., Ellerkmann, R. K., & Schewe, J.-C. (2021) · Notfall + Rettungsmedizin · doi:10.1007/s10049-021-00929-2 · Cited by 3
How to design and interpret a randomised controlled trial using Bayesian statistics
Charlesworth, M., & Carlisle, J. B. (2022) · Anaesthesia · doi:10.1111/anae.15800 · Cited by 3
Response by Ashburn et al. to Letter “ Caveat Cum CARES”
Ashburn, N. P., Snavely, A. C., Mahler, S. A., & Stopyra, J. P. (2022) · Prehospital Emergency Care · doi:10.1080/10903127.2022.2141933 · Cited by 3
Yumoto, T., Hongo, T., Hifumi, T., Inoue, A., Sakamoto, T., Kuroda, Y., Yorifuji, T., Nakao, A., & Naito, H. (2023) · Journal of the American College of Emergency Physicians Open · doi:10.1002/emp2.12948 · Cited by 3
Hou, M., Dong, S., Kan, Q., Ouyang, M., & Zhang, Y. (2023) · Acta Pharmaceutica · doi:10.2478/acph-2023-0022 · Cited by 3
Serpa, E., Zimmerman, S. A., Bauman, Z. M., & Kulvatunyou, N. (2023) · Cureus · doi:10.7759/cureus.48181 · Cited by 3
Sun, K., Ilić, K., Xu, P., Ye, R., Wu, J., & Song, I. H. (2024) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.1406 · Cited by 3
Pocock, H., Dove, A., Pointeer, L., Couper, K., & Perkins, G. D. (2024) · Emergency Medicine Journal · doi:10.1136/emermed-2023-213648 · Cited by 3
Self-citationPulmonary vasodilation during cardiopulmonary resuscitation – A randomized, controlled porcine study
Nørholt, C. H., Johannsen, C. M., Baltsen, C. D., Lund, M. H., Kjærsgaard, L., Solberg, S. M. A., Hørsdal, O. K., Vammen, L., Lyhne, M. D., Andersen, L. W., et al. (2024) · Resuscitation · doi:10.1016/j.resuscitation.2024.110329 · Cited by 3
Kanbakan, A. (2024) · doi:10.5152/2314 · Cited by 3
Müeller, M., Holzer, M., Losert, H., Grassmann, D., Ettl, F., Gatterbauer, M., Magnet, I. A. M., Nuernberger, A., Kienbacher, C. L., Gelbenegger, G., et al. (2025) · Critical Care · doi:10.1186/s13054-025-05255-4 · Cited by 3
Cardiac Arrest: Can Technology Be the Solution?
Lapostolle, F., Agostinucci, J., Pétrovic, T., & Féral‐Pierssens, A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14030972 · Cited by 3
Fluid balance after cardiac arrest: Any impact on outcome? Insights from the MIMIC IV database
Didier, J., Murris, J., Schopper, H., Guérin, E., Flajoliet, N., Amiot, M., Hermann, B., Germain, S., Cariou, A., Diehl, J., et al. (2025) · Resuscitation Plus · doi:10.1016/j.resplu.2025.101037 · Cited by 3
Laird, J. R., Costa-Arbulu, C., Marighetto, M., Grochal, A., Drennan, I. R., & Cheskes, S. (2020) · Prehospital Emergency Care · doi:10.1080/10903127.2020.1716283 · Cited by 3
Kovar, A. J., Olsen, J., & Augoustides, J. G. (2020) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2020.03.029 · Cited by 3
Resuscitating Resuscitation: Advanced Therapies for Resistant Ventricular Dysrhythmias
Roach, C., Tainter, C. “., Sell, R., & Wardi, G. (2020) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2020.10.051 · Cited by 3
Adrenaline effects on cerebral physiology during cardiac arrest: More to this story
Slovis, J., Morgan, R. W., Kilbaugh, T. J., & Berg, R. A. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.09.012 · Cited by 3
Murasaka, K., Yamashita, A., Wato, Y., & Inaba, H. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-062877 · Cited by 3
Battaglini, D., Bogossian, E. G., Anania, P., Premraj, L., Cho, S., Taccone, F. S., Sekhon, M. S., & Robba, C. (2023) · Neurocritical Care · doi:10.1007/s12028-023-01721-5 · Cited by 3
Macdonald, S., Fatovich, D. M., Finn, J., & Litton, E. (2024) · Critical Care Clinics · doi:10.1016/j.ccc.2024.03.009 · Cited by 3
Self-citationChen, H., Xia, F., Jin, Z., Shi, K., Xia, Y. L., Liu, L., Papadimos, T. J., Xu, X., & Chen, L. (2018) · BMC Anesthesiology · doi:10.1186/s12871-018-0627-0 · Cited by 3
Resuscitation highlights in 2018
Nolan, J. P., Ornato, J. P., Parr, M. J., Perkins, G. D., & Soar, J. (2019) · Resuscitation · doi:10.1016/j.resuscitation.2019.01.019 · Cited by 3
Self-citationAdrenalin bei Patienten mit prähospitalem Herz-Kreislauf-Stillstand
Janssens, U., & Michels, G. (2018) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-018-0478-y · Cited by 3
Adrenaline in Patients with out-of-hospital Cardiac Arrest PARAMEDIC2 Trial
Janssens, U., & Michels, G. (2019) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 3
Macchini, E., Dillenbeck, E., Jonsson, M. N., Annoni, F., Forsberg, S., Hollenberg, J., Truhlář, A., Svensson, L. A., Nordberg, P., & Taccone, F. S. (2022) · Brain Sciences · doi:10.3390/brainsci12101374 · Cited by 3
Feasibility of a Modified Strategy for 2-Rescuer Cardiopulmonary Resuscitation
Root, C. W., Deutsch, B. C., Lakha, S., Shah, A., Lin, H. M., & Hyman, J. B. (2019) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2019.03.009 · Cited by 3
Okuma, Y., Yagi, T., Yin, T., Kiguchi, T., Iwami, T., Becker, L. B., & Shinozaki, K. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-48238-1_44 · Cited by 3
RetractedTranslating Protective Hypothermia During Cardiac Arrest Into Clinical Practice
Hirsch, K. G., & Callaway, C. W. (2019) · JAMA · doi:10.1001/jama.2019.4253 · Cited by 3
Dual sequential defibrillation: Hold your horses!
Deakin, C. D. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.03.001 · Cited by 3
Self-citationResults of the PARAMEDIC-2 trial and how they relate to resuscitation after cardiac surgery
Dunning, J., & Trevis, J. (2020) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2020.02.050 · Cited by 3
Lee, S., & Okubo, M. (2021) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2021.10.016 · Cited by 3
Brown, A. R., Gajewski, B. J., Mudaranthakam, D. P., Pasnoor, M., Dimachkie, M. M., Jawdat, O., Herbelin, L. L., Mayo, M. S., & Barohn, R. J. (2023) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2023.101220 · Cited by 2
Pharmacotherapy Considerations for Inpatient Advanced Cardiac Life Support
Posgai, L., & Hochstetler, A. (2025) · AACN Advanced Critical Care · doi:10.4037/aacnacc2025540 · Cited by 2
Zhang, J., Guo, E., & Xin, Y. (2025) · Alexandria Engineering Journal · doi:10.1016/j.aej.2025.06.033 · Cited by 2
Lilien, E. J., Ashburn, N. P., George, T. S., Snavely, A. C., Beaver, B., Costa, C. G., Chado, M. A., Cannon, H. A., Winslow, J. E., Nelson, R. D., et al. (2025) · Academic Emergency Medicine · doi:10.1111/acem.70154 · Cited by 2
Adrenaline and return of spontaneous circulation during in-hospital cardiac arrest
Norvik, A., Unneland, E., Bergum, D., Loennechen, J. P., Kvaløy, J. T., Aramendi, E., Urtega, J. L. C., & Skogvoll, E. (2025) · Resuscitation Plus · doi:10.1016/j.resplu.2025.101140 · Cited by 2
Ko, Y., Lin, Y.-Y., Yang, W.-S., Tseng, Y.-T., Huang, T.-J., Lai, C.-T., Huang, S.-Y., Hsieh, C.-M., Wang, P.-L., Chen, H.-H., et al. (2025) · Resuscitation Plus · doi:10.1016/j.resplu.2025.101163 · Cited by 2
Emoto, R., Nishikimi, M., Kikutani, K., Ishii, J., Ohshimo, S., Matsui, S., Shime, N., & Iwami, T. (2026) · Resuscitation · doi:10.1016/j.resuscitation.2026.111116 · Cited by 2
2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 4. Adult advanced life support
Kim, T.-Y., Ahn, G. J., Cha, K., Kim, D., Sohn, Y. D., Song, Y. R., Shim, G. H., Kim, D. K., Oh, Y., Wi, J. H., et al. (2026) · Clinical and Experimental Emergency Medicine · doi:10.15441/ceem.26.073 · Cited by 2
Wilson, M., Schwartz, S., & Verbeek, P. R. (2019) · Prehospital Emergency Care · doi:10.1080/10903127.2019.1612972 · Cited by 2
Nakajima, J., Sawada, Y., Isshiki, Y., Ichikawa, Y., Fukushima, K., Aramaki, Y., & Oshima, K. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07708 · Cited by 2
Reanimación cardiopulmonar en el medio hospitalario
Debord, S., Peguet, O., Carry, P.-Y., & Gueugniaud, P.-Y. (2022) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(22)46406-1 · Cited by 2
A randomised preclinical trial of adrenaline use during cardiac arrest in mice
Donner, D. G., Bloom, J. E., Shihata, W., Brown, A., Cook, R. F., Tai, T. Y., Lambert, G. W., Chu, P., Chan, W., Stub, D. A., et al. (2022) · Resuscitation Plus · doi:10.1016/j.resplu.2022.100292 · Cited by 2
The Pharmacologic Management of Cardiac Arrest
Singh, A., Heeney, M. E., & Montgomery, M. E. (2023) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2023.03.010 · Cited by 2
State of the art post-cardiac arrest care: evolution and future of post cardiac arrest care
Grand, J., & Hassager, C. (2023) · European Heart Journal Acute Cardiovascular Care · doi:10.1093/ehjacc/zuad067 · Cited by 2
Corsetti, M., & Lubin, J. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-47873-4_13 · Cited by 2
Ray, L., Acquisto, N. M., Coralic, Z., Feldman, R., Mercer, K., Zimmerman, D. E., Howington, G. T., Slocum, G. W., Faine, B. A., & Rech, M. A. (2024) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxae186 · Cited by 2
Nakamura, A., & Odo, M. (2024) · Cureus · doi:10.7759/cureus.75736 · Cited by 2
The effects of norepinephrine in shockable cardiac arrest, a scoping review
Bouman, S. J. M., Baldussu, E., Franssen, G. H. L. M., van Geffen, G., Bruhn, J., Slagt, C., & Mommers, L. (2025) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-025-01480-6 · Cited by 2
The knowledge of and attitudes toward anaphylaxis emergency management among Polish dentists
Ptaszynski, P., Raczynski, A., Aluchna, M., Aluchna, A., & Smereka, J. (2018) · Disaster and Emergency Medicine Journal · doi:10.5603/demj.2018.0027 · Cited by 2
Arrêt cardiaque au bloc opératoire
Mongardon, N., de Roux, Q., Rkaiby, J., Boulanger, B., & Langeron, O. (2019) · Le Praticien en Anesthésie Réanimation · doi:10.1016/j.pratan.2019.10.005 · Cited by 2
Gazmuri, R. J., & Dhliwayo, N. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.02.014 · Cited by 2
Cardiopulmonary Resuscitation: Recent Advances
Kumar, A., Yadav, P., & Garg, R. K. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91866 · Cited by 2
Owen, P., & Sherriff, M. (2022) · British Paramedic Journal · doi:10.29045/14784726.2022.12.7.3.1 · Cited by 2
Intra‐arrest blood‐based biomarkers for out‐of‐hospital cardiac arrest: A scoping review
Benoit, J. L., Hogan, A. N., Connelly, K. M., & McMullan, J. T. (2024) · Journal of the American College of Emergency Physicians Open · doi:10.1002/emp2.13131 · Cited by 2
Otani, H., Sagisaka, R., Nakagawa, K., Morioka, D., & Tanaka, H. (2025) · Prehospital Emergency Care · doi:10.1080/10903127.2025.2589961 · Cited by 2
Cardiopulmonary resuscitation and post-resuscitation care
O'Connor, M. C., & Cattlin, C. S. (2018) · Anaesthesia & intensive care medicine · doi:10.1016/j.mpaic.2018.09.005 · Cited by 2
Hong Kong needs a territory-wide registry for out-of-hospital cardiac arrest
Lui, C., Lau, C., Siu, A. Y. C., Fan, K., & Leung, L. (2019) · Hong Kong Medical Journal · doi:10.12809/hkmj187661 · Cited by 2
Assessment of epinephrine efficacy in out-of-hospital cardiac arrest
(GrAM), G. D. A. M., Bonzi, M., Peta, J. A., Fusco, A., & Bosco, P. (2019) · Internal and Emergency Medicine · doi:10.1007/s11739-019-02158-5 · Cited by 2
Sharma, A., Sonny, A., Panaich, S., Walia, A., & Ramakrishna, H. (2020) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2020.05.031 · Cited by 2
Key articles and guidelines for the emergency medicine clinical pharmacist: 2011-2018 update
Acquisto, N. M., Slocum, G. W., Bilhimer, M. H., Awad, N. I., Baker, S. N., Kelly, G., Makhoul, T., Patanwala, A. E., Peksa, G. D., Porter, B. A., et al. (2020) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxaa178 · Cited by 2
Aziz, A. H. B. A., & Muhamad, N. A. N. (2020) · Journal of emergency medicine, trauma & acute care · doi:10.5339/jemtac.2020.11 · Cited by 2
Drug use during adult advanced cardiac life support: An overview of reviews
Vandersmissen, H., Gworek, H., Dewolf, P., & Sabbe, M. B. (2021) · Resuscitation Plus · doi:10.1016/j.resplu.2021.100156 · Cited by 2
Manzo‐Silberman, S., Nix, C., Goetzenich, A., Demondion, P., Kang, C., Bonneau, M., Solal, A. C., Leprince, P. N., & Lebreton, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163623 · Cited by 2
Okuma, Y., Yagi, T., Yin, T., Kiguchi, T., Iwami, T., Becker, L. B., & Shinozaki, K. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-48238-1_6 · Cited by 2
Zaitseva, D., & Abella, B. S. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.26200 · Cited by 2
Causal inference from observational data in emergency medicine research
Catoire, P., Genuer, R., & Proust‐Lima, C. (2023) · European Journal of Emergency Medicine · doi:10.1097/mej.0000000000001012 · Cited by 2
Müeller, M., Schnaubelt, S., Mitteregger, T., Grafeneder, J., & Ettl, F. (2024) · Resuscitation · doi:10.1016/j.resuscitation.2024.110293 · Cited by 2
Epinephrine in Out-Of-Hospital Cardiac Arrest
Rosenberg, K. E. (2018) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000549696.71574.fc · Cited by 2
Welsford, M., Buick, J. E., Drennan, I. R., Lin, S., & Atkinson, P. (2019) · Canadian Journal of Emergency Medicine · doi:10.1017/cem.2019.17 · Cited by 2
Ruch, R., Stoessel, L., Stein, P., Ganter, M. T., & Button, D. A. (2019) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-019-0682-7 · Cited by 2
Baird, A. S., Coppler, P. J., Callaway, C. W., Dezfulian, C., Flickinger, K. L., & Elmer, J. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.08.012 · Cited by 2
Cortesi, P. A., Botto, G. L., D’Angiolella, L. S., Scalone, L., Ponti, R. D., Boriani, G., & Mantovani, L. G. (2021) · Farmeconomia Health economics and therapeutic pathways · doi:10.7175/fe.v22i1s.1486 · Cited by 2
Improving Resuscitation Rates After Out-of-Hospital Cardiac Arrest
Dorian, P., & Lin, S. (2019) · Circulation · doi:10.1161/circulationaha.118.038822 · Cited by 2
Can a Physiologic Insight “Resuscitate” Research in Cardiopulmonary Resuscitation?
Scales, D. C., & Kavanagh, B. P. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201810-1912ed · Cited by 2
The need for comprehensive NIRS-measurement from on-scene treatment to post-ROSC phase
Schnaubelt, S., & Uray, T. (2019) · Resuscitation · doi:10.1016/j.resuscitation.2019.07.038 · Cited by 2
Difficulties in undertaking research in acutely ill cardiac patients
López‐Sobrino, T., & Gershlick, A. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz857 · Cited by 2
Epinephrine for Pediatric Out-of-Hospital Cardiac Arrest
de Caen, A. R., Moylan, A., & Maconochie, I. K. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.10.051 · Cited by 2
Intraosseous adrenaline for adult out-of-hospital cardiac arrest: Faster access with worse outcomes
Morgan, R. W., & Berg, R. A. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.02.009 · Cited by 2
Targeted Temperature Management for Cardiac Arrest
Moskowitz, A., Berg, K. M., & Donnino, M. W. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2011066 · Cited by 2
Resuscitation Plus: The right journal for a new dawn for experimental resuscitation science research
Granfeldt, A., Nolan, J. P., & Ristagno, G. (2020) · Resuscitation Plus · doi:10.1016/j.resplu.2020.100019 · Cited by 2
Self-citationThe neurologic impact of epinephrine during cardiac arrest: Much to learn
Kilbaugh, T. J., Morgan, R. W., & Berg, R. A. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.07.017 · Cited by 2
Neth, M. R., & Daya, M. R. (2022) · Resuscitation · doi:10.1016/j.resuscitation.2022.109674 · Cited by 2
Examining the benefits of paramedic engagement for the novice researcher
Coppola, A. (2018) · Journal of Paramedic Practice · doi:10.12968/jpar.2018.10.12.524 · Cited by 1
Advanced cardiac life support: lessons from recent trials on how to move forward
Berg, K. M., & Soar, J. (2021) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000875 · Cited by 1
Henao, S. A. M., Builes, D. E. G., Velásquez, J. C. V., Vidal, P. A. E., & Vallejo-Bocanumen, C. E. (2024) · Colombian Journal of Anesthesiology · doi:10.5554/22562087.e1102 · Cited by 1
Timing the key to meaningful survival: The importance of early epinephrine in cardiac arrest
Perlmutter, M. C., & Moore, J. (2025) · Academic Emergency Medicine · doi:10.1111/acem.70009 · Cited by 1
Management of sudden cardiac arrest
Kosmopoulos, M., & Benditt, D. G. (2025) · Minerva Cardiology and Angiology · doi:10.23736/s2724-5683.24.06607-9 · Cited by 1
The hemodynamic response to epinephrine during CPR: a renewed call for precision resuscitation
Morgan, R. W., & Berg, R. A. (2025) · Resuscitation · doi:10.1016/j.resuscitation.2025.110635 · Cited by 1
Pittiu, A., Locci, E., Ferino, G., Lai, E., Valenti, D., Casula, L., Sinico, C., Murgia, S., d’Aloja, E., Xanthos, T. T., et al. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125961 · Cited by 1
Yamazaki, S., Nakagawa, K., Ueta, H., & Tanaka, H. (2025) · Cureus · doi:10.7759/cureus.91022 · Cited by 1
Ijuin, S., Inoue, A., Hifumi, T., Taira, T., Moriyama, T., Suga, M., Nishimura, T., Sakamoto, T., Kuroda, Y., & Ishihara, S. (2025) · American Heart Journal · doi:10.1016/j.ahj.2025.08.012 · Cited by 1
The use of epinephrine in out-of-hospital cardiac arrest
Gruebl, T., Jungblut, J., Rupp, D., Ha, C. S. R., Ploeger, B., Haag, D. M., Uzun, D. D., Jänig, C. W., Sassen, M. C., Schieffer, B., et al. (2025) · BMC Emergency Medicine · doi:10.1186/s12873-025-01351-4 · Cited by 1
Intravenous adrenaline (epinephrine): its use in the critical care setting
Bright, M. R., Mudannayake, R., & Fanning, J. P. (2025) · Postgraduate Medical Journal · doi:10.1093/postmj/qgaf234 · Cited by 1
O’Callaghan, M., Bělohlávek, J., Cvetkovic, M., Davidson, M., Guerguerian, A. M., Hoskote, A. U., Pollak, U., Raman, L., Roeleveld, P. P., Thiruchelvam, T., et al. (2026) · ASAIO Journal · doi:10.1097/mat.0000000000002740 · Cited by 1
Lee, S. H., Hong, W. P., Park, J. H., Kim, M., & Kim, Y. S. (2026) · Emergency Medicine Journal · doi:10.1136/emermed-2025-215848 · Cited by 1
Paramedics with doctorates: providing an original contribution to paramedic knowledge?
Willis, S., & Copson, J. (2024) · International Journal for Advancing Practice · doi:10.12968/ijap.2024.2.1.46 · Cited by 1
Re-evaluating intra-cardiac arrest adjunctive medications and routes of drug administration
Lind, P., Vallentin, M. F., Granfeldt, A., & Andersen, L. W. (2024) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000001206 · Cited by 1
Metadata
- Authors
- Perkins, G. D., Ji, C., Deakin, C. D., Quinn, T., Nolan, J. P., Scomparin, C., Regan, S., Long, J., Slowther, A., Pocock, H., Black, J. J. M., Moore, F., Fothergill, R. T., Rees, N., O’Shea, L., Docherty, M., Gunson, I., Han, K., Charlton, K., Finn, J., Petrou, S., Stallard, N., Gates, S., & Lall, R.
- Affiliations
- University of Warwick (GB)
- National Institute for Health and Care Research (GB)
- St George's, University of London (GB)
- Royal United Hospital (GB)
- North East Ambulance Service NHS Foundation Trust (GB)
- Curtin University (AU)
- ORCID
- Perkins, Gavin D.
- Ji, Chen
- Deakin, Charles D.
- Quinn, Tom
- Nolan, Jerry P.
- Scomparin, Charlotte
- Regan, Scott
- Long, John
- Slowther, Anne
- Pocock, Helen
- Black, John J.M.
- Moore, Fionna
- Fothergill, Rachael T.
- Rees, Nigel
- O’Shea, Lyndsey
- Docherty, Mark
- Gunson, Imogen
- Han, Kyee
- Charlton, Karl
- Finn, Judith
- Petrou, Stavros
- Stallard, Nigel
- Gates, Simon
- Lall, Ranjit
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2018-08-23
- Volume
- 379
- Issue
- 8
- Pages
- 711-721
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2883159984
- Cited by
- 794
- References
- 35
- Citations by year
- 2026: 59 · 2025: 88 · 2024: 101 · 2023: 87 · 2022: 74 · 2021: 105 · 2020: 150 · 2019: 102 · 2018: 27
- FWCI
- 117.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- Monash University Research Portal (Monash University) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Research Repository (Kingston University London) (acceptedVersion)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion, other-oa)
- eSpace (Curtin University) (submittedVersion)
- amber - ambulance research repository (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Explore Bristol Research (submittedVersion)
- Funders
- Health Technology Assessment Programme (12/127/126)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- out-of-hospital cardiac arrest, epinephrine, cardiopulmonary resuscitation, 30-day survival, neurological outcome, modified Rankin Scale, paramedics, ambulance services, United Kingdom National Health Service, resuscitation guidelines
- MeSH terms
- Aged, Combined Modality Therapy, Double-Blind Method, Electric Countershock, Emergency Medical Services, Epinephrine, Female, United Kingdom, Humans, Male, Middle Aged, Nervous System Diseases, Sympathomimetics, Survival Rate, Cardiopulmonary Resuscitation, Hospital Mortality, Out-of-Hospital Cardiac Arrest, Time-to-Treatment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
