The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Robustness of circadian rhythms with respect to molecular noise
Open accessAbstract
We use a core molecular model capable of generating circadian rhythms to assess the robustness of circadian oscillations with respect to molecular noise. The model is based on the negative feedback exerted by a regulatory protein on the expression of its gene. Such a negative regulatory mechanism underlies circadian oscillations of the PER protein in Drosophila and of the FRQ protein in Neurospora . The model incorporates gene transcription into mRNA, translation of mRNA into protein, reversible phosphorylation leading to degradation of the regulatory protein, transport of the latter into the nucleus, and repression of gene expression by the nuclear form of the protein. To assess the effect of molecular noise, we perform stochastic simulations after decomposing the deterministic model into elementary reaction steps. The oscillations predicted by the stochastic simulations agree with those obtained with the deterministic version of the model. We show that robust circadian oscillations can occur already with a limited number of mRNA and protein molecules, in the range of tens and hundreds, respectively. Entrainment by light/dark cycles and cooperativity in repression enhance the robustness of circadian oscillations with respect to molecular noise.
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Cites
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Cited by
Computational systems biology.
Kitano, H. (2002) · Nature · doi:10.1038/nature01254 · Cited by 2,209
Control, exploitation and tolerance of intracellular noise
Rao, C. V., Wolf, D. M., & Arkin, A. P. (2002) · Nature · doi:10.1038/nature01258 · Cited by 1,006
Robustness can evolve gradually in complex regulatory gene networks with varying topology
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Phase maintenance in a rhythmic motor pattern during temperature changes in vivo
Soofi, W., Goeritz, M. L., Kispersky, T. J., Prinz, A. A., Marder, E., & Stein, W. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00906.2013 · Cited by 80
Metadata
- Authors
- Gonze, D., Halloy, J., & Goldbeter, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-01-15
- Volume
- 99
- Issue
- 2
- Pages
- 673-678
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2066440682
- Cited by
- 401
- References
- 29
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
