The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
The Asthma Epidemic
Abstract
This review surveys the data on the increase in the prevalence of asthma in recent decades and finds evidence of a plateau in many Western countries. The authors examine the evidence of possible causal relations to factors such as air pollution, obesity, diet, and exposure to infections, antibiotics, and allergens, including exposures at very young ages. The most strongly supported preventive measure is the avoidance of passive and active exposure to smoke.
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In the citing paper
“Although underlying mechanisms of asthma are not yet fully understood, they may include airway inflammation, control of airway tone and reactivity (4).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [4]
In the citing paper
“Although greater awareness, recognition, and/or diagnostic shifts have been suggested as contributory factors to the steep rise in asthma prevalence observed over the last four decades of the Twentieth century, repeated cross-sectional surveys using objective measures, such as bronchial hyperreactivity, have confirmed that these factors are unlikely to fully explain this epidemic (4).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [4]
Citations
Cites
Asher, M. I., Montefort, S., Björkstén, B., Lai, C. K., Strachan, D. P., Weiland, S. K., & Williams, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69283-0 · Cited by 4,223
O’Hollaren, M. T., Bardana, E. J., & Montanaro, A. J. (1991) · Cited by 1,360
Prevalence of Asthma and Atopy in Two Areas of West and East Germany
von Mutius, E., Martinez, F. D., Fritzsch, C., Nicolai, T., Roell, G., & Hh, T. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.2.8306030 · Cited by 897
Changes in asthma prevalence: two surveys 15 years apart.
Burr, M. L., Butland, B. K., King, S., & Vaughan‐Williams, E. (1989) · Archives of Disease in Childhood · doi:10.1136/adc.64.10.1452 · Cited by 859
Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
Illi, S., von Mutius, E., Lau, S., Niggemann, B., Grüber, C., & Wahn, U. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69286-6 · Cited by 720
Lau, S., Illi, S., Sommerfeld, C., Niggemann, B., Bergmann, R. L., von Mutius, E., & Wahn, U. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02842-7 · Cited by 701
Strachan, D. P., Butland, B. K., & ANDERSON, H. R. (1996) · BMJ · doi:10.1136/bmj.312.7040.1195 · Cited by 654
Parental smoking and childhood asthma: longitudinal and case-control studies
Strachan, D. P., & Cook, D. G. (1998) · Thorax · doi:10.1136/thx.53.3.204 · Cited by 597
Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany
von Mutius, E., Weiland, S. K., Fritzsch, C., Duhme, H., & Keil, U. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10100-3 · Cited by 572
Corne, J. M., Marshall, C., Smith, S. H., Schreiber, J., Sanderson, G., Holgate, S. T., & Johnston, S. L. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07953-9 · Cited by 571
Research works printed but not linked: 2
- Emeryk A, 2004, Ann Agric Environ Med, 11, 63
- Frank PI, 2005, Br J Gen Pract, 55, 596
Cited by
Sorted by citations
Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma
Program, P., & theDiagnosis, T. E. P. O. (1997) · Cited by 4,082
The development of allergic inflammation
Galli, S. J., Tsai, M., & Piliponsky, A. M. (2008) · Nature · doi:10.1038/nature07204 · Cited by 1,839
Disordered Microbial Communities in Asthmatic Airways
Hilty, M., Burke, C. M., Pedro, H., Cárdenas, P., Bush, A., Bossley, C. J., Davies, J. C., Ervine, A., Poulter, L. W., Pachter, L. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008578 · Cited by 1,874
Allergenic pollen and pollen allergy in Europe.
D’Amato, G., Cecchi, L., Bonini, S., Nunes, C., Annesi‐Maesano, I., Behrendt, H., Liccardi, G., Popov, T., & Van Cauwenberge, P. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01393.x · Cited by 1,342
Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200
Metadata
- Authors
- Eder, W., Ege, M. J., & von Mutius, E.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- ORCID
- Ege, Markus J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-11-23
- Volume
- 355
- Issue
- 21
- Pages
- 2226-2235
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2081375496
- Cited by
- 1,621
- References
- 99
- Citations by year
- 2026: 13 · 2025: 29 · 2024: 35 · 2023: 59 · 2022: 57 · 2021: 83 · 2020: 61 · 2019: 69 · 2018: 85 · 2017: 82 · 2016: 93 · 2015: 119 · 2014: 122 · 2013: 118 · 2012: 129
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- asthma, asthma prevalence, asthma epidemic, air pollution, obesity, diet, infection exposure, antibiotic exposure, allergen exposure, early life exposure, passive smoking, active smoking, asthma prevention
- MeSH terms
- Air Pollution, Allergens, Asthma, Bacteria, Diet, Humans, Hypersensitivity, Immediate, Infections, Tobacco Smoke Pollution, Causality, Prevalence, Bronchial Hyperreactivity
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