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The Serotonin Syndrome
Abstract
The serotonin syndrome is a potentially life-threatening drug reaction that may result from therapeutic medication use, self-poisoning, or interactions between drugs.
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“that is responsible for transient serotoninrelated symptoms such as nausea, anxiety, hypertension, tachycardia, visual deficits, motor incoordination, and mild tremors, even at therapeutic doses.”
From The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges (2024) · cites this paper as [42]
In the citing paper
“Both psychedelic effects and serotonin syndrome are associated with an increase in 5-HT2A neurotransmission 42,43”
From The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges (2024) · cites this paper as [42]
In the citing paper
“Serotonin stimulation is known to affect the whole organism not just the brain. It causes vegetative changes such as increase in systolic and diastolic blood pressure, pulse rate, provokes nausea, vomiting, and pupil dilation (Boyer and Shannon, 2005).”
From The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization (2016) · cites this paper as Boyer and Shannon, 2005
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Metadata
- Authors
- Boyer, E. W., & Shannon, M.
- Affiliations
- Boston Children's Hospital (US)
- ORCID
- Boyer, Edward W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2005-03-17
- Volume
- 352
- Issue
- 11
- Pages
- 1112-1120
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2123778879
- Cited by
- 1,821
- References
- 49
- Citations by year
- 2026: 47 · 2025: 65 · 2024: 84 · 2023: 53 · 2022: 78 · 2021: 74 · 2020: 92 · 2019: 86 · 2018: 99 · 2017: 96 · 2016: 98 · 2015: 112 · 2014: 121 · 2013: 109 · 2012: 93
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA14929, R21DA014929)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- serotonin syndrome, adverse drug reactions, drug interactions, self-poisoning, serotonin receptor agonists
- MeSH terms
- Algorithms, Antidepressive Agents, Diagnostic Errors, Drug Interactions, Humans, Monoamine Oxidase Inhibitors, Selective Serotonin Reuptake Inhibitors, Serotonin Syndrome, Drug Overdose
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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