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Relationship between psychosocial variables and compliance in patients with heart failure
Open accessAbstract
Objective The purpose of this study was to describe the socio-demographic, psychosocial, and social support variables that predict compliance to treatment regimens in HF patients.Design and setting Semistructured interviews were conducted on 82 patients at an outpatient heart failure clinic to gather data related to compliance behaviors. Five standardized instruments were used to gather data on patients' psychosocial health status and perceived social support.Results The overall compliance rate was 85.13 (10.01%). Higher levels of compliance (> 90%) were noted for follow-up appointments, medications, smoking, and alcohol cessation. Poor compliance was observed with dietary and exercise recommendations (71% and 53%, respectively). In a multivariate model, higher education, higher mental and physical health status and neuroticism independently contributed to 24% of the variance in overall compliance.Conclusion The study supports that HF patients had poor compliance with dietary and exercise regimens. Since following a dietary and exercise regimen has been demonstrated to reduce morbidity in this population, strategies to increase compliance should be rigorously pursued [corrected].
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“Lower levels of pain or good pain control are associated with better medication adherence, improved ability to self‐report symptoms and self‐care implying benefits beyond simply improved QoL. 87 , 88”
From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [88]
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“This is a relatively straightforward property to establish so it is somewhat surprising that more measures did not rate positively for this.”
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Conceptualizing Self-care in Heart Failure
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“Estimates of dietary nonadherence rates range from 43% to 92%.(9,11,14,23,24,26,28) Even patients recently discharged from a hospitalization for an exacerbation of HF demonstrate remarkably high rates of nonadherence to medication taking, following a low-sodium diet, daily weighing, and FIGURE 1.”
BackgroundInfluentialRodríguez‐Artalejo, F., Guallar‐Castillón, P., Herrera, M. C., Otero, C. M., Olcoz‐Chiva, M., Carreño, C., Banegas, J. R., & Pascual, C. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.06.471 · Cited by 175
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“, 1994) and 38% to 71% for diet (Evangelista et al., 2001; Ni et al., 1999).”
BackgroundInfluentialDefining an evidence-based cutpoint for medication adherence in heart failure
Wu, J. R., Moser, D. K., Jong, M. J. D., Rayens, M. K., Chung, M. L., Riegel, B. J., & Lennie, T. A. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.10.001 · Cited by 150
Vulnerabilities of patients recovering from an exacerbation of chronic heart failure
Moser, D. K., Doering, L. V., & Chung, M. L. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.07.028 · Cited by 148
Adherence to Medication According to Sex and Age in the CHARM Programme
Granger, B. B., Ekman, I., Granger, C. B., Östergren, J., Olofsson, B., Michelson, E. L., McMurray, J. J. V., Yusuf, S., Pfeffer, M. A., & Swedberg, K. B. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp142 · Cited by 143
What Do We Know About Adherence and Self-care?
Evangelista, L. S., & Shinnick, M. A. (2008) · The Journal of Cardiovascular Nursing · doi:10.1097/01.jcn.0000317428.98844.4d · Cited by 139
Compliance Behaviors of Elderly Patients With Advanced Heart Failure
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Cognitive Function and Treatment Adherence in Older Adults With Heart Failure
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“Treatment adherence was assessed using the Heart Failure Compliance Questionnaire (11).”
BackgroundMethodInfluentialAn integrative review of interventions promoting self‐care of patients with heart failure
Barnason, S. A., Zimmerman, L. M., & Young, L. (2011) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2011.03907.x · Cited by 119
“Conversely, factors associated with improved self-care include having higher levels of mental and physical functioning (Evangelista et al. 2001), higher levels of formal education (Rockwell & Riegel 2001) and support by spouse, partner, family or friends (Sayers et al.”
BackgroundImpact of Antidepressant Drug Adherence on Comorbid Medication Use and Resource Utilization
Katon, W. J., Cantrell, C. R., Sokol, M. C., Chiao, E., & Gdovin, J. M. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.21.2497 · Cited by 124
“In addition, the use of claims data may not allow for accurate representation of the incidence of depression and comorbid anxiety in this population.(11) More than 50% of the patients in this study did not have a coded diagnosis of depression or anxiety, and it is possible that some of these patients received antidepr…”
BackgroundFactors Related to Nonadherence to Low Sodium Diet Recommendations in Heart Failure Patients
Bentley, B., Jong, M. J. D., Moser, D. K., & Peden, A. R. (2005) · European Journal of Cardiovascular Nursing · doi:10.1016/j.ejcnurse.2005.04.009 · Cited by 120
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Ding, H., Jayasena, R., Chen, S. H., Maiorana, A., Dowling, A., Layland, J. J., Good, N. M., Karunanithi, M., & Edwards, I. (2020) · Journal of Medical Internet Research · doi:10.2196/17559 · Cited by 117
Psychological Determinants of Heart Failure Self-Care: Systematic Review and Meta-Analysis
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Medication Adherence Among Community-Dwelling Patients With Heart Failure
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“Studies have used various cut points to define poor adherence, ranging from patients taking less than 70% to less than 100% of a prescribed medication.(34,36) We used less than 80% to define poor adherence because this cut point has been used most frequently in the literature.”
MethodWu, J. R., Corley, D., Lennie, T. A., & Moser, D. K. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.09.006 · Cited by 98
A Trial of Family Partnership and Education Interventions in Heart Failure
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Klompstra, L. V., Jaarsma, T., & Strömberg, A. (2017) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000456 · Cited by 96
Adherence to exercise training in heart failure: a review
Barbour, K. A., & Miller, N. H. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9054-x · Cited by 97
“Consistent with the results of the Evangelista study [10], reasons provided by these patients for not engaging in exercise included limitations due to physical symptoms (27%) and lack of energy (25%).”
BackgroundResultPetter, M., Blanchard, C. M., Kemp, K., Mazoff, A. S., & Ferrier, S. N. (2009) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3283299585 · Cited by 94
Polypharmacy in Heart Failure Patients
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Determinants of adherence to heart failure medication: a systematic literature review
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“Of those that did find a significant relationship, three studies [25, 31, 34] found that higher age is related to more adherence.”
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Emilsson, M., Berndtsson, I., Lötvall, J. O., Millqvist, E., Lundgren, J., Johansson, Å., & Brink, E. (2011) · Primary Care Respiratory Journal · doi:10.4104/pcrj.2011.00005 · Cited by 84
Impact of exercise training on cardiovascular disease and risk
Adams, V., & Linke, A. H.-P. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.019 · Cited by 95
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Self-care and depression in patients with chronic heart failure
Holzapfel, N., Löwe, B., Wild, B., Schellberg, D., Zugck, C., Remppis, A. B., Katus, H. A., Haass, M., Rauch, B., Jünger, J., et al. (2009) · Heart & Lung · doi:10.1016/j.hrtlng.2008.11.001 · Cited by 82
Measuring Self-care in Chronic Heart Failure
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Klompstra, L. V., Jaarsma, T., & Strömberg, A. (2015) · Patient Preference and Adherence · doi:10.2147/ppa.s90942 · Cited by 81
“However, adherence to physical activity is less than 50% in HF patients;(4,5) it even seems more difficult to achieve than dietary modification and medication regimes.(6) Predictors of regular participation in physical activity in healthy adults have been well documented.”
Krousel-Wood, M. A., Holt, E. W., Joyce, C., Ruiz, R. L., Dornelles, A. C., Webber, L. S., Morisky, D. E., Frohlich, E. D., Ré, R. N., He, J., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000382 · Cited by 78
“[31] found that self-report adherence using a single item was not associated with outcomes in patients treated for heart failure, and discussed the issues regarding reliability [32,33] and the potential for recall and social desirability biases [34] with self-reported measures.”
BackgroundQuality of Life, Health Status, and Depression
Pike, N. A., Evangelista, L. S., Doering, L. V., Eastwood, J., Lewis, A. B., & CHILD, J. S. (2012) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0b013e31822ce5f6 · Cited by 76
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Determinants of heart failure self-care: a systematic literature review
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“[32] identified patients ≤60 years as most affected bynon-adherence.”
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“Self-reported adherence was measured with the Revised HF Compliance Questionnaire [14] on a five-point scale (10‘never’; 50‘always’).”
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“According to the data published by Ho et al(7) in the PREMIER study, MI patients without higher education were more likely to discontinue their medication, however according to other researchers, this factor was not relevant.(28,29) In our observation, the impact of”
ResultPrioritizing symptom management in the treatment of chronic heart failure
Koshy, A. O., Gallivan, E. R., McGinlay, M., Straw, S., Drozd, M., Toms, A. G., Gierula, J., Cubbon, R. M., Kearney, M. T., & Witte, K. K. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12875 · Cited by 66
“Dyspnoea is often ranked numerically or with ‘Likert’ scales based on how it impacts activities of daily living and thereby QoL.10,51 The commonly utilized NYHA class has variable sensitivity in gauging dyspnoea and classifying patients.54 Assessment of dyspnoea is challenging because patient activity level affects th…”
BackgroundInfluentialIdentification of psychosocial factors of noncompliance in hypertensive patients
Hassan, N. B., Hasanah, C. I., Foong, K., Naing, L., Awang, R., Ismail, S. B., Ishak, A., Yaacob, L. H., Yusoff, H. M., Daud, A., et al. (2005) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001930 · Cited by 65
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“Self-care behaviour did not change significantly from baseline (31, [23-39]) to 12 month (29 [22,5-37]).”
BackgroundPatient-, Provider-, and System-Level Barriers to Heart Failure Care
McEntee, M. L., Cuomo, L. R., & Himmelfarb, C. D. (2009) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0b013e3181a660a0 · Cited by 63
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Self-care practices in women with diastolic heart failure
GARY, R. A. (2006) · Heart & Lung · doi:10.1016/j.hrtlng.2005.04.005 · Cited by 62
Should Torsemide Be the Loop Diuretic of Choice in Systolic Heart failure?
DiNicolantonio, J. J. (2012) · Future Cardiology · doi:10.2217/fca.12.54 · Cited by 62
“6 billion [49].”
Predictors of quality of life in patients with heart failure
Hwang, S., Liao, W., & Huang, T. (2013) · Japan Journal of Nursing Science · doi:10.1111/jjns.12034 · Cited by 61
Heart failure patients' perceptions on nutrition and dietary adherence
Heo, S., Lennie, T. A., Moser, D. K., & Okoli, C. T. C. (2009) · European Journal of Cardiovascular Nursing · doi:10.1016/j.ejcnurse.2009.05.005 · Cited by 61
Testing the psychometric properties of the Medication Adherence Scale in patients with heart failure
Wu, J. R., Chung, M. L., Lennie, T. A., Hall, L. A., & Moser, D. K. (2008) · Heart & Lung · doi:10.1016/j.hrtlng.2007.10.001 · Cited by 59
Patient-Reported Compliance in older age patients with chronic heart failure
Jankowska‐Polańska, B., Świątoniowska-Lonc, N., Sławuta, A., Krówczyńska, D., Dudek, K. D., & Mazur, G. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231076 · Cited by 60
Depression in chronic heart failure: novel pathophysiological mechanisms and therapeutic approaches
Parissis, J., Fountoulaki, K., PARASKEVAIDIS, I. A., & Kremastinos, D. T. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.5.567 · Cited by 59
“Moreover, it seems likely that noncompliance to pharmacological and behavioural recommendations and lower levels of social support can affect outcomes in depressed patients with CHF [21-23].”
BackgroundSodium dietary restriction, knowledge, beliefs, and decision‐making behavior of older females
Sheahan, S. L., & Fields, B. (2008) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2008.00307.x · Cited by 58
“Adherence rates to SRD range from 22% to 55%, and nonadherence is a known antecedent to hospitalization (Evangelista et al., 2001; Michalsen et al.).”
BackgroundUnraveling the mechanisms for heart failure patients’ beliefs about compliance
van der Wal, M. H. L., Jaarsma, T., Moser, D. K., van Gilst, W. H., & van Veldhuisen, D. J. (2007) · Heart & Lung · doi:10.1016/j.hrtlng.2006.10.007 · Cited by 57
Self-care Behaviors in Indigent Patients With Heart Failure
Macabasco‐O’Connell, A., Crawford, M. H., Stotts, N. A., Stewart, A. L., & Froelicher, E. S. (2008) · The Journal of Cardiovascular Nursing · doi:10.1097/01.jcn.0000317427.21716.5f · Cited by 56
Long-Term Compliance With Nonpharmacologic Treatment of Patients With Heart Failure
Nieuwenhuis, M. M. W., Jaarsma, T., van Veldhuisen, D. J., Postmus, D., & van der Wal, M. H. L. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.03.039 · Cited by 55
Heart Failure and Exercise: A Narrative Review of the Role of Self-Efficacy
Ha, F. J., Hare, D. L., Cameron, J. D., & Toukhsati, S. R. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.08.012 · Cited by 55
The Lived Experience of Adherence for Patients With Heart Failure
Scotto, C. J. (2005) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200505000-00006 · Cited by 54
Smeulders, E. S. T. F., van Haastregt, J. C. M., Ambergen, T., Stoffers, J., Boyne, J. J., Uszko‐Lencer, N. H. M. K., Gorgels, A. P. M., der Bolt, C. L.-V., van Eijk, J. T. M., & Kempen, G. I. J. M. (2010) · Patient Education and Counseling · doi:10.1016/j.pec.2010.01.003 · Cited by 57
“The finding that lower educated persons benefited more from the programme may be explained by the fact that lower educated persons have less selfmanagement skills than their higher educated counterparts, so for them there may be more to learn with respect to, for example, disease-specific knowledge and healthy lifesty…”
BackgroundThe Pharmacist Role in Predicting and Improving Medication Adherence in Heart Failure Patients
Davis, E. M., Packard, K. A., & Jackevicius, C. A. (2014) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2014.20.7.741 · Cited by 54
Type D Personality Predicts Poor Medication Adherence in Patients with Heart Failure in the USA
Wu, J. R., & Moser, D. K. (2013) · International Journal of Behavioral Medicine · doi:10.1007/s12529-013-9366-2 · Cited by 53
“Age [52], gender [52, 53], ethnicity [26, 54], education level [33, 55, 56], left ventricular ejection fraction (a measure of ventricular function) [26, 57], comorbidity [58, 59], and perceived social support [26, 60, 61], which might influence medication adherence, were collected as covariates from the medical record…”
MethodBentley, B., Lennie, T. A., Biddle, M., Chung, M. L., & Moser, D. K. (2008) · Heart & Lung · doi:10.1016/j.hrtlng.2008.05.006 · Cited by 52
Family Partnership Intervention
Clark, P. C., & Dunbar, S. B. (2003) · AACN Clinical Issues Advanced Practice in Acute & Critical Care · doi:10.1097/00044067-200311000-00008 · Cited by 51
Shamaskin‐Garroway, A., Rybarczyk, B. D., Wang, E., White‐Williams, C., McGee, E. C., Cotts, W., & Grady, K. L. (2012) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2011.11.025 · Cited by 48
Alosco, M. L., Spitznagel, M. B., Raz, N., Cohen, R. A., Sweet, L. H., Colbert, L. H., Josephson, R., van Dulmen, M. H. M., Hughes, J. W., Rosneck, J., et al. (2013) · Journal of Clinical Nursing · doi:10.1111/jocn.12214 · Cited by 47
“Indeed, many IADLs consist of behaviors similar to those required for adherence to important HF treatment recommendations (i.e., dietary restriction, medication management) (Fitzgerald et al. 2011, Evangelista et al. 2001; Ni et al.,1999).”
BackgroundThe symptom of pain with heart failure: a systematic review
Godfrey, C., Harrison, M. B., Medves, J., & Tranmer, J. E. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.01.006 · Cited by 46
Nieuwenhuis, M. M. W., Jaarsma, T., van Veldhuisen, D. J., & van der Wal, M. H. L. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.04.004 · Cited by 46
“6% (20) 54% (182) 40% (135) 29 ± 52 27% (92) 45% (144) <0.”
Du, H., Everett, B., Newton, P. J., Salamonson, Y., & Davidson, P. M. (2011) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2011.03983.x · Cited by 49
Du, H., Newton, P. J., Zecchin, R. P., Denniss, R., Salamonson, Y., Everett, B., Currow, D. C., Macdonald, P. S., & Davidson, P. M. (2011) · Trials · doi:10.1186/1745-6215-12-63 · Cited by 45
“Although physical activity is important and beneficial in the management of CHF, many individuals consider that adhering to physical activity recommendations is harder compared to implementing strategies related to medications, dietary modifications or fluid restriction [5].”
BackgroundJones, C. D., Holmes, G. M., DeWalt, D. A., Erman, B., Wu, J. R., Cené, C. W., Baker, D. W., Schillinger, D., Ruo, B., Bibbins-Domingo, K. B., et al. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-12 · Cited by 45
“HF self-care behaviors are frequently assessed through global self-reported measures, including the Self-Care of HF Index (SCHFI), [3] the revised Heart Failure SelfCare Behavioral Scale [15,16], the European HF Self-Care Behavioral Scale (EHFScB Scale), [4] and the Revised HF Compliance scale, [5,17] all of which con…”
BackgroundMethodImpact of Obesity on Quality of Life and Depression in Patients with Heart Failure
Evangelista, L. S., Moser, D. K., Westlake, C. A., Hamilton, M. A., Fonarow, G. C., & Dracup, K. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.02.004 · Cited by 43
Medication and Dietary Compliance Beliefs in Heart Failure
Bennett, S. J., Lane, K. A., Welch, J. L., Perkins, S. M., Brater, D. C., & Murray, M. D. (2005) · Western Journal of Nursing Research · doi:10.1177/0193945905280253 · Cited by 45
“Poor compliance with dietary sodium restrictions is common (Bennett, Cordes, et al., 2000; Evangelista, Dracup, & Doering, 2000; Evangelista et al., 2001), and the results of the current study provide additional knowledge about the difficulties in following these restrictions.”
ResultRamaekers, B. L. T., Janssen-Boyne, J. J., Gorgels, A. P. M., & Vrijhoef, H. J. (2009) · Telemedicine Journal and e-Health · doi:10.1089/tmj.2009.0160 · Cited by 42
Chung, M. L., Lennie, T. A., Mudd‐Martin, G., & Moser, D. K. (2013) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000089 · Cited by 42
Gallagher, R. D. (2010) · European Journal of Cardiovascular Nursing · doi:10.1016/j.ejcnurse.2009.12.006 · Cited by 39
“For instance, adherence to medication regimens and medical appointments is closest to optimal [18], ranging from 34% to 98% for medications [19–24], and from 80% to 98% for appointments [22,23].”
BackgroundColomer-Pérez, N., Chover‐Sierra, E., Navarro-Martínez, R., Andriusevičienė, V., Vlachou, E. D., & Cauli, O. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16245042 · Cited by 45
Farrell, K. A., Shen, B., Mallon, S. M., Penedo, F. J., & Antoni, M. H. (2011) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-010-9217-0 · Cited by 41
Long-term exercise adherence in patients with heart failure: A qualitative study
Warehime, S., Dinkel, D. M., Alonso, W., & Pozehl, B. (2020) · Heart & Lung · doi:10.1016/j.hrtlng.2020.08.016 · Cited by 42
“; and (3) What longterm exercise advice would you give to a newly diagnosed heart failure patient?”
BackgroundWu, J. R., Lennie, T. A., Jong, M. J. D., Frazier, S. K., Heo, S., Chung, M. L., & Moser, D. K. (2009) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2009.10.017 · Cited by 40
“A number of investigators reported no differences in medication adherence based on race/ethnicity.(32,64,67,68) However, in 3 studies,(27,65,66) African-American participants were less adherent than Caucasian participants.”
Whelan-Gales, M. A., Griffin, M. T. Q., Maloni, J. A., & Fitzpatrick, J. J. (2009) · Geriatric Nursing · doi:10.1016/j.gerinurse.2009.04.001 · Cited by 39
Ritschl, V., Stamm, T., Aletaha, D., Bijlsma, J. W. J., Böhm, P., Dragoi, R. G., Dures, E. K., Estévez‐López, F., Gossec, L., Iagnocco, A., et al. (2020) · RMD Open · doi:10.1136/rmdopen-2020-001432 · Cited by 39
“115 The majority of tools do not have a proper description or testing of their metric properties available, except for the Heart Failure Compliance Questionnaire, 119 the Adherence to Exercise Scale for Older Patients (AESOP) 120 and The Proble-matic Experiences of Therapy Scale 121 ; however, none of these scales are…”
Method
Metadata
- Authors
- Evangelista, L. S., Berg, J., & Dracup, K.
- Affiliations
- California State University Los Angeles (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Venue
- Heart & Lung
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 30
- Issue
- 4
- Pages
- 294-301
- ISSN
- 0147-9563 (ISSN-L)
- OpenAlex
- W2171011852
- Cited by
- 240
- References
- 29
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 2 · 2020: 13 · 2019: 10 · 2018: 5 · 2017: 14 · 2016: 7 · 2015: 9 · 2014: 13 · 2013: 14 · 2012: 19
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- Locations
- Heart & Lung (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- heart failure, medication adherence, psychosocial factors, social support, perceived social support, neuroticism, health status, educational attainment, dietary adherence, exercise adherence, smoking cessation, alcohol cessation, follow-up visits
- MeSH terms
- Adult, Aged, Aged, 80 and over, Diet Therapy, Educational Status, Exercise Therapy, Female, Health Status, Heart Failure, Humans, Male, Mental Health, Middle Aged, Patient Compliance, Population Surveillance, Social Support, Socioeconomic Factors, Los Angeles, Reproducibility of Results, Multivariate Analysis, Patient Satisfaction
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