The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Mutations arising in the wave front of an expanding population
Open accessAbstract
The ability to infer the time and place of origin of a mutation can be very useful when reconstructing the evolutionary histories of populations and species. We use forward computer simulations of population growth, migration, and mutation in an analysis of an expanding population with a wave front that advances at a constant slow rate. A pronounced founder effect can be observed among mutations arising in this wave front where extreme population bottlenecks arise and are followed by major population growth. A fraction of mutations travel with the wave front and generate mutant populations that are on average much larger than those that remain stationary. Analysis of the diffusion of these mutants makes it possible to reconstruct migratory trajectories during population expansions, thus helping us better understand observed patterns in the evolution of species such as modern humans. Examination of some historical data supports our model.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“According to the expansion hypothesis (19), as HGs spread over Europe, their NE introgression levels increased because of a combination of stochastic demographic and migratory processes related to gene dilution (20, 31, 39) and gene surfing (22, 23), which explain the spatial gradients of NE ancestry observed in HGs (Fig. 5).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [22]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
THE WAVE OF ADVANCE OF ADVANTAGEOUS GENES
Fisher, R. A. (1937) · Annals of Eugenics · doi:10.1111/j.1469-1809.1937.tb02153.x · Cited by 4,937
The History and Geography of Human Genes
Cavalli-Sforza, L. L., Menozzi, P., & Piazza, A. (2018) · Princeton University Press eBooks · doi:10.2307/j.ctv301gjp · Cited by 3,175
Self-citationRANDOM DISPERSAL IN THEORETICAL POPULATIONS
Skellam, J. G. (1951) · Biometrika · doi:10.1093/biomet/38.1-2.196 · Cited by 2,637
History and Geography of Human Genes
Piazza, A. (1994) · Advances in forensic haemogenetics · doi:10.1007/978-3-642-78782-9_1 · Cited by 1,639
Natural selection shaped regional mtDNA variation in humans
Mishmar, D., Ruiz‐Pesini, E., Golik, P., Macaulay, V. A., Clark, A. G., Hosseini, S., Brandon, M., Easley, K. A., Chen, E., Brown, M. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0136972100 · Cited by 1,040
The Neolithic Transition and the Genetics of Populations in Europe
Ammerman, A. J., & Cavalli-Sforza, L. L. (1984) · Princeton University Press eBooks · doi:10.1515/9781400853113 · Cited by 979
Self-citationThe phylogeography of Y chromosome binary haplotypes and the origins of modern human populations
Underhill, P. A., Passarino, G., Lin, A. A., Shen, P., Lahr, M. M., Foley, R., Oefner, P. J., & Cavalli-Sforza, L. L. (2001) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2001.6510043.x · Cited by 782
Self-citationThe genetics of human populations
Cavalli-Sforza, L. L. (1974) · Journal of Human Evolution · doi:10.1016/0047-2484(74)90135-3 · Cited by 724
Self-citationThe application of molecular genetic approaches to the study of human evolution
Cavalli-Sforza, L. L., & Feldman, M. W. (2003) · Nature Genetics · doi:10.1038/ng1113 · Cited by 685
Self-citationParkington, J. E., & Klein, R. B. (1989) · Cited by 558
Research works printed but not linked: 2
- Rendine, S., Piazza, A. & Cavalli-Sforza, L. L. (1986) Am. Nat. 128, 762–768.
- Vlad, M. O., Moran, F., Tsuchiya, M., Cavalli-Sforza, L. L., Oefner, P. J. & Ross, J. (2002) Phys. Rev. E. 65, 061110-1–061110-17.
Cited by
Sorted by citations
Items 301–400 of 429
Ковалев, О. В., Tyutyunov, Y. V., Arkhipova, O. E., Качалина, Н. А., Iljina, L. P., & Titova, L. I. (2015) · Entomological Review · doi:10.1134/s0013873815010017 · Cited by 6
Investigating European Genetic History through Computer Simulations
Currat, M., & Silva, N. M. (2013) · Human Heredity · doi:10.1159/000360162 · Cited by 6
Kennett, D., Timpson, A., Balding, D. J., & Thomas, M. (2018) · Genealogy · doi:10.3390/genealogy2040047 · Cited by 6
Random Activation Energy Model and Disordered Kinetics, from Static to Dynamic Disorder
Vlad, M. O., Cerofolini, G., Oefner, P. J., & Ross, J. (2005) · The Journal of Physical Chemistry B · doi:10.1021/jp051085z · Cited by 6
Peischl, S., & Excoffier, L. (2016) · Wiley eBooks · doi:10.1002/9781119072799.ch13 · Cited by 6
Genetic surfing during the range expansion of an endangered large carnivore
Tensen, L., Currat, M., Davies‐Mostert, H. T., du Plessis, C., & Fischer, K. (2023) · Biodiversity and Conservation · doi:10.1007/s10531-023-02755-z · Cited by 5
Consequences of population expansions on European genetic diversity
Currat, M. (2012) · De Gruyter eBooks · doi:10.1515/9783110266306.3 · Cited by 5
Selecting among Alternative Scenarios of Human Evolution by Simulated Genetic Gradients
Branco, C., & Arenas, M. (2018) · Genes · doi:10.3390/genes9100506 · Cited by 5
Density-Dependent Selection during Range Expansion Affects Expansion Load in Life History Traits
Urquhart‐Cronish, M., Angert, A. L., Otto, S. P., & MacPherson, A. (2023) · The American Naturalist · doi:10.1086/728599 · Cited by 5
Hydrophobicity Patterns and Biological Adaptation: An Exemplary Case from Fish Hemoglobins
Colafranceschi, M., Giuliani, A., Andersen, Ø., Brix, O., Rosa, M. C. D., Giardina, B., & Colosimo, A. (2010) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2010.0007 · Cited by 5
Range expansion shifts clonal interference patterns in evolving populationsPreprint
Krishnan, N. P., Fusco, D., & Scott, J. G. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/794867 · Cited by 5
The Ecology and Evolution of Invasive Populations
Phillips, B. L. (2025) · doi:10.1093/9780191924910.001.0001 · Cited by 4
Luo, M., Tseng, Y.-T., Chang, J., Chao, C., & Liao, P. (2022) · Plants · doi:10.3390/plants11050644 · Cited by 4
Vishwakarma, R., Sgarlata, G. M., Soriano‐Paños, D., Rasteiro, R., Maié, T., Paixão, T., Tournebize, R., & Chikhi, L. (2024) · Molecular Ecology · doi:10.1111/mec.17597 · Cited by 4
Graciá, E., Rodríguez‐Caro, R. C., Jiménez‐Franco, M. V., Sanz‐Aguilar, A., Botella, F., Anadón, J. D., García-García, Á. L., Wiegand, T., & Giménez, A. (2023) · Ecosistemas · doi:10.7818/ecos.2454 · Cited by 4
degarmo, M. (2012) · Cited by 4
Mona, S. (2016) · Heredity · doi:10.1038/hdy.2016.73 · Cited by 4
Gene flow dynamics in Baboons - The influence of social systems
Kopp, G. H. (2015) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5237 · Cited by 4
Human Population Genetics: Simulations of human colonization history
Ibrahim, K. M. (2004) · Heredity · doi:10.1038/sj.hdy.6800495 · Cited by 4
Excess of mutational jackpot events in growing populations due to gene surfingPreprint
Fusco, D., Gralka, M., Anderson, A. S., Kayser, J., & Hallatschek, O. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/053405 · Cited by 4
Ancient DNA studies of human evolution
Adler, C. J. (2012) · Adelaide Research & Scholarship (AR&S) (University of Adelaide) · Cited by 4
Mutation load dynamics during environmentally-driven range shiftsPreprint
Gilbert, K. J., Peischl, S., & Excoffier, L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/333252 · Cited by 4
The Coalescent in Boundary-Limited Range Expansions
Nullmeier, J. (2014) · doi:10.53846/goediss-4734 · Cited by 4
State-dependent evolutionary models reveal modes of solid tumor growthPreprint
Lewinsohn, M. A., Bedford, T., Müller, N. F., & Feder, A. F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.05.502978 · Cited by 4
The effect of habitat loss and fragmentation on isolation-by-distance and timePreprint
Sgarlata, G. M., Maié, T., de Zoeten, T., Rasteiro, R., & Chikhi, L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.26.513874 · Cited by 4
Stuart, K. C., Santure, A. W., & Rollins, L. A. (2025) · CABI eBooks · doi:10.1079/9781800626263.0004 · Cited by 3
Joly, S., Archambault, A., Pellerin, S., & Nault, A. (2016) · Botany · doi:10.1139/cjb-2016-0144 · Cited by 3
Population Genetics and Genomics of Aleppo Pine (Pinus halepensis)
Vendramin, G. G., Avanzi, C., González‐Martínez, S. C., & Grivet, D. (2021) · Managing forest ecosystems · doi:10.1007/978-3-030-63625-8_2 · Cited by 3
Sarre, S. D., Adamack, A. T., Hitchen, Y., Soulsbury, C. D., Gruber, B., & Berry, O. (2024) · Ecology and Evolution · doi:10.1002/ece3.11212 · Cited by 2
Agostini, R. B., Vizzari, M. T., Benazzo, A., & Ghirotto, S. (2024) · Heredity · doi:10.1038/s41437-024-00735-9 · Cited by 3
Borinskaya, S. A., & Yankovsky, N. K. (2015) · Russian Journal of Genetics · doi:10.1134/s1022795415040031 · Cited by 3
Dai, Q., Zhan, X., Lu, B., Fu, J., Wang, Q., & Qi, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085778 · Cited by 3
Population genomic analyses support sympatric origins of parapatric morphs in a salamander
Buckingham, E., Streicher, J. W., Fisher‐Reid, M. C., Ježková, T., & Wiens, J. J. (2022) · Ecology and Evolution · doi:10.1002/ece3.9537 · Cited by 3
Hybridization and Evolution in the Genus Pinus
Wang, B. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 3
Strong neutral sweeps occurring during a population contractionPreprint
Moinet, A., Peischl, S., & Excoffier, L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.25.457712 · Cited by 3
Bernos, T. A., Day, C. C., Hill, J. M., Morissette, O., Jeffries, K. M., & Mandrak, N. E. (2023) · Molecular Ecology · doi:10.1111/mec.16964 · Cited by 2
Evolution of Functional Genomic Diversity During a Bottleneck
Schlichta, F., Peischl, S., & Excoffier, L. (2025) · Genome Biology and Evolution · doi:10.1093/gbe/evaf107 · Cited by 2
Genetic consequences of gene surfing and their relationship to fitness
Holtz, S., Hudson, A. I., Tittes, S. B., & Weiss‐Lehman, C. (2025) · Evolution · doi:10.1093/evolut/qpaf148 · Cited by 2
Doublet, V., Roques, L., Klein, E. K., Lefèvre, F., & Boivin, T. (2023) · Journal of Mathematical Biology · doi:10.1007/s00285-023-01981-x · Cited by 2
Once upon a time in Mexico: Holocene biogeography of the spotted bat (Euderma maculatum)
Sanchez, D. E., Walker, F. M., Sobek, C., Lausen, C., & Chambers, C. L. (2023) · PLoS ONE · doi:10.1371/journal.pone.0274342 · Cited by 1
Inside Dynamics of Integrodifference Equations with Mutations
Marculis, N. G., & Lewis, M. A. (2020) · Bulletin of Mathematical Biology · doi:10.1007/s11538-019-00683-0 · Cited by 2
Bors, E. K., Carlton, J. T., & Shank, T. M. (2019) · Marine Biology · doi:10.1007/s00227-019-3514-4 · Cited by 2
Evolution of colony characteristics in the harvester ant genus Pogonomyrmex
Strehl, C.-P. (2005) · Online Publication Service of Würzburg University (Würzburg University) · doi:10.13140/rg.2.1.3021.4809 · Cited by 2
Range expansion can promote the evolution of plastic generalism in coarse-grained landscapes
Miller, C. M., & Draghi, J. A. (2023) · Evolution Letters · doi:10.1093/evlett/qrad062 · Cited by 1
Fluid-derived lattices for unbiased modeling of bacterial colony growth
Verhoef, B., Hermsen, R., & de Graaf, J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0330491 · Cited by 1
The legacy of Luca Cavalli-Sforza on human evolution
Colucci, M., Leonardi, M., Hodgson, J. A., Stringer, C. B., & Scerri, E. M. L. (2025) · Human Population Genetics and Genomics · doi:10.47248/hpgg2505010001 · Cited by 1
Nuñez, J. G., & Beller, D. A. (2025) · Journal of The Royal Society Interface · doi:10.1098/rsif.2024.0698 · Cited by 1
Coalescent theory of the ψ directionality index
Lappo, E., & Rosenberg, N. A. (2025) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkaf202 · Cited by 1
Chikhi, L., Racine, J., Tournebize, R., & Pocheville, A. (2026) · Evolutionary Biology/Evolutionary biology · doi:10.1007/978-3-032-13925-2_10 · Cited by 1
A microbial therapy-mimicry assay shows how spatial resource dynamics control resistance escape
Appold, N., Citak, T., Palm, A., & Kayser, J. (2026) · Nature Ecology & Evolution · doi:10.1038/s41559-026-03178-z · Cited by 1
Luca Cavalli-Sforza, 100 years after his birth
Chikhi, L., & Barbujani, G. (2021) · Human Population Genetics and Genomics · doi:10.47248/hpgg2101010001 · Cited by 1
The influence of explicit local dynamics on range expansions driven by long-range dispersal
Villiger, N., & Paulose, J. (2023) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkad066 · Cited by 1
The Evolution of Lactose Tolerance in Dairying Populations
Gerbault, P., Walker, C., Yonova‐Doing, E., Brown, K., & Thomas, M. (2017) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199694013.013.12 · Cited by 1
L. Luca Cavalli-Sforza: A Renaissance Scientist
Feldman, M. W. (2020) · Theoretical Population Biology · doi:10.1016/j.tpb.2019.11.009 · Cited by 1
Simulations of Human Dispersal and Genetic Diversity
Currat, M., Quilodrán, C. S., & Excoffier, L. (2021) · Evolutionary studies · doi:10.1007/978-4-431-56904-6_12 · Cited by 1
Nonadaptive Genetic Change in Human and Primate Evolution
Meyer, D., & Harris, E. E. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0024607 · Cited by 1
Silverman, B. D. (2007) · Ecological Modelling · doi:10.1016/j.ecolmodel.2006.11.027 · Cited by 1
Blackburn, G. S. (2013) · cIRcle (University of British Columbia) · doi:10.14288/1.0073951 · Cited by 1
Calvin, W. H. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/053819 · Cited by 1
Spatial Structure in Extinction and Range Expansion: Models and Experiments
Weiss‐Lehman, C. (2017) · CU Scholar (University of Colorado Boulder) · Cited by 1
Genealogies in Growing Solid TumorsPreprint
Durrett, D. U. R. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/244160 · Cited by 1
Blanco‐Pastor, J. L., Manel, S., Barré, P., Roschanski, A. M., Willner, E., Dehmer, K. J., Hegarty, M., Muylle, H., Ruttink, T., Roldán-Ruíz, I., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/414227 · Cited by 1
Evolution of populations expanding on curved surfacesPreprint
Beller, D. A., Alards, K. M. J., Tesser, F., Mosna, R. A., Toschi, F., & Möbius, W. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/406280 · Cited by 1
Population genomics on the origin of lactase persistence in Europe and South AsiaPreprint
Satta, Y., & Takahata, N. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.30.179432 · Cited by 1
A non-adaptive demographic mechanism for genome expansion in StreptomycesPreprint
Choudoir, M. J., Järvenpää, M. J., Marttinen, P., & Buckley, D. H. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.09.426074 · Cited by 2
Nuñez, J. G., & Beller, D. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.07.614155 · Cited by 1
An Accurate Genetic ClockPreprint
Hamilton, D. (2015) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/026286
range margins due to mutation surfing.
Burton, O. J., & Travis, J. M. J. (2008)
Inférer les capacités de dispersion et de migration : de l'échelle locale à l'échelle globale -
Klein, E. K., Bontemps, A., Amm, A., Pichot, C., & Oddou‐Muratorio, S. (2011) · DSpace (Centre National De La Recherche Scientifique)
Inferences about the capacity to disperse and migrate : from a local scale to the wider landscape -
Klein, E. K., Oddou‐Muratorio, S., Pichot, C., Bontemps, A., & Amm, A. (2011) · DSpace (Centre National De La Recherche Scientifique)
Inference From Two Non-Equilibrium Models In Population Genetics
Peter, B. M. (2014) · eScholarship (California Digital Library)
Assessing natural selection during range expansions: Insights from a spatially explicit ABC studyPreprint
Kanitz, R., Neuenschwander, S., & Goudet, J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/391110
Godbout, J. (2011) · Corpus Université Laval (Université Laval)
On the accumulation of deleterious mutations during range expansionsPreprint
Peischl, S., Dupanloup, I., Kirkpatrick, M., & Excoffier, L. (2013) · arXiv (Cornell University) · doi:10.48550/arxiv.1306.1652
From sectors to speckles: The impact of long-range migration on gene surfingPreprint
Paulose, J., & Hallatschek, O. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/803189
Integrodifference models for neutral genetic patterns and trade-offs in ecology
Marculis, N. G. (2019) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-n7m7-hv77
Coalescent Models of Demographic History: Application to Plant Domestication
François, O., Cubry, P., Burgarella, C., & Vigouroux, Y. (2020) · Population genomics · doi:10.1007/13836_2020_74
The population genomics of invasive speciesPreprint
North, H. L., McGaughran, A., & Jiggins, C. D. (2021) · doi:10.22541/au.160968166.65928724/v1
Demographic Inferences and Loci Under Selection in a Recently Expanded Coral PopulationPreprint
Fifer, J. E., Yasuda, N., Yamakita, T., & Davies, S. W. (2021) · SSRN Electronic Journal · doi:10.1101/2021.06.17.448885 · Cited by 1
Dai, Q., Zhan, X., Lu, B., Fu, J., Wang, Q., & Qi, D. (2014) · PLoS ONE · doi:10.1371/annotation/92a1ff96-eb6f-45f8-bc66-09c08e0dbeeb
An Indexed Bibliography of Genetic Algorithms Theory and Comparisons
Alander, J. T., & Vose, M. D. (2008)
AN ACCURATE GENETIC CLOCKPreprint
Hamilton, D. (2015) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/019414
Once upon a time in Mexico: Holocene phylogeography of the spotted bat (Euderma maculatum)Preprint
Sanchez, D. E., Walker, F. M., Sobek, C., Lausen, C., & Chambers, C. L. (2022) · bioRxiv · doi:10.1101/2022.08.26.505484
A mechanistic-statistical approach for the field-based study of invasion dynamics
Kishino, H. (2023) · Peer Community In Mathematical and Computational Biology · doi:10.24072/pci.mcb.100191
Metadata
- Authors
- Edmonds, C. A., Lillie, A. S., & Cavalli-Sforza, L. L.
- Affiliations
- Stanford Medicine (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-01-19
- Volume
- 101
- Issue
- 4
- Pages
- 975-979
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC327127
- OpenAlex
- W2051334294
- Cited by
- 429
- References
- 12
- Citations by year
- 2026: 6 · 2025: 24 · 2024: 13 · 2023: 19 · 2022: 17 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 38 · 2017: 21 · 2016: 29 · 2015: 22 · 2014: 22 · 2013: 24 · 2012: 27
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (28428)
- National Institute of General Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- mutation origin, founder effect, population growth, wavefronts, population bottleneck, migration, migratory trajectories, human evolution, population genetics, forward modeling
- MeSH terms
- Biological Evolution, Mutation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
