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Cited by 314Thyroid Disorders and TreatmentsAtrial Fibrillation Management and OutcomesCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Subclinical hyperthyroidism as a risk factor for atrial fibrillation

Auer, Johann, Scheibner, Peter, Mische, Thomas, Langsteger, Werner, Eber, Otto, Eber, Bernd·2001·American Heart Journal
DOI 10.1067/mhj.2001.119370
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Abstract

Objectives Atrial fibrillation is a well-known manifestation of hyperthyroidism. We studied whether subclinical hyperthyroidism with low serum thyrotropin concentrations and free thyroid hormone concentrations within the normal range in clinically euthyroid persons is a risk factor for subsequent atrial fibrillation.Methods We studied 23,638 persons. The subjects were classified according to their serum thyrotropin concentrations: group 1 comprised those with normal values of serum thyrotropin concentration (>0.4-5.0 mU/L) and free tri-iodothyronine and free thyroxine concentrations were within the normal range (22,300 subjects), group 2 comprised those with both low serum thyrotropin values (</=0.03 mU/L) and elevated free tri-iodothyronine and free thyroxine concentrations (725 subjects), and group 3 comprised those with low values of serum thyrotropin (<0.4 mU/L) and free triiodothyronine and free thyroxine concentrations were within the normal range (613 subjects).Results Atrial fibrillation was present in 513 persons (2.3%) in group 1 with normal values for serum thyrotropin, 100 (13.8%) in group 2 with overt hyperthyroidism, and 78 (12.7%) in group 3 with subclinical hyperthyroidism. The prevalence of atrial fibrillation in patients with low serum thyrotropin concentrations (<0.4 mU/L) was 13.3% compared with 2.3% in patients with normal values for serum thyrotropin (P <.01). The relative risk of atrial fibrillation in subjects with low serum thyrotropin and normal free tri-iodothyronine and free thyroxine concentrations, compared with those with normal concentrations of serum thyrotropin, was 5.2 (95% CI 2.1-8.7, P <.01).Conclusion A low serum thyrotropin concentration is associated with a >5-fold higher likelihood for the presence of atrial fibrillation with no significant difference between subclinical and overt hyperthyroidism.

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Crossref · 10.1067/mhj.2001.119370

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1 of the 50 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Petersen, 1988, Stroke in thyrotoxicosis with atrial fibrillation, Stroke, 119, 15, 10.1161/01.STR.19.1.15 · DOI

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Metadata

Authors
Auer, J., Scheibner, P., Mische, T., Langsteger, W., Eber, O., & Eber, B.
Affiliations
Klinikum Wels-Grieskirchen (AT)
ORCID
Auer, Johann
Venue
American Heart Journal
Publisher
Elsevier BV
Published
2001-11
Volume
142
Issue
5
Pages
838-842
ISSN
0002-8703 (ISSN-L)
DOI
10.1067/mhj.2001.119370
OpenAlex
W2040416944
Cited by
314
References
50
Citations by year
2026: 4 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 8 · 2019: 14 · 2018: 12 · 2017: 11 · 2016: 11 · 2015: 14 · 2014: 12 · 2013: 25 · 2012: 16
FWCI
6.43
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
subclinical hyperthyroidism, atrial fibrillation, serum thyrotropin, free triiodothyronine, free thyroxine, overt hyperthyroidism, risk factors, thyroid function
MeSH terms
Atrial Fibrillation, Humans, Hyperthyroidism, Middle Aged, Risk Factors, Thyrotropin, Thyroxine, Triiodothyronine, Comorbidity

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