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Cited by 269

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria

Open access
Chico-Calero, Isabel, Suárez, Mónica, González-Zorn, Bruno, Scortti, Mariela, Slaghuis, Jörg, Goebel, Werner, The European Listeria Genome Consortium§, Vázquez-Boland, José A.·2002·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.012363899
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Abstract

Efficient replication in vivo is essential for a microparasite to colonize its host and the understanding of the molecular mechanisms by which microbial pathogens grow within host tissues can lead to the discovery of novel therapies to treat infection. Here we present evidence that the foodborne bacterial pathogen Listeria monocytogenes , a facultative intracellular parasite, exploits hexose phosphates (HP) from the host cell as a source of carbon and energy to fuel fast intracellular growth. HP uptake is mediated by Hpt, a bacterial homolog of the mammalian translocase that transports glucose-6-phosphate from the cytosol into the endoplasmic reticulum in the final step of gluconeogenesis and glycogenolysis. Expression of the Hpt permease is tightly controlled by the central virulence regulator PrfA, which upon entry into host cells induces a set of virulence factors required for listerial intracellular parasitism. Loss of Hpt resulted in impaired listerial intracytosolic proliferation and attenuated virulence in mice. Hpt is the first virulence factor to be identified as specifically involved in the replication phase of a facultative intracellular pathogen. It is also a clear example of how adaptation to intracellular parasitism by microbial pathogens involves mimicry of physiological mechanisms of their eukaryotic host cells.

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Crossref · 10.1073/pnas.012363899

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Metadata

Authors
Chico-Calero, I., Suárez, M., González-Zorn, B., Scortti, M., Slaghuis, J., Goebel, W., The European Listeria Genome Consortium§, & Vázquez-Boland, J. A.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2001-12-26
Volume
99
Issue
1
Pages
431-436
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.012363899
OpenAlex
W2032540830
Cited by
269
References
34
FWCI
6.07
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria. https://app.cochat.ai/papers/10.1073/pnas.012363899
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Chico-Calero, I., Suárez, M., González-Zorn, B., Scortti, M., Slaghuis, J., Goebel, W., The European Listeria Genome Consortium§, & Vázquez-Boland, J. A. (2002). Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.012363899

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.