The development of allergic inflammation

Galli, Stephen J.; Tsai, Mindy; Piliponsky, Adrian M.

doi:10.1038/nature07204

Cited by 1,839Mast cells and histamineAsthma and respiratory diseasesAllergic Rhinitis and Sensitization

The development of allergic inflammation

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Galli, Stephen J., Tsai, Mindy, Piliponsky, Adrian M.·2008·Nature

DOI 10.1038/nature07204PMC PMC3573758

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Abstract

Allergic disorders, such as anaphylaxis, hay fever, eczema and asthma, now afflict roughly 25% of people in the developed world. In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic inflammation. This in turn produces long-term changes in the structure of the affected organs and substantial abnormalities in their function. It is therefore important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reactivity.

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Inflammatory oxidative stress-related reactions are accumulative and somewhat irreversible, consequently age-related, and most diseases and causes of mortality prevalent in the developed world are largely manifestations of this kind of aging.
“Overall, we recognise that these kinds of inflammatory, oxidative stress-related reactions are accumulative and somewhat irreversible [161], that they are consequently age-related, and (see [162-165] and later), and that most diseases and causes of mortality that are prevalent in the developed world are in this sense largely manifestations of this kind of aging.”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [161]

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Authors: Galli, S. J., Tsai, M., & Piliponsky, A. M.
Affiliations: Stanford Medicine (US)
ORCID: Galli, Stephen J.
Tsai, Mindy
Piliponsky, Adrian M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-07-01
Volume: 454
Issue: 7203
Pages: 445-454
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07204
PMC: PMC3573758
OpenAlex: W2007589345
Cited by: 1,839
References: 102
Citations by year: 2026: 75 · 2025: 80 · 2024: 100 · 2023: 127 · 2022: 117 · 2021: 113 · 2020: 133 · 2019: 125 · 2018: 97 · 2017: 101 · 2016: 102 · 2015: 94 · 2014: 124 · 2013: 106 · 2012: 95
FWCI: 6.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA072074)
National Institute of Allergy and Infectious Diseases (R01AI023990, R01AI070813)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Keywords: allergic inflammation, mast cells, anaphylaxis, allergic rhinitis, atopic dermatitis, asthma, allergen exposure, chronic inflammation, hypersensitivity
MeSH terms: Allergens, Animals, Chronic Disease, Epithelium, Humans, Hypersensitivity, Immunoglobulin E, Inflammation

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