The Randomized Registry Trial — The Next Disruptive Technology in Clinical Research?
Abstract
The registry-based randomized trial may make less expensive, more efficient clinical studies possible. But before the new study design can be widely used, questions about the quality of the underlying data sets must be addressed.
Integrity signals
Registry
Cites
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Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RCTs can suffer from a high risk of failure and a restricted external validity, limiting conclusions on effectiveness in clinical practice settings-if ideal conditions cannot be realized.
“Finally, RCTs can suffer from a high risk of failure and a restricted external validity, limiting conclusions on effectiveness in clinical practice settings—if ideal conditions cannot be realized (Lauer and D'Agostino 2013).”
From Dental Research in the Digital Age: The Registry-Based Clinical Trial. (2026) · cites this paper as Lauer and D'Agostino 2013
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Sorted by citations
Ramsey, S. D., Willke, R. J., Glick, H., Reed, S. D., Augustovski, F., Jonsson, B., Briggs, A., & Sullivan, S. D. (2015) · Value in Health · doi:10.1016/j.jval.2015.02.001 · Cited by 811 · see citing works
Registry-based randomized clinical trials—a new clinical trial paradigm
James, S., Rao, S. V., & Granger, C. B. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.33 · Cited by 331 · see citing works
Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes
Holman, R. R., Sourij, H., & Califf, R. M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60794-7 · Cited by 227 · see citing works
Fanaroff, A. C., Califf, R. M., Windecker, S., Smith, S. C., & Lopes, R. D. (2019) · JAMA · doi:10.1001/jama.2019.1122 · Cited by 228 · see citing works
Using e-technologies in clinical trials
Rosa, C., Campbell, A. N. C., Miele, G. M., Brunner, M., & Winstanley, E. L. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.07.007 · Cited by 147 · see citing works
The Evolution and Future of ACC/AHA Clinical Practice Guidelines: A 30-Year Journey
Jacobs, A. K., Anderson, J. L., & Halperin, J. L. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.06.001 · Cited by 109 · see citing works
Tissot, H. C., Shah, A. D., Brealey, D., Harris, S., Agbakoba, R., Folarin, A., Romao, L., Roguski, L., Dobson, R., & Asselbergs, F. W. (2020) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2020.2977925 · Cited by 61 · see citing works
Åsberg, S., Hijazi, Z., Norrving, B., Terént, A., Öhagen, P., & Oldgren, J. (2017) · Trials · doi:10.1186/s13063-017-2313-9 · Cited by 43 · see citing works
Strom, J. B., Faridi, K. F., Butala, N. M., Zhao, Y., Tamez, H., Valsdottir, L. R., Brennan, J. M., Shen, C., Popma, J. J., Kazi, D. S., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.046159 · Cited by 37 · see citing works
The Randomized Registry Trial: Two Birds, One Stone
Liu, J. B., D’Angelica, M. I., & Ko, C. Y. (2017) · Annals of Surgery · doi:10.1097/sla.0000000000002166 · Cited by 15 · see citing works
Dental Research in the Digital Age: The Registry-Based Clinical Trial.
Joda, T., Settecase, E., Heitz‐Mayfield, L., Derks, J., Jung, R. E., & Zitzmann, N. U. (2026) · Clinical oral implants research · doi:10.1111/clr.70061 · Cited by 2 · see citing works
- Authors
- Lauer, M. S., & D'Agostino, R. B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2013-10-24
- Volume
- 369
- Issue
- 17
- Pages
- 1579-1581
- ISSN
- 0028-4793
- 1533-4406
- Cited by
- 497
- References
- 0
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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