Origin of Slow Cortical Oscillations in Deafferented Cortical Slabs

Timofeev, I.

doi:10.1093/cercor/10.12.1185

Cited by 710Neural dynamics and brain functionSleep and Wakefulness ResearchNeuroscience and Neuropharmacology Research

Origin of Slow Cortical Oscillations in Deafferented Cortical Slabs

Timofeev, I.·2000·Cerebral Cortex

DOI 10.1093/cercor/10.12.1185

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Abstract

An in vivo preparation has been developed to study the mechanisms underlying spontaneous sleep oscillations. Dual and triple simultaneous intracellular recordings were made from neurons in small isolated cortical slabs (10 mm x 6 mm) in anesthetized cats. Spontaneously occurring slow sleep oscillations, present in the adjacent intact cortex, were absent in small slabs. However, the isolated slabs displayed brief active periods separated by long periods of silence, up to 60 s in duration. During these silent periods, 60% of neurons showed non-linear amplification of low-amplitude depolarizing activity. Nearly 40% of the cells, twice as many as in intact cortex, were classified as intrinsically bursting. In cortical network models based on Hodgkin-Huxley-like neurons, the summation of simulated spontaneous miniature excitatory postsynaptic potentials was sufficient to activate a persistent sodium current, initiating action potentials in single neurons that then spread through the network. Consistent with this model, enlarging the isolated cortical territory to an isolated gyrus (30 mm x 20 mm) increased the probability of initiating large-scale activity. In these larger territories, both the frequency and regularity of the slow oscillation approached that generated in intact cortex. The frequency of active periods in an analytical model of the cortical network accurately predicted the scaling observed in simulations and from recordings in cortical slabs of increasing size.

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Collective dynamics of ‘small-world’ networks
Watts, D. J., & Strogatz, S. H. (1998) · Nature · doi:10.1038/30918 · Cited by 43,060 · see citing works
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Markram, H., Lübke, J., Frotscher, M., & Sakmann, B. (1997) · Science · doi:10.1126/science.275.5297.213 · Cited by 3,832 · see citing works
Thalamocortical oscillations in the sleeping and aroused brain
Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564 · see citing works
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick, D. A., Connors, B. W., Lighthall, J. W., & Prince, D. A. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.4.782 · Cited by 1,935 · see citing works
Spontaneous subthreshold activity at motor nerve endings
Fatt, P., & Katz, B. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004735 · Cited by 1,847 · see citing works
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.
Hille, B. (1977) · The Journal of General Physiology · doi:10.1085/jgp.69.4.497 · Cited by 1,765 · see citing works
The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability
Tsodyks, M. V., & Markram, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.719 · Cited by 1,607 · see citing works
Influence of dendritic structure on firing pattern in model neocortical neurons
Mainen, Z. F., & Sejnowski, T. J. (1996) · Nature · doi:10.1038/382363a0 · Cited by 1,231 · see citing works
Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex
Gupta, A., Wang, Y., & Markram, H. (2000) · Science · doi:10.1126/science.287.5451.273 · Cited by 1,036 · see citing works
Collective dynamics of 'small-world' networks
Watts, D. J., & Strogatz, S. H. (2011) · Princeton University Press eBooks · doi:10.1515/9781400841356.301 · Cited by 1,027 · see citing works
Coherent 40-Hz oscillation characterizes dream state in humans.
Llinás, R., & Ribary, U. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2078 · Cited by 962 · see citing works
Electrophysiological properties of neocortical neurons in vitro.
Connors, B. W., Gutnick, M., & Prince, D. (1982) · Journal of Neurophysiology · doi:10.1152/jn.1982.48.6.1302 · Cited by 954 · see citing works
Hippocampal sharp waves: Their origin and significance
Buzsáki, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)91483-6 · Cited by 925 · see citing works
Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex
Gray, C. M., & McCormick, D. A. (1996) · Science · doi:10.1126/science.274.5284.109 · Cited by 906 · see citing works
Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships
Contreras, D., & Steriade, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00604.1995 · Cited by 700 · see citing works
Synchronization of fast (30-40 Hz) spontaneous cortical rhythms during brain activation
Steriade, M., Amzica, F., & Contreras, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00392.1996 · Cited by 646 · see citing works
Persistent Sodium Current in Mammalian Central Neurons
Crill, W. E. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.002025 · Cited by 634 · see citing works
Impact of Network Activity on the Integrative Properties of Neocortical Pyramidal Neurons In Vivo
Alain Destexhe, A., & Paré, D. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.4.1531 · Cited by 621 · see citing works
Heterogeneous Release Properties of Visualized Individual Hippocampal Synapses
Murthy, V. N., B, T. J. S. A., & Stevens, C. F. (1997) · Neuron · doi:10.1016/s0896-6273(00)80301-3 · Cited by 596 · see citing works
Horizontal integration and cortical dynamics
Gilbert, C. D. (1992) · Neuron · doi:10.1016/0896-6273(92)90215-y · Cited by 581 · see citing works
Quantal analysis of synaptic potentials in neurons of the central nervous system.
Redman, S. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.1.165 · Cited by 571 · see citing works
Horizontal spread of synchronized activity in neocortex and its control by GABA-mediated inhibition
Amitai, Y., & Connors, B. W. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.4.747 · Cited by 535 · see citing works
Miniature synaptic events maintain dendritic spines via AMPA receptor activation
McKinney, R. A., Capogna, M., Dürr, R., Gähwiler, B. H., & Thompson, A. S. M. (1999) · Nature Neuroscience · doi:10.1038/4548 · Cited by 523 · see citing works
Two inhibitory postsynaptic potentials, and GABAA and GABAB receptor‐mediated responses in neocortex of rat and cat.
Connors, B. W., Malenka, R. C., & Silva, L. R. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017390 · Cited by 522 · see citing works
Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex
Galarreta, M., & Hestrin, S. (1998) · Nature Neuroscience · doi:10.1038/2822 · Cited by 436 · see citing works
Synchronous Membrane Potential Fluctuations in Neurons of the Cat Visual Cortex
Lampl, I., Reichova, I., & Ferster, D. (1999) · Neuron · doi:10.1016/s0896-6273(00)81096-x · Cited by 434 · see citing works
Synchronized activities of coupled oscillators in the cerebral cortex and thalamus at different levels of vigilance [published erratum appears in Cereb Cortex 1997 Dec;7(8):779]
Steriade, M. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.583 · Cited by 429 · see citing works
Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitro
Stafstrom, C. E., Schwindt, P. C., Chubb, M. C., & Crill, W. E. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.53.1.153 · Cited by 414 · see citing works
Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans
KATTLER, H., DIJK, D., & BORBÉLY, A. A. (1994) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1994.tb00123.x · Cited by 401 · see citing works
Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons
Malgaroli, A., & Tsien, R. (1992) · Nature · doi:10.1038/357134a0 · Cited by 384 · see citing works
The mechanisms of generation and propagation of synchronized bursting in developing networks of cortical neurons
Maeda, E., Robinson, H., & Kawana, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06834.1995 · Cited by 365 · see citing works
Natural patterns of activity and long-term synaptic plasticity
Paulsen, O. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00076-3 · Cited by 347 · see citing works
Propagating Neuronal Discharges in Neocortical Slices: Computational and Experimental Study
Golomb, D., & Amitai, Y. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.3.1199 · Cited by 320 · see citing works
Synaptic interactions in neocortical local circuits: dual intracellular recordings in vitro
Thomson, A. M. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.510 · Cited by 318 · see citing works
Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD
Wang, Z., & McCormick, D. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02199.1993 · Cited by 307 · see citing works
Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex
Alzheimer, C., Schwindt, P. C., & Crill, W. E. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00660.1993 · Cited by 300 · see citing works
Single axon IPSPs elicited in pyramidal cells by three classes of interneurones in slices of rat neocortex.
Thomson, A. M., West, D. C., Hahn, J. D., & Deuchars, J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021667 · Cited by 275 · see citing works
Activity‐dependent properties of synaptic transmission at two classes of connections made by rat neocortical pyramidal axons in vitro
Thomson, A. M. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.131bl.x · Cited by 270 · see citing works
Negative slope conductance due to a persistent subthreshold sodium current in cat neocortical neurons in vitro
Stafstrom, C. E., Schwindt, P. C., & Crill, W. E. (1982) · Brain Research · doi:10.1016/0006-8993(82)90050-6 · Cited by 259 · see citing works
Dynamic Properties of Corticothalamic Neurons and Local Cortical Interneurons Generating Fast Rhythmic (30–40 Hz) Spike Bursts
Steriade, M., Timofeev, I., Dürmüller, N., & Grenier, F. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.483 · Cited by 254 · see citing works
Self-citation
Spontaneous GABAA receptor-mediated inhibitory currents in adult rat somatosensory cortex
Salin, P. A., & Prince, D. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.4.1573 · Cited by 247 · see citing works
A network of tufted layer 5 pyramidal neurons
Markram, H. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.523 · Cited by 233 · see citing works
Short- and long-range neuronal synchronization of the slow (< 1 Hz) cortical oscillation
Amzica, F., & Steriade, M. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.1.20 · Cited by 230 · see citing works
Quantal release of neurotransmitter and long-term potentiation.
Stevens, C. (1993) · Cell · doi:10.1016/s0092-8674(05)80028-5 · Cited by 222 · see citing works
Disconnection of intracortical synaptic linkages disrupts synchronization of a slow oscillation
Amzica, F., & Steriade, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04658.1995 · Cited by 221 · see citing works
Properties of subthreshold response and action potential recorded in layer V neurons from cat sensorimotor cortex in vitro
Stafstrom, C. E., Schwindt, P. C., Flatman, J. A., & Crill, W. E. (1984) · Journal of Neurophysiology · doi:10.1152/jn.1984.52.2.244 · Cited by 185 · see citing works
Self–sustained rhythmic activity in the thalamic reticular nucleus mediated by depolarizing GABAA receptor potentials
Bazhenov, M., Timofeev, I., Steriade, M., & Sejnowski, T. J. (1999) · Nature Neuroscience · doi:10.1038/5729 · Cited by 183 · see citing works
Self-citation
Voltage-dependent currents prolong single-axon postsynaptic potentials in layer III pyramidal neurons in rat neocortical slices
Thomson, A. M., Girdlestone, D., & West, D. C. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.6.1896 · Cited by 163 · see citing works
Some properties of the cat's isolated cerebral cortex
Burns, B. D. (1950) · The Journal of Physiology · doi:10.1113/jphysiol.1950.sp004463 · Cited by 149 · see citing works
Kinetic and Stochastic Properties of a Persistent Sodium Current in Mature Guinea Pig Cerebellar Purkinje Cells
Kay, A. R., Sugimori, M., & Llinás, R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.3.1167 · Cited by 140 · see citing works
Kinetics of slow inactivation of persistent sodium current in layer V neurons of mouse neocortical slices
Fleidervish, I. A., & Gutnick, M. J. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.2125 · Cited by 139 · see citing works
Electrophysiology of cat association cortical cells in vivo: intrinsic properties and synaptic responses
Nunez, A., Amzica, F., & Steriade, M. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.1.418 · Cited by 128 · see citing works
Correlation of Miniature Synaptic Activity and Evoked Release Probability in Cultures of Cortical Neurons
Prange, O., & Murphy, T. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06427.1999 · Cited by 127 · see citing works
Paroxysmal high voltage discharges from isolated and partially isolated human and animal cerebral cortex
Echlin, F. A., Arnett, V., & Zoll, J. G. (1952) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(52)90004-7 · Cited by 121 · see citing works
Computational Models of Thalamocortical Augmenting Responses
Bazhenov, M., Timofeev, I., Steriade, M., & B, T. J. S. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06444.1998 · Cited by 114 · see citing works
Self-citation
Inhibitory potentials in neurons of the deep layers of the in vitro neocortical slice
Avoli, M. (1986) · Brain Research · doi:10.1016/0006-8993(86)91118-2 · Cited by 102 · see citing works
Brain temperature dependent changes in the electroencephalogram power spectrum of humans and animals
Deboer, T. (1998) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1998.00125.x · Cited by 101 · see citing works
Organization of the association cortical afferent connections of area 5: A retrograde tracer study in the cat
Avendaño, C., Rausell, E., Aguilar, D. P., & Isorna, S. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902780102 · Cited by 97 · see citing works
Role of Thalamic and Cortical Neurons in Augmenting Responses and Self-Sustained Activity: Dual Intracellular Recordings In Vivo
Steriade, M., Timofeev, I., Grenier, F., & Dürmüller, N. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06425.1998 · Cited by 89 · see citing works
Self-citation
Blockade of neurotransmitter-activated K+ conductance by QX-314 in the rat hippocampus
Andrade, R. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90467-5 · Cited by 87 · see citing works
Temperature‐sensitive aspects of evoked and spontaneous transmitter release at the frog neuromuscular junction.
Barrett, E. F., Barrett, J. N., Botz, D., et al. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012343 · Cited by 85 · see citing works
Quantitative Analysis of Firing Properties of Pyramidal Neurons From Layer 5 of Rat Sensorimotor Cortex
Schwindt, P. C., O'Brien, J. A., & Crill, W. E. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.5.2484 · Cited by 71 · see citing works
Dynamics of dendritic calcium transients evoked by quantal release at excitatory hippocampal synapses
Murthy, V. N., Sejnowski, T. J., & Stevens, C. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.901 · Cited by 70 · see citing works
Differential Impact of Miniature Synaptic Potentials on the Soma and Dendrites of Pyramidal Neurons In Vivo
Paré, D., Lebel, E., & Lang, E. J. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.3.1735 · Cited by 58 · see citing works
Influence of anomalous rectifier activation on afterhyperpolarizations of neurons from cat sensorimotor cortex in vitro
Schwindt, P. C., Spain, W. J., & Crill, W. E. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.59.2.468 · Cited by 55 · cited 2× · see citing works
“The AHP following the action potentials results in a large conductance increase that significantly decreases the slow regenerative I Na(p) (Schwindt et al., 1988).”
Background
Persistent Sodium Current in Mammalian Central Neurons
Crill, W. E. (1996) · Annual Review of Physiology · doi:10.1146/annurev.physiol.58.1.349 · Cited by 23 · see citing works

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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
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Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., Ailamaki, A., Alonso-Nanclares, L., Antille, N., Arsever, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.029 · Cited by 1,705 · see citing works
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Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592 · see citing works
Natural waking and sleep states: a view from inside neocortical neurons
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Massimini, M., Huber, R., Ferrarelli, F., Hill, S., & Tononi, G. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1318-04.2004 · Cited by 1,221 · see citing works
The role of sleep in learning and memory
Maquet, P. (2001) · Science · doi:10.1126/science.1062856 · Cited by 1,177 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
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Haider, B., Duque, A., Hasenstaub, A. R., & McCormick, D. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5297-05.2006 · Cited by 962 · see citing works
Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep
Staresina, B. P., Bergmann, T. O., Bonnefond, M., van der Meij, R., Jensen, O., Deuker, L., Elger, C. E., Axmacher, N., & Fell, J. (2015) · Nature Neuroscience · doi:10.1038/nn.4119 · Cited by 831 · see citing works
Spontaneous Events Outline the Realm of Possible Sensory Responses in Neocortical Populations
Luczak, A., Barthó, P., & Harris, K. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.014 · Cited by 593 · see citing works
Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function
Zelano, C., Jiang, H., Zhou, G., Arora, N., Schuele, S., Rosenow, J., & Gottfried, J. A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2586-16.2016 · Cited by 599 · see citing works
The criticality hypothesis: how local cortical networks might optimize information processing
Beggs, J. M. (2008) · Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rsta.2007.2092 · Cited by 533 · see citing works
Why do we sleep?11Published on the World Wide Web on 7 November 2000.
Sejnowski, T. J., & Destexhe, A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03007-9 · Cited by 489 · see citing works
Source modeling sleep slow waves
Murphy, M., Riedner, B. A., Huber, R., Massimini, M., Ferrarelli, F., & Tononi, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807933106 · Cited by 454 · see citing works
Rapid Neocortical Dynamics: Cellular and Network Mechanisms
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Modeling Sleep and Wakefulness in the Thalamocortical System
Hill, S., & Tononi, G. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00915.2004 · Cited by 417 · see citing works
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Destexhe, A., Hughes, S. W., Rudolph, M., & Crunelli, V. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.04.006 · Cited by 355 · see citing works
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Sleep homeostasis and cortical synchronization: I. Modeling the effects of synaptic strength on sleep slow waves
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Colonnese, M. T., Kaminska, A., Minlebaev, M., Milh, M., Bloem, B., Lescure, S., Moriette, G., Chiron, C., Ben-Ari, Y., & Khazipov, R. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.015 · Cited by 273 · see citing works
Enhancement of sleep slow waves: underlying mechanisms and practical consequences
Bellesi, M., Riedner, B. A., Garcia-Molina, G. N., Cirelli, C., & Tononi, G. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00208 · Cited by 239 · see citing works
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Acetylcholine systems and rhythmic activities during the waking—sleep cycle
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Fellin, T., Halassa, M. M., Terunuma, M., Succol, F., Takano, H., Frank, M., Moss, S. J., & Haydon, P. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906419106 · Cited by 227 · see citing works
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Slow oscillation electrical brain stimulation during waking promotes EEG theta activity and memory encoding
Kirov, R., Weiss, C., Siebner, H. R., Born, J., & Marshall, L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904438106 · Cited by 208 · see citing works
Cortical Synaptic Integration<i>In Vivo</i>Is Disrupted by Amyloid-β Plaques
Stern, E. A., Bacskai, B. J., Hickey, G. A., Attenello, F. J., Lombardo, J. A., & Hyman, B. T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0462-04.2004 · Cited by 210 · see citing works
Two distinct synchronization processes in the transition to sleep: a high-density electroencephalographic study
Siclari, F., Bernardi, G., Riedner, B. A., LaRocque, J. J., Benca, R. M., & Tononi, G. (2014) · Sleep · doi:10.5665/sleep.4070 · Cited by 181 · see citing works
Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients
Rosanova, M., Fecchio, M., Casarotto, S., Sarasso, S., Casali, A. G., Pigorini, A., Comanducci, A., Seregni, F., Devalle, G., Citerio, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06871-1 · Cited by 167 · see citing works
Are there islands of awareness?
Bayne, T., Seth, A. K., & Massimini, M. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2019.11.003 · Cited by 145 · see citing works
Enhancement of visual responsiveness by spontaneous local network activity in vivo
Haider, B., Duque, A., Hasenstaub, A. R., Yu, Y., & McCormick, D. A. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01114.2006 · Cited by 130 · see citing works
Temporal dynamics of cortical sources underlying spontaneous and peripherally evoked slow waves
Riedner, B. A., Hulse, B. K., Murphy, M. J., Ferrarelli, F., & Tononi, G. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00013-2 · Cited by 130 · see citing works
Synaptic Mechanisms of Memory Consolidation during Sleep Slow Oscillations
Wei, Y., Krishnan, G. P., & Bazhenov, M. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3648-15.2016 · Cited by 116 · see citing works
Modulation of synaptic transmission in neocortex by network activities
Crochet, S., Chauvette, S., Boucetta, S., & Timofeev, I. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03932.x · Cited by 106 · see citing works
Self-citation
Breakdown of effective connectivity during slow wave sleep: investigating the mechanism underlying a cortical gate using large-scale modeling
Esser, S. K., Hill, S., & Tononi, G. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00059.2009 · Cited by 97 · see citing works
Spatio-temporal properties of sleep slow waves and implications for development
Timofeev, I., Schoch, S. F., LeBourgeois, M. K., Huber, R., Riedner, B. A., & Kurth, S. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.01.007 · Cited by 83 · see citing works
Self-citation
The human thalamus orchestrates neocortical oscillations during NREM sleep
Schreiner, T., Kaufmann, E., Noachtar, S., Mehrkens, J.-H., & Staudigl, T. (2022) · Nature Communications · doi:10.1038/s41467-022-32840-w · Cited by 77 · see citing works
General Anesthesia Disrupts Complex Cortical Dynamics in Response to Intracranial Electrical Stimulation in Rats
Arena, A., Comolatti, R., Thon, S., Casali, A. G., & Storm, J. F. (2021) · eneuro · doi:10.1523/eneuro.0343-20.2021 · Cited by 66 · see citing works
Thalamocortical Oscillations: Local Control of EEG Slow Waves
Timofeev, I., & Chauvette, S. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611797470376 · Cited by 55 · see citing works
Self-citation
Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized, double-blind, sham-controlled pilot trial in adult females with internalizing disorders
Perez, T. M., Glue, P., Adhia, D. B., Navid, M. S., Zeng, J., Dillingham, P., Smith, M., Niazi, I. K., Young, C. K., & De Ridder, D. (2022) · Trials · doi:10.1186/s13063-022-06863-z · Cited by 8 · see citing works
“Putatively engendered by a combination of neuronal and glial currents [63, 68, 71–76], eISFs have been shown in both cortical [65, 66, 77] and subcortical [76, 78–82] tissues and are believed to coordinate large-scale ICN organization and long-range information exchange [68, 83–91].”
Background

Novel Frequency Control in a Population of Bursting Neurons with Excitatory Synaptic Coupling
Butera, R. J., Rinzel, J., & Smith, J. C. (1998) · Springer eBooks · doi:10.1007/978-1-4615-4831-7_55 · Cited by 2 · see citing works
Pentobarbital modulates transmitter effects on mouse spinal neurones grown in tissue culture
Ransom, B. R., & Barker, J. L. (1975) · Nature · doi:10.1038/254703a0 · Cited by 92 · see citing works
Inhibitory postsynaptic density from the lens of phase separation
Bai, G., & Zhang, M. (2022) · Oxford Open Neuroscience · doi:10.1093/oons/kvac003 · Cited by 7 · see citing works
Pentobarbital: Selective Depression of Excitatory Postsynaptic Potentials
Barker, J. L., & Gainer, H. (1973) · Science · doi:10.1126/science.182.4113.720 · Cited by 114 · see citing works
Excitatory synaptic potentials in neurons of the deep nuclei in olivo-cerebellar slice cultures
Audinat, É., Gähwiler, B. H., & Knöpfel, T. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90366-a · Cited by 90 · see citing works

Authors: Timofeev, I.
Affiliations: Université Laval (CA)
Corresponding author: Timofeev, I.
ORCID: Timofeev, I.
Venue: Cerebral Cortex
Publisher: Oxford University Press (OUP)
Published: 2000-12-01
Volume: 10
Issue: 12
Pages: 1185-1199
ISSN: 1047-3211 (ISSN-L)
1460-2199
DOI: 10.1093/cercor/10.12.1185
OpenAlex: W2152587029
Cited by: 710
References: 66
Citations by year: 2026: 17 · 2025: 33 · 2024: 26 · 2023: 43 · 2022: 32 · 2021: 24 · 2020: 28 · 2019: 30 · 2018: 25 · 2017: 37 · 2016: 31 · 2015: 34 · 2014: 35 · 2013: 32 · 2012: 31
FWCI: 9.78
Type: journal article
Language: en
Open access: closed
Locations: Cerebral Cortex (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: sleep oscillations, deafferentation, spontaneous neuronal activity, silent period, miniature excitatory postsynaptic potentials, persistent sodium current, bursting neurons, cortical network model, Hodgkin-Huxley neurons, network size scaling, cats
MeSH terms: Animals, Cats, Cerebral Cortex, Denervation, Electrophysiology, Models, Neurological, Nerve Net, Neurons, Oscillometry, Thalamus, Excitatory Postsynaptic Potentials, In Vitro Techniques

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Origin of Slow Cortical Oscillations in Deafferented Cortical Slabs

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