The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Protein folding mediated by solvation: Water expulsion and formation of the hydrophobic core occur after the structural collapse
Open accessAbstract
The interplay between structure-search of the native structure and desolvation in protein folding has been explored using a minimalist model. These results support a folding mechanism where most of the structural formation of the protein is achieved before water is expelled from the hydrophobic core. This view integrates water expulsion effects into the funnel energy landscape theory of protein folding. Comparisons to experimental results are shown for the SH3 protein. After the folding transition, a near-native intermediate with partially solvated hydrophobic core is found. This transition is followed by a final step that cooperatively squeezes out water molecules from the partially hydrated protein core.
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Cites
From Levinthal to pathways to funnels
Dill, K. A., & Chan, H. S. (1997) · Nature Structural & Molecular Biology · doi:10.1038/nsb0197-10 · Cited by 2,293
THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective
Onuchic, J. N., Luthey-Schulten, Z., & Wolynes, P. G. (1997) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.48.1.545 · Cited by 2,210
Self-citationShea, J.-E., & Brooks III, C. L. (2001) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.52.1.499 · Cited by 481
Cited by
Protein folding and misfolding
Dobson, C. M. (2003) · Nature · doi:10.1038/nature02261 · Cited by 4,791
Water as an active constituent in cell biology
Ball, P. (2008) · Chemical Reviews · doi:10.1021/cr068037a · Cited by 2,177
WATER MEDIATION IN PROTEIN FOLDING AND MOLECULAR RECOGNITION
Levy, Y., & Onuchic, J. N. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.102134 · Cited by 1,048
Self-citationPerspective: Coarse-grained models for biomolecular systems
Noid, W. G. (2013) · The Journal of Chemical Physics · doi:10.1063/1.4818908 · Cited by 893
Koch, M. H. J., Vachette, P., & Svergun, D. I. (2003) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583503003871 · Cited by 560
Metadata
- Authors
- Cheung, M. S., García, A. E., & Onuchic, J. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-01-22
- Volume
- 99
- Issue
- 2
- Pages
- 685-690
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2085142174
- Cited by
- 507
- References
- 3
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cheung, M. S., García, A. E., & Onuchic, J. N. (2002). Protein folding mediated by solvation: Water expulsion and formation of the hydrophobic core occur after the structural collapse. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.022387699
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
