The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
The diverse potential effector and immunoregulatory roles of mast cells in allergic disease
Open accessAbstract
Mast cells are of hematopoietic origin but typically complete their maturation in peripheral connective tissues, especially those near epithelial surfaces. Mast cells express receptors that bind IgE antibodies with high affinity (FcepsilonRI), and aggregation of these FcepsilonRI by the reaction of cell-bound IgE with specific antigens induces mast cells to secrete a broad spectrum of biologically active preformed or lipid mediators, as well as many cytokines. Mast cells are widely thought to be essential for the expression of acute allergic reactions, but the importance of mast cells in late-phase reactions and chronic allergic inflammation has remained controversial. Although it is clear that many cell types may be involved in the expression of late-phase reactions and chronic allergic inflammation, studies in genetically mast cell-deficient and congenic normal mice indicate that mast cells may be critical for the full expression of certain features of late-phase reactions and may also contribute importantly to clinically relevant aspects of chronic allergic inflammation. Moreover, the pattern of cytokines that can be produced by mast cell populations, and the enhancement of such cytokine production in mast cells that have undergone IgE-dependent up-regulation of their surface expression of FcepsilonRI, suggests that mast cells may contribute to allergic diseases (and host defense) by acting as immunoregulatory cells, as well as by providing effector cell function.
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Cited by
MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M., & Tsai, M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141025 · Cited by 1,017
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A critical role of IL-33 in experimental allergic rhinitis
Haenuki, Y., Matsushita, K., Futatsugi-Yumikura, S., Ishii, K. J., Kawagoe, T., Imoto, Y., Fujieda, S., Yasuda, M., Hisa, Y., Akira, S., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.02.013 · Cited by 233
Baram, D., Vaday, G. G., Salamon, P., Drucker, I., Hershkoviz, R., & Mekori, Y. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.4008 · Cited by 233
Intestinal Mast Cell Progenitors Require CD49dβ7 (α4β7 Integrin) for Tissue-specific Homing
Gurish, M. F., Tao, H., Abonia, J. P., Arya, A., Friend, D. S., Parker, C. M., & Austen, K. F. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1243 · Cited by 193
Metadata
- Authors
- Williams, C. M. M., & Galli, S. J.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 105
- Issue
- 5
- Pages
- 847-859
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2100516030
- Cited by
- 355
- References
- 147
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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