CoChat
Sign Up
Cited by 72Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Spike-and-wave epilepsy in rats: sex differences and inheritance of physiological traits

Open access
Jando´, G., Carpi, D., Kandel, A., Urioste, R., Horvath, Z., Pierre, E., Vadi, D., Vadasz, C. +1 more·1995·Neuroscience
DOI 10.1016/0306-4522(94)00329-4
Open this paper in CoChat — free account

Abstract

Spontaneously occurring spike-and-wave patterns were examined in seven to eight-month-old rats of the inbred Fischer 344 and Brown Norway strains and their F1 and F2 hybrids. Neocortical activity and movement were monitored for 12 night h. Spike-and-wave episodes were identified by a three-layer back-propagation neural network. The incidence, average duration and total duration of spike-and-wave episodes were significantly higher in F1 males and F2 hybrids than in the parental strains. Male rats of the Brown Norway strain had significantly more and longer episodes than females, whereas no sex differences were present in Fischer rats. The average intraepisodic frequency of spike-and-wave patterns was significantly lower in Fischer rats than in the other groups and significantly higher in males than females. Tremor (myoclonic movements) associated with spike-and-wave episodes was absent or of very small amplitude in Fischer rats but frequent and of large amplitude in Brown Norway rats and their F1 and F2 descendants. Most of the interstrain differences were limited to male rats. Spike-and-wave episodes recurred at predictable short-term (10-30 s) and long-term (15-30 min) periods. The long-term oscillation corresponded to a similar fluctuation of motor activity. The maximum probability of spike-and-wave patterns occurred at a relatively narrow range of delta power (0-3.1 Hz) of the background EEG activity. Systemic administration of the adrenergic alpha-2 agonist, clonidine, increased the incidence of spike-and-wave episodes several-fold. The total duration of spike-and-wave episodes in the clonidine sessions (15 min) and night sessions (12 h test) correlated significantly. We suggest that several genes interact with maturational, environmental and endocrine factors, resulting in sex differences, and produce the variety of EEG and behavioral findings encountered. In addition, we submit that the clonidine test may be useful in genetic investigations of human absence epilepsies. The findings of this work demonstrate that genetic manipulation of rodents is a promising method for producing analogous models for the various forms of human absence epilepsies.

Integrity signals

Registry

Crossref · 10.1016/0306-4522(94)00329-4

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In rodents, brief periods of 6-10 Hz thalamocortical oscillations known as high voltage spindles appear in the quiet resting state and are enhanced by cessation of locomotion.

    “In rodents, brief (seconds) periods of 6–10 Hz thalamocortical oscillations known as high voltage spindles can appear in the quiet resting state and are enhanced by the cessation of locomotion”

    From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Jando et al., 1995

Cites

Flagged first, then by citations

2 of the 85 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Jando´, G., Carpi, D., Kandel, A., Urioste, R., Horvath, Z., Pierre, E., Vadi, D., Vadasz, C., & Buzsa´ki, G.
Affiliations
Rutgers, The State University of New Jersey (US)
Venue
Neuroscience
Publisher
Elsevier BV
Published
1995-01
Volume
64
Issue
2
Pages
301-317
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/0306-4522(94)00329-4
OpenAlex
W2101662298
Cited by
72
References
85
Citations by year
2021: 2 · 2020: 5 · 2017: 2 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 5
FWCI
2.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
absence epilepsy, sex differences, genetic inheritance, F344 rats, Brown Norway rats, interspecific hybrids, clonidine, spontaneous epileptiform activity, BP neural network
MeSH terms
Animals, Clonidine, Electroencephalography, Epilepsy, Absence, Female, Hybridization, Genetic, Male, Motor Activity, Rats, Inbred BN, Rats, Inbred F344, Sex Factors, Tremor, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review