Cited by 1,206Cancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesT-cell and B-cell Immunology

Immune checkpoint therapy—current perspectives and future directions

Open access
Sharma, Padmanee, Goswami, Sangeeta, Raychaudhuri, Deblina, Siddiqui, Bilal A., Singh, Pratishtha, Nagarajan, Ashwat, Liu, Jielin, Subudhi, Sumit K. +8 more·2023·Cell

Abstract

Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer patients and conferred durable clinical benefits, including cure in a subset of patients. Varying response rates across tumor types and the need for predictive biomarkers to optimize patient selection to maximize efficacy and minimize toxicities prompted efforts to unravel immune and non-immune factors regulating the responses to ICT. This review highlights the biology of anti-tumor immunity underlying response and resistance to ICT, discusses efforts to address the current challenges with ICT, and outlines strategies to guide the development of subsequent clinical trials and combinatorial efforts with ICT.

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Crossref · 10.1016/j.cell.2023.03.006

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  • Obesity is a risk factor for and exacerbates the clinical course of a number of autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease and psoriasis.

    “Obesity is a risk factor for and exacerbates the clinical course of a number of AIDs including rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease and psoriasis (43).”
  • More recent work in mice revealed the roles of T cell inhibitory receptors in restraining immune responses leading to checkpoint blockade, which revolutionized cancer immunotherapy.

    “More recent work in mice revealed the roles of T cell inhibitory receptors in restraining immune responses leading to checkpoint blockade, which revolutionized cancer immunotherapy(43).”

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Authors
Sharma, P., Goswami, S., Raychaudhuri, D., Siddiqui, B. A., Singh, P., Nagarajan, A., Liu, J., Subudhi, S. K., Poon, C., Gant, K. L., Herbrich, S. M., Anandhan, S., Islam, S., Amit, M., Anandappa, G., & Allison, J. P.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Sharma, Padmanee
Venue
Cell
Publisher
Elsevier BV
Published
2023-04
Volume
186
Issue
8
Pages
1652-1669
ISSN
0092-8674 (ISSN-L)
OpenAlex
W4365446410
Cited by
1,206
References
38
Citations by year
2026: 411 · 2025: 435 · 2024: 291 · 2023: 69
FWCI
39.20
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Commons-TMC (Texas Medical Center) (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
immune checkpoint inhibitors, antitumor immunity, predictive biomarkers, treatment resistance, patient selection, combination therapy, cancer immunotherapy, immune response mechanisms
MeSH terms
Immune Checkpoint Inhibitors, Clinical Trials as Topic, Humans, Immunotherapy, Neoplasms, B7-H1 Antigen

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