The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
The Serotonin Syndrome
Abstract
The serotonin syndrome is a potentially life-threatening drug reaction that may result from therapeutic medication use, self-poisoning, or interactions between drugs.
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Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“that is responsible for transient serotoninrelated symptoms such as nausea, anxiety, hypertension, tachycardia, visual deficits, motor incoordination, and mild tremors, even at therapeutic doses.”
From The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges (2024) · cites this paper as [42]
In the citing paper
“Both psychedelic effects and serotonin syndrome are associated with an increase in 5-HT2A neurotransmission 42,43”
From The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges (2024) · cites this paper as [42]
In the citing paper
“Serotonin stimulation is known to affect the whole organism not just the brain. It causes vegetative changes such as increase in systolic and diastolic blood pressure, pulse rate, provokes nausea, vomiting, and pupil dilation (Boyer and Shannon, 2005).”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as Boyer and Shannon, 2005
Citations
Cites
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
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Neuroleptic malignant syndrome
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Interactions Between Herbal Medicines and Prescribed Drugs
Izzo, A., & Ernst, E. (2012) · Drugs · doi:10.2165/00003495-200161150-00002 · Cited by 464
Relative Toxicity of Selective Serotonin Reuptake Inhibitors (SSRIs) in Overdose
Isbister, G. K., Bowe, S. J., Dawson, A. H., & Whyte, I. M. (2004) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-120037428 · Cited by 432
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Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity
Parrott, A. C. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00711-0 · Cited by 325
Research works printed but not linked: 8
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- Hoyer D, 1994, Pharmacol Rev, 46, 157
- Saper CB. Brain stem modulation of sensation, movement, and consciousness. In: Kandel ER, Schwartz JH, Jessell TM, eds. Principles of neural science. 4th ed. New York: McGraw-Hill, 2000:896.
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Cited by
Sorted by citations
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914
PRACTICE GUIDELINE FOR THE Treatment of Patients With Major Depressive Disorder
Gelenberg, A. J., Freeman, P. B., Markowitz, J. C., Rosenbaum, J. F., Thase, M. E., Trivedi, M. H., & Rhoads, R. S. (2010) · Cited by 1,372
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206
Birmaher, B., & Brent, D. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318145ae1c · Cited by 1,056
Hudak, M. L., Tan, R. C., Frattarelli, D. A. C., Galinkin, J. L., Green, T. P., Neville, K. A., Paul, I. M., van den Anker, J. N., Papile, L. A., Baley, J. E., et al. (2012) · PEDIATRICS · doi:10.1542/peds.2011-3212 · Cited by 889
Metadata
- Authors
- Boyer, E. W., & Shannon, M.
- Affiliations
- Boston Children's Hospital (US)
- ORCID
- Boyer, Edward W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-03-17
- Volume
- 352
- Issue
- 11
- Pages
- 1112-1120
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2123778879
- Cited by
- 1,821
- References
- 49
- Citations by year
- 2026: 47 · 2025: 65 · 2024: 84 · 2023: 53 · 2022: 78 · 2021: 74 · 2020: 92 · 2019: 86 · 2018: 99 · 2017: 96 · 2016: 98 · 2015: 112 · 2014: 121 · 2013: 109 · 2012: 93
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA14929, R21DA014929)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- serotonin syndrome, adverse drug reactions, drug interactions, self-poisoning, serotonin receptor agonists
- MeSH terms
- Algorithms, Antidepressive Agents, Diagnostic Errors, Drug Interactions, Humans, Monoamine Oxidase Inhibitors, Selective Serotonin Reuptake Inhibitors, Serotonin Syndrome, Drug Overdose
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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