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PDK1 regulates growth through Akt and S6K in Drosophila
Open accessAbstract
The insulin/insulin-like growth factor-1 signaling pathway promotes growth in invertebrates and vertebrates by increasing the levels of phosphatidylinositol 3,4,5-triphosphate through the activation of p110 phosphatidylinositol 3-kinase. Two key effectors of this pathway are the phosphoinositide-dependent protein kinase 1 (PDK1) and Akt/PKB. Although genetic analysis in Caenorhabditis elegans has implicated Akt as the only relevant PDK1 substrate, cell culture studies have suggested that PDK1 has additional targets. Here we show that, in Drosophila, dPDK1 controls cellular and organism growth by activating dAkt and S6 kinase, dS6K. Furthermore, dPDK1 genetically interacts with dRSK but not with dPKN , encoding two substrates of PDK1 in vitro . Thus, the results suggest that dPDK1 is required for dRSK but not dPKN activation and that it regulates insulin-mediated growth through two main effector branches, dAkt and dS6K.
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Cites
Phosphorylation and Activation of p70 s6k by PDK1
Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G. (1998) · Science · doi:10.1126/science.279.5351.707 · Cited by 826
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Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405775102 · Cited by 822
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Metadata
- Authors
- Rintelen, F., Stocker, H., Thomas, G., & Hafen, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-12-18
- Volume
- 98
- Issue
- 26
- Pages
- 15020-15025
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2015239877
- Cited by
- 170
- References
- 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Rintelen, F., Stocker, H., Thomas, G., & Hafen, E. (2001). PDK1 regulates growth through Akt and S6K in Drosophila. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.011318098
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