In Search of a Better Equation — Performance and Equity in Estimates of Kidney Function
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In Search of a Better Equation Although many experts agree that we should reconsider the use of race in equations for estimated glomerular filtration rate and in medicine more generally, precisely ...
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This provides empirical genetic evidence to the observation that eGFR models have reduced performance in individuals self-identifying as Black or African American.
“thus providing empirical genetic evidence to the observation that eGFR models have reduced performance in individuals self-identifying as Black or African American.45”
From Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy (2023) · cites this paper as [45]
The paper says earlier kidney-function equations derived exclusively from White people had decreased accuracy in Black Americans, and that some race-free alternatives had decreased accuracy and increased bias, especially in Black patients. It does not establish reduced performance for eGFR models generally: it also says validation of the CKD-EPI equations found no substantial bias in either Black Americans or the general population. The paper does not present genetic evidence. (LLM, conf=0.85)
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Cites
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New GFR-estimating equations for children and young adults in North America and Europe
Inker, L. A., & Levey, A. S. (2021) · Kidney International · doi:10.1016/j.kint.2020.12.032 · Cited by 3 · see citing works
Self-citationImpact of pancreas transplantation alone on kidney function: A multicenter clinical cohort study
Kaur, R. J., Mujtahedi, S., Fridell, J. A., Benavides, X., Smith, B. H., Larson, T. S., Rizvi, S., Kukla, A., Dean, P. G., Kudva, Y. C., et al. (2023) · Clinical Transplantation · doi:10.1111/ctr.15212 · Cited by 3 · see citing works
Race‐conscious medicine: a response to critique
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Self-citationClinical practice guidelines for management of hyperglycaemia in adults with diabetic kidney disease
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Black Race Coefficient in GFR Estimation and Prevalence of CKD-Related Complications
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- Authors
- Diao, J. A., Inker, L. A., Levey, A. S., Tighiouart, H., Powe, N. R., & Manrai, A. K.
- Affiliations
- Boston Children's Hospital (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-02-04
- Volume
- 384
- Issue
- 5
- Pages
- 396-399
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC8084706
- OpenAlex
- W3121110988
- Cited by
- 115
- References
- 5
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 12 · 2023: 27 · 2022: 32 · 2021: 33
- FWCI
- 17.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K01HL138259)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- estimated glomerular filtration rate, renal function, chronic kidney disease, racial disparities in health care
- MeSH terms
- Female, Glomerular Filtration Rate, Humans, Kidney, Kidney Function Tests, Male, Reference Values, Racial Groups
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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