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Cited by 517

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep

Open access
Vanhatalo, S., Palva, J. M., Holmes, M. D., Miller, J. W., Voipio, J., Kaila, K.·2004·Proceedings of the National Academy of Sciences

Abstract

Human cortical activity has been intensively examined at frequencies ranging from 0.5 Hz to several hundred Hz. Recent studies have, however, reported also infraslow fluctuations in neuronal population activity, magnitude of electroencephalographic oscillations, discrete sleep events, as well as in the occurrence of interictal events. Here we use direct current electroencephalography to demonstrate large-scale infraslow oscillations in the human cortex at frequencies ranging from 0.02 to 0.2 Hz. These oscillations, which are not detectable in conventional electroencephalography because of its limited recording bandwidth (typical lower limit 0.5 Hz), were observed in widespread cortical regions. Notably, the infraslow oscillations were strongly synchronized with faster activities, as well as with the interictal epileptic events and K complexes. Our findings suggest that the infraslow oscillations represent a slow, cyclic modulation of cortical gross excitability, providing also a putative mechanism for the as yet enigmatic aggravation of epileptic activity during sleep.

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Metadata

Authors
Vanhatalo, S., Palva, J. M., Holmes, M. D., Miller, J. W., Voipio, J., & Kaila, K.
Venue
Proceedings of the National Academy of Sciences
Published
2004-03-24
Volume
101
Issue
14
Pages
5053-5057
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2130243088
Cited by
517
References
6
FWCI
6.72
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep. https://app.cochat.ai/papers/10.1073/pnas.0305375101
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Vanhatalo, S., Palva, J. M., Holmes, M. D., Miller, J. W., Voipio, J., & Kaila, K. (2004). Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0305375101

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