The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer
Open accessAbstract
BACKGROUND: Standard therapy for advanced endometrial cancer after failure of platinum-based chemotherapy remains unclear. METHODS: In this phase 3 trial, we randomly assigned, in a 1:1 ratio, patients with advanced endometrial cancer who had previously received at least one platinum-based chemotherapy regimen to receive either lenvatinib (20 mg, administered orally once daily) plus pembrolizumab (200 mg, administered intravenously every 3 weeks) or chemotherapy of the treating physician's choice (doxorubicin at 60 mg per square meter of body-surface area, administered intravenously every 3 weeks, or paclitaxel at 80 mg per square meter, administered intravenously weekly [with a cycle of 3 weeks on and 1 week off]). The two primary end points were progression-free survival as assessed on blinded independent central review according to the Response Evaluation Criteria in Solid Tumors, version 1.1, and overall survival. The end points were evaluated in patients with mismatch repair-proficient (pMMR) disease and in all patients. Safety was also assessed. RESULTS: A total of 827 patients (697 with pMMR disease and 130 with mismatch repair-deficient disease) were randomly assigned to receive lenvatinib plus pembrolizumab (411 patients) or chemotherapy (416 patients). The median progression-free survival was longer with lenvatinib plus pembrolizumab than with chemotherapy (pMMR population: 6.6 vs. 3.8 months; hazard ratio for progression or death, 0.60; 95% confidence interval [CI], 0.50 to 0.72; P<0.001; overall: 7.2 vs. 3.8 months; hazard ratio, 0.56; 95% CI, 0.47 to 0.66; P<0.001). The median overall survival was longer with lenvatinib plus pembrolizumab than with chemotherapy (pMMR population: 17.4 vs. 12.0 months; hazard ratio for death, 0.68; 95% CI, 0.56 to 0.84; P<0.001; overall: 18.3 vs. 11.4 months; hazard ratio, 0.62; 95% CI, 0.51 to 0.75; P<0.001). Adverse events of grade 3 or higher occurred in 88.9% of the patients who received lenvatinib plus pembrolizumab and in 72.7% of those who received chemotherapy. CONCLUSIONS: Lenvatinib plus pembrolizumab led to significantly longer progression-free survival and overall survival than chemotherapy among patients with advanced endometrial cancer. (Funded by Eisai and Merck Sharp and Dohme [a subsidiary of Merck]; Study 309-KEYNOTE-775 ClinicalTrials.gov number, NCT03517449.).
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Pembrolizumab versus Ipilimumab in Advanced Melanoma
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Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid Cancer
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Self-citationLandscape of Microsatellite Instability Across 39 Cancer Types
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Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer
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Metadata
- Authors
- Makker, V., Colombo, N., Casado Herráez, A., Santin, A. D., Colomba, E., Miller, D. S., Fujiwara, K., Pignata, S., Baron-Hay, S., Ray-Coquard, I., Shapira-Frommer, R., Ushijima, K., Sakata, J., Yonemori, K., Kim, Y. M., Guerra, E. M., Sanli, U. A., McCormack, M. M., Smith, A. D., Keefe, S., Bird, S., Dutta, L., Orlowski, R. J., & Lorusso, D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2022-02-03
- Volume
- 386
- Issue
- 5
- Pages
- 437-448
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4205306227
- Cited by
- 930
- References
- 28
- FWCI
- 168.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Makker, V., Colombo, N., Casado Herráez, A., Santin, A. D., Colomba, E., Miller, D. S., Fujiwara, K., Pignata, S., Baron-Hay, S., Ray-Coquard, I., Shapira-Frommer, R., Ushijima, K., Sakata, J., Yonemori, K., Kim, Y. M., Guerra, E. M., Sanli, U. A., McCormack, M. M., Smith, A. D., . . . Lorusso, D. (2022). Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer. New England Journal of Medicine. https://doi.org/10.1056/nejmoa2108330
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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