Pragmatic Trials

Improving the reporting of pragmatic trials: An extension of the CONSORT statement

Zwarenstein, M., Treweek, S., Gagnier, J. J., Altman, D. G., Tunis, S., Haynes, B., Oxman, A. D., Moher, D., & groups, F. T. C. A. P. T. I. H. (. (2008) · BMJ · doi:10.1136/bmj.a2390 · Cited by 1,813 · see citing works

Long-term follow-up of the West of Scotland Coronary Prevention Study

Ford, I., Murray, H., Packard, C. J., Shepherd, J., Macfarlane, P. W., & Cobbe, S. M. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065994 · Cited by 416 · see citing works

2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation

Ibanez, B., James, S., Agewall, S., Antunes, M. J., Bucciarelli-Ducci, C., Bueno, H., Caforio, A. L. P., Crea, F., Goudevenos, J. A., Halvorsen, S., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx393 · Cited by 9,728 · see citing works

Machine Learning in Medicine

Rajkomar, A., Dean, J., & Kohane, I. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1814259 · Cited by 4,579 · see citing works

Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers: A Randomized Controlled Trial

Bundgaard, H., Bundgaard, J. S., Raaschou-Pedersen, D. E. T., von Buchwald, C., Todsen, T., Norsk, J. B., Pries-Heje, M. M., Vissing, C. R., Nielsen, P. B., Winsløw, U. C., et al. (2021) · Annals of Internal Medicine · doi:10.7326/m20-6817 · Cited by 388 · see citing works

Challenges in the design and interpretation of Noninferiority trials

Mauri, L., & D’Agostino, R. B. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1510063 · Cited by 395 · see citing works

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease

Jones, W. S., Mulder, H., Wruck, L. M., Pencina, M. J., Kripalani, S., Muñoz, D., Crenshaw, D. L., Effron, M. B., Re, R. N., Gupta, K., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2102137 · Cited by 307 · see citing works

Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework

Gold, S. M., Enck, P., Hasselmann, H., Friede, T., Hegerl, U., Mohr, D. C., & Otte, C. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30153-0 · Cited by 236 · see citing works

The role of the Quality and Outcomes Framework in the care of long-term conditions: a systematic review

Forbes, L. J., Marchand, C., Doran, T., & Peckham, S. (2017) · British Journal of General Practice · doi:10.3399/bjgp17x693077 · Cited by 187 · see citing works

Clinical utility of polygenic risk scores for coronary artery disease

Klarin, D., & Natarajan, P. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00638-w · Cited by 152 · see citing works

Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects

Volpi, S., Bult, C. J., Chisholm, R. L., Deverka, P. A., Ginsburg, G. S., Jacob, H. J., Kasapi, M., McLeod, H. L., Roden, D. M., Williams, M. S., et al. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1048 · Cited by 135 · see citing works

Post-Marketing Safety Concerns with Esketamine: A Disproportionality Analysis of Spontaneous Reports Submitted to the FDA Adverse Event Reporting System

Gastaldon, C., Raschi, E., Kane, J. M., Barbui, C., & Schoretsanitis, G. (2021) · Psychotherapy and Psychosomatics · doi:10.1159/000510703 · Cited by 134 · see citing works

ECG AI-Guided Screening for Low Ejection Fraction (EAGLE): Rationale and design of a pragmatic cluster randomized trial

Yao, X., McCoy, R. G., Friedman, P. A., Shah, N. D., Barry, B. A., Behnken, E. M., Inselman, J. W., Attia, Z. I., & Noseworthy, P. A. (2020) · American Heart Journal · doi:10.1016/j.ahj.2019.10.007 · Cited by 98 · see citing works

Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential?

Kočárová, R., Horáček, J., & Carhart-Harris, R. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.661233 · Cited by 96 · see citing works

Mailed outreach invitations significantly improve HCC surveillance rates in patients with cirrhosis: a randomized clinical trial

Singal, A. G., Tiro, J. A., Murphy, C. C., Marrero, J. A., McCallister, K., Fullington, H., Mejias, C., Waljee, A. K., Pechero Bishop, W., Santini, N. O., et al. (2019) · Hepatology · doi:10.1002/hep.30129 · Cited by 89 · see citing works

Results of the Optimune trial: A randomized controlled trial evaluating a novel Internet intervention for breast cancer survivors

Holtdirk, F., Mehnert, A., Weiss, M., Mayer, J., Meyer, B., Bröde, P., Claus, M., & Watzl, C. (2021) · PLOS ONE · doi:10.1371/journal.pone.0251276 · Cited by 62 · see citing works

Fool’s gold? Why blinded trials are not always best

Anand, Norrie, Bradley, McAuley, & Clarke (2020) · BMJ · doi:10.1136/bmj.l6228 · Cited by 58 · see citing works

The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders

on behalf of the Ethics of Pragmatic Trials project, Nicholls, S. G., Carroll, K., Zwarenstein, M., Brehaut, J. C., Weijer, C., Hey, S. P., Goldstein, C. E., Graham, I. D., Grimshaw, J. M., et al. (2019) · Trials · doi:10.1186/s13063-019-3899-x · Cited by 56 · see citing works

Effectiveness of a collaborative care intervention for managing major depression and chronic musculoskeletal pain in primary care: A cluster-randomised controlled trial

Aragonès, E., Rambla, C., López-Cortacans, G., Tomé-Pires, C., Sánchez-Rodríguez, E., Caballero, A., & Miró, J. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.004 · Cited by 50 · see citing works

Feasibility randomized-controlled trial of online acceptance and commitment therapy for painful peripheral neuropathy in people living with HIV: the OPEN study

Scott, W., Guildford, B. J., Badenoch, J., Driscoll, E., Chilcot, J., Norton, S., Kemp, H. I., Lee, M. J., Lwanga, J., Boffito, M., et al. (2021) · European Journal of Pain · doi:10.1002/ejp.1762 · Cited by 36 · see citing works

Effect of smartphone-based stress management programs on depression and anxiety of hospital nurses in Vietnam: a three-arm randomized controlled trial

Imamura, K., Tran, T. T. T., Nguyen, H. T., Sasaki, N., Kuribayashi, K., Sakuraya, A., Bui, T. M., Nguyen, A. Q., Nguyen, Q. T., Nguyen, N. T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90320-5 · Cited by 31 · see citing works

Effectiveness of Combining Antiobesity Medication With an Employer-Based Weight Management Program for Treatment of Obesity: A Randomized Clinical Trial

Pantalone, K. M., Smolarz, B. G., Ramasamy, A., Baz Hecht, M., Harty, B. J., Rogen, B., Griebeler, M. L., Borukh, E., Young, J. B., & Burguera, B. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.16595 · Cited by 31 · see citing works

Effects of smartphone-based stress management on improving work engagement among nurses in Vietnam: secondary analysis of a three-arm randomized controlled trial

Sasaki, N., Imamura, K., Tran, T. T. T., Nguyen, H. T., Kuribayashi, K., Sakuraya, A., Bui, T. M., Nguyen, Q. T., Nguyen, N. T., Nguyen, G. T. H., et al. (2021) · Journal of Medical Internet Research · doi:10.2196/20445 · Cited by 30 · see citing works

Improvements in hepatic steatosis, obesity, and insulin resistance in adults with nonalcoholic fatty liver disease after the primary obesity surgery endoluminal 2.0 procedure

AlKhatry, M., Rapaka, B., Maselli, D. B., Abboud, D. M., Brunaldi, V. O., Mahmoud, T., Ghazi, R., Abdul Razzak, F., Gala, K., Joudah, I., et al. (2023) · Endoscopy · doi:10.1055/a-2117-6274 · Cited by 23 · see citing works

Adoption, Acceptability, and Effectiveness of a Mobile Health App for Personalized Prostate Cancer Survivorship Care: Protocol for a Realist Case Study of the Ned App

Pham, Q., Cafazzo, J. A., & Feifer, A. (2017) · JMIR Research Protocols · doi:10.2196/resprot.8051 · Cited by 22 · see citing works

Pragmatic Comparative Effectiveness Trials and Learning Health Systems in Pain Medicine

Salmasi, V., Terkawi, A. S., & Mackey, S. C. (2023) · Anesthesiology Clinics · doi:10.1016/j.anclin.2023.03.010 · Cited by 16 · see citing works

Pragmatic Clinical Trials: A Study Design for Real-World Evidence

Capili, B., & Anastasi, J. K. (2025) · AJN American Journal of Nursing · doi:10.1097/ajn.0000000000000014 · Cited by 15 · see citing works

Exploring the Feasibility of Digital Voice Assistants for Delivery of a Home-Based Exercise Intervention in Older Adults With Obesity and Type 2 Diabetes Mellitus: Randomized Controlled Trial

Glavas, C., Scott, D., Sood, S., George, E. S., Daly, R. M., Gvozdenko, E., de Courten, B., & Jansons, P. (2024) · JMIR Aging · doi:10.2196/53064 · Cited by 13 · see citing works

Ethical and epistemic issues in the design and conduct of pragmatic stepped-wedge cluster randomized clinical trials

Federico, C. A., Heagerty, P. J., Lantos, J., O'Rourke, P., Rahimzadeh, V., Sugarman, J., Weinfurt, K., Wendler, D., Wilfond, B. S., & Magnus, D. (2022) · Contemporary Clinical Trials · doi:10.1016/j.cct.2022.106703 · Cited by 11 · see citing works

Re-Evaluating Evidence for Best Practice in Paediatric Speech-Language Pathology

Dodd, B. (2021) · Folia Phoniatrica et Logopaedica · doi:10.1159/000505265 · Cited by 12 · see citing works

Rationale and design of a pilot study examining Acceptance and Commitment Therapy for persistent pain in an integrated primary care clinic

Kanzler, K. E., Robinson, P. J., McGeary, D. D., Mintz, J., Potter, J. S., Muñante, M., Lopez, E. J., Dougherty, D. M., Hale, W. J., & Velligan, D. I. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.01.004 · Cited by 7 · see citing works

Protocol for a cervical screening implementation trial comparing two approaches for delivering HPV self-collection in low-resource settings in India: a type 3 hybrid cluster randomised controlled trial (SHE-CAN)

Oommen, A. M., Ashfaq, M., Tonsing, M. V., Cherian, A. G., Singarayar, P., Viswanathan, V., Muniswamy, V., Hawkes, D., Abraham, P., Pricilla, R. A., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-101599 · Cited by 1 · see citing works