The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Evaluation of oocyte quality: morphological, cellular and molecular predictors
Abstract
Mounting evidence that oocyte quality profoundly affects fertilisation and subsequent embryo development drives the continued search for reliable predictors of oocyte developmental competence. In the present review, we provide an overall summary and analysis of potential criteria that can be used to evaluate oocyte quality. These criteria are specifically classified as morphological and cellular/molecular predictors. Traditional methods for the evaluation of oocyte quality are based on morphological classification of the follicle, cumulus–oocyte complex, polar body and/or meiotic spindle. Although the use of morphological characteristics as predictors of oocyte quality is controversial, such a grading system can provide valuable information for the preselection of oocytes with higher developmental competence and, therefore, may maximise embryo developmental outcome. Several intrinsic markers (such as mitochondrial status and glucose-6-phosphate dehydrogenase l activity) and extrinsic markers (such as apoptosis of follicular cells and levels of the transforming growth factor-ß superfamily in follicular fluid or serum) have also been reported as useful indicators of oocyte competence and embryo quality. Compared with the morphological parameters, these cellular and molecular predictors of oocyte quality may prove to be more precise and objective, although further studies and refinement of techniques are needed.
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Metadata
- Authors
- Wang, Q., & Sun, Q.-Y.
- Venue
- Reproduction, Fertility and Development
- Publisher
- CSIRO Publishing
- Published
- 2006-12-12
- Volume
- 19
- Issue
- 1
- Pages
- 1-12
- ISSN
- 1031-3613 (ISSN-L)
- 1448-5990
- OpenAlex
- W2045869961
- Cited by
- 306
- References
- 66
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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