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Cited by 480Pharmaceutical Practices and Patient OutcomesPharmacovigilance and Adverse Drug ReactionsEmergency and Acute Care Studies

The DOI matches its Crossref record; 19 of the 22 references it cites were found in a registry or an index.

Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department

Hohl, Corinne Michèle, Dankoff, Jerrald, Colacone, Antoinette, Afilalo, Marc·2001·Annals of Emergency Medicine
DOI 10.1067/mem.2001.119456
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Abstract

Study objectives We sought to document the degree of polypharmacy, the frequency of adverse drug-related events (ADREs) leading to emergency department presentation that were recognized by emergency physicians, and the frequency of potential adverse drug interactions (PADIs) in medication regimens of elderly patients in the ED.Methods We conducted a retrospective chart review on 300 randomly selected ED visits made by patients 65 years of age and older between January 1 and December 31, 1998. ADREs were defined according to a standardized algorithm. PADIs were identified by using the drug interaction database PharmVigilance.Results After excluding 17 patient visits with inadequate documentation, 283 were left for review. Of these, 257 (90.8%) patients were taking 1 or more medications (prescribed or over the counter). The number of medications consumed ranged from 0 to 17 and averaged 4.2 (SD+/-3.1) drugs per patient. ADREs accounted for 10.6% of all ED visits in our patient group. The most frequently implicated classes of medications were nonsteroidal anti-inflammatory drugs, antibiotics, anticoagulants, diuretics, hypoglycemics, beta-blockers, calcium-channel blockers, and chemotherapeutic agents. Thirty-one percent of all patients in our group had at least 1 PADI in their medication list. Among patients who presented because of an ADRE, 50% had at least 1 PADI in their medication list that was unrelated to the ADRE with which they presented.Conclusion ADREs are an important cause of ED presentation in the elderly. PADIs are found in a significant proportion of medication lists. Emergency physicians must be vigilant in monitoring elderly patients for medication-related problems.

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Metadata

Authors
Hohl, C. M., Dankoff, J., Colacone, A., & Afilalo, M.
Affiliations
Jewish General Hospital (CA)
ORCID
Venue
Annals of Emergency Medicine
Publisher
Elsevier BV
Published
2001-12
Volume
38
Issue
6
Pages
666-671
ISSN
0196-0644 (ISSN-L)
DOI
10.1067/mem.2001.119456
OpenAlex
W2034981842
Cited by
477
References
22
Citations by year
2026: 11 · 2025: 15 · 2024: 20 · 2023: 14 · 2022: 20 · 2021: 15 · 2020: 16 · 2019: 22 · 2018: 33 · 2017: 24 · 2016: 21 · 2015: 28 · 2014: 25 · 2013: 29 · 2012: 24
FWCI
4.18
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Annals of Emergency Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Emergency Medicine › Emergency and Acute Care Studies
Keywords
polypharmacy, adverse drug interactions, elderly patients, emergency department visits, drug-related problems, drug safety, nonsteroidal anti-inflammatory drugs, anticoagulants, antibiotics, over-the-counter drugs
MeSH terms
Aged, Aged, 80 and over, Cross-Sectional Studies, Drug Interactions, Drug Therapy, Combination, Emergency Service, Hospital, Female, Hospitals, General, Humans, Male, Quebec, Retrospective Studies

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