The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
β3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics
Open accessAbstract
The voltage-sensitive sodium channel confers electrical excitability on neurons, a fundamental property required for higher processes including cognition. The ion-conducting α-subunit of the channel is regulated by two known auxiliary subunits, β1 and β2. We have identified rat and human forms of an additional subunit, β3. It is most closely related to β1 and is the product of a separate gene localized to human chromosome 11q23.3. When expressed in Xenopus oocytes, β3 inactivates sodium channel opening more slowly than β1 does. Structural modeling has identified an amino acid residue in the putative α-subunit binding site of β3 that may play a role in this difference. The expression of β3 within the central nervous system differs significantly from β1. Our results strongly suggest that β3 performs a distinct neurophysiological function.
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Cites
Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Wallace, R. H., Wang, D. W., Singh, R., Scheffer, I. E., George, A. L., Phillips, H. A., Saar, K., Reis, A., Johnson, E. W., Sutherland, G. R., et al. (1998) · Nature Genetics · doi:10.1038/1252 · Cited by 996
Cited by
Voltage‐gated sodium channels at 60: structure, function and pathophysiology
Catterall, W. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.224204 · Cited by 719
Resurgence of sodium channel research
Goldin, A. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.871 · Cited by 688
Voltage-gated ion channels and gating modifier toxins
Catterall, W. A., Cestèle, S., Yarov-Yarovoy, V., Yu, F. H., Konoki, K., & Scheuer, T. (2007) · Toxicon · doi:10.1016/j.toxicon.2006.09.022 · Cited by 640
Sodium channel SCN1A and epilepsy: Mutations and mechanisms
Escayg, A., & Goldin, A. L. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02640.x · Cited by 398
Sodium Channel β Subunits: Anything but Auxiliary
Isom, L. L. (2001) · The Neuroscientist · doi:10.1177/107385840100700108 · Cited by 353
Metadata
- Authors
- Morgan, K., Stevens, E. B., Shah, B., Cox, P. J., Dixon, A. K., Lee, K., Pinnock, R. D., Hughes, J., Richardson, P. J., Mizuguchi, K., & Jackson, A. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-02-25
- Volume
- 97
- Issue
- 5
- Pages
- 2308-2313
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2019268667
- Cited by
- 298
- References
- 2
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Morgan, K., Stevens, E. B., Shah, B., Cox, P. J., Dixon, A. K., Lee, K., Pinnock, R. D., Hughes, J., Richardson, P. J., Mizuguchi, K., & Jackson, A. P. (2000). β3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.030362197
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