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Hematopoietic Stem-Cell Transplantation
Abstract
Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically. This review summarizes background information about hematopoietic stem-cell transplantation and discusses the current role of the procedure.
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“Currently, HSC transplantation is the only stem cell–based therapy widely accepted and used clinically, and it provides an effective cure for hematologic diseases such as leukemia and lymphoma135.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [135]
In the citing paper
“Currently, HSC transplantation is the only stem cell–based therapy widely accepted and used clinically, and it provides an effective cure for hematologic diseases such as leukemia and lymphoma135.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [135]
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Metadata
- Authors
- Copelan, E. A.
- Affiliations
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Corresponding author
- Copelan, Edward A.
- ORCID
- Copelan, Edward A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-04-27
- Volume
- 354
- Issue
- 17
- Pages
- 1813-1826
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2160666689
- Cited by
- 2,522
- References
- 102
- Citations by year
- 2026: 89 · 2025: 99 · 2024: 121 · 2023: 143 · 2022: 163 · 2021: 149 · 2020: 128 · 2019: 126 · 2018: 128 · 2017: 161 · 2016: 123 · 2015: 162 · 2014: 142 · 2013: 142 · 2012: 120
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- hematopoietic stem cell transplantation, hematopoietic stem cells, immunomodulation, history of transplantation
- MeSH terms
- Graft vs Host Disease, Humans, Major Histocompatibility Complex, Transplantation Immunology, Transplantation, Autologous, Transplantation, Homologous, Hematopoietic Stem Cell Transplantation, Transplantation Conditioning, Cord Blood Stem Cell Transplantation
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