Obstructive sleep apnea in infants: relation to family history of sudden infant death syndrome, apparent life-threatening events, and obstructive sleep apnea
Abstract
Objectives Familial aggregation of obstructive sleep apnea (OSA) has been shown to be associated with sudden infant death syndrome (SIDS) and apparent life-threatening events (ALTE) in infants. We wanted to determine the incidence of OSA in infants with siblings with ALTE and SIDS referred to our sleep clinic and to ascertain whether OSA was more common in infants who have family histories of SIDS, ALTE, and OSA.Study design We studied 125 infants (mean age, 11.5 +/- 0.6 weeks) who were separated into 2 groups on the basis of their family history; polysomnographic studies were performed on each infant.Results Twenty infants had a multiple family history of SIDS, ALTE, or OSA (group 1), whereas the other 105 infants (group 2) had only one case of SIDS or ALTE within the family and no known history of OSA. We found that 19 of 20 infants in group 1 had OSA, whereas only 31 of 105 infants in group 2 had OSA (chi-squared analysis, P <.05). The OSA recorded was more frequent in infants of group 1 than in those of group 2. Follow-up studies in some infants with OSA demonstrated a progressive decrease in OSA, which resolved between 6 and 12 months of age.Conclusion We conclude that infants of families with multiple histories of SIDS, ALTE, and OSA are more likely to have OSA than infants of families with only one case of SIDS or ALTE.
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The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
Young, T., Palta, M., Dempsey, J., Skatrud, J., Weber, S., & Badr, S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304293281704 · Cited by 10,183 · see citing works
The Familial Aggregation of Obstructive Sleep Apnea
Redline, S., Tishler, P. V., Tosteson, T. D., Williamson, J., Kump, K., Browner, I., Ferrette, V., & Krejci, P. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.3_pt_1.682 · Cited by 473 · see citing works
Kahn, A., Groswasser, J., Rebuffat, E., Sottiaux, M., Blum, D. L., Foerster, M., Franco, P., Bochner, A., Alexander, M., Bachy, A., et al. (1992) · SLEEP · doi:10.1093/sleep/15.4.287 · Cited by 277 · see citing works
Obstructive Sleep Apnea in Family Members
Strohl, K. P., Saunders, N. A., Feldman, N. T., & Hallett, M. (1978) · New England Journal of Medicine · doi:10.1056/nejm197811022991801 · Cited by 245 · see citing works
Family Studies in Patients with the Sleep Apnea-Hypopnea Syndrome
Mathur, R., & Douglas, N. J. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-3-199502010-00003 · Cited by 225 · see citing works
Familial Aggregates in Obstructive Sleep Apnea Syndrome
Guilleminault, C., Partinen, M., Hollman, K., Powell, N. B., & Stoohs, R. A. (1995) · CHEST Journal · doi:10.1378/chest.107.6.1545 · Cited by 216 · see citing works
Owen, G. D., & Spink, M. S. (1948) · The Lancet · doi:10.1016/s0140-6736(48)90267-0 · Cited by 193 · see citing works
Sullivan, C. E., & Issa, F. G. (1985) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00401-9 · Cited by 139 · see citing works
Self-citationAssessment of the Role of Inheritance in Sleep Apnea Syndrome
Pillar, G., & Lavie, P. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.3_pt_1.688 · Cited by 127 · see citing works
BAYADI, S. E., Millman, R. P., Tishler, P. V., Rosenberg, C. L., Saliski, D. W., Boucher, M. A., & Redline, S. S. (1990) · CHEST Journal · doi:10.1378/chest.98.3.554 · Cited by 85 · see citing works
Obstructive Sleep Apnea and Near Miss for SIDS: I. Report of an Infant With Sudden Death
Guilleminault, C., Ariagno, R. L., Forno, L. S., et al. (1979) · PEDIATRICS · doi:10.1542/peds.63.6.837 · Cited by 84 · see citing works
Ventilatory-control Abnormalities in Familial Sleep Apnea
Redline, S. S., Leitner, J., Arnold, J. L., Tishler, P. V., & Altose, M. D. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.1.9610016 · Cited by 79 · see citing works
The Association of Sudden Unexpected Infant Death With Obstructive Sleep Apnea
Tishler, P. V., Redline, S. S., Ferrette, V., et al. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.6.8665046 · Cited by 77 · see citing works
SMALL UPPER AIRWAY IN NEAR-MISS SUDDEN INFANT DEATH SYNDROME INFANTS AND THEIR FAMILIES
Guilleminault, C., Powell, N. B., Heldt, G. P., et al. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92369-x · Cited by 59 · see citing works
Ventilatory response to carbon dioxide in young athletes: a family study.
Saunders, N. A., Leeder, S., & Rebuck, A. S. (1976) · PubMed · doi:10.1164/arrd.1976.113.4.497 · Cited by 58 · see citing works
Clinical Symptoms Associated With Brief Obstructive Sleep Apnea in Normal Infants
Kahn, A., Groswasser, J., Sottiaux, M., et al. (1993) · SLEEP · doi:10.1093/sleep/16.5.409 · Cited by 55 · see citing works
Pillar, G., Schnall, R. P., Peled, N., Oliven, A., & Lavie, P. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.5.9154864 · Cited by 53 · see citing works
From Apnea of Infancy to Obstructive Sleep Apnea Syndrome in the Young Child
Guilleminault, C., & Stoohs, R. A. (1992) · CHEST Journal · doi:10.1378/chest.102.4.1065 · Cited by 47 · see citing works
Control of ventilation in subsequent siblings of victims of sudden infant death syndrome
Brady, J. P., & McCann, E. M. (1985) · The Journal of Pediatrics · doi:10.1016/s0022-3476(85)80289-4 · Cited by 47 · see citing works
Sleep-Disordered Breathing and Its Effects on Sleep in Infants
McNamara, F., & Sullivan, C. E. (1996) · SLEEP · doi:10.1093/sleep/19.1.4 · Cited by 40 · see citing works
Self-citationFamilial Occurrence of Sudden Infant Death Syndrome and Apnea of Infancy
Oren, J., Kelly, D. H., & Shannon, D. C. (1987) · PEDIATRICS · doi:10.1542/peds.80.3.355 · Cited by 33 · see citing works
Facial structure in the sudden infant death syndrome: case-control study
Rees, K., Wright, A., Keeling, J. W., et al. (1998) · BMJ · doi:10.1136/bmj.317.7152.179 · Cited by 32 · see citing works
Relation between sudden infant death syndrome and adult sleep apnoea/hypopnoea syndrome
Mathur, R., & Douglas, N. J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92375-2 · Cited by 27 · see citing works
Developmental aspects of sleep and breathing.
Guilleminault, C., & Robinson, A. G. (1996) · PubMed · Cited by 15 · see citing works
Evolution of sleep‐disordered breathing and sleep in infants
McNamara, F., & Sullivan, C. (1998) · Journal of Paediatrics and Child Health · doi:10.1046/j.1440-1754.1998.00150.x · Cited by 13 · see citing works
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England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181 · see citing works
- Authors
- McNamara, F., & Sullivan, C. E.
- Affiliations
- The University of Sydney (AU)
- ORCID
- Sullivan, Colin E.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 136
- Issue
- 3
- Pages
- 318-323
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2001174872
- Cited by
- 67
- References
- 25
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 5 · 2012: 6
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- obstructive sleep apnea, infants, sudden infant death syndrome, apparent life-threatening event, familial aggregation, family history (medicine), polysomnography
- MeSH terms
- Age Factors, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Risk Factors, Sudden Infant Death, Incidence, Polysomnography, Sleep Apnea, Obstructive
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