The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Sodium Channel β Subunits: Anything but Auxiliary
Abstract
Voltage-gated sodium channels are glycoprotein complexes responsible for initiation and propagation of action potentials in excitable cells such as central and peripheral neurons, cardiac and skeletal muscle myocytes, and neuroendocrine cells. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The α subunits form a gene family with at least 10 members. Mutations in α subunit genes have been linked to paroxysmal disorders such as epilepsy, long QT syndrome, and hyperkalemic periodic paralysis in humans, and motor endplate disease and cerebellar ataxia in mice. Three genes encode sodium channel β subunits with at least one alternative splice product. A mutation in the β1 subunit gene has been linked to generalized epilepsy with febrile seizures plus type 1 (GEFS + 1) in a human family with this disease. Sodium channel β subunits are multifunctional. They modulate channel gating and regulate the level of channel expression at the plasma membrane. More recently, they have been shown to function as cell adhesion molecules in terms of interaction with extracellular matrix, regulation of cell migration, cellular aggregation, and interaction with the cytoskeleton. Structure-function studies have resulted in the preliminary assignment of functional domains in the β1 subunit. A sodium channel signaling complex is proposed that involves β subunits as channel modulators as well as cell adhesion molecules, other cell adhesion molecules such as neurofascin and contactin, RPTPβ, and extracellular matrix molecules such as tenascin.
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Cites
From Ionic Currents to Molecular Mechanisms
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Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2
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Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel
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Self-citationAuxiliary subunits of voltage-gated ion channels
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Cited by
Vassar, R., Kovacs, D. M., Yan, R., & Wong, P. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3657-09.2009 · Cited by 577
Developmental Neurotoxicity of Pyrethroid Insecticides: Critical Review and Future Research Needs
Shafer, T. J., Meyer, D. A., & Crofton, K. M. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7254 · Cited by 538
The roles of sodium channels in nociception: Implications for mechanisms of pain
Cummins, T. R., Sheets, P. L., & Waxman, S. G. (2007) · Pain · doi:10.1016/j.pain.2007.07.026 · Cited by 485
Cheah, C. S., Yu, F. H., Westenbroek, R. E., Kalume, F. K., Oakley, J. C., Potter, G. B., Rubenstein, J. L., & Catterall, W. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211591109 · Cited by 336
Vassar, R., Kuhn, P., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C., & Lichtenthaler, S. F. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12715 · Cited by 311
Metadata
- Authors
- Isom, L. L.
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2001-02
- Volume
- 7
- Issue
- 1
- Pages
- 42-54
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2105498897
- Cited by
- 353
- References
- 45
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
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