Multiplicity Considerations in Clinical Trials

Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol

Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407 · see citing works

Enzalutamide in Metastatic Prostate Cancer before Chemotherapy

Beer, T. M., Armstrong, A. J., Rathkopf, D. E., Loriot, Y., Sternberg, C. N., Higano, C. S., Iversen, P., Bhattacharya, S., Carles, J., Chowdhury, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1405095 · Cited by 3,028 · see citing works

Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy

Ryan, C. J., Smith, M. R., de Bono, J. S., Molina, A., Logothetis, C. J., de Souza, P., Fizazi, K., Mainwaring, P., Piulats, J. M., Ng, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209096 · Cited by 2,796 · see citing works

Increased MET Gene Copy Number Negatively Affects Survival of Surgically Resected Non–Small-Cell Lung Cancer Patients

Cappuzzo, F., Marchetti, A., Skokan, M. C., Rossi, E., Gajapathy, S., Felicioni, L., Grammastro, M. D., Sciarrotta, M., Buttitta, F., Incarbone, M., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.1635 · Cited by 557 · see citing works

Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients

Cohen, A. T., Harrington, R. A., Goldhaber, S. Z., Hull, R. D., Wiens, B. L., Gold, A., Hernandez, A. F., & Gibson, C. M. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1601747 · Cited by 439 · see citing works

Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies

Bretz, F., Pinheiro, J. C., & Branson, M. (2005) · Biometrics · doi:10.1111/j.1541-0420.2005.00344.x · Cited by 399 · see citing works

Tutorial in biostatistics: data‐driven subgroup identification and analysis in clinical trials

Lipkovich, I., Dmitrienko, A., & B., R. (2017) · Statistics in Medicine · doi:10.1002/sim.7064 · Cited by 291 · see citing works

Multiple Testing Problems in Pharmaceutical Statistics

(2009) · Chapman & Hall/CRC eBooks · doi:10.1201/9781584889854 · Cited by 274 · see citing works

Lurasidone in the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo- and Olanzapine-Controlled Study

Meltzer, H. Y., Cucchiaro, J. B., Silva, R., Ogasa, M., Phillips, D., Xu, J., Kalali, A. H., Schweizer, E. E., Pikalov, A., & Loebel, A. D. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10060907 · Cited by 249 · see citing works

Multiple testing in clinical trials

Bauer, P. (1991) · Statistics in Medicine · doi:10.1002/sim.4780100609 · Cited by 241 · see citing works

Traditional multiplicity adjustment methods in clinical trials

Dmitrienko, A. A., & D’Agostino, R. B. (2013) · Statistics in Medicine · doi:10.1002/sim.5990 · Cited by 153 · see citing works

Lurasidone for the treatment of acutely psychotic patients with schizophrenia: A 6-week, randomized, placebo-controlled study

Nasrallah, H. A., Silva, R., Phillips, D., Cucchiaro, J. B., Hsu, J., Xu, J., & Loebel, A. D. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.01.020 · Cited by 144 · see citing works

Use of the false discovery rate for evaluating clinical safety data

Mehrotra, D. V., & Heyse, J. F. (2004) · Statistical Methods in Medical Research · doi:10.1191/0962280204sm363ra · Cited by 126 · see citing works

Multiple Co-primary Endpoints: Medical and Statistical Solutions: A Report from the Multiple Endpoints Expert Team of the Pharmaceutical Research and Manufacturers of America

Offen, W., Chuang‐Stein, C., Dmitrienko, A. A., Littman, G. S., Maca, J., Meyerson, L., Muirhead, R. J., Stryszak, P., Baddy, A., Chen, K., et al. (2007) · Drug Information Journal · doi:10.1177/009286150704100105 · Cited by 122 · see citing works

Methods correcting for multiple testing: operating characteristics

Brown, B. W., & Russell, K. E. (1997) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19971130)16:22 · Cited by 118 · see citing works

Key multiplicity issues in clinical drug development

Dmitrienko, A. A., D’Agostino, R. B., & Huque, M. F. (2012) · Statistics in Medicine · doi:10.1002/sim.5642 · Cited by 96 · see citing works

Use of composite endpoints in clinical trials

Sankoh, A. J., Li, H., & D’Agostino, R. B. (2014) · Statistics in Medicine · doi:10.1002/sim.6205 · Cited by 74 · see citing works

Alpha calculus in clinical trials: considerations and commentary for the new millennium

Moy�, L. A. (2000) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(20000330)19:6 · Cited by 69 · see citing works

Mixtures of multiple testing procedures for gatekeeping applications in clinical trials

Dmitrienko, A. A., & Tamhane, A. C. (2011) · Statistics in Medicine · doi:10.1002/sim.4008 · Cited by 61 · see citing works

Addressing Multiplicity Issues of a Composite Endpoint and Its Components in Clinical Trials

Huque, M. F., Alosh, M., & Bhore, R. (2011) · Journal of Biopharmaceutical Statistics · doi:10.1080/10543406.2011.551327 · Cited by 48 · see citing works

Multiple comparisons in over‐the‐ounter drug clinical trials with both positive and placebo controls

D’Agostino, R. B., & Heeren, T. (1991) · Statistics in Medicine · doi:10.1002/sim.4780100102 · Cited by 46 · see citing works

A Statistical Framework for Decision Making in Confirmatory Multipopulation Tailoring Clinical Trials

Millen, B. A., Dmitrienko, A. A., Ruberg, S. J., & Shen, L. (2012) · Drug Information Journal · doi:10.1177/0092861512454116 · Cited by 41 · see citing works

A Mixture Gatekeeping Procedure Based on the Hommel Test for Clinical Trial Applications

Brechenmacher, T., Xu, J., Dmitrienko, A. A., & Tamhane, A. C. (2011) · Journal of Biopharmaceutical Statistics · doi:10.1080/10543406.2011.551334 · Cited by 33 · see citing works

General theory of mixture procedures for gatekeeping

Dmitrienko, A. A., & Tamhane, A. C. (2013) · Biometrical Journal · doi:10.1002/bimj.201100258 · Cited by 30 · see citing works

Strategies for Dealing with Multiple Treatment Comparisons in Confirmatory Clinical Trials

D’Agostino, R. B., Massaro, J. M., Russell, H. K., & Cabral, H. (1993) · Drug Information Journal · doi:10.1177/009286159302700307 · Cited by 24 · see citing works

Multiplicity Issues in Clinical Trials With Multiple Objectives

Huque, M. F., Dmitrienko, A. A., & D’Agostino, R. B. (2013) · Statistics in Biopharmaceutical Research · doi:10.1080/19466315.2013.807749 · Cited by 24 · see citing works

Multiple Testing Methodology

Dmitrienko, A. A., Bretz, F., Westfall, P. H., Troendle, J. F., Wiens, B. L., Tamhane, A. C., & Hsu, J. (2009) · Chapman & Hall/CRC biostatistics series · doi:10.1201/9781584889854-c2 · Cited by 23 · see citing works

Gatekeeping Procedures in Clinical Trials

Dmitrienko, A. A., & Tamhane, A. C. (2009) · Chapman & Hall/CRC biostatistics series · doi:10.1201/9781584889854-c5 · Cited by 14 · see citing works

Clinical Trial Optimization Using R

(2017) · Chapman & Hall/CRC eBooks · doi:10.1201/9781315120836 · Cited by 12 · see citing works

Discussion of “Some Controversial Multiple Testing Problems in Regulatory Applications”

Chuang‐Stein, C., Dmitrienko, A. A., & Offen, W. (2009) · Journal of Biopharmaceutical Statistics · doi:10.1080/10543400802541719 · Cited by 10 · see citing works

First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer

Horn, L., Mansfield, A. S., Szczęsna, A., Havel, L., Krzakowski, M., Hochmair, M. J., Huemer, F., Losonczy, G., Johnson, M. L., Nishio, M., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1809064 · Cited by 3,586 · see citing works

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): A double-blind, randomised placebo-controlled trial

Hernandez, A. F., Green, J. B., Janmohamed, S., D'Agostino, R. B., Granger, C. B., Jones, N. P., Leiter, L. A., Rosenberg, A. E., Sigmon, K. N., Somerville, M. C., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32261-x · Cited by 1,829 · see citing works

Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer

Turner, N. C., Slamon, D. J., Ro, J., Bondarenko, I., Im, S.-A., Masuda, N., Colleoni, M., DeMichele, A., Loi, S., Verma, S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1810527 · Cited by 1,276 · see citing works

Overall survival with ribociclib plus endocrine therapy in breast cancer

Im, S.-A., Lu, Y.-S., Bardia, A., Harbeck, N., Colleoni, M., Franke, F., Chow, L., Sohn, J., Lee, K.-S., Campos-Gomez, S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1903765 · Cited by 1,001 · see citing works

Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder

Pittock, S. J., Berthele, A., Fujihara, K., Kim, H. J., Levy, M., Palace, J. A., Nakashima, I., Terzi, M., Totolyan, N. A., Viswanathan, S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1900866 · Cited by 887 · see citing works

Trial of Spesolimab for Generalized Pustular Psoriasis

Bachelez, H., Choon, S. E., Marrakchi, S., Burden, A. D., Tsai, T., Morita, A., Navarini, A. A., Zheng, M., Xu, J., Turki, H., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2111563 · Cited by 358 · see citing works

New Guidelines for Statistical Reporting in the Journal

Harrington, D. P., D’Agostino, R. B., Gatsonis, C., Hogan, J. W., Hunter, D. J., Normand, S. T., Drazen, J. M., & Hamel, M. B. (2019) · New England Journal of Medicine · doi:10.1056/nejme1906559 · Cited by 337 · see citing works

Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity

Baker, C. W., Glassman, A. R., Beaulieu, W. T., Antoszyk, A. N., Browning, D. J., Chalam, K. V., Grover, S., Jampol, L. M., Jhaveri, C. D., Melia, M., et al. (2019) · JAMA · doi:10.1001/jama.2019.5790 · Cited by 299 · see citing works

Drug-Coated Balloons for Dysfunctional Dialysis Arteriovenous Fistulas

Lookstein, R., Haruguchi, H., Ouriel, K. M., Weinberg, I., Lei, L., Cihlar, S., & Holden, A. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1914617 · Cited by 223 · see citing works

Advances in molecular pathology and therapy of non-small cell lung cancer

Huang, Q., Li, Y., Huang, Y., Wu, J., Bao, W., Xue, C., Li, X., Dong, S., Dong, Z., & Hu, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02243-6 · Cited by 197 · see citing works

SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials

Hróbjartsson, A., Boutron, I., Hopewell, S., Moher, D., Schulz, K. F., Collins, G. S., Tunn, R., Aggarwal, R., Berkwits, M., Berlin, J. A., et al. (2025) · BMJ · doi:10.1136/bmj-2024-081660 · Cited by 171 · see citing works

The Evolution of Master Protocol Clinical Trial Designs: A Systematic Literature Review

Meyer, E. L., Mesenbrink, P. G., Dunger‐Baldauf, C., Fülle, H., Glimm, E., Li, Y., Posch, M., & König, F. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.05.010 · Cited by 136 · see citing works

Efficacy and safety of first-line maintenance therapy with lurbinectedin plus atezolizumab in extensive-stage small-cell lung cancer (IMforte): a randomised, multicentre, open-label, phase 3 trial

Paz-Ares, L. G., Borghaei, H., Liu, S. V., Peters, S., Herbst, R. S., Stencel, K. M., Majem, M., Şendur, M. A. N., Czyżewicz, G., Caro, R. B., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01011-6 · Cited by 108 · see citing works

STROKE-CARD care to prevent cardiovascular events and improve quality of life after acute ischaemic stroke or TIA: A randomised clinical trial

Willeit, P., Toell, T., Boehme, C., Krebs, S., Mayer‐Suess, L., Lang, C., Seekircher, L., Tschiderer, L., Willeit, K., Rumpold, G., et al. (2020) · EClinicalMedicine · doi:10.1016/j.eclinm.2020.100476 · Cited by 87 · see citing works

Mapping ongoing nutrition intervention trials in muscle, sarcopenia, and cachexia: a scoping review of future research

Orsso, C. E., Montes‐Ibarra, M., Findlay, M., van der Meij, B. S., de van der Schueren, M. A. E., Landi, F., Laviano, A., & Prado, C. M. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12954 · Cited by 73 · see citing works

Effectiveness of different combinations of DMARDs and glucocorticoid bridging in early rheumatoid arthritis: two-year results of CareRA

Stouten, V., Westhovens, R., Pazmiño, S., Cock, D. D., der Elst, K. V., Joly, J., Verschueren, P., on behalf of the CareRA study group, Maeyaert, B., Brabanter, G. D., et al. (2019) · Lara D. Veeken · doi:10.1093/rheumatology/kez213 · Cited by 62 · see citing works

Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial

Legaard, G. E., Lyngbæk, M. P. P., Almdal, T., Karstoft, K., Bennetsen, S. L., Feineis, C. S., Nielsen, N. S., Durrer, C. G., Liebetrau, B., Nystrup, U., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00799-7 · Cited by 55 · see citing works

Common Sense Oncology principles for the design, analysis, and reporting of phase 3 randomised clinical trials

Gyawali, B., Eisenhauer, E. A., van der Graaf, W., Booth, C. M., Cherny, N. I., Goodman, A. M., Koven, R., Pe, M. L., Marini, B. L., Mohyuddin, G. R., et al. (2025) · The Lancet Oncology · doi:10.1016/s1470-2045(24)00451-0 · Cited by 50 · see citing works

Essential statistical principles of clinical trials of pain treatments

Dworkin, R. H., Evans, S. R., Mbowe, O. B., & McDermott, M. (2020) · PAIN Reports · doi:10.1097/pr9.0000000000000863 · Cited by 46 · see citing works

Azithromycin to Reduce Mortality — An Adaptive Cluster-Randomized Trial

O’Brien, K. S., Arzika, A. M., Amza, A., Maliki, R., Aichatou, B., Bello, I. M., Beidi, D., Galo, N., Harouna, A. N., Karamba, A. M., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2312093 · Cited by 46 · see citing works

Strategies in adjusting for multiple comparisons: A primer for pediatric surgeons

Staffa, S. J., & Zurakowski, D. (2020) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2020.01.003 · Cited by 44 · see citing works

Individual Patient Data from the Pivotal Randomized Controlled Trials of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation (COMBINE AF): Design and Rationale

Carnicelli, A., Hong, H., Giugliano, R. P., Connolly, S. J., Eikelboom, J. W., Patel, M. R., Wallentin, L. C., Morrow, D. A., WOJDYLA, D. M., Hua, K., et al. (2020) · American Heart Journal · doi:10.1016/j.ahj.2020.12.002 · Cited by 37 · see citing works

Selective outcome reporting in randomized clinical trials of dental implants

Sendyk, D. I., Rovai, E. S., Souza, N. V., Deboni, M. C. Z., & Pannuti, C. M. (2019) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13128 · Cited by 35 · see citing works

One-year intensive lifestyle intervention and improvements in health-related quality of life and mental health in persons with type 2 diabetes: a secondary analysis of the U-TURN randomized controlled trial

MacDonald, C., Nielsen, S. M., Bjørner, J. B., Johansen, M. Y., Christensen, R., Vaag, A. A., Lieberman, D. E., Pedersen, B. K., Langberg, H., Ried‐Larsen, M., et al. (2021) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001840 · Cited by 36 · see citing works

The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: A randomized crossover trial

Thorsen, I. K., Johansen, M. Y., Pilmark, N. S., Jespersen, N. Z., Brinkløv, C. F., Benatti, F. B., Dunstan, D. W., Karstoft, K., Pedersen, B. K., & Ried‐Larsen, M. (2019) · Metabolism · doi:10.1016/j.metabol.2019.04.003 · Cited by 35 · see citing works

Sustained Intensive Treatment and Long-term Effects on HbA1c Reduction (SILVER Study) by CGM in People With Type 1 Diabetes Treated With MDI

Lind, M., Ólafsdóttir, A. F., Hirsch, I. B., Bolinder, J., Dahlqvist, S., Pivodic, A., Hellman, J., Wijkman, M. O., Schwarcz, E., Albrektsson, H., et al. (2020) · Diabetes Care · doi:10.2337/dc20-1468 · Cited by 35 · see citing works

Heart Failure End Points in Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus

Butler, J., Packer, M., Greene, S. J., Fiuzat, M., Anker, S. D., Anstrom, K. J., Carson, P. E., Cooper, L. B., Fonarow, G. C., Hernandez, A. F., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.042155 · Cited by 29 · see citing works

Digital Health Technology to Measure Drug Efficacy in Clinical Trials for Parkinson’s Disease: A Regulatory Perspective

Sacks, L. V., & Kunkoski, E. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-202416 · Cited by 27 · see citing works

Efficacy of Risankizumab versus Secukinumab in Patients with Moderate-to-Severe Psoriasis: Subgroup Analysis from the IMMerge Study

Crowley, J., Langley, R. G. B., Gordon, K. B., Pinter, A., Ferris, L. K., Rubant, S., Photowala, H., Xue, Z., Wu, T., Zhan, T., et al. (2022) · Dermatology and Therapy · doi:10.1007/s13555-021-00679-6 · Cited by 27 · see citing works

Dose-Response Effects of Exercise on Glucose-Lowering Medications for Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial

MacDonald, C., Johansen, M. Y., Nielsen, S. M., Christensen, R., Hansen, K. B., Langberg, H., Vaag, A. A., Karstoft, K., Lieberman, D. E., Pedersen, B. K., et al. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.09.005 · Cited by 25 · see citing works

A pilot multicentre randomised controlled trial of lidocaine infusion in women undergoing breast cancer surgery

Toner, A. J., Bailey, M., Schug, S. A., & Corcoran, T. B. (2021) · Anaesthesia · doi:10.1111/anae.15440 · Cited by 25 · see citing works

Age-based targeting of biannual azithromycin distribution for child survival in Niger: an adaptive cluster-randomized trial protocol (AVENIR)

the AVENIR Study Group, O’Brien, K. S., Arzika, A. M., Amza, A., Maliki, R., Ousmane, S., Kadri, B., Nassirou, B., Mankara, A. K., Harouna, A. N., et al. (2021) · BMC Public Health · doi:10.1186/s12889-021-10824-7 · Cited by 25 · see citing works

Dosage reduction and discontinuation of biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis: protocol for a pragmatic, randomised controlled trial (the BIOlogical Dose OPTimisation (BIODOPT) trial)

Uhrenholt, L., Schlemmer, A., Hauge, E., Christensen, R., Dreyer, L., Suarez-Almazor, M. E., & Kristensen, S. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028517 · Cited by 25 · see citing works

Multiplicity corrections in life sciences: challenges and consequences

Menyhárt, O., & Győrffy, B. (2025) · International Journal of Epidemiology · doi:10.1093/ije/dyaf098 · Cited by 24 · see citing works

Selective outcome reporting in root coverage randomized clinical trials

Sendyk, D. I., Vilela, N., Neto, J. B. C., Tatakis, D. N., & Pannuti, C. M. (2021) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13451 · Cited by 24 · see citing works

Mesh implants for hernia repair: an update

Klinge, U., & Klosterhalfen, B. (2018) · Expert Review of Medical Devices · doi:10.1080/17434440.2018.1529565 · Cited by 24 · see citing works

Using Bayesian statistics in confirmatory clinical trials in the regulatory setting: a tutorial review

Lee, S. Y. (2024) · BMC Medical Research Methodology · doi:10.1186/s12874-024-02235-0 · Cited by 22 · see citing works

How Not to Fool Ourselves About Heterogeneity of Treatment Effects

von Hippel, P. V., & Schuetze, B. A. (2025) · Advances in Methods and Practices in Psychological Science · doi:10.1177/25152459241304347 · Cited by 20 · see citing works

Prevalence of Multiplicity and Appropriate Adjustments Among Cardiovascular Randomized Clinical Trials Published in Major Medical Journals

Khan, M. S., Khan, M. S., Ansari, Z. N., Siddiqi, T. J., Khan, S. U., Riaz, I. B., Asad, Z. U. A., Mandrola, J. M., Wason, J. M. S., Warraich, H. J., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.3082 · Cited by 22 · see citing works

Characteristics of Design and Analysis of Ophthalmic Randomized Controlled Trials

Dong, R., & Ying, G. (2022) · Ophthalmology Science · doi:10.1016/j.xops.2022.100266 · Cited by 21 · see citing works

The handling oxygenation targets in the intensive care unit (HOT‐ICU) trial: Detailed statistical analysis plan

Schjørring, O. L., Klitgaard, T. L., Perner, A., Wetterslev, J., Lange, T., Keus, F., Laake, J. H., Morgan, M., Bäcklund, M., Siegemund, M., et al. (2020) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13569 · Cited by 18 · see citing works

Rethinking clinical endpoints in kidney transplant trials

Maggiore, U., Leventhal, J. S., & Cravedi, P. (2019) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000719 · Cited by 18 · see citing works

Tracheomalacia and tracheomegaly in infants and children with congenital diaphragmatic hernia managed with and without fetoscopic endoluminal tracheal occlusion (FETO): a multicentre, retrospective cohort study

Basurto, D., Watananirun, K., Cordier, A., Otaño, J., Carrière, D., Scuglia, M., Vargas, A. M. D. L. F., Prat, J., Russo, F. M., Debeer, A., et al. (2024) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(24)00109-3 · Cited by 16 · see citing works

Project Rebuild the Evidence Base (REB): a method to interpret randomised clinical trials and their meta-analysis to present solid benefit-risk assessments to patients.

Boussageon, R., Blanchard, C., Charuel, É., Ménini, T., Pereira, B., Naudet, F., Kassaï, B., Gueyffier, F., Cucherat, M., & Vaillant-Roussel, H. (2022) · Therapies · doi:10.1016/j.therap.2022.10.008 · Cited by 15 · see citing works

The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial

Lyngbæk, M. P. P., Legaard, G. E., Bennetsen, S. L., Feineis, C. S., Rasmussen, V., Moegelberg, N., Brinkløv, C. F., Nielsen, A. B., Kofoed, K. S., Lauridsen, C. A., et al. (2021) · Trials · doi:10.1186/s13063-021-05207-7 · Cited by 14 · see citing works

Examining self-defining memories and aggression in a sample of criminal offenders

Taple, B. J., Zabala-Baños, M. D. C., Jiménez, M. V. J., Griffith, J. W., & Ricarte, J. J. (2018) · Memory · doi:10.1080/09658211.2018.1557209 · Cited by 12 · see citing works

Leveraging Serial Low-Dose CT Scans in Radiomics-based Reinforcement Learning to Improve Early Diagnosis of Lung Cancer at Baseline Screening

Wang, Y., Zhou, C., Ying, L., Lee, E., Chan, H., Chughtai, A. R., Hadjiiski, L. M., & Kazerooni, E. A. (2024) · Radiology Cardiothoracic Imaging · doi:10.1148/ryct.230196 · Cited by 11 · see citing works

Statistical significance and p-values

Parsons, N., Carey-Smith, R. L., Dritsaki, M., Griffin, X. L., Metcalfe, D., Perry, D. C., Stengel, D., & Costa, M. L. (2019) · The Bone & Joint Journal · doi:10.1302/0301-620x.101b10.bjj-2019-0890 · Cited by 11 · see citing works

Causal Considerations Can Inform the Interpretation of Surprising Associations in Medical Registries

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Survival, treatment pattern, and treatment outcome in patients with cervical cancer metastatic to distant lymph nodes

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