Nitric oxide and nitrite-based therapeutic opportunities in intimal hyperplasia

Alef, Matthew J.; Tzeng, Edith; Zuckerbraun, Brian S.

doi:10.1016/j.niox.2012.03.014

Cited by 20Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionAtherosclerosis and Cardiovascular Diseases

Nitric oxide and nitrite-based therapeutic opportunities in intimal hyperplasia

Alef, Matthew J., Tzeng, Edith, Zuckerbraun, Brian S.·2012·Nitric Oxide

DOI 10.1016/j.niox.2012.03.014

Open this paper in CoChat — free account

Abstract

Vascular intimal hyperplasia (IH) limits the long term efficacy of current surgical and percutaneous therapies for atherosclerotic disease. There are extensive changes in gene expression and cell signaling in response to vascular therapies, including changes in nitric oxide (NO) signaling. NO is well recognized for its vasoregulatory properties and has been investigated as a therapeutic treatment for its vasoprotective abilities. The circulating molecules nitrite (NO(2)(-)) and nitrate (NO(3)(-)), once thought to be stable products of NO metabolism, are now recognized as important circulating reservoirs of NO and represent a complementary source of NO in contrast to the classic L-arginine-NO-synthase pathway. Here we review the background of IH, its relationship with the NO and nitrite/nitrate pathways, and current and future therapeutic opportunities for these molecules.

Integrity signals

Registry

Crossref · 10.1016/j.niox.2012.03.014

Cites

166 of 166 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Dietary nitrate and nitrite confer protection from intimal hyperplasia in rodents.
“Further, dietary nitrate and nitrite confer protection from intimal hyperplasia in rodents[117–119]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [118]
Multiple preclinical studies suggest nitrite may be effective for prevention and/or treatment of many cardiovascular disorders or risk factors for cardiovascular disease including peripheral artery disease, atherosclerosis, chronic heart failure, stroke, diabetes, and hypertension.
“multiple studies in preclinical models suggest that nitrite also may be effective for the prevention and/or treatment of many cardiovascular disorders or risk factors for CVD including peripheral artery disease (4, 69, 146), atherosclerosis (2, 3, 5, 127), chronic heart failure (32, 122), stroke (50, 82, 150), diabetes (138), and hypertension (22, 57, 58, 128).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [2]

The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery
Moses, J. W., Leon, M. B., Popma, J. J., Fitzgerald, P. J., Holmes, D. R., O’Shaughnessy, C. D., Caputo, R. P., Kereiakes, D. J., Williams, D. O., Teirstein, P. S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035071 · Cited by 4,222 · see citing works
A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization
Morice, M., Serruys, P. W. J. C., Sousa, J. E., Fajadet, J. C., Hayashi, E. B., Perin, M. A., Colombo, A., Schuler, G. C., Barragan, P. T., Guagliumi, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012843 · Cited by 4,028 · see citing works
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,052 · see citing works
Nitric oxide synthases: Roles, tolls, and controls
Nathan, C., & Xie, Q. W. (1994) · Cell · doi:10.1016/0092-8674(94)90266-6 · Cited by 2,920 · see citing works
NITRIC OXIDE: A Physiologic Messenger Molecule
Bredt, D. S., & Snyder, S. H. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.001135 · Cited by 2,315 · see citing works
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437 · see citing works
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,201 · see citing works
Nitric oxide synthases: which, where, how, and why?
Michel, T. M., & Féron, O. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119750 · Cited by 1,018 · see citing works
Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women
Fung, T. T., Rexrode, K. M., Mantzoros, C. S., Manson, J. E., Willett, W. C., & Hu, F. B. (2009) · Circulation · doi:10.1161/circulationaha.108.816736 · Cited by 916 · see citing works
Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.
Ziche, M., Morbidelli, L., Choudhuri, R., Zhang, H. T., Donnini, S., Granger, H. J., & Bicknell, R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119451 · Cited by 914 · see citing works
The discovery of nitric oxide and its role in vascular biology
Moncada, S., & Higgs, E. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706458 · Cited by 863 · see citing works
Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.
Ziche, M., Morbidelli, L., Masini, E., Amerini, S., Granger, H. J., Maggi, C. A., Geppetti, P., & Ledda, F. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117557 · Cited by 861 · see citing works
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788 · see citing works
Molecular mechanisms and therapeutic strategies related to nitric oxide
Moncada, S., & Higgs, E. A. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.13.7557022 · Cited by 776 · see citing works
Comparison of a Polymer-Based Paclitaxel-Eluting Stent With a Bare Metal Stent in Patients With Complex Coronary Artery Disease
Stone, G. W., Ellis, S. G., Cannon, L., Mann, J. T., Greenberg, J. D., Spriggs, D. J., O’Shaughnessy, C. D., DeMaio, S. J., Hall, P. A. X., Popma, J. J., et al. (2005) · JAMA · doi:10.1001/jama.294.10.1215 · Cited by 765 · see citing works
Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene.
von der Leyen, H. E., Gibbons, G. H., Morishita, R., Lewis, N. P., Zhang, L., Nakajima, M., Kaneda, Y., Cooke, J. P., & Dzau, V. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.4.1137 · Cited by 763 · see citing works
Nitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739 · see citing works
Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate
Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M., & Benjamin, N. (1995) · Nature Medicine · doi:10.1038/nm0695-546 · Cited by 734 · see citing works
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.
Xia, Y., Dawson, V. L., Dawson, T. M., Snyder, S. H., & Zweier, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6770 · Cited by 718 · see citing works
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · see citing works
Stomach NO synthesis
Benjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665 · see citing works
Intragastric nitric oxide production in humans: measurements in expelled air.
Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661 · see citing works
Inorganic nitrate is a possible source for systemic generation of nitric oxide
Lundberg, J. O., & Govoni, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.027 · Cited by 657 · see citing works
Nitrate and nitrite in biology, nutrition and therapeutics
Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., Cabrales, P., Fago, A., Feelisch, M., Ford, P. C., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.260 · Cited by 617 · see citing works
The emerging biology of the nitrite anion
Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio1105-308 · Cited by 609 · see citing works
Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia–reperfusion damage
Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · see citing works
Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599 · see citing works
Influence of dietary nitrate on nitrite content of human saliva: Possible relevance to in vivo formation of N-nitroso compounds
Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596 · see citing works
New insights into the regulation of inducible nitric oxide synthesis
Morris, S. M., & Billiar, T. R. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.6.e829 · Cited by 570 · see citing works
Identification of the enzymatic mechanism of nitroglycerin bioactivation
Chen, Z., Zhang, J., & Stamler, J. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122225199 · Cited by 541 · see citing works
Mitochondrial generation of free radicals and hypoxic signaling
Poyton, R. Ο., Ball, K. A., & Castello, P. R. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.04.001 · Cited by 525 · see citing works
Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: Implications for oxygen sensing and hypoxic signaling in eukaryotes
Castello, P. R., David, P. S., McClure, T., Crook, Z., & Poyton, R. O. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.011 · Cited by 495 · see citing works
The discovery of nitric oxide as the endogenous nitrovasodilator.
Moncada, S., Palmer, R. M. J., & Higgs, E. A. (1988) · Hypertension · doi:10.1161/01.hyp.12.4.365 · Cited by 493 · see citing works
Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions
Millar, T. M., Stevens, C. R., Benjamin, N., Eisenthal, R., Harrison, R., & Blake, D. R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00430-x · Cited by 491 · see citing works
Comparison of a Polymer-Based Paclitaxel-Eluting Stent With a Bare Metal Stent in Patients With Complex Coronary Artery Disease: A Randomized Controlled Trial
Stone, G. W., Ellis, S. G., & Cannon, L. (2005) · ACC Current Journal Review · doi:10.1016/j.accreview.2005.11.049 · Cited by 435 · see citing works
Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium
Parenti, A., Morbidelli, L., Cui, X.-L., Douglas, J. G., Hood, J. D., Granger, H. J., Ledda, F., & Ziche, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4220 · Cited by 434 · see citing works
Nitric Oxide and Cyclic GMP in Cell Signaling and Drug Development
Murad, F. (2006) · New England Journal of Medicine · doi:10.1056/nejmsa063904 · Cited by 420 · see citing works
Nitric Oxide Reversibly Inhibits the Migration of Cultured Vascular Smooth Muscle Cells
Sarkar, R., Meinberg, E., Stanley, J. C., Gordon, D., & Webb, R. C. (1996) · Circulation Research · doi:10.1161/01.res.78.2.225 · Cited by 419 · see citing works
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
Godber, B. L. J., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., & Harrison, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7757 · Cited by 411 · see citing works
Nitric Oxide and the Vascular Endothelium
Moncada, S., & Higgs, E. A. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6_7 · Cited by 408 · see citing works
Gene therapy inhibiting neointimal vascular lesion
Leyen, V. D. (1995) · Medical Entomology and Zoology · Cited by 386 · see citing works
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
Shiva, S., Wang, X., Ringwood, L. A., Xu, X., Yuditskaya, S., Annavajjhala, V., Miyajima, H., Hogg, N., Harris, Z. L., & Gladwin, M. T. (2006) · Nature Chemical Biology · doi:10.1038/nchembio813 · Cited by 359 · see citing works
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
Jansson, E. Å., Huang, L., Malkey, R., Govoni, M., Nihlén, C., Olsson, A., Stensdotter, M., Petersson, J., Holm, L., Weitzberg, E., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.92 · Cited by 356 · see citing works
Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349 · see citing works
Health Implications of Exposure to Environmental Nitrogenous Compounds
Mensinga, T. T., Speijers, G. J. A., & Meulenbelt, J. (2003) · Toxicological Reviews · doi:10.2165/00139709-200322010-00005 · Cited by 347 · see citing works
NO Generation From Nitrite and Its Role in Vascular Control
Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341 · see citing works
Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. Role of cyclic-nucleotides and angiotensin1 receptors.
Dubey, R. K., Jackson, E. K., & Lüscher, T. F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118014 · Cited by 317 · see citing works
Reactive Oxygen Species and Endothelial Function – Role of Nitric Oxide Synthase Uncoupling and Nox Family Nicotinamide Adenine Dinucleotide Phosphate Oxidases
Montezano, A. C. I., & Touyz, R. M. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00785.x · Cited by 309 · see citing works
Inducible nitric oxide synthase‐deficient mice have enhanced leukocyte–endothelium interactions in endotoxemia
Hickey, M. J., Sharkey, K. A., Sihota, E., Reinhardt, P. H., MacMicking, J. D., Nathan, C., & Kubes, P. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.12.9337148 · Cited by 288 · see citing works
Nitrite Reductase Function of Deoxymyoglobin: Oxygen Sensor and Regulator of Cardiac Energetics and Function
Rassaf, T., Flögel, U., Drexhage, C., Hendgen-Cotta, U., Kelm, M., & Schrader, J. (2007) · Circulation Research · doi:10.1161/circresaha.107.152488 · Cited by 284 · see citing works
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine · doi:10.1038/nm1109 · Cited by 281 · see citing works
Nitric Oxide–Generating Compounds Inhibit Total Protein and Collagen Synthesis in Cultured Vascular Smooth Muscle Cells
Kolpakov, V., Gordon, D., & Kulik, T. J. (1995) · Circulation Research · doi:10.1161/01.res.76.2.305 · Cited by 278 · see citing works
Relative role of heme nitrosylation and β-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation
Gladwin, M. T., Ognibene, F. P., Pannell, L. K., Nichols, J. S., Pease‐Fye, M. E., Shelhamer, J. H., & Schechter, A. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180155397 · Cited by 274 · see citing works
Nitrite Infusions to Prevent Delayed Cerebral Vasospasm in a Primate Model of Subarachnoid Hemorrhage
Pluta, R. M. (2005) · JAMA · doi:10.1001/jama.293.12.1477 · Cited by 261 · see citing works
Early Intravenous Infusion of Sodium Nitrite Protects Brain Against In Vivo Ischemia-Reperfusion Injury
Jung, K.-H., Chu, K., Ko, S.-Y., Lee, S.-T., Sinn, D.-I., Park, D.-K., Kim, J.-M., Song, E.-C., Kim, M., & Roh, J.-K. (2006) · Stroke · doi:10.1161/01.str.0000245116.40163.1c · Cited by 253 · see citing works
<scp>l</scp> -Arginine Supplementation in Peripheral Arterial Disease: No Benefit and Possible Harm
Wilson, A. M., Harada, R., Nair, N., Balasubramanian, N., & Cooke, J. P. (2007) · Circulation · doi:10.1161/circulationaha.106.683656 · Cited by 241 · see citing works
Human Endothelial Nitric Oxide Synthase Gene Transfer Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation After Balloon Injury in Rats
Janssens, S. P., Flaherty, D., Nong, Z., Varenne, O., Pelt, N. V., Haustermans, K. M., Zoldhelyi, P., Gerard, R. D., & Collen, D. (1998) · Circulation · doi:10.1161/01.cir.97.13.1274 · Cited by 239 · see citing works
Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin
Moens, A. L., Takimoto, E., Tocchetti, C. G., Chakir, K., Bedja, D., Cormaci, G., Ketner, E., Majmudar, M. D., Gabrielson, K., Halushka, M. K., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.737031 · Cited by 235 · see citing works
Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide.
Marks, D. S., Vita, J. A., Folts, J. D., Keaney, J. F., Welch, G. N., & Loscalzo, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118328 · Cited by 230 · see citing works
Efficient Inhibition of Intimal Hyperplasia by Adenovirus-Mediated Inducible Nitric Oxide Synthase Gene Transfer to Rats and Pigs in Vivo
Shears, L. L., Kibbe, M. R., Murdock, A. D., Billiar, T. R., Lizonová, A., Kovesdi, I., Watkins, S. C., & Tzeng, E. (1998) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(98)00163-x · Cited by 227 · see citing works
Nitrite-Derived Nitric Oxide Protects the Rat Kidney against Ischemia/Reperfusion Injury In Vivo: Role for Xanthine Oxidoreductase
Tripatara, P., Patel, N. S. A., Webb, A., Rathod, K., Lecomte, F. M. J., Mazzon, E., Cuzzocrea, S., Yaqoob, M. M., Ahluwalia, A., & Thiemermann, C. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006050450 · Cited by 226 · see citing works
Long-Term Clinical Outcomes With Sirolimus-Eluting Coronary Stents
Morice, M., Serruys, P. W. J. C., Barragan, P. T., Bode, C., van Es, G., Stoll, H., Snead, D., Mauri, L., Cutlip, D. E., & Sousa, E. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.06.029 · Cited by 224 · see citing works
L-Arginine Inhibits Balloon Catheter-Induced Intimal Hyperplasia
McNamara, D. B., Bedi, B., Aurora, H., Tena, L., Ignarro, L. J., Kadowitz, P. J., & Akers, D. L. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1622 · Cited by 218 · see citing works
Nitric Oxide Modulates Expression of Cell Cycle Regulatory Proteins
Tanner, F. C., Meier, P., Greutert, H., Champion, C., Nabel, E. G., & Lüscher, T. F. (2000) · Circulation · doi:10.1161/01.cir.101.16.1982 · Cited by 213 · see citing works
Tetrahydrobiopterin and Cardiovascular Disease
Moens, A. L., & Kass, D. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000243924.00970.cb · Cited by 193 · see citing works
Local Adenovirus-Mediated Transfer of Human Endothelial Nitric Oxide Synthase Reduces Luminal Narrowing After Coronary Angioplasty in Pigs
Varenne, O., Pislaru, S. V., Gillijns, H., Pelt, N. V., Gerard, R. D., Zoldhelyi, P., de Werf, F. V., Collen, D., & Janssens, S. P. (1998) · Circulation · doi:10.1161/01.cir.98.9.919 · Cited by 188 · see citing works
Cardioprotective effects of vegetables: is nitrate the answer?
Lundberg, J. O., Feelisch, M., Björne, H., Jansson, E. Å., & Weitzberg, E. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.01.013 · Cited by 185 · see citing works
The biology of saphenous vein graft occlusion
Bryan, A. J., & Angelini, G. D. (1994) · Current Opinion in Cardiology · doi:10.1097/00001573-199411000-00002 · Cited by 172 · see citing works
The role of inflammation in vascular injury and repair
Davis, C., Fischer, J. E., Ley, K. F., & Sarembock, I. J. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00292.x · Cited by 167 · see citing works
Induction of the Cyclin-dependent Kinase Inhibitor p21 by Nitric Oxide-generating Vasodilator in Vascular Smooth Muscle Cells
Ishida, A., Sasaguri, T., Kosaka, C., Nojima, H., & Ogata, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.10050 · Cited by 162 · see citing works
Nitric oxide and arterial disease
Barbato, J. E., & Tzeng, E. (2004) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.03.043 · Cited by 162 · see citing works
Endothelial Nitric Oxide Synthase
Tai, S. C., Robb, G. B., & Marsden, P. A. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000109171.50229.33 · Cited by 153 · see citing works
Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALBc 3T3 fibroblasts by a cyclic GMP-independent mechanism
Garg, U. C., & Hassid, A. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91417-q · Cited by 149 · see citing works
Regulators of angiogenesis and strategies for their therapeutic manipulation
Milkiewicz, M., Ispanovic, E., Doyle, J. L., & Haas, T. L. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.10.006 · Cited by 149 · see citing works
eNOS Gene Transfer Inhibits Smooth Muscle Cell Migration and MMP-2 and MMP-9 Activity
Gurjar, M. V., Sharma, R. V., & Bhalla, R. C. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.12.2871 · Cited by 147 · see citing works
Cytochrome c oxidase and nitric oxide in action: Molecular mechanisms and pathophysiological implications
Sarti, P., Forte, E., Mastronicola, D., Giuffrè, A., & Arese, M. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.09.002 · Cited by 146 · see citing works
Causes of primary graft failure after in situ saphenous vein bypass grafting
Wengerter, K. R., Donaldson, M. C., & Mannick, J. A. (1992) · Journal of Vascular Surgery · doi:10.1067/mva.1992.32984 · Cited by 141 · see citing works
Nitrite confers protection against myocardial infarction: Role of xanthine oxidoreductase, NADPH oxidase and KATP channels
Baker, J. E., Su, J., Fu, X., Hsu, A., Gross, G. J., Tweddell, J. S., & Hogg, N. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.07.057 · Cited by 137 · see citing works
The comparative pathobiology of atherosclerosis and restenosis
Orford, J. L., Selwyn, A. P., Ganz, P., Popma, J. J., & Rogers, C. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01094-8 · Cited by 135 · see citing works
Nitric oxide and nanotechnology: A novel approach to inhibit neointimal hyperplasia
Kapadia, M. R., Chow, L. W., Tsihlis, N. D., Ahanchi, S. S., Eng, J. W. ‐., Murar, J., Martínez, J., Popowich, D. A., Jiang, Q., Hrabie, J. A., et al. (2008) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.09.005 · Cited by 130 · see citing works
Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite
Li, H., Kundu, T. K., & Zweier, J. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019125 · Cited by 126 · see citing works
Causes of primary graft failure after in situ saphenous vein bypass grafting
Donaldson, M. C., Mannick, J. A., & Whittemore, A. D. (1992) · Journal of Vascular Surgery · doi:10.1016/0741-5214(92)70019-h · Cited by 126 · see citing works
Expression of Inducible Nitric Oxide Synthase Inhibits Platelet Adhesion and Restores Blood Flow in the Injured Artery
Yan, Z.-Q., Yokota, T., Zhang, W., & Hansson, G. K. (1996) · Circulation Research · doi:10.1161/01.res.79.1.38 · Cited by 124 · see citing works
Nitric Oxide-Loaded Echogenic Liposomes for Nitric Oxide Delivery and Inhibition of Intimal Hyperplasia
Huang, S.-L., Kee, P. H., Kim, H., Moody, M. R., Chrzanowski, S. M., MacDonald, R. C., & McPherson, D. D. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.039 · Cited by 120 · see citing works
Morphology of saphenous vein-coronary artery bypass grafts: Seven to 116 months after surgery.
Sh, S., & Geer, J. C. (1983) · PubMed · Cited by 117 · see citing works
Local Intramural Delivery of l -Arginine Enhances Nitric Oxide Generation and Inhibits Lesion Formation After Balloon Angioplasty
Schwarzacher, S. P., Lim, T. T., Wang, B., Kernoff, R. S., Niebauer, J., Cooke, J. P., & Yeung, A. C. (1997) · Circulation · doi:10.1161/01.cir.95.7.1863 · Cited by 113 · see citing works
Chronic Inhalation of Nitric Oxide Inhibits Neointimal Formation After Balloon-Induced Arterial Injury
Lee, J. S., Adrie, C., Jacob, H. J., Roberts, J. D., Zapol, W. M., & Bloch, K. D. (1996) · Circulation Research · doi:10.1161/01.res.78.2.337 · Cited by 113 · see citing works
Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate
Kibbe, M. R., Li, J., Nie, S., Watkins, S. C., Lizonová, A., Kovesdi, I., Simmons, R. L., Billiar, T. R., & Tzeng, E. (2000) · Journal of Vascular Surgery · doi:10.1067/mva.2000.105006 · Cited by 112 · see citing works
Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall
Alzawahra, W. F., Talukder, M. A. H., Liu, X., Samouilov, A., & Zweier, J. L. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00374.2008 · Cited by 111 · see citing works
Effect of the Direct Nitric Oxide Donors Linsidomine and Molsidomine on Angiographic Restenosis After Coronary Balloon Angioplasty
Lablanche, J., Grollier, G., Lusson, J., Bassand, J., Drobinski, G., Bertrand, B., Battaglia, S., Desveaux, B., Juillière, Y., Juliard, J., et al. (1997) · Circulation · doi:10.1161/01.cir.95.1.83 · Cited by 110 · see citing works
The role of nitric oxide in the pathophysiology of intimal hyperplasia
Ahanchi, S. S., Tsihlis, N. D., & Kibbe, M. R. (2007) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.02.027 · Cited by 109 · see citing works
Final 5-Year Results of the TAXUS II Trial
Silber, S., Colombo, A., BANNING, A. P., Hauptmann, K. E., Drzewiecki, J., Grube, E., Dudek, D., & Baim, D. S. (2009) · Circulation · doi:10.1161/circulationaha.109.849877 · Cited by 108 · see citing works
Overexpression of Human Endothelial Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells and in Balloon-Injured Carotid Artery
Chen, L., Daum, G., Forough, R., Clowes, M. M., Walter, U., & Clowes, A. W. (1998) · Circulation Research · doi:10.1161/01.res.82.8.862 · Cited by 104 · see citing works
The effects of exogenous nitric oxide on smooth muscle cell proliferation following porcine carotid angioplasty
Groves, P. H., BANNING, A. P., Penny, W. J., Newby, A. C., Cheadle, H. A., & LEWIS, M. J. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(95)00009-7 · Cited by 103 · see citing works
Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats
Alef, M. J., Vallabhaneni, R., Carchman, E., Morris, S. M., Shiva, S., Wang, Y., Kelley, E. E., Tarpey, M. M., Gladwin, M. T., Tzeng, E., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44079 · Cited by 101 · see citing works
Self-citation
Differential gene expression of extracellular matrix components in dilated cardiomyopathy
Tyagi, S. C., Kumar, S., Voelker, D. J., Reddy, H. K., Janicki, J. S., & Curtis, J. J. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19961101)63:2 · Cited by 100 · see citing works
Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling
Zuckerbraun, B. S., George, M. P., & Gladwin, M. T. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq370 · Cited by 97 · see citing works
Adventitial Gene Transfer of Recombinant Endothelial Nitric Oxide Synthase to Rabbit Carotid Arteries Alters Vascular Reactivity
Kullo, I. J., Mozes, G. I., Schwartz, R. S., Gloviczki, P., Crotty, T. B., Barber, D. A., Katušić, Z. S., & O’Brien, T. (1997) · Circulation · doi:10.1161/01.cir.96.7.2254 · Cited by 93 · see citing works
Characterization of in vivo gene transfer into the arterial wall mediated by the Sendai virus (hemagglutinating virus of Japan) liposomes: an effective tool for the in vivo study of arterial diseases.
Yonemitsu, Y., Kaneda, Y., Morishita, R., Nakagawa, K., Nakashima, Y., & Sueishi, K. (1996) · PubMed · Cited by 92 · see citing works
Untitled work
(2005) · PubMed · Cited by 88 · see citing works
Adenovirus-mediated gene transfer of human inducible nitric oxide synthase in porcine vein grafts inhibits intimal hyperplasia
Kibbe, M. R., Tzeng, E., Gleixner, S. L., Watkins, S. C., Kovesdi, I., Lizonová, A., Makaroun, M. S., Billiar, T. R., & Rhee, R. Y. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.113983 · Cited by 88 · see citing works
Cell cycle effects of nitric oxide on vascular smooth muscle cells
Sarkar, R., Gordon, D., Stanley, J. C., & Webb, R. C. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.272.4.h1810 · Cited by 87 · see citing works
Gene-eluting Stents: Adenovirus-mediated Delivery of eNOS to the Blood Vessel Wall Accelerates Re-endothelialization and Inhibits Restenosis
Sharif, F., Hynes, S. O., Cooney, R., Howard, L., McMahon, J. M., Daly, K. M., Crowley, J. J., Barry, F., & O’Brien, T. (2008) · Molecular Therapy · doi:10.1038/mt.2008.165 · Cited by 86 · see citing works
Endovascular Management as First Therapy for Chronic Total Occlusion of the Lower Extremity Arteries: Comparison of Balloon Angioplasty, Stenting, and Directional Atherectomy
Gallagher, K. A., Meltzer, A. J., Ravin, R. A., Graham, A. R., Shrikhande, G., Connolly, P. H., Aiello, F., Dayal, R., & McKinsey, J. F. (2011) · Journal of Endovascular Therapy · doi:10.1583/11-3539.1 · Cited by 85 · see citing works
Human xanthine oxidase converts nitrite ions into nitric oxide (NO)
Zhang, Z., Naughton, D. P., Blake, D. R., Benjamin, N., Stevens, C. R., Winyard, P. G., Symons, M. C. R., & Harrison, R. (1997) · Biochemical Society Transactions · doi:10.1042/bst025524s · Cited by 85 · see citing works
Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice
Claudio Napoli, A., Cirino, G., Soldato, P. D., Sorrentino, R., Sica, V., Condorelli, M., Pinto, A., & Ignarro, L. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041602898 · Cited by 84 · see citing works
Mechanisms of vascular preservation by a novel NO donor following rat carotid artery intimal injury
Guo, J. P., Panday, M., Consigny, P. M., & Lefer, A. M. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.3.h1122 · Cited by 83 · see citing works
Low-dose intravenous nitrite improves hemodynamics in a canine model of acute pulmonary thromboembolism
Dias-Junior, C. A. C., Gladwin, M. T., & Tanus-Santos, J. E. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.08.022 · Cited by 82 · see citing works
An overview of the vascular response to injury: a tribute to the late Russell Ross
Newby, A. C. (2000) · Toxicology Letters · doi:10.1016/s0378-4274(99)00212-x · Cited by 80 · see citing works
Nitric Oxide Modulates Basal and Endothelin-induced Coronary Artery Vascular Smooth Muscle Cell Proliferation and Collagen Levels
Rizvi, M. A., & Myers, P. R. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0480 · Cited by 78 · see citing works
L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous?
Böger, R. H. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f2b0c3 · Cited by 77 · see citing works
Nitrite reduction by xanthine oxidase family enzymes: a new class of nitrite reductases
Maia, L. B., & Moura, J. J. G. (2011) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-010-0741-z · Cited by 75 · see citing works
Beneficial effect of a short-acting NO donor for the prevention of neointimal hyperplasia
Pearce, C. G., Najjar, S. F., Kapadia, M. R., Murar, J., Eng, J. W. ‐., Lyle, B., Aalami, O., Jiang, Q., Hrabie, J. A., Saavedra, J. E., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.09.010 · Cited by 75 · see citing works
Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis
Claudio Napoli, A., Aldini, G., Wallace, J. L., de Nigris, F., Maffei, R., Abete, P., Bonaduce, D., Condorelli, G., Rengo, F., Sica, V., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022639399 · Cited by 75 · see citing works
Local Delivery of Gene Vectors From Bare-Metal Stents by Use of a Biodegradable Synthetic Complex Inhibits In-Stent Restenosis in Rat Carotid Arteries
Fishbein, I., Alferiev, I. S., Bakay, M. A., Stachelek, S. J., Sobolewski, P., Lai, M., Choi, H., Chen, I., & Levy, R. J. (2008) · Circulation · doi:10.1161/circulationaha.107.746412 · Cited by 72 · see citing works
Polymeric-based perivascular delivery of a nitric oxide donor inhibits intimal thickening after balloon denudation arterial injury: role of nuclear factor-kappaB11This work was supported by a grant from the Henry W. Wheeler Research Fund.
Kaul, S., Cercek, B., Rengstrom, J., Xu, X.-P., Molloy, M. D., Dimayuga, P. C., Parikh, A. K., Fishbein, M. C., Nilsson, J. Å., Rajavashisth, T. B., et al. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00543-4 · Cited by 71 · see citing works
Perivascular Delivery Of A Nitric Oxide Donor Inhibits Neointimal Hyperplasia In Vein Grafts Implanted In The Arterial Circulation
Chaux, A., Ruan, X. M., Fishbein, M. C., Ouyang, Y., Kaul, S., Pass, J. A., & Matloff, J. M. (1998) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70325-3 · Cited by 71 · see citing works
Hemagglutinating virus of Japan-liposome–mediated gene transfer of endothelial cell nitric oxide synthase inhibits intimal hyperplasia of canine vein grafts under conditions of poor runoff
Matsumoto, T., Komori, K., Yonemitsu, Y., Morishita, R., Sueishi, K., Kaneda, Y., & Sugimachi, K. (1998) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(98)70300-3 · Cited by 70 · see citing works
Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury
Cooney, R., Hynes, S. O., Sharif, F., Howard, L., & O’Brien, T. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302882 · Cited by 69 · see citing works
Long-Term Safety and Efficacy of Paclitaxel-Eluting Stents
Stone, G. W., Ellis, S. G., Colombo, A., Grube, E., Popma, J. J., Uchida, T., Bleuit, J. S., Dawkins, K. D., & Russell, M. E. (2011) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2011.03.005 · Cited by 67 · see citing works
Xanthine Oxidase Catalyzes Anaerobic Transformation of Organic Nitrates to Nitric Oxide and Nitrosothiols
Li, H., Cui, H., Liu, X., & Zweier, J. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411905200 · Cited by 64 · see citing works
The biological significance of nitric oxide formation from l -arginine
Moncada, S., Palmer, R. M. J., & Higgs, E. A. (1989) · Biochemical Society Transactions · doi:10.1042/bst0170642 · Cited by 62 · see citing works
Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis
Minneci, P. C., Deans, K. J., Shiva, S., Zhi, H., Banks, S. M., Kern, S. J., Natanson, C., Solomon, S. B., & Gladwin, M. T. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00151.2008 · Cited by 60 · see citing works
Gene transfer of endothelial NO synthase, but not eNOS, plus inducible NOS regressed atherosclerosis in rabbits
Hayashi, T. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.09.027 · Cited by 59 · see citing works
Hypothesis: the effect of oral nitrite on blood pressure in the spontaneously hypertensive rat. Does dietary nitrate mitigate hypertension after conversion to nitrite?
Classen, H. G., Stein-Hammer, C., & Thöni, H. (1990) · Journal of the American College of Nutrition · doi:10.1080/07315724.1990.10720407 · Cited by 59 · see citing works
Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries
Peyton, K. J., Ensenat, D., Azam, M. A., Keswani, A. N., Kannan, S., Liu, X.-M., Wang, H., Tulis, D. A., & Durante, W. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.183392 · Cited by 59 · see citing works
Reduction of Organic Nitrites to Nitric Oxide Catalyzed by Xanthine Oxidase: Possible Role in Metabolism of Nitrovasodilators
Doel, J. J., GODBER, B. L. J., GOULT, T. A., Eisenthal, R., & Harrison, R. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2534 · Cited by 51 · see citing works
Endothelium-dependent vasorelaxations in response to aggregating platelets are impaired in reversed vein grafts
Komori, K., Gloviczki, P., Bourchier, R. G., Miller, V. M., & Vanhoutte, P. M. (1990) · Journal of Vascular Surgery · doi:10.1016/0741-5214(90)90102-g · Cited by 49 · see citing works
Hemorrhage and thrombosis as early complications of femoropopliteal bypass grafts: causes, treatment, and prognostic implications.
Jm, C., Ottinger, L. W., Rc, D., Wg, A., & Rr, L. (1973) · PubMed · Cited by 47 · see citing works
L -arginine polymers inhibit the development of vein graft neointimal hyperplasia
Kown, M. H., Yamaguchi, A., Jahncke, C. L., Miniati, D., Murata, S., Grünenfelder, J., Koransky, M. L., Rothbard, J. B., & Robbins, R. C. (2001) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2001.112532 · Cited by 44 · see citing works
Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented model
Wang, K., Kessler, P., Zhou, Z., Penn, M. S., Forudi, F., Zhou, X., Tarakji, K. G., Kibbe, M. R., Kovesdi, I., Brough, D. E., et al. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00061-3 · Cited by 43 · see citing works
Intraluminal gene transfer of endothelial cell-nitric oxide synthase suppresses intimal hyperplasia of vein grafts in cholesterol-fed rabbit: A limited biological effect as a result of the loss of medial smooth muscle cells
Ohta, S., Komori, K., Yonemitsu, Y., Onohara, T., Matsumoto, T., & Sugimachi, K. (2002) · Surgery · doi:10.1067/msy.2002.124878 · Cited by 42 · see citing works
Nitric oxide synthase gene therapy: progress and prospects
O’Connor, D. M. A., & O’Brien, T. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903002047 · Cited by 42 · see citing works
The mediterranean diet: Rationale and evidence for its benefit
de Lorgeril, M., & Salen, P. (2008) · Current Atherosclerosis Reports · doi:10.1007/s11883-008-0080-5 · Cited by 41 · see citing works
?-Arginine inhibits smooth muscle cell proliferation of vein graft intimal thickness in hypercholesterolemic rabbits
Okazaki, J. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00188-0 · Cited by 39 · see citing works
Mechanisms of Vasodilatation Induced by Nitrite Instillation in Intestinal Lumen: Possible Role of Hemoglobin
Kozlov, A. V., Costantino, G., Sobhian, B., Szalay, L., Umar, F., Nohl, H., Bahrami, S., & Redl, H. R. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.515 · Cited by 39 · see citing works
In-Stent Restenosis Limitation with Stent-based Controlled-Release Nitric Oxide: Initial Results in Rabbits
Do, Y. S., Kao, E. Y., Ganaha, F., Minamiguchi, H., Sugimoto, K., Lee, J., Elkins, C. J., Amabile, P. G., Kuo, M., Wang, D. S., et al. (2004) · Radiology · doi:10.1148/radiol.2302020417 · Cited by 36 · see citing works
Effects of dietary sodium on reactive oxygen species formation and endothelial dysfunction in low-density lipoprotein receptor-deficient mice on high-fat diet
Ketonen, J., & Mervaala, E. M. A. (2008) · Heart and Vessels · doi:10.1007/s00380-008-1066-5 · Cited by 36 · see citing works
The impairment of endothelium-dependent relaxations in reversed vein grafts is associated with a reduced production of cyclic guanosine monophosphate
Komori, K., Schini‐Kerth, V. B., Gloviczki, P., Bourchier, R. G., & Vanhoutte, P. M. (1991) · Journal of Vascular Surgery · doi:10.1016/0741-5214(91)90156-o · Cited by 35 · see citing works
Local effects of nitric oxide supplementation and suppression in the development of intimal hyperplasia in experimental vein grafts
Fulton, G. J., Davies, M. G., Barber, L., Gray, J. L., SVENDSEN, E. K., & Hagen, P. O. (1998) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/s1078-5884(98)80030-0 · Cited by 35 · see citing works
Intimal hyperplasia of experimental autologous vein graft in hyperlipidemic rabbits with poor distal run-off
Itoh, H., Komori, K., FUNAHASHI, S., Okadome, K., & Sugimachi, K. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90210-0 · Cited by 34 · see citing works
Nitric Oxide–Eluting Polyurethanes — Vascular Grafts of the Future?
Verma, S., & Marsden, P. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmcibr052030 · Cited by 31 · see citing works
Malfunction of Vascular Control in Lifestyle-Related Diseases: Formation of Systemic Hemoglobin-Nitric Oxide Complex (HbNO) From Dietary Nitrite
Tsuchiya, K., Takiguchi, Y., Okamoto, M., Izawa, Y., Kanematsu, Y., Yoshizumi, M., & Tamaki, T. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fmj04006x3 · Cited by 29 · see citing works
Adenoviral-Mediated Gene Transfer of Nitric Oxide Synthase Isoforms and Vascular Cell Proliferation
Cooney, R., Hynes, S. O., Duffy, A. M., Sharif, F., & O’Brien, T. (2006) · Journal of Vascular Research · doi:10.1159/000095163 · Cited by 29 · see citing works
Oral Administration ofl-Arginine Reduces Intimal Hyperplasia in Balloon-Injured Rat Carotid Arteries
Chen, C., Mattar, S. G., & Lumsden, A. B. (1999) · Journal of Surgical Research · doi:10.1006/jsre.1998.5476 · Cited by 29 · see citing works
Profiling of Aortic Smooth Muscle Cell Gene Expression in Response to Chronic Inhibition of Nitric Oxide Synthase in Rats
Dupuis, M., Soubrier, F., Brochériou, I., Raoux, S., Haloui, M., Louedec, L., Michel, J., & Nadaud, S. (2004) · Circulation · doi:10.1161/01.cir.0000138850.72900.fe · Cited by 28 · see citing works
Effects of Slow, Sustained, and Rate‐Tunable Nitric Oxide Donors on Human Aortic Smooth Muscle Cells Proliferation
Yu, H., Payne, T. J., & Mohanty, D. K. (2011) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2011.01174.x · Cited by 27 · see citing works
Exogenous nitric oxide causes overexpression of TGF-β1 and overproduction of extracellular matrix in human coronary smooth muscle cells
Schmidt, A. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00322-5 · Cited by 26 · see citing works
Insights into the effect of nitric oxide and its metabolites nitrite and nitrate at inhibiting neointimal hyperplasia
Vavra, A. K., Havelka, G. E., Martinez, J., Lee, V. R., Fu, B., Jiang, Q., Keefer, L. K., & Kibbe, M. R. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.04.013 · Cited by 24 · see citing works
Functional effects of nitric oxide-releasing aspirin on vein conduits of diabetic patients undergoing CABG
Lorusso, R., Cicco, G. D., Beghi, C., Gherli, T., Poli, E., Corradi, D., Maestri, R., Bonadonna, S., Mancini, T., & Giustina, A. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.07.014 · Cited by 23 · see citing works
Endovascular Treatment of Persistent Epistaxis due to Pseudoaneurysm Formation of the Ophthalmic Artery Secondary to Nasogastric Tube
Selçuk, H., Soylu, N., Albayram, S., Selçuk, D., Özer, H., Koçer, N., & Işlak, C. (2004) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-004-0206-2 · Cited by 22 · see citing works
Adenovirus-Mediated Gene Transfer of Macrophage Colony Stimulating Factor to the Arterial Wall In Vivo
Mozes, G. I., Mohácsi, T., Gloviczki, P., Menawat, S. S., Kullo, I., Spector, D. J., Taylor, J. M., Crotty, T. B., & O’Brien, T. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.7.1157 · Cited by 22 · see citing works
Drug-eluting stents and balloons in peripheral arterial disease: evidence so far
Chan, Y. C., & Cheng, S. (2011) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2011.02639.x · Cited by 20 · see citing works
Efficacy of Local Molsidomine Delivery from a Hydrogel-Coated Angioplasty Balloon Catheter in the Atherosclerotic Porcine Model
Rolland, P. H., Mekkaoui, C., Palassi, M., Friggi, A., Moulin, G., Piquet, P., & Bartoli, J. (2003) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-002-1940-y · Cited by 18 · see citing works
Local Infusion of the Nitric oxide Donor Sin-1 After Angioplasty . Effects on intimal hyperplasia in porcine coronary arteries
Harnek, J., Zoucas, E., Sjuve, R., Arner, P., Ekblad, E., Schou, H., de Sa, V. P., & Stenram, U. (2003) · Acta Radiologica · doi:10.1034/j.1600-0455.2003.00079.x · Cited by 17 · see citing works
Evolution of atherectomy devices.
Khoury, G. A., & Chaer, R. A. (2011) · PubMed · Cited by 14 · see citing works
Nitric oxide-releasing aspirin: Will it say NO to atherothrombosis?
Antoniades, C. A., Tousoulis, D., & Stefanadis, C. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.08.002 · Cited by 13 · see citing works
Drug-Eluting Introducer Sheath Prevents Local Peripheral Complications
Hemetsberger, R., Pósa, A., Farhan, S., Hemetsberger, H., Redwan, B., Pávó, N., Pavo, I. J., Plass, C. A., Petneházy, Ö., Petrási, Z., et al. (2011) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2010.09.018 · Cited by 11 · see citing works
Cryoplasty of the Venous Anastomosis for Prevention of Intimal Hyperplasia in a Validated Porcine Arteriovenous Graft Model
Huijbregts, H. J. T. A. M., de Borst, G. J., Veldhuis, W. B., Verhagen, H. J. M., Velema, E., Pasterkamp, G., Moll, F. L., Blankestijn, P. J., & Hoefer, I. E. (2010) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2009.12.030 · Cited by 11 · see citing works
Intimal Hyperplasia in Balloon Dilated Coronary Arteries is Reduced by Local Delivery of the NO Donor, SIN-1 Via a cGMP-Dependent Pathway
Harnek, J., Zoucas, E., Perez‐de‐Sá, V., Ekblad, E., Arner, A., & Stenram, U. (2011) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-11-30 · Cited by 9 · see citing works
The Nitric Oxide Precursorl-Arginine Reduces Expression of Hyaluronan Synthase in Experimental Vein Bypass Grafts
Dattilo, J. B., Dattilo, M. P. M., Crane, J. T., Yager, D. R., & Makhoul, R. G. (1998) · Journal of Surgical Research · doi:10.1006/jsre.1997.5224 · Cited by 6 · see citing works
Photodynamic Therapy Reduces Intimal Hyperplasia in Prosthetic Vascular Bypass Grafts in a Pig Model
Heckenkamp, J., Mellander, S., Fogelstrand, P., Breuer, S., Brunkwall, J. S., & Mattsson, E. J. R. (2007) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2007.04.002 · Cited by 6 · see citing works
Adjunct brachytherapy: a new concept to prevent intimal hyperplasia after surgical endarterectomy?
Beller, C. J., Kosse, J., Radovits, T., Krempien, R. C., GROSS, M., Berger, I., Hagl, S., & Szabo, G. B. (2006) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2005.12.019 · Cited by 5 · see citing works
Letter by Teerlink Regarding Article, “L-Arginine Supplementation in Peripheral Arterial Disease: No Benefit and Possible Harm”
Teerlink, T. (2008) · Circulation · doi:10.1161/circulationaha.107.729830 · Cited by 4 · see citing works

Flagged first, then by citations

1 of the 167 references couldn’t be matched to a known paper.

Sorted by citations

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
Adaptation of Endothelial Cells to Physiologically-Modeled, Variable Shear Stress
Uzarski, J. S., Scott, E. W., & McFetridge, P. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057004 · Cited by 72 · see citing works
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works
Nitric oxide improves regeneration and prevents calcification in bio-hybrid vascular grafts via regulation of vascular stem/progenitor cells
Wang, F., Qin, K., Wang, K., Wang, H., Liu, Q., Qian, M., Chen, S., Sun, Y., Hou, J., Wei, Y., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110981 · Cited by 51 · see citing works
Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction
Madigan, M. C., & Zuckerbraun, B. S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00174 · Cited by 51 · see citing works
Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular Injection
Chan, A., Jiang, J., Fridman, A., Guo, L. T., Shelton, G. D., Liu, M., Green, C., Haushalter, K. J., Patel, H. H., Lee, J., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501565k · Cited by 43 · see citing works
Nitric oxide metabolism is impaired by type 1 diabetes and diabetic nephropathy
Sokolovska, J., Dekante, A., Baumane, L., Pahirko, L., Valeinis, J., Dišlere, K., Rovīte, V., Pīrāgs, V., & Sjakste, N. (2020) · Biomedical Reports · doi:10.3892/br.2020.1288 · Cited by 29 · see citing works
S-Nitrosothiols—NO donors regulating cardiovascular cell proliferation: Insight into intracellular pathway alterations
Rychter, M., Gaucher, C., Boudier, A., Leroy, P., & Lulek, J. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.003 · Cited by 21 · see citing works
Effects of inhalation of low-dose nitrite or carbon monoxide on post-reperfusion mitochondrial function and tissue injury in hemorrhagic shock swine
Haugaa, H., Gómez, H., Maberry, D. R., Holder, A. L., Ogundele, O., Quintero, A. M. B., Escobar, D. A., Tønnessen, T. I., Airgood, H., Dezfulian, C., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0903-z · Cited by 19 · see citing works
Cardiac catheterization: consequences for the endothelium and potential for nanomedicine
Sobolewski, P., & Fray, M. E. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1316 · Cited by 18 · see citing works
Nanofiber-Coated Drug Eluting Stent for the Stabilization of Mast Cells
Oh, B., & Lee, C. H. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1341-3 · Cited by 18 · see citing works
Ultrathin Metal Films with Defined Topographical Structures as In Vitro Cell Culture Platforms for Unveiling Vascular Cell Behaviors
Jun, I., Chung, Y., Park, J., Han, H., Park, J., Kim, S., Lee, H., Kim, S. H., Han, J. H., Kim, H., et al. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600333 · Cited by 14 · see citing works
Phenotypic switching prevention and proliferation/migration inhibition of vascular smooth muscle cells by the ruthenium nitrosyl complex trans -[Ru(NO)Cl(cyclam](PF6)2
de Oliveira, M. G., Doro, F. G., Tfouni, E., & Krieger, M. H. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12755 · Cited by 10 · see citing works
Nitrite and Nitrate: From Bench to Bedside
Kevil, C. G., & Lefer, D. J. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.04.165 · Cited by 9 · see citing works
Cerebral atherosclerosis: a biomarker profile
Tanashyan, M. M., Лагода, О. В., Евдокименко, А. Н., Шабалина, А. А., & Раскуражев, А. А. (2018) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20181185123 · Cited by 4 · see citing works
UNIVERSIDADE FEDERAL DO CEARÁ DEPARTAMENTO DE CIRURGIA PROGRAMA DE PÓS-GRADUAÇÃO STRICTO SENSU EM CIÊNCIAS MÉDICO- CIRÚRGICAS
Lima, J. J. D. (2015)
Caracterização do perfil dos componentes do sistema das cininas, óxido nítrico e metaloproteinases como marcadores na reestenose precoce de stents revestidos pós angioplastia transluminal percutânea periférica
da Rocha, L. D. A. (2017) · doi:10.11606/t.17.2017.tde-20072016-115252
Estudo da perviedade e do perfil sérico de marcadores inflamatórios com uso de stents impregnados de carbono no território vascular periférico
Campos, C. P. (2018) · doi:10.11606/t.17.2018.tde-25072018-103058
Ascorbate elastomer-coated ePTFE grafts inhibit neointimal hyperplasia and enhance vascular healing
Yu, L., Newton, E. R., Gillis, D. C., Cooley, B. C., Sun, K., Dandurand, B. R., Siletzky, R. M., Tsihlis, N. D., & Kibbe, M. R. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.10.014
Photolibération de monoxyde d'azote dans des complexes de ruthénium nitrosyle à ligands polypyridines fonctionnalisés par des groupes fluorène ou méthoxyphényle
Roose, M. (2018) · doi:10.70675/edc9f7c2za246z4bc9z8f4dz1c8bd24b0dee

Nitrite-Generated Nitric Oxide to Protect Against Intimal Hyperplasia Formation
Ataya, B., Tzeng, E., & Zuckerbraun, B. S. (2011) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.05.002 · Cited by 17 · see citing works
The role of nitric oxide in the pathophysiology of intimal hyperplasia
Ahanchi, S. S., Tsihlis, N. D., & Kibbe, M. R. (2007) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.02.027 · Cited by 109 · see citing works
Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats
Alef, M. J., Vallabhaneni, R., Carchman, E., Morris, S. M., Shiva, S., Wang, Y., Kelley, E. E., Tarpey, M. M., Gladwin, M. T., Tzeng, E., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44079 · Cited by 101 · see citing works
Sodium Nitrite Reverses Vascular Intimal Hyperplasia Via An Autophagic Mechanism
Alef, M. J., Carchman, E. H., Tzeng, E., & Zuckerbraun, B. S. (2011) · Journal of Surgical Research · doi:10.1016/j.jss.2010.11.479
Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction
Madigan, M. C., & Zuckerbraun, B. S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00174 · Cited by 51 · see citing works

Authors: Alef, M. J., Tzeng, E., & Zuckerbraun, B. S.
Affiliations: University of Pittsburgh (US)
Corresponding author: Zuckerbraun, Brian S.
ORCID: Tzeng, Edith
Zuckerbraun, Brian S.
Venue: Nitric Oxide
Publisher: Elsevier BV
Published: 2012-05
Volume: 26
Issue: 4
Pages: 285-294
ISSN: 1089-8603 (ISSN-L)
DOI: 10.1016/j.niox.2012.03.014
OpenAlex: W2026972928
Cited by: 20
References: 167
Citations by year: 2025: 1 · 2022: 1 · 2020: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 1
FWCI: 0.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nitric Oxide (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs (I01 BX000635)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: intimal hyperplasia, nitrite, nitrate, no-signaling, atherosclerosis, vascular protection, therapeutic target
MeSH terms: Animals, Humans, Hyperplasia, Nitrates, Nitric Oxide, Nitrites, Vascular Diseases, Xanthine Dehydrogenase, Signal Transduction, Tunica Intima

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nitric oxide and nitrite-based therapeutic opportunities in intimal hyperplasia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks