Timing of oral anticoagulant therapy in acute ischemic stroke with atrial fibrillation: study protocol for a registry-based randomised controlled trial
Open accessAbstract
BACKGROUND: Oral anticoagulation therapy is recommended for the prevention of recurrent ischemic stroke in patients with atrial fibrillation (AF). Current guidelines do not provide evidence-based recommendations on optimal time-point to start anticoagulation therapy after an acute ischemic stroke. Non-vitamin K antagonist oral anticoagulants (NOACs) may offer advantages compared to warfarin because of faster and more predictable onset of action and potentially a lower risk of intracerebral haemorrhage also in the acute phase after an ischemic stroke. The TIMING study aims to establish the efficacy and safety of early vs delayed initiation of NOACs in patients with acute ischemic stroke and AF. METHODS/DESIGN: The TIMING study is a national, investigator-led, registry-based, multicentre, open-label, randomised controlled study. The Swedish Stroke Register is used for enrolment, randomisation and follow-up of 3000 patients, who are randomised (1:1) within 72 h from ischemic stroke onset to either early (≤ 4 days) or delayed (≥ 5-10 days) start of NOAC therapy. The primary outcome is the composite of recurrent ischemic stroke, symptomatic intracerebral haemorrhage, or all-cause mortality within 90 days after randomisation. Secondary outcomes include: individual components of the primary outcome at 90 and 365 days; major haemorrhagic events; functional outcome by the modified Rankin Scale at 90 days; and health economics. In an optional biomarker sub-study, blood samples will be collected after randomisation from approximately half of the patients for central analysis of cardiovascular biomarkers after study completion. The study is funded by the Swedish Medical Research Council. Enrolment of patients started in April 2017. CONCLUSION: The TIMING study addresses the ongoing clinical dilemma of when to start NOAC after an acute ischemic stroke in patients with AF. By the inclusion of a randomisation module within the Swedish Stroke Register, the advantages of a prospective randomised study design are combined with the strengths of a national clinical quality register in allowing simplified enrolment and follow-up of study patients. In addition, the register adds the possibility of directly assessing the external validity of the study findings. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02961348 . Registered on 8 November 2016.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609 · see citing works
Dabigatran versus warfarin in patients with atrial fibrillation
Connolly, S. J., Ezekowitz, M. D., Yusuf, S., Eikelboom, J., Oldgren, J., Parekh, A., Pogue, J., Reilly, P. A., Themeles, E., Varrone, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905561 · Cited by 11,215 · see citing works
Self-citationRivaroxaban versus warfarin in nonvalvular atrial fibrillation
Patel, M. R., Mahaffey, K. W., Garg, J., Pan, G., Singer, D. E., Hacke, W., Breithardt, G., Halperin, J. L., Hankey, G. J., Piccini, J. P., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1009638 · Cited by 9,430 · see citing works
Apixaban versus warfarin in patients with atrial fibrillation
Granger, C. B., Alexander, J. H., McMurray, J. J. V., Lopes, R. D., Hylek, E. M., Hanna, M., Al-Khalidi, H. R., Ansell, J., Atar, D., Avezum, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1107039 · Cited by 8,943 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
Self-citation2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
Self-citationKernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., et al. (2014) · Stroke · doi:10.1161/str.0000000000000024 · Cited by 5,170 · see citing works
Edoxaban versus warfarin in patients with atrial fibrillation
Giugliano, R. P., Ruff, C. T., Braunwald, E., Murphy, S. A., Wiviott, S. D., Halperin, J. L., Waldo, A. L., Ezekowitz, M. D., Weitz, J. I., Špinar, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1310907 · Cited by 5,164 · see citing works
Ruff, C. T., Giugliano, R. P., Braunwald, E., Hoffman, E. B., Deenadayalu, N., Ezekowitz, M. D., Camm, A. J., Weitz, J. I., Lewis, B. S., Parkhomenko, A., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62343-0 · Cited by 5,051 · see citing works
Schulman, S., & Kearon, C. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01204.x · Cited by 5,025 · see citing works
Schulman, S., Angerås, U., Bergqvist, D., ERIKSSON, B., Lassen, M. R., & FISHER, W. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03678.x · Cited by 3,761 · see citing works
2016 ESC Guidelines for the Management of Atrial Fibrillation Developed in Collaboration With EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2016.11.033 · Cited by 1,801 · see citing works
Self-citationThe Heidelberg Bleeding Classification
von Kummer, R., Broderick, J. P., Campbell, B. C. V., Demchuk, A. M., Goyal, M., Hill, M. D., Treurniet, K. M., Majoie, C. B. L. M., Marquering, H. A., Mazya, M. V., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.010049 · Cited by 1,430 · see citing works
Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI
Götberg, M., Christiansen, E. H., Guðmundsdóttir, I. J., Sandhall, L., Danielewicz, M., Jakobsen, L., Olsson, S.-E., Öhagen, P., Olsson, H., Ömerovic, E., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1616540 · Cited by 987 · see citing works
Self-citationThe Randomized Registry Trial — The Next Disruptive Technology in Clinical Research?
Lauer, M. S., & D'Agostino, R. B. (2013) · New England Journal of Medicine · doi:10.1056/nejmp1310102 · Cited by 497 · see citing works
Hijazi, Z., Oldgren, J., Lindbäck, J., Alexander, J. H., Connolly, S. J., Eikelboom, J. W., Ezekowitz, M. D., Held, C., Hylek, E. M., Lopes, R. D., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00741-8 · Cited by 490 · see citing works
Self-citationDiener, H.-C., Connolly, S. J., Ezekowitz, M. D., Wallentin, L., Reilly, P. A., Yang, S., Xavier, D., Di Pasquale, G., & Yusuf, S. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70274-x · Cited by 451 · see citing works
Hijazi, Z., Lindbäck, J., Alexander, J. H., Hanna, M., Held, C., Hylek, E. M., Lopes, R. D., Oldgren, J., Siegbahn, A., Stewart, R. A. H., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw054 · Cited by 437 · see citing works
Self-citationHankey, G. J. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70255-2 · Cited by 392 · see citing works
Oxygen Therapy in Suspected Acute Myocardial Infarction
Hofmann, R., James, S. K., Jernberg, T., Lindahl, B., Erlinge, D., Witt, N., Arefalk, G., Frick, M., Alfredsson, J., Nilsson, L. E., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1706222 · Cited by 384 · see citing works
Hankey, G. J., Patel, M. R., Stevens, S. R., Becker, R. C., Breithardt, G., Carolei, A., Diener, H.-C., Donnan, G. A., Halperin, J. L., Mahaffey, K. W., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70042-x · Cited by 354 · see citing works
Self-citationHigh Prevalence of Atrial Fibrillation Among Patients With Ischemic Stroke
Friberg, L., Rosenqvist, M., Lindgren, A. G., Terént, A., Norrving, B. G., & Asplund, K. (2014) · Stroke · doi:10.1161/strokeaha.114.006070 · Cited by 319 · see citing works
Self-citationPaciaroni, M., Agnelli, G., Micheli, S., & Caso, V. (2007) · Stroke · doi:10.1161/01.str.0000254600.92975.1f · Cited by 307 · see citing works
Bivalirudin versus Heparin Monotherapy in Myocardial Infarction
Erlinge, D., Ömerovic, E., Fröbert, O., Linder, R. B. A., Danielewicz, M., Hamid, M., Swahn, E., Henareh, L., Wagner, H., Hårdhammar, P., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1706443 · Cited by 300 · see citing works
Biomarkers in atrial fibrillation: a clinical review
Hijazi, Z., Oldgren, J., Siegbahn, A., Granger, C. B., & Wallentin, L. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht024 · Cited by 298 · see citing works
Self-citationEaston, J. D., Lópes, R. D., Bahit, M. C., WOJDYLA, D. M., Granger, C. B., Wallentin, L. C., Alings, M., Goto, S., Lewis, B. S., Rosenqvist, M., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70092-3 · Cited by 283 · see citing works
Paciaroni, M., Agnelli, G., Falocci, N., Caso, V., Becattini, C., Marcheselli, S., Rueckert, C. M., Pezzini, A., Poli, L., Padovani, A., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.008891 · Cited by 279 · see citing works
Underestimation of the Early Risk of Recurrent Stroke
Coull, A. J., & Rothwell, P. M. (2004) · Stroke · doi:10.1161/01.str.0000133129.58126.67 · Cited by 185 · see citing works
Toyoda, Ḱ., Arihiro, S., Todo, K., Yamagami, H., Kimura, K., Furui, E., Terasaki, T., Shiokawa, Y., Kamiyama, K., Takizawa, S., et al. (2015) · International Journal of Stroke · doi:10.1111/ijs.12452 · Cited by 107 · see citing works
Performance and Validation of a Novel Biomarker-Based Stroke Risk Score for Atrial Fibrillation
Oldgren, J., Hijazi, Z., Lindbäck, J., Alexander, J. H., Connolly, S. J., Eikelboom, J. W., Ezekowitz, M. D., Granger, C. B., Hylek, E. M., Lópes, R. D., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.022802 · Cited by 105 · see citing works
Self-citationRecommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 13–15 November 2016
Ahmed, N., Steiner, T., Caso, V., Wahlgren, N. G., & participants, F. T. E.-K. S. (2017) · European Stroke Journal · doi:10.1177/2396987317699144 · Cited by 87 · see citing works
Ischemic Stroke and Secondary Prevention in Clinical Practice
Åsberg, S., Henriksson, K. M., Farahmand, B. Y., Asplund, K., Norrving, B. G., Appelros, P., Stegmayr, B., Åsberg, K. H., & Terént, A. (2010) · Stroke · doi:10.1161/strokeaha.110.580209 · Cited by 78 · see citing works
Self-citationAbdul‐Rahim, A. H., Fulton, R. L., Frank, B., Tatlisumak, T., Paciaroni, M., Caso, V., Diener, H., Lees, K. R., & collaborators, T. V. (2014) · European Journal of Neurology · doi:10.1111/ene.12577 · Cited by 77 · see citing works
Hankey, G. J. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-09-0741 · Cited by 44 · see citing works
Shibazaki, K., Kimura, K., Aoki, J., Saji, N., & Sakai, K. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.05.016 · Cited by 32 · see citing works
Terént, A., Åsberg, S., Oldgren, J., Hijazi, Z., & Norrving, B. G. (2016) · Lund University Publications (Lund University) · Cited by 1 · see citing works
Self-citation[Anticoagulants after acute ischemic stroke with atrial fibrillation].
Terént, A., Åsberg, S., Oldgren, J., Hijazi, Z., & Norrving, B. G. (2016) · PubMed · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [29]Terent A, Asberg S, Oldgren J, Hijazi Z, Norrving B. Antikoagulantia efter akut ischemisk stroke med förmaksflimmer. Läkartidningen. 2016;113:DUFT [Swedish]. http://www.lakartidningen.se/EditorialFiles/FT/%5bDUFT%5d/DUFT.pdf. 26928683
Cited by
Sorted by citations
Oldgren, J., Åsberg, S., Hijazi, Z., Wester, P. O., Bertilsson, M., Norrving, B. G., & Collaborators, F. T. N. T. (2022) · Circulation · doi:10.1161/circulationaha.122.060666 · Cited by 183 · see citing works
Self-citationKwakkenbos, L., Imran, M., McCall, S. J., McCord, K. A., Fröbert, O., Hemkens, L. G., Zwarenstein, M., Relton, C., Rice, D. B., Langan, S., et al. (2021) · BMJ · doi:10.1136/bmj.n857 · Cited by 136 · see citing works
Stroke Prevention in Atrial Fibrillation
Katsanos, A. H., Kamel, H., Healey, J. S., & Hart, R. G. (2020) · Circulation · doi:10.1161/circulationaha.120.049768 · Cited by 106 · see citing works
Werring, D. J., Dehbi, H., Ahmed, N., Arram, E., Best, J. G., Balogun, M., Bennett, K., Bordea, E., Caverly, E., Chau, M., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)02197-4 · Cited by 80 · see citing works
Self-citationWilson, D., Ambler, G., Banerjee, G., Shakeshaft, C., Cohen, H., Yousry, T. A., Salman, R. A., Lip, G. Y. H., Houlden, H., Brown, M. M., et al. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-318890 · Cited by 66 · see citing works
Stroke prevention strategies in high-risk patients with atrial fibrillation
Kotalczyk, A., Mazurek, M., Kalarus, Z. F., Potpara, T., & Lip, G. Y. H. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00459-3 · Cited by 60 · see citing works
Anticoagulants for acute ischaemic stroke
Wang, X., Ouyang, M., Yang, J., Song, L., Yang, M., & Anderson, C. S. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000024.pub5 · Cited by 56 · see citing works
Best, J. G., Arram, E., Ahmed, N., Balogun, M., Bennett, K., Bordea, E., Campos, M. G., Caverly, E., Chau, M., Cohen, H., et al. (2022) · International Journal of Stroke · doi:10.1177/17474930211057722 · Cited by 55 · see citing works
Self-citationBae, H., Kim, J. Y., Kang, J., Kim, B. J., Han, M., Choi, K., Kim, J., Park, M., Cho, K., Kim, B.-K., et al. (2022) · Stroke · doi:10.1161/strokeaha.122.039212 · Cited by 40 · see citing works
Muscari, A., Faccioli, L., Lega, M. V., Lorusso, A., Masetti, M., Trossello, M. P., Puddu, G. M., Spinardi, L., & Zoli, M. (2019) · Brain and Behavior · doi:10.1002/brb3.1497 · Cited by 38 · see citing works
Liebeskind, D. S., Derdeyn, C. P., Wechsler, L. R., Albers, G. W., Ankerud, E. P., Boltze, J., Broderick, J. P., Campbell, B. C. V., Elkind, M. S. V., En’Wezoh, D. C., et al. (2018) · Stroke · doi:10.1161/strokeaha.118.021424 · Cited by 30 · see citing works
Registry-based randomised controlled trials: conduct, advantages and challenges—a systematic review
Shiely, F., O Shea, N., Murphy, E., & Eustace, J. (2024) · Trials · doi:10.1186/s13063-024-08209-3 · Cited by 24 · see citing works
Acute ischemic stroke management: concepts and controversies.A narrative review
Li, K. H. C., Jesuthasan, A., Kui, C., Davies, R., Tse, G., & Lip, G. Y. H. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1836963 · Cited by 27 · see citing works
Shi, M., Chen, L. Y., Bekwelem, W., Norby, F. L., Soliman, E. Z., Alam, A. B., & Alonso, Á. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016724 · Cited by 23 · see citing works
Weber, R., Stracke, P., & Chapot, R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00204 · Cited by 15 · see citing works
Timing of symptomatic intracranial hemorrhage after endovascular stroke treatment
van der Steen, W., van der Ende, N. A. M., van Kranendonk, K. R., Chalos, V., Brouwer, J., van Oostenbrugge, R. J., van Zwam, W. H., van Doormaal, P., van Es, A. C., Majoie, C. B. L. M., et al. (2022) · European Stroke Journal · doi:10.1177/23969873221112279 · Cited by 12 · see citing works
Early apixaban therapy after ischemic stroke in patients with atrial fibrillation
Alrohimi, A., Buck, B. H., Jickling, G. C., Shuaib, A. M., Thirunavukkarasu, S., & Butcher, K. (2021) · Journal of Neurology · doi:10.1007/s00415-020-10335-2 · Cited by 11 · see citing works
Ischemic stroke and non-valvular atrial fibrillation: When to introduce anticoagulant therapy?
Bossy, V., Zuber, M., & Emmerich, J. (2020) · JMV-Journal de Médecine Vasculaire · doi:10.1016/j.jdmv.2020.01.153 · Cited by 11 · see citing works
Ganesh, A., Ospel, J. M., Marko, M., van Zwam, W. H., Roos, Y. B. W. E. M., Majoie, C. B. L. M., & Goyal, M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.713738 · Cited by 10 · see citing works
Alrohimi, A., Ng, K., Dowlatshahi, D. D., Buck, B. H., Stotts, G., Thirunavukkarasu, S., Shamy, M. C. F., Kalashyan, H., Sivakumar, L., Shuaib, A. M., et al. (2020) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2020.84 · Cited by 9 · see citing works
Gómez‐Outes, A., Suárez‐Gea, M. L., Pérez-Cabeza, A., & García‐Pinilla, J. M. (2022) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2022.2149323 · Cited by 9 · see citing works
Follow-up of Patients With Stroke Based on Opt-out Choice
Rohrpasser‐Napierkowski, I., Lorenz‐Meyer, I., Hille, A., Ebinger, M., Freitag, E., Harmel, P., Endres, M., Hagemann, G., Koennecke, H., Mackert, B., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200916 · Cited by 8 · see citing works
Timing of Anticoagulation after Acute Ischemic Stroke in Patients with Atrial Fibrillation
Alrohimi, A., Jickling, G. C., Buck, B. H., & Butcher, K. (2022) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2022.268 · Cited by 8 · see citing works
Alrohimi, A., Jickling, G. C., Jeerakathil, T., Shuaib, A. M., Khan, K. A., Kate, M. P., Hill, M. D., Buck, B. H., & Butcher, K. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.645822 · Cited by 6 · see citing works
Große, G. M., Weimar, C., Kuklik, N., Hüsing, A., Stang, A., Brinkmann, M., Eschenfelder, C. C., Diener, H., & on behalf of the PRODAST Investigators (2021) · European Stroke Journal · doi:10.1177/23969873211060219 · Cited by 6 · see citing works
Lee, K., Shin, D. W., Park, H., Kim, B. J., Park, J., Kang, K., Park, T. H., Lee, K. B., Hong, K., Cho, Y., et al. (2022) · Journal of Korean Medical Science · doi:10.3346/jkms.2022.37.e254 · Cited by 4 · see citing works
Dental Research in the Digital Age: The Registry-Based Clinical Trial.
Joda, T., Settecase, E., Heitz‐Mayfield, L., Derks, J., Jung, R. E., & Zitzmann, N. U. (2026) · Clinical oral implants research · doi:10.1111/clr.70061 · Cited by 2 · see citing works
Fasth, O., Oldgren, J., Lakic, T. G., Hijazi, Z., Norrving, B. G., Wester, P. O., & Åsberg, S. (2026) · European Stroke Journal · doi:10.1093/esj/aakag010 · Cited by 2 · see citing works
Self-citationCappellari, M., Emiliani, A., Zivelonghi, C., Micheletti, N., Tomelleri, G., & Bonetti, B. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06717-9 · Cited by 2 · see citing works
Beginn der Antikoagulation nach akutem Schlaganfall
Große, G. M., Weimar, C., & Diener, H. (2021) · InFo Neurologie + Psychiatrie · doi:10.1007/s15005-020-1784-5 · Cited by 1 · see citing works
Ryan, D., Girotra, T., & Feng, W. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230309100626 · Cited by 1 · see citing works
Kim, D. Y., Kang, J., Jeong, H., Park, C.-Y., Kim, J. Y., Kim, B. J., Han, M., Bae, H., & Kim, B.-K. (2022) · Journal of Neurocritical Care · doi:10.18700/jnc.220063 · Cited by 1 · see citing works
The role of disease registers in dermatology
Rammanohar, J., & Flohr, C. (2024) · British Journal of Dermatology · doi:10.1093/bjd/ljae002
Anticoagulant therapy in secondary stroke prevention in patients with atrial fibrillation
Petrovska, M., Stojanovska, A. T., Gashpar, G., & Arsovska, A. A. (2023) · Rad Hrvatske akademije znanosti i umjetnosti Medicinske znanosti · doi:10.21857/moxpjh1w2m
Oral Anticoagulation in Patients with Acute Stroke and Atrial Fibrillation
Abdulan, I. M., Leon, M. M., Maștaleru, A., Ivan, L. C., & Mitu, F. (2024) · Annals of the Academy of Romanian Scientists Series of Medicine · doi:10.56082/annalsarscimed.2024.1.39
Srivastava, M., Gulia, A., Patel, K. K., Upadhyay, A. D., Vibha, D., & Kumar, P. (2025) · medRxiv · doi:10.1101/2025.05.18.25327653
Aderinto, N., Aljamea, L. H., & Aljamea, F. H. (2025) · Cureus · doi:10.7759/cureus.93275
Srivastava, M., Gulia, A., Patel, K. K., Upadhyay, A. D., Vibha, D., & Kumar, P. (2025) · Indian Heart Journal · doi:10.1016/j.ihj.2025.12.002
Shiely, F., O Shea, N., Murphy, E. K., & Eustace, J. A. (2024) · Figshare · doi:10.6084/m9.figshare.26732278
Shiely, F., O Shea, N., Murphy, E. K., & Eustace, J. A. (2024) · Figshare · doi:10.6084/m9.figshare.26732284
Shiely, F., O Shea, N., Murphy, E. K., & Eustace, J. A. (2024) · Figshare · doi:10.6084/m9.figshare.26732281
The multiple facets of registry-based randomised controlled trials
Karanatsios, B., Prang, K.-H., & Gibbs, P. (2026) · Trials · doi:10.1186/s13063-026-09444-6
- Authors
- Åsberg, S., Hijazi, Z., Norrving, B., Terént, A., Öhagen, P., & Oldgren, J.
- Affiliations
- Uppsala University (SE)
- Lund University (SE)
- Corresponding author
- Åsberg, Signild
- Venue
- Trials
- Published
- 2017-12
- Volume
- 18
- Issue
- 1
- Pages
- 581-581
- ISSN
- 1745-6215 (ISSN-L)
- PMC
- PMC5712199
- OpenAlex
- W2771591850
- Cited by
- 43
- References
- 37
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 2 · 2018: 3
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Trials (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Vetenskapsrådet (2015-00881)
- Uppsala-Örebro Regional Research Council (RFR-655101)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- oral anticoagulation, direct oral anticoagulants, atrial fibrillation, acute ischemic stroke, timing of anticoagulation initiation, recurrent ischemic stroke, intracerebral hemorrhage, all-cause mortality, functional outcome, cardiovascular biomarkers
- MeSH terms
- Administration, Oral, Anticoagulants, Atrial Fibrillation, Cerebral Hemorrhage, Brain Ischemia, Clinical Protocols, Drug Administration Schedule, Humans, Prospective Studies, Recurrence, Registries, Research Design, Risk Factors, Sweden, Time Factors, Treatment Outcome, Recovery of Function, Stroke, Secondary Prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
