The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8 + T Cells
Open accessAbstract
IL-15 and IL-2 possess similar properties, including the ability to induce T cell proliferation. However, whereas IL-2 can promote apoptosis and limit CD8 + memory T cell survival and proliferation, IL-15 helps maintain a memory CD8 + T cell population and can inhibit apoptosis. We sought to determine whether IL-15 could enhance the in vivo function of tumor/self-reactive CD8 + T cells by using a T cell receptor transgenic mouse (pmel-1) whose CD8 + T cells recognize an epitope derived from the self/melanoma antigen gp100. By removing endogenous IL-15 by using tumor-bearing IL-15 knockout hosts or supplementing IL-15 by means of exogenous administration, as a component of culture media or as a transgene expressed by adoptively transferred T cells, we demonstrate that IL-15 can improve the in vivo antitumor activity of adoptively transferred CD8 + T cells. These results provide several avenues for improving adoptive immunotherapy of cancer in patients.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Migratory properties of naive, effector, and memory CD8(+) T cells
Weninger, W., Crowley, M. A., Manjunath, N., & von Andrian, U. H. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.7.953 · Cited by 515
Cited by
Regulatory T cells, tumour immunity and immunotherapy
Zou, W. (2006) · Nature Reviews Immunology · doi:10.1038/nri1806 · Cited by 2,085
Adoptive immunotherapy for cancer: harnessing the T cell response
Restifo, N. P., Dudley, M. E., & Rosenberg, S. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3191 · Cited by 1,688
Self-citationDudley, M. E., Wunderlich, J. R., Yang, J. C., Sherry, R. M., Topalian, S. L., Restifo, N. P., Royal, R. E., Kammula, U., White, D. E., Mavroukakis, S. A., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.00.240 · Cited by 1,639
Self-citationCytokines in clinical cancer immunotherapy
Berraondo, P., Sanmamed, M. F., Ochoa, M. C., Etxeberria, I., Aznar, M. A., Pérez-Gracia, J. L., Rodríguez-Ruiz, M. E., Ponz-Sarvise, M., Castañón, E., & Melero, I. (2019) · British Journal of Cancer · doi:10.1038/s41416-018-0328-y · Cited by 1,205
Turtle, C. J., Hanafi, L.-A., Berger, C., Hudecek, M., Pender, B., Robinson, E., Hawkins, R., Chaney, C., Cherian, S., Chen, X., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf8621 · Cited by 1,016
“Additional improvements in the cell manufacturing process might be achieved using cytokines, such as IL-7, IL-21, and/or IL-15, that have been reported to improve the growth of human T cells in vitro and enhance the therapeutic efficacy of adoptively transferred murine T cells in preclinical models (15, 19, 20).”
Background
Metadata
- Authors
- Klebanoff, C. A., Finkelstein, S. E., Surman, D. R., Lichtman, M. K., Gattinoni, L., Theoret, M. R., Grewal, N., Spiess, P. J., Antony, P. A., Palmer, D. C., Tagaya, Y., Rosenberg, S. A., Waldmann, T. A., & Restifo, N. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-02-04
- Volume
- 101
- Issue
- 7
- Pages
- 1969-1974
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2164364292
- Cited by
- 577
- References
- 3
- FWCI
- 11.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8 + T Cells. https://app.cochat.ai/papers/10.1073/pnas.0307298101
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- Klebanoff, C. A., Finkelstein, S. E., Surman, D. R., Lichtman, M. K., Gattinoni, L., Theoret, M. R., Grewal, N., Spiess, P. J., Antony, P. A., Palmer, D. C., Tagaya, Y., Rosenberg, S. A., Waldmann, T. A., & Restifo, N. P. (2004). IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8 + T Cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0307298101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
