Antidepressants' Black-Box Warning — 10 Years Later
Open accessAbstract
In 2004, the FDA issued a black-box warning linking antidepressants to an increased risk of suicidal thinking, feeling, and behavior in young people. But some worrisome trends suggest that the warning may inadvertently discourage appropriate treatment of depression.
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Slight impairments in executive control and memory may remain after remission in MDD.
“slight impairments in executive control 207,210 and memory 207 may remain”
From Major depressive disorder (2016) · cites this paper as [207]
The passages from “Antidepressants’ Black-Box Warning — 10 Years Later” discuss antidepressant warnings, prescribing, and depression diagnoses, not cognition after remission. Searches for executive control, memory, and cognitive impairment after remission found no passage addressing the claim; page numbers were not available in our copy. (LLM, conf=0.77)
Experimental — accuracy not yet measuredExecutive function, memory, and attention are the predominantly affected cognitive domains in MDD.
“One meta-analysis identified executive function, memory, and attention as the predominantly affected domains 207 .”
From Major depressive disorder (2016) · cites this paper as [207]
The available passages from “Antidepressants’ Black-Box Warning — 10 Years Later” (page unavailable) discuss antidepressant warnings, depression diagnoses, prescribing, and suicidality. Searches for executive function, memory, attention, and cognitive domains found no passage addressing which domains are predominantly affected in MDD; the meta-analyses discussed concern suicidality instead. (LLM, conf=0.76)
Experimental — accuracy not yet measuredCognitive deficits are more modest after remission in euthymic patients with MDD.
“Although the cognitive deficits are more modest after remission (i.e. in euthymic patients with MDD)”
From Major depressive disorder (2016) · cites this paper as [207]
The indexed paper discusses the FDA antidepressant warning, depression diagnosis, prescribing, and suicide risk, but not cognitive deficits after remission in euthymic patients with MDD. Searches for cognitive deficits, remission, and euthymia found no passage addressing that comparison; no page number is available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredThe meta-analysis which led to the black box warning showed that rate of suicidal thinking or suicidal behavior was 4% among patients being prescribed an antidepressant, as compared with 2% among those being taken placebo.
“Moreover, the meta-analysis which lead to the black box warning in fact showed that rate of suicidal thinking or suicidal behavior was 4% among patients being prescribed an antidepressant, as compared with 2% among those being taken placebo.58”
From Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review (2018) · cites this paper as [58]
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Lu, C. Y., Zhang, F., Lakoma, M. D., Madden, J. M., Rusinak, D., Penfold, R. B., Simon, G. E., Ahmedani, B. K., Clarke, G. N., Hunkeler, E. M., et al. (2014) · BMJ · doi:10.1136/bmj.g3596 · Cited by 229 · see citing works
Suicide among adults aged 35-64 years--United States, 1999-2010.
Sullivan, E., Annest, J. L., Luo, F., Simon, T. R., & Dahlberg, L. L. (2013) · PubMed Central · Cited by 155 · see citing works
Persisting Decline in Depression Treatment After FDA Warnings
Libby, A. M., Orton, H. D., & Valuck, R. J. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.46 · Cited by 153 · see citing works
Valuck, R. J., Libby, A. M., Orton, H. D., Morrato, E. H., Allen, R. R., & Baldessarini, R. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07010007 · Cited by 137 · see citing works
The FDA Warning on Antidepressants and Suicidality — Why the Controversy?
Stone, M. B. (2014) · New England Journal of Medicine · doi:10.1056/nejmp1411138 · Cited by 45 · see citing works
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Research works printed but not linked: 5
- [1]1. Johnson KM, Lange JV, Webb PA, Murphy FA. Isolation and partial characterisation of a new virus causing acute haemorrhagic fever in Zaire. Lancet 1977;1:569-71.
- [2]2. Baize S, Pannetier D, Oestereich L, et al. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med 2014;371:1418-25.
- [3]3. Ebola hemorrhagic fever in Zaire, 1976. Bull World Health Organ 1978;56:271-93.
- [4]4. Breman JG, Piot P, Johnson K, et al. The epidemiology of Ebola hemorrhagic fever in Zaire, 1976. In Pattyn SR, ed. Ebola virus hemor rhagic fever. Amsterdam: Elsevier, 1978:85-97.
- [5]5. Isaacson M, Ruppol JF, Collas R, et al. Containment and surveillance of a hospital outbreak of Ebola virus disease in Kinshasa, Zaire, 1976. In: Pattyn SR, ed. Ebola virus hemorrhagic fever. Amsterdam: Elsevier, 1978:122-6.
Cited by
Sorted by citations
Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., Mohr, D. C., & Schatzberg, A. F. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.65 · Cited by 2,269 · see citing works
Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review
Wang, S.-M., Han, C., Bahk, W.-M., Lee, S.-J., Patkar, A. A., Masand, P. S., & Pae, C.-U. (2018) · Chonnam Medical Journal · doi:10.4068/cmj.2018.54.2.101 · Cited by 299 · see citing works
Suicide risk assessment and intervention in people with mental illness
Bolton, J. M., Gunnell, D., & Turecki, G. (2015) · BMJ · doi:10.1136/bmj.h4978 · Cited by 294 · see citing works
Lenze, E. J., Mulsant, B. H., Blumberger, D. M., Karp, J. F., Newcomer, J. W., Anderson, S. J., Dew, M. A., Butters, M. A., Stack, J. A., Begley, A. E., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00308-6 · Cited by 283 · see citing works
Andrews, G., Bell, C., Boyce, P., Gale, C., Lampe, L., Marwat, O., Rapee, R., & Wilkins, G. (2018) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867418799453 · Cited by 243 · see citing works
Bachmann, C., Aagaard, L., Burcu, M., Glaeske, G., Kalverdijk, L. J., Petersen, I., Schuiling‐Veninga, C. C. M., Wijlaars, L. P. M. M., ZITO, J. M., & Hoffmann, F. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.02.001 · Cited by 207 · see citing works
Van Meter, A. R., Knowles, E. A., & Mintz, E. H. (2023) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2022.07.867 · Cited by 193 · see citing works
Qato, D. M., Ozenberger, K., & Olfson, M. (2018) · JAMA · doi:10.1001/jama.2018.6741 · Cited by 136 · see citing works
Boaden, K., Tomlinson, A., Cortese, S., & Cipriani, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00717 · Cited by 120 · see citing works
The FDA “Black Box” Warning on Antidepressant Suicide Risk in Young Adults: More Harm Than Benefits?
Fornaro, M., Anastasia, A., Valchera, A., Carano, A., Orsolini, L., Vellante, F., Rapini, G., Olivieri, L., Natale, S. D., Perna, G., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00294 · Cited by 99 · see citing works
Dodd, S., Mitchell, P. B., Bauer, M., Yatham, L. N., Young, A. H., Kennedy, S. H., Williams, L. J., Suppes, T. M., López‐Jaramillo, C., Trivedi, M. H., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1379609 · Cited by 66 · see citing works
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Lagerberg, T., Molero, Y., D'Onofrio, B. M., de la Cruz, L. F., Lichtenstein, P., Mataix‐Cols, D., Rück, C., Hellner, C., & Chang, Z. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-018-01269-2 · Cited by 63 · see citing works
Jha, M. K., Minhajuddin, A., Fatt, C. C., Kircanski, K., Stringaris, A. K., Leibenluft, E., & Trivedi, M. H. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0769-x · Cited by 51 · see citing works
Chan, J. K. N., Solmi, M., Lo, H. K. Y., Chan, M. W. Y., Choo, L. L. T., Lai, E. T. H., Wong, C. S. M., Correll, C. U., & Chang, W. C. (2025) · World Psychiatry · doi:10.1002/wps.21354 · Cited by 53 · see citing works
Garcia, I., & O’Neil, J. (2020) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2020.08.021 · Cited by 50 · see citing works
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Bushnell, G., Compton, S. N., Dusetzina, S. B., Gaynes, B. N., Brookhart, M. A., Walkup, J. T., Rynn, M. A., & Stürmer, T. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m11415 · Cited by 45 · see citing works
Schwitzer, T., Lavoie, J., Giersch, A., Schwan, R., & Laprévote, V. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.09.003 · Cited by 44 · see citing works
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Revet, A., Montastruc, F., Raynaud, J., Baricault, B., Montastruc, J., & Lapeyre‐Mestre, M. (2018) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000891 · Cited by 42 · see citing works
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Rosenbaum, L. R. (2016) · New England Journal of Medicine · doi:10.1056/nejmms1516161 · Cited by 40 · see citing works
Näslund, J., Hieronymus, F., Lisinski, A., Nilsson, S., & Eriksson, E. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2017.24 · Cited by 39 · see citing works
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López‐León, S., Lopez-Gomez, M. I., Warner, B., & Ruiter-Lopez, L. (2018) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-018-0204-6 · Cited by 36 · see citing works
Antidepressants and suicidality: History, the black-box warning, consequences, and current evidence
Noel, C. (2015) · Mental Health Clinician · doi:10.9740/mhc.2015.09.202 · Cited by 33 · see citing works
Xiao, Y., & Lu, W. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.4498 · Cited by 31 · see citing works
Pharmacologic approaches to suicide prevention
Zisook, S., Domingues, I., & Compton, J. (2023) · Focus · doi:10.1176/appi.focus.20220076 · Cited by 30 · see citing works
Managing depression in primary care
Ng, C., How, C., & Ng, Y. (2017) · Singapore Medical Journal · doi:10.11622/smedj.2017080 · Cited by 28 · see citing works
Adeline, T. A. N., Schwitzer, T., Conart, J., & Angioï-Duprez, K. (2020) · Journal Français d Ophtalmologie · doi:10.1016/j.jfo.2020.04.004 · Cited by 28 · see citing works
Suicidal Behavior Associated with Mixed Features in Major Mood Disorders
Tondo, L., Vázquez, G. H., & Baldessarini, R. J. (2019) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2019.10.008 · Cited by 25 · see citing works
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van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205 · Cited by 22 · see citing works
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Krol, F. J., Hagin, M., Vieta, E., Harazi, R., Lotan, A., Strous, R. D., Lerer, B., & Popović, D. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.12.117 · Cited by 22 · see citing works
Boudes, P. F. (2017) · Drugs in R&D · doi:10.1007/s40268-017-0175-y · Cited by 21 · see citing works
Fanelli, G., Sokolowski, M., Wasserman, D., Kasper, S., Zohar, J., Souery, D., Montgomery, S., Albani, D., Forloni, G., Ferentinos, P. P., et al. (2022) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32891 · Cited by 19 · see citing works
Zamani, R., & Yamini, Y. (2023) · Biosensors · doi:10.3390/bios13010139 · Cited by 18 · see citing works
Treatment of Major Depressive Disorder in Pediatric Populations
Neavin, D. R., Joyce, J., & Swintak, C. C. (2018) · Diseases · doi:10.3390/diseases6020048 · Cited by 16 · see citing works
Challenging the promotion of antidepressants for nonsevere depression
Braillon, A., Lexchin, J., Noble, J. H., Menkes, D., M'sahli, L., Fierlbeck, K., Blumsohn, A., & Naudet, F. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13010 · Cited by 16 · see citing works
Korean Medication Algorithm for Depressive Disorder 2021, Fourth Revision: An Executive Summary
Seo, J. S., Bahk, W., Woo, Y. S., Park, Y., Kim, W., Jeong, J., Shim, S.-H., Lee, J. G., Jang, S.-H., Yang, C.-M., et al. (2021) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2021.19.4.751 · Cited by 16 · see citing works
Nobile, B., Ramoz, N., Jaussent, I., Dubois, J., Guillaume, S., Gorwood, P. A. P. M., & Courtet, P. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01003-0 · Cited by 16 · see citing works
Black, J. J., & Rofey, D. L. (2017) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2017.08.007 · Cited by 15 · see citing works
Carson, N. J., Progovac, A. M., Ye, W., & Cook, B. (2017) · Depression and Anxiety · doi:10.1002/da.22681 · Cited by 13 · see citing works
Denying renal transplantation to an adolescent medical cannabis user: An ethical case study
Ryan, J. E., Noeder, M. M., Burke, C., Stubblefield, S., Sulieman, S. E., & Miller, E. G. (2019) · Pediatric Transplantation · doi:10.1111/petr.13467 · Cited by 14 · see citing works
Thinking Outside the Black Box: Current Perceptions on Breast Implant Safety and Utility
Yesantharao, P. S., Lee, E. J., Khavanin, N., Persing, S. M., Jenny, H. E., Abousy, M., Broderick, K. P., & Sacks, J. M. (2021) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000007626 · Cited by 13 · see citing works
‘Prescribing’ psychotropic medication to our rivers and estuaries
Ford, A. T., & Herrera, H. (2018) · BJPsych Bulletin · doi:10.1192/bjb.2018.72 · Cited by 13 · see citing works
Morkem, R., Williamson, T. S., Patten, S. B., Queenan, J. A., Wong, S. T., Manca, D. P., & Barber, D. (2017) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4240 · Cited by 13 · see citing works
Suicidality among users of glucagon‐like peptide‐1 receptor agonists: An emerging signal?
Lau, D., & Gamble, J. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15459 · Cited by 12 · see citing works
Suicidality: prevention, detection and intervention
Anderson, J., Mitchell, P. B., & Brodaty, H. (2017) · Australian Prescriber · doi:10.18773/austprescr.2017.058 · Cited by 12 · see citing works
Antidepressants and, suicide and self-injury: Causal or casual association?
Pozzi, M., Radice, S., Clementi, E., Molteni, M., & Nobile, M. (2016) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2015.1117111 · Cited by 12 · see citing works
Ethical and Practical Considerations in Removing Black Box Warnings from Drug Labels
Yeh, J. S.-J., Sarpatwari, A., & Kesselheim, A. S. (2016) · Drug Safety · doi:10.1007/s40264-016-0419-8 · Cited by 12 · see citing works
Do anti-epileptic drugs increase suicide in epilepsy? 10 years after the FDA alert
Mula, M. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1427067 · Cited by 12 · see citing works
Bailly, F., & Belaïd, H. (2020) · Joint Bone Spine · doi:10.1016/j.jbspin.2020.04.016 · Cited by 11 · see citing works
Fluvoxamine for the treatment of COVID-19
Nyirenda, J. L. Z., Sofroniou, M., Toews, I., Mikołajewska, A., Lehane, C., Monsef, I., Abu-Taha, A., Maun, A., Stegemann, M. S., & Schmucker, C. M. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015391 · Cited by 12 · see citing works
Dauchot, D., Rettey, S., Melton, B. L., & Moeller, K. E. (2024) · Mental Health Clinician · doi:10.9740/mhc.2024.02.010 · Cited by 10 · see citing works
Zeitoun, J., Lefèvre, J. H., Downing, N. S., Bergeron, H., & Ross, J. S. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3910 · Cited by 10 · see citing works
Reflexive thematic analysis of job-related problems associated with pharmacist suicide, 2003–2019
Groner-Richardson, M. A., Cotton, S. A., Ali, S., Davidson, J. E., Ye, G. Y., Zisook, S., & Lee, K. C. (2023) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2023.02.001 · Cited by 9 · see citing works
Challenges and Limitations to Treating ADHD in Incarcerated Populations.
Hall, R. C. W., & Myers, W. C. (2016) · PubMed · Cited by 9 · see citing works
Zhao, Y., Zhang, Y., Yang, L., Zhang, K., & Li, S. (2024) · Annals of Pharmacotherapy · doi:10.1177/10600280241231116 · Cited by 8 · see citing works
Pediatric suicide: Review of a preventable tragedy.
Greydanus, D., Nazeer, A., Qayyum, Z., Patel, D. R., Rausch, R., Hoang, L.-N., Miller, C. M., Chahin, S., Apple, R., Saha, G., et al. (2024) · Disease-a-month : DM · doi:10.1016/j.disamonth.2024.101725 · Cited by 7 · see citing works
Bahri, P. (2020) · Springer eBooks · doi:10.1007/978-981-15-3013-5_1 · Cited by 8 · see citing works
Barthez, S., Revet, A., Chouchana, L., Jonville‐Béra, A. ‐., Pizzoglio, V., Raynaud, J., Chebane, L., Lapeyre‐Mestre, M., & Montastruc, F. (2020) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-020-02944-7 · Cited by 8 · see citing works
Wilk, E. J., Howton, T. C., Fisher, J. L., Oza, V. H., Brownlee, R. T., McPherson, K. C., Cleary, H. L., Yoder, B. K., George, J. F., Mrug, M. M., et al. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00664-z · Cited by 7 · see citing works
Weekly links among irritability and suicidal thoughts and behaviors in high‐risk youth
Kaurin, A., Wright, A. G. C., Porta, G., Hamilton, E., Poling, K. D., Bero, K., Brent, D. A., & Goldstein, T. R. (2024) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13988 · Cited by 6 · see citing works
Huang, S., Chen, Y.-T., Su, M., Tsai, S., Chen, H.-H., Yang, A. C., Liu, Y., & Kuo, P. (2023) · The Pharmacogenomics Journal · doi:10.1038/s41397-023-00298-8 · Cited by 6 · see citing works
Mika Kivimaki, B., & Batty, G. D. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv186 · Cited by 6 · see citing works
Primavera, D., Urban, A., Cantone, E., Nonnis, M., González, C. I. A., Perra, A., Tusconi, M., & Sancassiani, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144203 · Cited by 5 · see citing works
Tan, J., & Zhang, L. F. (2026) · ALPHA PSYCHIATRY · doi:10.31083/ap48183 · Cited by 5 · see citing works
FDA Black Box Warning for SSRI: Reexamining the Role of High-Functioning Autism as a Confounder
Gupta, M., & Gupta, N. (2022) · Advances in Neurodevelopmental Disorders · doi:10.1007/s41252-022-00301-6 · Cited by 5 · see citing works
Ruddock, M. W., Watt, J., Kurth, M. J., Lamont, J. V., Mooney, L., & FitzGerald, P. S. (2023) · Frontiers in Drug Safety and Regulation · doi:10.3389/fdsfr.2023.1303572 · Cited by 5 · see citing works
Amerio, A., Arduino, G., Fesce, F., Costanza, A., Aguglia, A., Amore, M., & Serafini, G. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2386429 · Cited by 6 · see citing works
Perspectives on depression—past, present, futurea
Barchas, J. D., & Brody, B. D. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12773 · Cited by 5 · see citing works
Content, Consistency, and Quality of Black Box Warnings: Time for a Change
Elraiyah, T. A., Gionfriddo, M. R., Montori, V. M., & Murad, M. H. (2015) · Annals of Internal Medicine · doi:10.7326/m15-1097 · Cited by 5 · see citing works
The Impact of US FDA and Health Canada Warnings Related to the Safety of High-dose Simvastatin
Anand, K., SKETRIS, I. S., Zhang, Y., Levy, A. R., & Gamble, J. (2017) · Drugs - Real World Outcomes · doi:10.1007/s40801-017-0116-7 · Cited by 5 · see citing works
Farahani, M. H., Dawande, M., Janakiraman, G., & Wang, S. (2021) · Management Science · doi:10.1287/mnsc.2021.03030 · Cited by 5 · see citing works
Psychopharmacology in Primary Care Settings
Benich, J. J., Bragg, S. W., & Freedy, J. R. (2016) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2016.01.002 · Cited by 5 · see citing works
Medication Safety: What Nurses Should Know About Black Box Warnings
Leahy, L. G. (2017) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20170519-01 · Cited by 5 · see citing works
Bos, M., Hertzberg, A., & Liberman, A. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4573307 · Cited by 5 · see citing works
Antidepressiva und Selbstgefährdung: ein Widerspruch?
Hatzinger, M. (2019) · Praxis · doi:10.1024/1661-8157/a003235 · Cited by 4 · see citing works
Boggs, J. M., Simon, G. E., Beck, A. L., Rossom, R. C., Lynch, F. L., Lu, C. Y., Owen‐Smith, A. A., Waring, S. C., & Ahmedani, B. K. (2022) · Archives of Suicide Research · doi:10.1080/13811118.2022.2072253 · Cited by 4 · see citing works
Margherio, S. M., Morse, S. T., DuPaul, G. J., & Evans, S. W. (2024) · Journal of Substance Use and Addiction Treatment · doi:10.1016/j.josat.2024.209523 · Cited by 4 · see citing works
Migraine and the Risk of Suicide
Aly, Z., Rosen, N. L., & Evans, R. W. (2016) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12815 · Cited by 4 · see citing works
Ikawa, H., Takeda, Y., Osawa, R., Sato, A., Mizuno, H., & Noda, Y. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020399 · Cited by 4 · see citing works
Management of childhood sleep disorders
Salkind, J., & Sutcliffe, A. G. (2015) · Prescriber · doi:10.1002/psb.1410 · Cited by 4 · see citing works
Ketamine as a Bridge Therapy: Reducing Acute Suicidality in Hospital Settings
Lie, P. E., Lie, T., Nguyen, M., & Lie, D. Y. C. (2026) · Healthcare · doi:10.3390/healthcare14050634 · Cited by 3 · see citing works
Antidepressants and Suicidality—Controversies and Possible Mechanisms
Witt-Doerring, J., & Mathew, S. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00027-5 · Cited by 3 · see citing works
Neininger, M. P., Wehr, R., Kiesel, L. M., Neubert, A. C., Kieß, W., Bertsche, A., & Bertsche, T. (2021) · Journal of Patient Safety · doi:10.1097/pts.0000000000000934 · Cited by 3 · see citing works
O’Donnell, C., Demler, T. L., & Trigoboff, E. (2022) · PubMed Central · Cited by 3 · see citing works
Time-to-effect of fluoxetine in children with depression.
Yan, T. D., & Goldman, R. D. (2019) · Europe PMC (PubMed Central) · Cited by 3 · see citing works
Colon, I. E. P., Kroin, J., Kaushal, S. A., Khan, S. A., & Villalba, C. L. A. (2022) · Cureus · doi:10.7759/cureus.31987 · Cited by 3 · see citing works
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Pederson, M., & Mayo, M. J. (2018) · Current Hepatology Reports · doi:10.1007/s11901-018-0397-7 · Cited by 3 · see citing works
Courtet, P., Nobile, B., & Olié, É. (2020) · HAL · doi:10.1051/medsci/2020229
Zhang, W., Zhao, M., Dai, J., Zhuo, L., Ye, H., Wang, J., & Wang, W. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.24.590964 · Cited by 3 · see citing works
Tremey, A., Courty, E., & Jalenques, I. (2016) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/j.amp.2016.03.005 · Cited by 2 · see citing works
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van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.003 · Cited by 2 · see citing works
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Deshmukh, A. D., Kesselheim, A. S., Tsacogianis, T., & Rome, B. N. (2024) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.70009 · Cited by 2 · see citing works
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Kaguelidou, F., & Acquaviva, É. (2015) · Springer eBooks · doi:10.1007/978-3-319-24741-0_13 · Cited by 2 · see citing works
Daviss, W. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-64251-2_7 · Cited by 2 · see citing works
Adeline, T. A. N., Schwitzer, T., Conart, J., & Angioï-Duprez, K. (2020) · Journal Français d Ophtalmologie · doi:10.1016/j.jfo.2019.10.029 · Cited by 2 · see citing works
Campos, A. I., Byrne, E. M., Iorfino, F., Fabbri, C., Hickie, I. B., Lewis, C. M., Wray, N. R., Medland, S. E., Rentería, M. E., & Martin, N. G. (2022) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32913 · Cited by 2 · see citing works
Update on Common Psychiatric Medications for Children
Sharma, A. (2018) · Pediatric Annals · doi:10.3928/19382359-20180702-01 · Cited by 2 · see citing works
Braillon, A. (2018) · Drug Safety · doi:10.1007/s40264-018-0714-7 · Cited by 2 · see citing works
Bailly, F., & Belaïd, H. (2021) · Revue du Rhumatisme · doi:10.1016/j.rhum.2021.03.006 · Cited by 1 · see citing works
- Authors
- Friedman, R. A.
- Affiliations
- Cornell University (US)
- Corresponding author
- Friedman, Richard A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-10-30
- Volume
- 371
- Issue
- 18
- Pages
- 1666-1668
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2006985105
- Cited by
- 171
- References
- 5
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 19 · 2023: 11 · 2022: 14 · 2021: 9 · 2020: 15 · 2019: 13 · 2018: 34 · 2017: 14 · 2016: 11 · 2015: 11 · 2014: 1
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- antidepressants, black box warning, suicide risk, FDA drug labeling, treatment underuse, depression treatment
- MeSH terms
- Suicide Prevention, Adolescent, Adult, Aged, Antidepressive Agents, Child, Depressive Disorder, Drug Labeling, Drug Utilization, Humans, Risk Factors, Suicide, United States, United States Food and Drug Administration, Government Regulation
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