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Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates
Open accessAbstract
In vivo transcranial and noninvasive cavitation detection with blood-brain barrier (BBB) opening in nonhuman primates is hereby reported. The BBB in monkeys was opened transcranically using focused ultrasound (FUS) in conjunction with microbubbles. A passive cavitation detector, confocal with the FUS transducer, was used to identify and monitor the bubble behavior. During sonication, the cavitation spectrum, which was found to be region-, pressure-, and bubble-dependent, provided real-time feedback regarding the opening occurrence and its properties. These findings demonstrate feasibility of transcranial, cavitation-guided BBB opening using FUS and microbubbles in noninvasive human applications.
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“A more localized transient disruption of BBB is accomplished by using magnetic resonance imaging-guided focused ultrasound in combination with IV infusion of microbubbles (FUS-MB) (Fig. 4b), which induce temporary BBB opening even in NHPs [134–137].”
From Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedside (2024) · cites this paper as [134]
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Citations
Cites
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits
Hynynen, K., McDannold, N. J., Vykhodtseva, N. I., & Jolesz, F. A. (2001) · Radiology · doi:10.1148/radiol.2202001804 · Cited by 1,463
Microbubble size isolation by differential centrifugation
Feshitan, J. A., Chen, C., Kwan, J. J., & Borden, M. A. (2008) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2008.09.066 · Cited by 447
Mechanisms of contrast agent destruction
Chomas, J. E., Dayton, P. A., Allen, J. S., Morgan, K. E., & Ferrara, K. W. (2001) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/58.896136 · Cited by 362
Microbubble-Size Dependence of Focused Ultrasound-Induced Blood–Brain Barrier Opening in MiceIn Vivo
Choi, J. J., Feshitan, J. A., Baseri, B., Wang, S., Tung, Y., Borden, M. A., & Konofagou, E. E. (2009) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2009.2034533 · Cited by 258
Self-citationTung, Y., Vlachos, F., Choi, J. J., Deffieux, T., Selert, K., & Konofagou, E. E. (2010) · Physics in Medicine and Biology · doi:10.1088/0031-9155/55/20/007 · Cited by 246
Self-citationTung, Y., Vlachos, F., Feshitan, J. A., Borden, M. A., & Konofagou, E. E. (2011) · The Journal of the Acoustical Society of America · doi:10.1121/1.3646905 · Cited by 195
Self-citationHynynen, K., McDannold, N., Martin, H., Jolesz, F. A., & Vykhodtseva, N. (2003) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(02)00741-x · Cited by 144
Choi, J. J., Pernot, M., Brown, T. R., Small, S. A., & Konofagou, E. E. (2007) · Physics in Medicine and Biology · doi:10.1088/0031-9155/52/18/004 · Cited by 141
Self-citationLiu, H.-L., Wai, Y., Chen, W.-S., Chen, J.-C., Hsu, P.-H., Wu, X.-Y., Huang, W.-C., Yen, T., & Wang, J.-J. (2008) · Ultrasound in Medicine and Biology · doi:10.1016/j.ultrasmedbio.2008.01.011 · Cited by 139
Deffieux, T., & Konofagou, E. E. (2010) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2010.1738 · Cited by 126
Self-citationXie, F., Boska, M. D., Lof, J., Uberti, M. G., Tsutsui, J. M., & Porter, T. R. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2008.05.004 · Cited by 90
Tung, Y., Choi, J. J., Baseri, B., & Konofagou, E. E. (2010) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2010.02.009 · Cited by 89
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- Noninvasive microbubble enhanced FUS BBB opening in vivo feasibility in nonhuman primates
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Sorted by citations
McDannold, N. J., Arvanitis, C., Vykhodtseva, N. I., & Livingstone, M. S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0128 · Cited by 600
Aryal, M., Arvanitis, C., Alexander, P. M., & McDannold, N. J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.01.008 · Cited by 461
Non-invasive transcranial ultrasound stimulation for neuromodulation
Darmani, G., Bergmann, T. O., Pauly, K. B., Caskey, C. F., de Lecea, L., Fomenko, A., Fouragnan, E. F., Legon, W., Murphy, K. R., Nandi, T., et al. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.12.010 · Cited by 335
Chen, H., & Konofagou, E. E. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.71 · Cited by 265
Self-citationDowns, M. E., Buch, A., Sierra, C., Karakatsani, M. E., Chen, S., Konofagou, E. E., & Ferrera, V. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125911 · Cited by 218
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Metadata
- Authors
- Tung, Y.-S., Marquet, F., Teichert, T., Ferrera, V., & Konofagou, E. E.
- Affiliations
- Columbia University (US)
- Columbia University Irving Medical Center (US)
- Venue
- Applied Physics Letters
- Publisher
- AIP Publishing
- Published
- 2011-04-18
- Volume
- 98
- Issue
- 16
- Pages
- 163704-163704
- ISSN
- 0003-6951 (ISSN-L)
- 1077-3118
- PMC
- PMC3094460
- OpenAlex
- W2094621092
- Cited by
- 119
- References
- 13
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 13 · 2015: 14 · 2014: 10 · 2013: 8 · 2012: 10
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Applied Physics Letters (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Science Foundation (0644713, MH059244)
- National Institutes of Health (NIHR01EB009041)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Physics and Astronomy › Acoustics and Ultrasonics › Ultrasound and Cavitation Phenomena
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- blood-brain barrier opening, focused ultrasound, microbubbles, cavitation detection, transcranial ultrasound, non-human primates, monkeys, passive cavitation detection, real-time feedback
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