The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Label-free probing of the binding state of DNA by time-domain terahertz sensing
Abstract
We present a promising approach for the label-free characterization of genetic material. Time-resolved terahertz (THz) transmission analysis of polynucleotides demonstrate a strong dependence of the complex refractive index on the binding state (hybridized/denatured) of deoxyribonucleic acid (DNA) molecules. By monitoring THz transients, one can thus infer the binding state of oligo- and polynucleotides, and hence identify polynucleotides by detecting the binding of unknown polynucleotide DNA sequences to known probe molecules. A broadband experimental demonstration in a free-space configuration, as well as a discussion of the potential application for next generation gene chips is presented.
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Cites
A reliable method for extraction of material parameters in terahertz time-domain spectroscopy
Duvillaret, L., Garet, F., & Coutaz, J.-L. (1996) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/2944.571775 · Cited by 994
Subpicosecond photoconducting dipole antennas
Smith, P. R., Auston, D. H., & Nuss, M. C. (1988) · IEEE Journal of Quantum Electronics · doi:10.1109/3.121 · Cited by 805
Characterization of an optoelectronic terahertz beam system
van Exter, M., & Grischkowsky, D. R. (1990) · IEEE Transactions on Microwave Theory and Techniques · doi:10.1109/22.60016 · Cited by 486
Cited by
Imaging with terahertz radiation
Chan, W. L., Deibel, J., & Mittleman, D. M. (2007) · Reports on Progress in Physics · doi:10.1088/0034-4885/70/8/r02 · Cited by 965
Integrated THz technology for label-free genetic diagnostics
Nagel, M., Haring Bolivar, P., Brucherseifer, M., Kurz, H., Bosserhoff, A., & Büttner, R. (2002) · Applied Physics Letters · doi:10.1063/1.1428619 · Cited by 543
Self-citationThin-film sensing with planar terahertz metamaterials: sensitivity and limitations
O'Hara, J. F., Singh, R., Brener, I., Smirnova, E., Han, J., Taylor, A. J., & Zhang, W. (2008) · Optics Express · doi:10.1364/oe.16.001786 · Cited by 521
Terahertz Pulsed Imaging of Human Breast Tumors
Fitzgerald, A. J., Wallace, V. P., Jimenez-Linan, M., Bobrow, L., Pye, R. J., Purushotham, A. D., & Arnone, D. D. (2006) · Radiology · doi:10.1148/radiol.2392041315 · Cited by 396
THz time domain spectroscopy of biomolecular conformational modes
Markelz, A., Whitmire, S., Hillebrecht, J., & Birge, R. (2002) · Physics in Medicine and Biology · doi:10.1088/0031-9155/47/21/318 · Cited by 309
Metadata
- Authors
- Brucherseifer, M., Nagel, M., Haring Bolivar, P., Kurz, H., Bosserhoff, A., & Büttner, R.
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2000-12-11
- Volume
- 77
- Issue
- 24
- Pages
- 4049-4051
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- OpenAlex
- W2062801086
- Cited by
- 416
- References
- 3
- FWCI
- 18.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brucherseifer, M., Nagel, M., Haring Bolivar, P., Kurz, H., Bosserhoff, A., & Büttner, R. (2000). Label-free probing of the binding state of DNA by time-domain terahertz sensing. Applied Physics Letters. https://doi.org/10.1063/1.1332415
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