The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Complete genome sequence of Clostridium perfringens , an anaerobic flesh-eater
Open accessAbstract
Clostridium perfringens is a Gram-positive anaerobic spore-forming bacterium that causes life-threatening gas gangrene and mild enterotoxaemia in humans, although it colonizes as normal intestinal flora of humans and animals. The organism is known to produce a variety of toxins and enzymes that are responsible for the severe myonecrotic lesions. Here we report the complete 3,031,430-bp sequence of C. perfringens strain 13 that comprises 2,660 protein coding regions and 10 rRNA genes, showing pronounced low overall G + C content (28.6%). The genome contains typical anaerobic fermentation enzymes leading to gas production but no enzymes for the tricarboxylic acid cycle or respiratory chain. Various saccharolytic enzymes were found, but many enzymes for amino acid biosynthesis were lacking in the genome. Twenty genes were newly identified as putative virulence factors of C. perfringens , and we found a total of five hyaluronidase genes that will also contribute to virulence. The genome analysis also proved an efficient method for finding four members of the two-component VirR/VirS regulon that coordinately regulates the pathogenicity of C. perfringens . Clearly, C. perfringens obtains various essential materials from the host by producing several degradative enzymes and toxins, resulting in massive destruction of the host tissues.
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Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
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The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessières, P., Bolotin, A., Borchert, S., et al. (1997) · Nature · doi:10.1038/36786 · Cited by 3,679
Self-citationNakai, K., & Horton, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01336-x · Cited by 2,181
Massive gene decay in the leprosy bacillus.
Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., et al. (2001) · Nature · doi:10.1038/35059006 · Cited by 1,777
The Complete Genome Sequence of the Lactic Acid Bacterium Lactococcus lactis ssp. lactis IL1403
Bolotin, A., Wincker, P., Mauger, S., Jaillon, O., Malarme, K., Weissenbach, J., Ehrlich, S. D., & Sorokin, A. (2001) · Genome Research · doi:10.1101/gr.gr-1697r · Cited by 1,139
Cited by
Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364
Pathogenicity Islands in BacterialPathogenesis
Schmidt, H., & Hensel, M. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.1.14-56.2004 · Cited by 776
Portune, K. J., Beaumont, M., Davila, A.-M., Tomé, D., Blachier, F., & Sanz, Y. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.08.011 · Cited by 356
Assembly of pili on the surface of Corynebacterium diphtheriae
Ton‐That, H., & Schneewind, O. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03782.x · Cited by 354
A Comparative Genome Analysis Identifies Distinct Sorting Pathways in Gram-Positive Bacteria
Comfort, D., & Clubb, R. T. (2004) · Infection and Immunity · doi:10.1128/iai.72.5.2710-2722.2004 · Cited by 203
Metadata
- Authors
- Shimizu, T., Ohtani, K., Hirakawa, H., Ohshima, K., Yamashita, A., Shiba, T., Ogasawara, N., Hattori, M., Kuhara, S., & Hayashi, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-01-15
- Volume
- 99
- Issue
- 2
- Pages
- 996-1001
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2146755217
- Cited by
- 725
- References
- 6
- FWCI
- 30.92
- Type
- journal article
- Language
- en
- Open access
- green
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