Nitric Oxide and Cyclic GMP in Cell Signaling and Drug Development
Abstract
In the 116th Shattuck Lecture, Nobel laureate Ferid Murad explains how nitric oxide was discovered to be a biologically important molecule and outlines its multiple roles.
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Constitutive eNOS/NOS3 and nNOS/NOS1 produce low cellular NO, generally for cGMP regulation and subsequent events.
“The constitutive isoforms, endothelial and neuronal NOS (eNOS/NOS3 and nNOS/NOS1), produce low cellular levels of NO, generally for regulation of cGMP and subsequent events (for example, [15]).”
From Signaling and stress: The redox landscape in NOS2 biology (2015) · cites this paper as [15]
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Self-citationMyocardial protection by nitrite
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Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes
Beyer, A. M., Guo, D.-F., Sheffield, V. C., & Rahmouni, K. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00336.2010 · Cited by 14 · see citing works
- Authors
- Murad, F.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Murad, Ferid
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-11-09
- Volume
- 355
- Issue
- 19
- Pages
- 2003-2011
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1973082528
- Cited by
- 420
- References
- 0
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 14 · 2023: 21 · 2022: 21 · 2021: 24 · 2020: 27 · 2019: 13 · 2018: 15 · 2017: 22 · 2016: 18 · 2015: 19 · 2014: 26 · 2013: 16 · 2012: 28
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- nitric oxide, cyclic GMP, signal transduction, drug development, soluble guanylate cyclase
- MeSH terms
- Cyclic GMP, Guanylate Cyclase, Humans, Nitric Oxide, Drug Design, Signal Transduction, Reactive Oxygen Species, Nitric Oxide Synthase, Protein Isoforms
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